{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T11:28:48Z","timestamp":1777721328966,"version":"3.51.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"6467","license":[{"start":{"date-parts":[[1994,3,1]],"date-time":"1994-03-01T00:00:00Z","timestamp":762480000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1994,3]]},"DOI":"10.1038\/368113a0","type":"journal-article","created":{"date-parts":[[2003,6,12]],"date-time":"2003-06-12T23:51:13Z","timestamp":1055461873000},"page":"113-119","source":"Crossref","is-referenced-by-count":1634,"title":["Single myosin molecule mechanics: piconewton forces and nanometre steps"],"prefix":"10.1038","volume":"368","author":[{"given":"Jeffrey T.","family":"Finer","sequence":"first","affiliation":[]},{"given":"Robert M.","family":"Simmons","sequence":"additional","affiliation":[]},{"given":"James A.","family":"Spudich","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF368113a0_CR1","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1038\/2071276a0","volume":"207","author":"MK Reedy","year":"1965","unstructured":"Reedy, M. K., Holmes, K. C. & Tregear, R. T. Nature 207, 1276\u20131280 (1965).","journal-title":"Nature"},{"key":"BF368113a0_CR2","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1126\/science.164.3886.1356","volume":"164","author":"HE Huxley","year":"1969","unstructured":"Huxley, H. E. Science 164, 1356\u20131366 (1969).","journal-title":"Science"},{"key":"BF368113a0_CR3","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1126\/science.8316857","volume":"261","author":"I Rayment","year":"1993","unstructured":"Rayment, I. et al. Science 261, 50\u201358 (1993).","journal-title":"Science"},{"key":"BF368113a0_CR4","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/233533a0","volume":"233","author":"AF Huxley","year":"1971","unstructured":"Huxley, A. F. & Simmons, R. M. Nature 233, 533\u2013538 (1971).","journal-title":"Nature"},{"key":"BF368113a0_CR5","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1113\/jphysiol.1977.sp011911","volume":"269","author":"LE Ford","year":"1977","unstructured":"Ford, L. E., Huxley, A. F. & Simmons, R. M. J. Physiol. 269, 441\u2013515 (1977).","journal-title":"J. Physiol."},{"key":"BF368113a0_CR6","doi-asserted-by":"publisher","first-page":"7130","DOI":"10.1073\/pnas.87.18.7130","volume":"87","author":"YY Toyoshima","year":"1990","unstructured":"Toyoshima, Y. Y., Kron, S. J. & Spudich, J. A. Proc. natn. Acad. Sci. U.S.A. 87, 7130\u20137134 (1990).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF368113a0_CR7","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/0022-2836(90)90287-V","volume":"214","author":"TQP Uyeda","year":"1990","unstructured":"Uyeda, T. Q. P., Kron, S. J. & Spudich, J. A. J. molec. Biol. 214, 699\u2013710 (1990).","journal-title":"J. molec. Biol."},{"key":"BF368113a0_CR8","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/352307a0","volume":"352","author":"TQP Uyeda","year":"1991","unstructured":"Uyeda, T. Q. P., Warrick, H. M., Kron, S. J. & Spudich, J. A. Nature 352, 307\u2013311 (1991).","journal-title":"Nature"},{"key":"BF368113a0_CR9","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1002\/cm.970100112","volume":"10","author":"Y Harada","year":"1988","unstructured":"Harada, Y. & Yanagida, T. Cell Motil. Cytoskel. 10, 71\u201376 (1988).","journal-title":"Cell Motil. Cytoskel."},{"key":"BF368113a0_CR10","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S0022-2836(05)80060-9","volume":"216","author":"Y Harada","year":"1990","unstructured":"Harada, Y., Sakurada, K., Aoki, T., Thomas, D. D. & Yanagida, T. J. molec. Biol. 216, 49\u201368 (1990).","journal-title":"J. molec. Biol."},{"key":"BF368113a0_CR11","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/316366a0","volume":"316","author":"T Yanagida","year":"1985","unstructured":"Yanagida, T., Arata, T. & Oosawa, F. Nature 316, 366\u2013369 (1985).","journal-title":"Nature"},{"key":"BF368113a0_CR12","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/352352a0","volume":"352","author":"H Higuchi","year":"1991","unstructured":"Higuchi, H. & Goldman, Y. E. Nature 352, 352\u2013354 (1991).","journal-title":"Nature"},{"key":"BF368113a0_CR13","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/352301a0","volume":"352","author":"A Ishijima","year":"1991","unstructured":"Ishijima, A., Doi, T., Sakurada, K. & Yanagida, T. Nature 352, 301\u2013306 (1991).","journal-title":"Nature"},{"key":"BF368113a0_CR14","doi-asserted-by":"publisher","first-page":"10490","DOI":"10.1073\/pnas.88.23.10490","volume":"88","author":"B Brenner","year":"1991","unstructured":"Brenner, B. Proc. natn. Acad. Sci. U.S.A. 88, 10490\u201310494 (1991).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF368113a0_CR15","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/355638a0","volume":"355","author":"V Lombardi","year":"1992","unstructured":"Lombardi, V., Piazzesi, G. & Linari, M. Nature 355, 638\u2013641 (1992).","journal-title":"Nature"},{"key":"BF368113a0_CR16","first-page":"55p","volume":"269","author":"YE Goldman","year":"1977","unstructured":"Goldman, Y. E. & Simmons, R. M. J. Physiol. 269, 55p\u201357p (1977).","journal-title":"J. Physiol."},{"key":"BF368113a0_CR17","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/BF00713057","volume":"6","author":"HE Huxley","year":"1985","unstructured":"Huxley, H. E. & Kress, M. J. Muscle Res. Cell Motil. 6, 153\u2013161 (1985).","journal-title":"J. Muscle Res. Cell Motil."},{"key":"BF368113a0_CR18","doi-asserted-by":"publisher","first-page":"3812","DOI":"10.1021\/bi00065a038","volume":"32","author":"CL Berger","year":"1993","unstructured":"Berger, C. L. & Thomas, D. D. Biochemistry 32, 3812\u20133821 (1993).","journal-title":"Biochemistry"},{"key":"BF368113a0_CR19","doi-asserted-by":"publisher","first-page":"5538","DOI":"10.1073\/pnas.87.14.5538","volume":"87","author":"PG Fajer","year":"1990","unstructured":"Fajer, P. G., Fajer, E. A. & Thomas, D. D. Proc. natn. Acad. Sci. U.S.A. 87, 5538\u20135542 (1990).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF368113a0_CR20","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/342154a0","volume":"342","author":"J Howard","year":"1989","unstructured":"Howard, J., Hudspeth, A. J. & Vale, R. D. Nature 342, 154\u2013158 (1989).","journal-title":"Nature"},{"key":"BF368113a0_CR21","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/334074a0","volume":"334","author":"A Kishino","year":"1988","unstructured":"Kishino, A. & Yanagida, T. Nature 334, 74\u201376 (1988).","journal-title":"Nature"},{"key":"BF368113a0_CR22","volume-title":"Mechanism of Myofilament Sliding in Muscle","author":"RM Simmons","year":"1993","unstructured":"Simmons, R. M. et al. in Mechanism of Myofilament Sliding in Muscle (eds Sugi, H. & Pollack, G. H. J.) (Plenum, New York and London, 1993)."},{"key":"BF368113a0_CR23","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/348348a0","volume":"348","author":"SM Block","year":"1990","unstructured":"Block, S. M., Goldstein, L. S. B. & Schnapp, B. J. Nature 348, 348\u2013352 (1990).","journal-title":"Nature"},{"key":"BF368113a0_CR24","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1126\/science.8469975","volume":"260","author":"SC Kuo","year":"1993","unstructured":"Kuo, S. C. & Sheetz, M. P. Science 260, 232\u2013234 (1993).","journal-title":"Science"},{"key":"BF368113a0_CR25","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/365721a0","volume":"365","author":"K Svoboda","year":"1993","unstructured":"Svoboda, K., Schmidt, C. F., Schnapp, B. J. & Block, S. M. Nature 365, 721\u2013727 (1993).","journal-title":"Nature"},{"key":"BF368113a0_CR26","unstructured":"Simmons, R. M., Finer, J. T., Chu, S. & Spudich, J. A. Biophys. J. (submitted)."},{"key":"BF368113a0_CR27","doi-asserted-by":"publisher","first-page":"6272","DOI":"10.1073\/pnas.83.17.6272","volume":"83","author":"SJ Kron","year":"1986","unstructured":"Kron, S. J. & Spudich, J. A. Proc. natn. Acad. Sci. U.S.A. 83, 6272\u20136276 (1986).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF368113a0_CR28","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3109\/10409237909102562","volume":"6","author":"EW Taylor","year":"1979","unstructured":"Taylor, E. W. Crit. Rev. Biochem. 6, 103\u2013164 (1979).","journal-title":"Crit. Rev. Biochem."},{"key":"BF368113a0_CR29","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3109\/10409238609113609","volume":"21","author":"R Cooke","year":"1986","unstructured":"Cooke, R. Crit. Rev. Biochem. 21, 53\u2013118 (1986).","journal-title":"Crit. Rev. Biochem."},{"key":"BF368113a0_CR30","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1126\/science.2377894","volume":"249","author":"JR Sellers","year":"1990","unstructured":"Sellers, J. R. & Kachar, B. Science 249, 406\u2013408 (1990).","journal-title":"Science"},{"key":"BF368113a0_CR31","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1093\/oxfordjournals.jbchem.a123203","volume":"108","author":"A Yamada","year":"1990","unstructured":"Yamada, A., Ishii, N. & Takahashi, K. J. Biochem. 108, 341\u2013343 (1990).","journal-title":"J. Biochem."},{"key":"BF368113a0_CR32","doi-asserted-by":"publisher","first-page":"5818","DOI":"10.1021\/bi00671a020","volume":"15","author":"HD White","year":"1976","unstructured":"White, H. D. & Taylor, E. W. Biochemistry 15, 5818\u20135826 (1976).","journal-title":"Biochemistry"},{"key":"BF368113a0_CR33","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1113\/jphysiol.1984.sp015394","volume":"354","author":"YE Goldman","year":"1984","unstructured":"Goldman, Y. E., Hibberd, M. G. & Trentham, D. R. J. Physiol. 354, 577\u2013604 (1984).","journal-title":"J. Physiol."},{"key":"BF368113a0_CR34","first-page":"225","volume":"7","author":"AF Huxley","year":"1957","unstructured":"Huxley, A. F. Prog. Biophys. 7, 225\u2013318 (1957).","journal-title":"Prog. Biophys."},{"key":"BF368113a0_CR35","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0021-9258(18)52434-0","volume":"266","author":"EW Taylor","year":"1991","unstructured":"Taylor, E. W. J. biol. Chem. 266, 294\u2013302 (1991).","journal-title":"J. biol. Chem."},{"key":"BF368113a0_CR36","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1113\/jphysiol.1991.sp018774","volume":"441","author":"B Brenner","year":"1991","unstructured":"Brenner, B. & Yu, L. C. J. Physiol. 441, 703\u2013718 (1991).","journal-title":"J. Physiol."},{"key":"BF368113a0_CR37","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1007\/978-94-015-6839-5","volume-title":"Muscle Contraction.","author":"CR Bagshaw","year":"1993","unstructured":"Bagshaw, C. R. Muscle Contraction. 98 (Chapman & Hall, London, 1993)."},{"key":"BF368113a0_CR38","first-page":"103","volume-title":"Energetic Aspects of Muscle Contraction","author":"RC Woledge","year":"1985","unstructured":"Woledge, R. C., Curtin, N. A. & Homsher, E. Energetic Aspects of Muscle Contraction, 103 (Academic, London, 1985)."},{"key":"BF368113a0_CR39","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/0022-2836(73)90222-2","volume":"77","author":"JC Haselgrove","year":"1973","unstructured":"Haselgrove, J. C. & Huxley, H. E. J. molec. Biol. 77, 549\u2013568 (1973).","journal-title":"J. molec. Biol."},{"key":"BF368113a0_CR40","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0076-6879(82)85009-X","volume":"85","author":"SS Margossian","year":"1982","unstructured":"Margossian, S. S. & Lowey, S. Meth. Enzym. 85, 55\u201371 (1982).","journal-title":"Meth. Enzym."},{"key":"BF368113a0_CR41","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/328536a0","volume":"328","author":"YY Toyoshima","year":"1987","unstructured":"Toyoshima, Y. Y. et al. Nature 328, 536\u2013539 (1987).","journal-title":"Nature"},{"key":"BF368113a0_CR42","first-page":"1","volume-title":"Methods in Cell Biology","author":"HM Warrick","year":"1993","unstructured":"Warrick, H. M. et al. in Methods in Cell Biology (eds Scholey, J. M.) 1\u201321 (Academic, San Diego, 1993)."},{"key":"BF368113a0_CR43","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/0301-4622(78)80014-3","volume":"8","author":"S Yoshino","year":"1978","unstructured":"Yoshino, S., Umazume, Y., Natori, R., Fujime, S. & Chiba, S. Biophys. Chem. 8, 317\u2013326 (1978).","journal-title":"Biophys. Chem."},{"key":"BF368113a0_CR44","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1113\/jphysiol.1981.sp013582","volume":"311","author":"LE Ford","year":"1981","unstructured":"Ford, L. E., Huxley, A. F. & Simmons, R. M. J. Physiol. 311, 219\u2013249 (1981).","journal-title":"J. Physiol."},{"key":"BF368113a0_CR45","unstructured":"Svoboda, K. & Block, S. M. A. Rev. Biophys. biomol. Str. (in the press)."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/368113a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/368113a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/368113a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T03:01:03Z","timestamp":1684292463000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/368113a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,3]]},"references-count":45,"journal-issue":{"issue":"6467","published-print":{"date-parts":[[1994,3]]}},"alternative-id":["BF368113a0"],"URL":"https:\/\/doi.org\/10.1038\/368113a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,3]]}}}