{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:57:22Z","timestamp":1791194242358,"version":"4.1.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"6468","license":[{"start":{"date-parts":[[1994,3,1]],"date-time":"1994-03-01T00:00:00Z","timestamp":762480000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1994,3]]},"DOI":"10.1038\/368246a0","type":"journal-article","created":{"date-parts":[[2003,6,12]],"date-time":"2003-06-12T19:44:15Z","timestamp":1055447055000},"page":"246-249","source":"Crossref","is-referenced-by-count":843,"title":["Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk\/NGF receptor gene"],"prefix":"10.1038","volume":"368","author":[{"given":"Richard J.","family":"Smeyne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcdiger","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schnapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda K.","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherri","family":"Bryant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Lewin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio A.","family":"Lira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Barbacid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF368246a0_CR1","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1002\/j.1460-2075.1987.tb02347.x","volume":"6","author":"R Levi-Montalcini","year":"1987","unstructured":"Levi-Montalcini, R. EMBO J. 6, 1145\u20131154 (1987).","journal-title":"EMBO J."},{"key":"BF368246a0_CR2","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/0968-0004(93)90052-O","volume":"18","author":"RA Bradshaw","year":"1993","unstructured":"Bradshaw, R. A., Blundell, R. L., Lapato, R., McDonald, N. Q. & Murray-Rust, J. Trends biochem. Sci. 18, 48\u201352 (1993).","journal-title":"Trends biochem. Sci."},{"key":"BF368246a0_CR3","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/0165-6147(89)90166-1","volume":"10","author":"CF Dreyfus","year":"1989","unstructured":"Dreyfus, C. F. Trends pharmac. Sci. 10, 145\u2013149 (1989).","journal-title":"Trends pharmac. Sci."},{"key":"BF368246a0_CR4","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/0166-2236(92)90047-C","volume":"15","author":"SO Meakin","year":"1992","unstructured":"Meakin, S. O. & Shooter, E. M. Trends Neurosci. 15, 323\u2013331 (1992).","journal-title":"Trends Neurosci."},{"key":"BF368246a0_CR5","first-page":"2033","volume":"8","author":"M Barbacid","year":"1993","unstructured":"Barbacid, M. Oncogene 8, 2033\u20132042 (1993).","journal-title":"Oncogene"},{"key":"BF368246a0_CR6","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0092-8674(05)80088-1","volume":"75","author":"R Klein","year":"1993","unstructured":"Klein, R. et al. Cell 75, 113\u2013122 (1993).","journal-title":"Cell"},{"key":"BF368246a0_CR7","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1101\/gad.4.5.683","volume":"4","author":"D Martin-Zanca","year":"1990","unstructured":"Martin-Zanca, D., Barbacid, M. & Parada, L. Genes Dev. 4, 683\u2013694 (1990).","journal-title":"Genes Dev."},{"key":"BF368246a0_CR8","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1242\/dev.118.2.463","volume":"118","author":"L Tessarollo","year":"1993","unstructured":"Tessarollo, L. et al. Development 118, 463\u2013475 (1993).","journal-title":"Development"},{"key":"BF368246a0_CR9","doi-asserted-by":"publisher","first-page":"4029","DOI":"10.1523\/JNEUROSCI.13-09-04029.1993","volume":"13","author":"X Mu","year":"1993","unstructured":"Mu, X., Silos-Santiago, I., Carroll, S. L. & Snider, W. D. J. Neurosci. 13, 4029\u20134041 (1993).","journal-title":"J. Neurosci."},{"key":"BF368246a0_CR10","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/0896-6273(92)90184-F","volume":"9","author":"DM Holtzman","year":"1992","unstructured":"Holtzman, D. M. et al. Neuron 9, 465\u2013478 (1992).","journal-title":"Neuron"},{"key":"BF368246a0_CR11","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/0006-8993(93)91681-H","volume":"612","author":"TL Steininger","year":"1993","unstructured":"Steininger, T. L., Wainer, B. H., Klein, R., Barbacid, M. & Palfrey, H. C. Brain Res. 612, 330\u2013335 (1993).","journal-title":"Brain Res."},{"key":"BF368246a0_CR12","volume-title":"Handbook of Chemical Neuroanatomy","author":"LL Butcher","year":"1984","unstructured":"Butcher, L. L. & Woolf, N. J. in Handbook of Chemical Neuroanatomy Vol. II (eds Bjorkland, A., Hokfelt, T. & Kuhar, M. J.) (Elsevier, Amsterdam, 1984)."},{"key":"BF368246a0_CR13","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/0896-6273(93)90069-4","volume":"11","author":"AM Davies","year":"1993","unstructured":"Davies, A. M., Lee, K.-F. & Jaenisch, R. Neuron 11, 565\u2013574 (1993).","journal-title":"Neuron"},{"key":"BF368246a0_CR14","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1126\/science.7192014","volume":"210","author":"EM Johnson Jr","year":"1980","unstructured":"Johnson, E. M. Jr, Gorin, P. D., Brandeis, L. D. & Pearson, J. Science 210, 916\u2013918 (1980).","journal-title":"Science"},{"key":"BF368246a0_CR15","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/0896-6273(92)90284-K","volume":"8","author":"KG Ruit","year":"1992","unstructured":"Ruit, K. G., Elliott, J. L., Osborn, P. A., Yan, Q. & Snider, W. D. Neuron 8, 573\u2013587 (1992).","journal-title":"Neuron"},{"key":"BF368246a0_CR16","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/0092-8674(92)90286-L","volume":"69","author":"KF Lee","year":"1992","unstructured":"Lee, K. F. et al. Cell 69, 737\u2013749 (1992).","journal-title":"Cell"},{"key":"BF368246a0_CR17","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/368249a0","volume":"368","author":"R Klein","year":"1994","unstructured":"Klein, R. et al. Nature 368, 249\u2013251 (1994).","journal-title":"Nature"},{"key":"BF368246a0_CR18","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1128\/MCB.9.1.24","volume":"9","author":"D Martin-Zanca","year":"1989","unstructured":"Martin-Zanca, D., Oskam, R., Mira, G., Copeland, T. & Barbacid, M. Molec. cell. Biol. 9, 24\u201333 (1989).","journal-title":"Molec. cell. Biol."},{"key":"BF368246a0_CR19","doi-asserted-by":"publisher","first-page":"5755","DOI":"10.1093\/nar\/19.20.5755","volume":"20","author":"MW McBurney","year":"1991","unstructured":"McBurney, M. W. et al. Nucleic Acids Res. 20, 5755\u20135761 (1991).","journal-title":"Nucleic Acids Res."},{"key":"BF368246a0_CR20","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/336348a0","volume":"336","author":"SL Mansour","year":"1988","unstructured":"Mansour, S. L., Thomas, K. R. & Capecchi, M. R. Nature 336, 348\u2013352 (1988).","journal-title":"Nature"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/368246a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/368246a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/368246a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T23:01:54Z","timestamp":1684278114000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/368246a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,3]]},"references-count":20,"journal-issue":{"issue":"6468","published-print":{"date-parts":[[1994,3]]}},"alternative-id":["BF368246a0"],"URL":"https:\/\/doi.org\/10.1038\/368246a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,3]]}}}