{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:54:49Z","timestamp":1779342889344,"version":"3.51.4"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"6490","license":[{"start":{"date-parts":[[1994,8,1]],"date-time":"1994-08-01T00:00:00Z","timestamp":775699200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1994,8]]},"DOI":"10.1038\/370533a0","type":"journal-article","created":{"date-parts":[[2003,8,12]],"date-time":"2003-08-12T01:13:54Z","timestamp":1060650834000},"page":"533-539","source":"Crossref","is-referenced-by-count":500,"title":["Structure of ribonucleotide reductase protein R1"],"prefix":"10.1038","volume":"370","author":[{"given":"Ulla","family":"Uhlin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Eklund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF370533a0_CR1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/0968-0004(92)90249-9","volume":"17","author":"SJ Elledge","year":"1992","unstructured":"Elledge, S. J., Zhou, Z. & Allen, J. B. Trends biochem. Sci. 17, 119\u2013123 (1992).","journal-title":"Trends biochem. Sci."},{"key":"BF370533a0_CR2","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1128\/jb.172.4.1711-1718.1990","volume":"172","author":"CK Tuggle","year":"1990","unstructured":"Tuggle, C. K. & Fuchs, J. A. J. Bact. 172, 1711\u20131718 (1990).","journal-title":"J. Bact."},{"key":"BF370533a0_CR3","doi-asserted-by":"publisher","first-page":"5452","DOI":"10.1021\/bi00475a007","volume":"29","author":"S Bj\u00f6rklund","year":"1990","unstructured":"Bj\u00f6rklund, S., Skog, S., Tribukait, B. & Thelander, L. Biochemistry 29, 5452\u20135458 (1990).","journal-title":"Biochemistry"},{"key":"BF370533a0_CR4","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1126\/science.8511586","volume":"260","author":"P Reichard","year":"1993","unstructured":"Reichard, P. Science 260, 1773\u20131777 (1993).","journal-title":"Science"},{"key":"BF370533a0_CR5","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1126\/science.6306767","volume":"221","author":"P Reichard","year":"1983","unstructured":"Reichard, P. & Ehrenberg, A. Science 221, 514\u2013519 (1983).","journal-title":"Science"},{"key":"BF370533a0_CR6","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/345593a0","volume":"345","author":"P Nordlund","year":"1990","unstructured":"Nordlund, P., Sj\u00f6berg, B.-M. & Eklund, H. Nature 345, 593\u2013598 (1990).","journal-title":"Nature"},{"key":"BF370533a0_CR7","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1006\/jmbi.1993.1374","volume":"232","author":"P Nordlund","year":"1993","unstructured":"Nordlund, P. & Eklund, H. J. molec. Biol. 232, 123\u2013164 (1993).","journal-title":"J. molec. Biol."},{"key":"BF370533a0_CR8","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/S0021-9258(17)33753-5","volume":"251","author":"L Thelander","year":"1976","unstructured":"Thelander, L., Larsson, B., Hobbs, J. & Eckstein, F. J. biol. Chem. 251, 1398\u20131405 (1976).","journal-title":"J. biol. Chem."},{"key":"BF370533a0_CR9","doi-asserted-by":"publisher","first-page":"9733","DOI":"10.1021\/bi00155a029","volume":"31","author":"SS Mao","year":"1992","unstructured":"Mao, S. S. et al. Biochemistry 31, 9733\u20139743 (1992).","journal-title":"Biochemistry"},{"key":"BF370533a0_CR10","doi-asserted-by":"publisher","first-page":"9744","DOI":"10.1021\/bi00155a030","volume":"31","author":"SS Mao","year":"1992","unstructured":"Mao, S. S. et al. Biochemistry 31, 9744\u20139751 (1992).","journal-title":"Biochemistry"},{"key":"BF370533a0_CR11","doi-asserted-by":"publisher","first-page":"9752","DOI":"10.1021\/bi00155a031","volume":"31","author":"SS Mao","year":"1992","unstructured":"Mao, S. S., Yu, G. X., Chalfoun, D. & Stubbe, J. Biochemistry 31, 9752\u20139759 (1992).","journal-title":"Biochemistry"},{"key":"BF370533a0_CR12","doi-asserted-by":"crossref","first-page":"13463","DOI":"10.1016\/S0021-9258(18)71625-6","volume":"264","author":"A Holmgren","year":"1989","unstructured":"Holmgren, A. J. biol. Chem. 264, 13463\u201313460 (1989).","journal-title":"J. biol. Chem."},{"key":"BF370533a0_CR13","doi-asserted-by":"publisher","first-page":"3005","DOI":"10.1021\/jm00072a021","volume":"36","author":"N Moss","year":"1993","unstructured":"Moss, N. et al. J. med. Chem. 36, 3005\u20133009 (1993).","journal-title":"J. med. Chem."},{"key":"BF370533a0_CR14","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/321441a0","volume":"321","author":"EA Cohen","year":"1986","unstructured":"Cohen, E. A., Gaudreau, P., Brazeau, P. & Langlier, Y. Nature 321, 441\u2013443 (1986).","journal-title":"Nature"},{"key":"BF370533a0_CR15","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/321439a0","volume":"321","author":"BM Dutia","year":"1986","unstructured":"Dutia, B. M., Frame, M. C., Subak-Sharpe, J. H., Clark, W. N. & Marsden, H. S. Nature 321, 439\u2013441 (1986).","journal-title":"Nature"},{"key":"BF370533a0_CR16","doi-asserted-by":"publisher","first-page":"5164","DOI":"10.1021\/bi00235a008","volume":"30","author":"I Climent","year":"1991","unstructured":"Climent, I., Sj\u00f6berg, B.-M. & Huang, C. Y. Biochemistry 30, 5164\u20135171 (1991).","journal-title":"Biochemistry"},{"key":"BF370533a0_CR17","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/0014-5793(93)81629-E","volume":"336","author":"U Uhlin","year":"1993","unstructured":"Uhlin, U., Uhlin, T. & Eklund, H. FEBS Lett. 336, 148\u2013152 (1993).","journal-title":"FEBS Lett."},{"key":"BF370533a0_CR18","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1107\/S0108767389012158","volume":"A46","author":"KYJ Zhang","year":"1990","unstructured":"Zhang, K. Y. J. & Main, P. Acta crystallogr. A46, 377\u2013381 (1990).","journal-title":"Acta crystallogr."},{"key":"BF370533a0_CR19","first-page":"91","volume-title":"Molecular Replacement","author":"TA Jones","year":"1992","unstructured":"Jones, T. A. in Molecular Replacement (ed. Dodson, E. J.) 91\u2013105 (SERC, Daresbury, UK, 1992)."},{"key":"BF370533a0_CR20","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/0968-0004(90)90035-A","volume":"15","author":"GK Farber","year":"1990","unstructured":"Farber, G. K. & Petsko, G. A. Trends biochem. Sci. 15, 228\u2013234 (1990).","journal-title":"Trends biochem. Sci."},{"key":"BF370533a0_CR21","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/0959-440X(91)90094-A","volume":"1","author":"C-I Br\u00e4nd\u00e9n","year":"1991","unstructured":"Br\u00e4nd\u00e9n, C.-I. Curr. Opin. struct. Biol. 1, 978\u2013983 (1991).","journal-title":"Curr. Opin. struct. Biol."},{"key":"BF370533a0_CR22","doi-asserted-by":"crossref","first-page":"12249","DOI":"10.1016\/S0021-9258(18)63849-9","volume":"264","author":"A \u00c5berg","year":"1989","unstructured":"\u00c5berg, A. et al. J. biol. Chem. 264, 12249\u201312252 (1989).","journal-title":"J. biol. Chem."},{"key":"BF370533a0_CR23","unstructured":"\u00c5berg, A. thesis, Univ. Stockholm (1993)."},{"key":"BF370533a0_CR24","doi-asserted-by":"publisher","first-page":"6905","DOI":"10.1021\/bi00396a006","volume":"26","author":"A-NI Lin","year":"1987","unstructured":"Lin, A.-N.I., Ashley, G. W. & Stubbe, J. Biochemistry 26, 6905\u20136909 (1987).","journal-title":"Biochemistry"},{"key":"BF370533a0_CR25","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1073\/pnas.86.5.1485","volume":"86","author":"SS Mao","year":"1989","unstructured":"Mao, S. S., Jokuston, M. I., Bollinger, J.-M. & Stubbe, J. Proc. natn. Acad. Sci. U.S.A. 86, 1485\u20131489 (1989).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF370533a0_CR26","doi-asserted-by":"crossref","first-page":"12622","DOI":"10.1016\/S0021-9258(18)42322-8","volume":"267","author":"M Karlsson","year":"1992","unstructured":"Karlsson, M., Sahlin, M. & Sj\u00f6berg, B.-M. J. biol. Chem. 267, 12622\u201312626 (1992).","journal-title":"J. biol. Chem."},{"key":"BF370533a0_CR27","doi-asserted-by":"publisher","first-page":"9161","DOI":"10.1021\/bi00102a006","volume":"30","author":"M Wilmanns","year":"1991","unstructured":"Wilmanns, M., Hyde, C. C., Davies, D. R., Kirschner, K. & Jansonius, J. N. Biochemistry 30, 9161\u20139169 (1991).","journal-title":"Biochemistry"},{"key":"BF370533a0_CR28","doi-asserted-by":"publisher","first-page":"8352","DOI":"10.1073\/pnas.90.18.8352","volume":"90","author":"S Booker","year":"1993","unstructured":"Booker, S. & Stubbe, J. Proc. natn. Acad. Sci. U.S.A. 90, 8352\u20138356 (1993).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF370533a0_CR29","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1042\/bst0210727","volume":"21","author":"S Booker","year":"1993","unstructured":"Booker, S., Broderick, J. & Stubbe, J. Biochem. Soc. Trans. 21, 727\u2013730 (1993).","journal-title":"Biochem. Soc. Trans."},{"key":"BF370533a0_CR30","doi-asserted-by":"publisher","first-page":"4801","DOI":"10.1021\/bi00135a009","volume":"31","author":"I Climent","year":"1992","unstructured":"Climent, I., Sj\u00f6berg, B.-M. & Huang, C. Y. Biochemistry 31, 4801\u20134807 (1992).","journal-title":"Biochemistry"},{"key":"BF370533a0_CR31","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.1021\/bi00176a013","volume":"33","author":"P-O Lycksell","year":"1994","unstructured":"Lycksell, P.-O., Ingemarson, R., Davis, R., Gr\u00e4slund, A. & Thelander, L. Biochemistry 33, 2838\u20132842 (1994).","journal-title":"Biochemistry"},{"key":"BF370533a0_CR32","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/273120a0","volume":"273","author":"GE Schulz","year":"1978","unstructured":"Schulz, G. E., Schirmer, R. H., Sachsenheimer, W. & Pai, E. F. Nature 273, 120\u2013124 (1978).","journal-title":"Nature"},{"key":"BF370533a0_CR33","doi-asserted-by":"crossref","first-page":"18968","DOI":"10.1016\/S0021-9258(17)30610-5","volume":"265","author":"AJ Prongay","year":"1990","unstructured":"Prongay, A. J. & Williams, C. H. Jr J. biol. Chem. 265, 18968\u201318975 (1990).","journal-title":"J. biol. Chem."},{"key":"BF370533a0_CR34","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1016\/S0021-9258(17)36024-6","volume":"261","author":"S Eriksson","year":"1986","unstructured":"Eriksson, S., Sj\u00f6berg, B.-M., J\u00f6rnvall, H. & Carlquist, M. J. biol. Chem. 261, 1878\u20131882 (1986).","journal-title":"J. biol. Chem."},{"key":"BF370533a0_CR35","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1107\/S0021889887086783","volume":"20","author":"M Blum","year":"1987","unstructured":"Blum, M., Metcalf, P., Harrison, S. C. & Wiley, D. C. J. appl. Crystallogr. 20, 235\u2013242 (1987).","journal-title":"J. appl. Crystallogr."},{"key":"BF370533a0_CR36","first-page":"139","volume-title":"The Rotation Method in Crystallography","author":"J Nyborg","year":"1977","unstructured":"Nyborg, J. & Wonacott, A. J. in The Rotation Method in Crystallography 139\u2013152 (North Holland, Amsterdam, 1977)."},{"key":"BF370533a0_CR37","volume-title":"Denzo Manual","author":"Z Otwinowski","year":"1991","unstructured":"Otwinowski, Z. Denzo Manual (Yale University, New Haven, 1991)."},{"key":"BF370533a0_CR38","unstructured":"Knight, S. thesis, Swedish Univ. Agricultural Sciences (1989)."},{"key":"BF370533a0_CR39","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1107\/S0108767383001592","volume":"A39","author":"TC Terwillinger","year":"1983","unstructured":"Terwillinger, T. C. & Eisenberg, D. Acta crystallogr. A39, 813\u2013817 (1983).","journal-title":"Acta crystallogr."},{"key":"BF370533a0_CR40","unstructured":"Otwinowski, Z. MLPHARE, CCP4 Proc. 80-88 (Daresbury Laboratories, Warrington, UK, 1991)."},{"key":"BF370533a0_CR41","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/0076-6879(85)15009-3","volume":"115","author":"BC Wang","year":"1985","unstructured":"Wang, B. C. Meth. Enzym. 115, 90\u2013112 (1985).","journal-title":"Meth. Enzym."},{"key":"BF370533a0_CR42","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1107\/S0108767390010224","volume":"47","author":"TA Jones","year":"1991","unstructured":"Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard, M. Acta crystallogr. 47, 110\u2013119 (1991).","journal-title":"Acta crystallogr."},{"key":"BF370533a0_CR43","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1002\/j.1460-2075.1986.tb04287.x","volume":"5","author":"TA Jones","year":"1986","unstructured":"Jones, T. A. & Thirup, S. EMBO J. 5, 819\u2013822 (1986).","journal-title":"EMBO J."},{"key":"BF370533a0_CR44","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1107\/S0567739474010722","volume":"A30","author":"G Bricogne","year":"1974","unstructured":"Bricogne, G. Acta crystallogr. A30, 395\u2013405 (1974).","journal-title":"Acta crystallogr."},{"key":"BF370533a0_CR45","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1126\/science.235.4787.458","volume":"235","author":"TA Br\u00fcnger","year":"1987","unstructured":"Br\u00fcnger, T. A., Kuriyan, J. & Karplus, M. Science 235, 458\u2013460 (1987).","journal-title":"Science"},{"key":"BF370533a0_CR46","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1107\/S0021889891004399","volume":"24","author":"P Kraulis","year":"1991","unstructured":"Kraulis, P. J. appl. Crystallogr. 24, 946\u2013950 (1991).","journal-title":"J. appl. Crystallogr."},{"key":"BF370533a0_CR47","doi-asserted-by":"publisher","first-page":"6592","DOI":"10.1073\/pnas.86.17.6592","volume":"86","author":"SR Presnell","year":"1989","unstructured":"Presnell, S. R. & Cohen, F. E. Proc. natn. Acad. Sci. U.S.A. 86, 6592\u20136596 (1989).","journal-title":"Proc. natn. Acad. Sci. U.S.A."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/370533a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/370533a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/370533a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:24:25Z","timestamp":1684290265000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/370533a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,8]]},"references-count":47,"journal-issue":{"issue":"6490","published-print":{"date-parts":[[1994,8]]}},"alternative-id":["BF370533a0"],"URL":"https:\/\/doi.org\/10.1038\/370533a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,8]]}}}