{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:26:00Z","timestamp":1779344760830,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6521","license":[{"start":{"date-parts":[[1995,3,1]],"date-time":"1995-03-01T00:00:00Z","timestamp":794016000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1995,3]]},"DOI":"10.1038\/374467a0","type":"journal-article","created":{"date-parts":[[2003,8,12]],"date-time":"2003-08-12T01:30:19Z","timestamp":1060651819000},"page":"467-470","source":"Crossref","is-referenced-by-count":323,"title":["Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav"],"prefix":"10.1038","volume":"374","author":[{"given":"Alexander","family":"Tarakhovsky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Turner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Schaal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. Joseph","family":"Mee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda P.","family":"Duddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Rajewsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor L. J.","family":"Tybulewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF374467a0_CR1","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1126\/science.256.5060.1196","volume":"256","author":"XR Bustelo","year":"1992","unstructured":"Bustelo, X. R. & Barbacid, M. Science 256, 1196\u20131199 (1992).","journal-title":"Science"},{"key":"BF374467a0_CR2","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/356068a0","volume":"356","author":"XR Bustelo","year":"1992","unstructured":"Bustelo, X. R., Ledbetter, J. A. & Barbacid, M. Nature 356, 68\u201371 (1992).","journal-title":"Nature"},{"key":"BF374467a0_CR3","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/356071a0","volume":"356","author":"B Margolis","year":"1992","unstructured":"Margolis, B. et al. Nature 356, 71\u201374 (1992).","journal-title":"Nature"},{"key":"BF374467a0_CR4","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1126\/science.1708916","volume":"252","author":"CA Koch","year":"1991","unstructured":"Koch, C. A., Anderson, D., Moran, M. F., Ellis, C. & Pawson, T. Science 252, 668\u2013674 (1991).","journal-title":"Science"},{"key":"BF374467a0_CR5","first-page":"95","volume":"2","author":"J Coppola","year":"1991","unstructured":"Coppola, J., Bryant, S., Koda, T., Conway, D. & Barbacid, M. Cell Growth Differ. 2, 95\u2013105 (1991).","journal-title":"Cell Growth Differ."},{"key":"BF374467a0_CR6","first-page":"585","volume":"7","author":"F Galland","year":"1992","unstructured":"Galland, F., Katzav, S. & Birnbaum, D. Oncogene 7, 585\u2013587 (1992).","journal-title":"Oncogene"},{"key":"BF374467a0_CR7","first-page":"611","volume":"7","author":"JM Adams","year":"1992","unstructured":"Adams, J. M., Houston, H., Allen, J., Lints, T. & Harvey, R. Oncogene 7, 611\u2013618 (1992).","journal-title":"Oncogene"},{"key":"BF374467a0_CR8","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/358113a0","volume":"358","author":"MS Boguski","year":"1992","unstructured":"Boguski, M. S., Bairoch, A., Attwood, T. K. & Michaels, G. S. Nature 358, 113 (1992).","journal-title":"Nature"},{"key":"BF374467a0_CR9","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/0968-0004(93)90071-T","volume":"18","author":"A Musacchio","year":"1993","unstructured":"Musacchio, A., Gibson, T., Rice, P., Thompson, J. & Saraste, M. Trends biochem. Sci. 18, 343\u2013348 (1993).","journal-title":"Trends biochem. Sci."},{"key":"BF374467a0_CR10","doi-asserted-by":"publisher","first-page":"4528","DOI":"10.1073\/pnas.90.10.4528","volume":"90","author":"J Chen","year":"1993","unstructured":"Chen, J., Lansford, R., Stewart, V., Young, F. & Alt, F. W. Proc. natn. Acad. Sci. U.S.A. 90, 4528\u20134532 (1993).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF374467a0_CR11","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0065-2776(08)60487-3","volume":"51","author":"EV Rothenberg","year":"1992","unstructured":"Rothenberg, E. V. Adv. Immun. 51, 85\u2013214 (1992).","journal-title":"Adv. Immun."},{"key":"BF374467a0_CR12","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1146\/annurev.iy.04.040186.003113","volume":"4","author":"A Weiss","year":"1986","unstructured":"Weiss, A. et al. A. Rev. Immun. 4, 593\u2013619 (1986).","journal-title":"A. Rev. Immun."},{"key":"BF374467a0_CR13","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1126\/science.7688139","volume":"261","author":"A Shahinian","year":"1993","unstructured":"Shahinian, A. et al. Science 261, 609\u2013612 (1993).","journal-title":"Science"},{"key":"BF374467a0_CR14","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/0092-8674(92)90029-C","volume":"68","author":"Y Shinkai","year":"1992","unstructured":"Shinkai, Y. et al. Cell 68, 855\u2013867 (1992).","journal-title":"Cell"},{"key":"BF374467a0_CR15","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1101\/gad.8.9.1030","volume":"8","author":"E Spanopoulou","year":"1994","unstructured":"Spanopoulou, E. et al. Genes Dev. 8, 1030\u20131042 (1994).","journal-title":"Genes Dev."},{"key":"BF374467a0_CR16","first-page":"87.1","volume-title":"Genetics and Molecular Immunology","author":"L Smith","year":"1986","unstructured":"Smith, L., Steinmetz, M. & Hood, L. in Genetics and Molecular Immunology Vol. 3 (ed. Weir, D. M.) 87.1\u201387.10 (Blackwell Scientific, Oxford, 1986)."},{"key":"BF374467a0_CR17","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1126\/science.8372353","volume":"261","author":"K Nakayama","year":"1993","unstructured":"Nakayama, K. et al. Science 261, 1584\u20131588 (1993).","journal-title":"Science"},{"key":"BF374467a0_CR18","doi-asserted-by":"publisher","first-page":"3320","DOI":"10.1073\/pnas.89.8.3320","volume":"89","author":"AB Kantor","year":"1992","unstructured":"Kantor, A. B., Stall, A. M., Adams, S., Herzenberg, L. A. & Herzenberg, L. A. Proc. natn. Acad. Sci. U.S.A. 89, 3320\u20133324 (1992).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF374467a0_CR19","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/374470a0","volume":"374","author":"R Zhang","year":"1995","unstructured":"Zhang, R., Alt, F. W., Davidson, L., Orkin, S. H. & Swat, W. Nature 374, 470\u2013473 (1995).","journal-title":"Nature"},{"key":"BF374467a0_CR20","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/B978-0-12-105760-2.50007-8","volume-title":"Transgenesis and Targeted Mutagenesis in Immunology","author":"J Chen","year":"1994","unstructured":"Chen, J. & Alt, F. W. in Transgenesis and Targeted Mutagenesis in Immunology (eds Bluethmann, H. & Ohashi, P. S.) 35\u201349 (Academic, New York, 1994)."},{"key":"BF374467a0_CR21","doi-asserted-by":"publisher","first-page":"7410","DOI":"10.1073\/pnas.88.16.7410","volume":"88","author":"AL Burkhardt","year":"1991","unstructured":"Burkhardt, A. L., Brunswick, M., Bolen, J. B. & Mond, J. J. Proc. natn. Acad. Sci. U.S.A. 88, 7410\u20137414 (1991).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF374467a0_CR22","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1084\/jem.177.4.1209","volume":"177","author":"P Lane","year":"1993","unstructured":"Lane, P. et al. J. exp. Med. 177, 1209\u20131213 (1993).","journal-title":"J. exp. Med."},{"key":"BF374467a0_CR23","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1084\/jem.179.6.2023","volume":"179","author":"S Jung","year":"1994","unstructured":"Jung, S., Siebenkotten, G. & Radbruch, A. J. exp. Med. 179, 2023\u20132026 (1994).","journal-title":"J. exp. Med."},{"key":"BF374467a0_CR24","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/0092-8674(91)90011-M","volume":"65","author":"VL Tybulewicz","year":"1991","unstructured":"Tybulewicz, V. L., Crawford, C. E., Jackson, P. K., Bronson, R. T. & Mulligan, R. C. Cell 65, 1153\u20131163 (1991).","journal-title":"Cell"},{"key":"BF374467a0_CR25","doi-asserted-by":"publisher","first-page":"7036","DOI":"10.1073\/pnas.88.16.7036","volume":"88","author":"RM Mortensen","year":"1991","unstructured":"Mortensen, R. M., Zubiar, M., Neer, E. J. & Seidman, J. G. Proc. natn. Acad. Sci. U.S.A. 88, 7036\u20137040 (1991).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF374467a0_CR26","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1084\/jem.177.1.45","volume":"177","author":"J Roes","year":"1993","unstructured":"Roes, J. & Rajewsky, K. J. exp. Med. 177, 45\u201355 (1993).","journal-title":"J. exp. Med."},{"key":"BF374467a0_CR27","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/0092-8674(92)90309-Z","volume":"70","author":"MW Appleby","year":"1992","unstructured":"Appleby, M. W. et al. Cell 70, 751\u2013763 (1992).","journal-title":"Cell"},{"key":"BF374467a0_CR28","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1073\/pnas.84.5.1374","volume":"84","author":"O Leo","year":"1987","unstructured":"Leo, O., Foo, M., Sachs, D. H., Samelson, L. E. & Bluestone, J. A. Proc. natn. Acad. Sci. U.S.A. 84, 1374\u20131378 (1987).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF374467a0_CR29","unstructured":"Gr\u00fctzmann, R. (thesis, Univ. Cologne, Germany, 1981)."},{"key":"BF374467a0_CR30","first-page":"97.1","volume-title":"Genetics and Molecular Immunology","author":"M Parson","year":"1986","unstructured":"Parson, M., Herzenberg, Le. A., Stall, A. M. & Herzenberg, L. A. in Genetics and Molecular Immunology Vol. 3 (ed. Weir, D. M.) 97.1\u201397.17 (Blackwell Scientific, Oxford, 1986)."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/374467a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/374467a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/374467a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:47:18Z","timestamp":1684291638000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/374467a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3]]},"references-count":30,"journal-issue":{"issue":"6521","published-print":{"date-parts":[[1995,3]]}},"alternative-id":["BF374467a0"],"URL":"https:\/\/doi.org\/10.1038\/374467a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,3]]}}}