{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:59:50Z","timestamp":1779343190695,"version":"3.51.4"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"6523","license":[{"start":{"date-parts":[[1995,4,13]],"date-time":"1995-04-13T00:00:00Z","timestamp":797731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[1995,4,13]],"date-time":"1995-04-13T00:00:00Z","timestamp":797731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1995,4,13]]},"DOI":"10.1038\/374617a0","type":"journal-article","created":{"date-parts":[[2003,8,12]],"date-time":"2003-08-12T01:30:33Z","timestamp":1060651833000},"page":"617-622","source":"Crossref","is-referenced-by-count":410,"title":["Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos"],"prefix":"10.1038","volume":"374","author":[{"given":"Xi","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Saint-Jeannet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Woodgett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold E.","family":"Varmus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor B.","family":"Dawid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF374617a0_CR1","doi-asserted-by":"crossref","first-page":"6259","DOI":"10.1016\/S0021-9258(17)37362-3","volume":"269","author":"IB Dawid","year":"1994","unstructured":"Dawid, I. B. J. biol. Chem. 269, 6259\u20136262 (1994).","journal-title":"J. biol. Chem."},{"key":"BF374617a0_CR2","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1126\/science.7939714","volume":"266","author":"DS Kessler","year":"1994","unstructured":"Kessler, D. S. & Melton, D. A. Science 266, 596\u2013604 (1994).","journal-title":"Science"},{"key":"BF374617a0_CR3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1242\/dev.107.Supplement.37","volume":"107","author":"JC Gerhart","year":"1989","unstructured":"Gerhart, J. C. et al. Development (suppl.) 107, 37\u201351 (1989).","journal-title":"Development"},{"key":"BF374617a0_CR4","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/0092-8674(91)90616-7","volume":"66","author":"E Amaya","year":"1991","unstructured":"Amaya, E., Musci, T. J. & Kirschner, M. W. Cell 66, 257\u2013270 (1991).","journal-title":"Cell"},{"key":"BF374617a0_CR5","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/359609a0","volume":"359","author":"A Hemmati-Brivanlou","year":"1992","unstructured":"Hemmati-Brivanlou, A. & Melton, D. A. Nature 359, 609\u2013614 (1992).","journal-title":"Nature"},{"key":"BF374617a0_CR6","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/0092-8674(90)90445-K","volume":"63","author":"G Thomsen","year":"1990","unstructured":"Thomsen, G. et al. Cell 63, 485\u2013493 (1990).","journal-title":"Cell"},{"key":"BF374617a0_CR7","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/0092-8674(93)80045-G","volume":"74","author":"GH Thomsen","year":"1993","unstructured":"Thomsen, G. H. & Melton, D. A. Cell 74, 433\u2013441 (1993).","journal-title":"Cell"},{"key":"BF374617a0_CR8","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/0092-8674(92)90630-U","volume":"69","author":"R Nusse","year":"1992","unstructured":"Nusse, R. & Varmus, H. A. Cell 69, 1073\u20131087 (1992).","journal-title":"Cell"},{"key":"BF374617a0_CR9","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/0092-8674(89)90506-0","volume":"58","author":"AP McMahon","year":"1989","unstructured":"McMahon, A. P. & Moon, R. T. Cell 58, 1075\u20131084 (1989).","journal-title":"Cell"},{"key":"BF374617a0_CR10","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/0092-8674(91)90070-F","volume":"67","author":"WC Smith","year":"1991","unstructured":"Smith, W. C. & Harland, R. M. Cell 67, 753\u2013765 (1991).","journal-title":"Cell"},{"key":"BF374617a0_CR11","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/0092-8674(91)90069-B","volume":"67","author":"S Sokol","year":"1991","unstructured":"Sokol, S., Christian, J. L., Moon, R. T. & Melton, D. A. Cell 67, 741\u2013752 (1991).","journal-title":"Cell"},{"key":"BF374617a0_CR12","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1101\/gad.7.1.13","volume":"7","author":"JL Christian","year":"1993","unstructured":"Christian, J. L. & Moon, R. T. Genes Dev. 7, 13\u201328 (1993).","journal-title":"Genes Dev."},{"key":"BF374617a0_CR13","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/0092-8674(92)90316-5","volume":"70","author":"WC Smith","year":"1992","unstructured":"Smith, W. C. & Harland, R. M. Cell 70, 829\u2013840 (1992).","journal-title":"Cell"},{"key":"BF374617a0_CR14","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/0092-8674(94)90068-X","volume":"79","author":"Y Sasai","year":"1994","unstructured":"Sasai, Y. et al. Cell 79, 779\u2013790 (1994).","journal-title":"Cell"},{"key":"BF374617a0_CR15","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1002\/j.1460-2075.1992.tb05024.x","volume":"11","author":"JL Christian","year":"1992","unstructured":"Christian, J. L., Olson, D. J. & Moon, R. T. EMBO J. 11, 33\u201341 (1992).","journal-title":"EMBO J."},{"key":"BF374617a0_CR16","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/0092-8674(94)90351-4","volume":"76","author":"N Perrimon","year":"1994","unstructured":"Perrimon, N. Cell 76, 781\u2013784 (1994).","journal-title":"Cell"},{"key":"BF374617a0_CR17","first-page":"269","volume":"5","author":"JR Woodgett","year":"1994","unstructured":"Woodgett, J. R. Sem. Cancer Biol. 5, 269\u2013275 (1994).","journal-title":"Sem. Cancer Biol."},{"key":"BF374617a0_CR18","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1002\/j.1460-2075.1990.tb07419.x","volume":"9","author":"JR Woodgett","year":"1990","unstructured":"Woodgett, J. R. EMBO J. 9, 2431\u20132448 (1990).","journal-title":"EMBO J."},{"key":"BF374617a0_CR19","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1042\/bj2960015","volume":"296","author":"C Sutherland","year":"1993","unstructured":"Sutherland, C., Leighton, I. A. & Cohen, P. Biochem. J. 296, 15\u201319 (1993).","journal-title":"Biochem. J."},{"key":"BF374617a0_CR20","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1042\/bj3030701","volume":"303","author":"V Stambolic","year":"1994","unstructured":"Stambolic, V. & Woodgett, J. R. Biochem. J. 303, 701\u2013704 (1994).","journal-title":"Biochem. J."},{"key":"BF374617a0_CR21","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/S0092-8674(05)80065-0","volume":"71","author":"E Siegfried","year":"1992","unstructured":"Siegfried, E., Chou, T.-B. & Perrimon, N. Cell 71, 1167\u20131179 (1992).","journal-title":"Cell"},{"key":"BF374617a0_CR22","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/362557a0","volume":"362","author":"L Ruel","year":"1993","unstructured":"Ruel, L., Bourouis, M., Heitzler, P., Pantesco, V. & Simpson, P. Nature 362, 557\u2013560 (1993).","journal-title":"Nature"},{"key":"BF374617a0_CR23","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/363133a0","volume":"363","author":"M Han","year":"1993","unstructured":"Han, M., Golden, A., Han, V. & Sternberg, P. W. Nature 363, 133\u2013140 (1993).","journal-title":"Nature"},{"key":"BF374617a0_CR24","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1101\/gad.8.16.1897","volume":"8","author":"D Dumont","year":"1994","unstructured":"Dumont, D. et al. Genes Dev. 8, 1897\u20131909 (1994).","journal-title":"Genes Dev."},{"key":"BF374617a0_CR25","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1101\/gad.8.20.2389","volume":"8","author":"K Ogura","year":"1994","unstructured":"Ogura, K. et al. Genes Dev. 8, 2389\u20132400 (1994).","journal-title":"Genes Dev."},{"key":"BF374617a0_CR26","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/0092-8674(93)90143-E","volume":"73","author":"AM MacNicol","year":"1993","unstructured":"MacNicol, A. M., Muslin, A. J. & Williams, L. T. Cell 73, 571\u2013583 (1993).","journal-title":"Cell"},{"key":"BF374617a0_CR27","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1242\/dev.115.2.573","volume":"115","author":"L Dale","year":"1992","unstructured":"Dale, L., Howes, G., Price, B. M. & Smith, J. C. Development 115, 573\u2013585 (1992).","journal-title":"Development"},{"key":"BF374617a0_CR28","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1242\/dev.115.2.639","volume":"115","author":"CM Jones","year":"1992","unstructured":"Jones, C. M., Lyons, K. M., Lapan, P. M., Wright, C. V. E. & Hogan, B. L. M. Development 115, 639\u2013647 (1992).","journal-title":"Development"},{"key":"BF374617a0_CR29","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/0012-1606(88)90189-3","volume":"127","author":"KR Kao","year":"1988","unstructured":"Kao, K. R. & Elinson, R. P. Devl Biol. 127, 64\u201377 (1988).","journal-title":"Devl Biol."},{"key":"BF374617a0_CR30","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/0092-8674(91)90288-A","volume":"67","author":"KWY Cho","year":"1991","unstructured":"Cho, K. W. Y., Blumberg, B., Steinbeisser, H. & De Robertis, E. M. Cell 67, 1111\u20131120 (1991).","journal-title":"Cell"},{"key":"BF374617a0_CR31","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1242\/dev.112.3.747","volume":"112","author":"SM Sato","year":"1991","unstructured":"Sato, S. M. & Sargent, T. D. Development 112, 747\u2013753 (1991).","journal-title":"Development"},{"key":"BF374617a0_CR32","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/367076a0","volume":"367","author":"E Siegfried","year":"1994","unstructured":"Siegfried, E., Wilder, E. L. & Perrimon, N. Nature 367, 76\u201379 (1994).","journal-title":"Nature"},{"key":"BF374617a0_CR33","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/367080a0","volume":"367","author":"J Noordermeer","year":"1994","unstructured":"Noordermeer, J., Klingensmith, J., Perrimon, N. & Nusse, R. Nature 367, 80\u201382 (1994).","journal-title":"Nature"},{"key":"BF374617a0_CR34","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1083\/jcb.123.2.477","volume":"123","author":"PD McCrea","year":"1993","unstructured":"McCrea, P. D., Brieher, W. M. & Gumbiner, B. M. J. cell Biol. 123, 477\u2013484 (1993).","journal-title":"J. cell Biol."},{"key":"BF374617a0_CR35","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/0092-8674(94)90069-8","volume":"79","author":"J Heasman","year":"1994","unstructured":"Heasman, J. et al. Cell 79, 791\u2013803 (1994).","journal-title":"Cell"},{"key":"BF374617a0_CR36","doi-asserted-by":"publisher","first-page":"4471","DOI":"10.1002\/j.1460-2075.1993.tb06136.x","volume":"12","author":"L Dale","year":"1993","unstructured":"Dale, L., Matthews, G. & Colman, A. EMBO J. 12, 4471\u20134480 (1993).","journal-title":"EMBO J."},{"key":"BF374617a0_CR37","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/357252a0","volume":"357","author":"M Whitman","year":"1992","unstructured":"Whitman, M. & Melton, D. A. Nature 357, 252\u2013254 (1992).","journal-title":"Nature"},{"key":"BF374617a0_CR38","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/0092-8674(93)90732-6","volume":"74","author":"G Campbell","year":"1993","unstructured":"Campbell, G., Weaver, T. & Tomlinson, A. Cell 74, 1113\u20131123 (1993).","journal-title":"Cell"},{"key":"BF374617a0_CR39","doi-asserted-by":"publisher","first-page":"10255","DOI":"10.1073\/pnas.91.22.10255","volume":"91","author":"A Suzuki","year":"1994","unstructured":"Suzuki, A. et al. Proc. natn. Acad. Sci. U.S.A. 91, 10255\u201310259 (1994).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF374617a0_CR40","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0092-8674(94)90409-X","volume":"79","author":"JM Graff","year":"1994","unstructured":"Graff, J. M., Thies, R. S., Song, J. J., Celeste, A. J. & Melton, D. A. Cell 79, 169\u2013179 (1994).","journal-title":"Cell"},{"key":"BF374617a0_CR41","first-page":"185","volume":"28","author":"H Bohn","year":"1992","unstructured":"Bohn, H. J. Embryol. exp. Morph. 28, 185\u2013208 (1992).","journal-title":"J. Embryol. exp. Morph."},{"key":"BF374617a0_CR42","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/0092-8674(93)90072-X","volume":"72","author":"G Struhl","year":"1993","unstructured":"Struhl, G. & Basler, K. Cell 72, 527\u2013540 (1993).","journal-title":"Cell"},{"key":"BF374617a0_CR43","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1242\/dev.120.6.1661","volume":"120","author":"FJ Diaz-Benjumea","year":"1994","unstructured":"Diaz-Benjumea, F. J. & Cohen, S. M. Development 120, 1661\u20131670 (1994).","journal-title":"Development"},{"key":"BF374617a0_CR44","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0092-8674(95)90458-1","volume":"80","author":"AJ Harwood","year":"1995","unstructured":"Harwood, A. J., Plyte, S. E., Woodgett, J., Strutt, H. & Kay, R. R. Cell 80, 139\u2013148 (1995).","journal-title":"Cell"},{"key":"BF374617a0_CR45","doi-asserted-by":"publisher","first-page":"7057","DOI":"10.1093\/nar\/12.18.7057","volume":"12","author":"PA Krieg","year":"1984","unstructured":"Krieg, P. A. & Melton, D. A. Nucleic Acids Res. 12, 7057\u20137070 (1984).","journal-title":"Nucleic Acids Res."},{"key":"BF374617a0_CR46","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1073\/pnas.82.2.488","volume":"82","author":"TA Kunkel","year":"1985","unstructured":"Kunkel, T. A. Proc. natn. Acad. Sci. U.S.A. 82, 488\u2013492 (1985).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF374617a0_CR47","volume-title":"Normal table of Xenopus laevis","author":"PD Nieuwkoop","year":"1967","unstructured":"Nieuwkoop, P. D. & Faber, J. Normal table of Xenopus laevis (Daudin) (North-Holland, Amsterdam, 1967)."},{"key":"BF374617a0_CR48","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1016\/S0006-291X(05)81574-8","volume":"186","author":"S Nishimatsu","year":"1992","unstructured":"Nishimatsu, S., Suzuki, A., Shoda, A., Murakami, K. & Ueno, N. Biochem. biophys. Res. Commun. 186, 1487\u20131495 (1992).","journal-title":"Biochem. biophys. Res. Commun."},{"key":"BF374617a0_CR49","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/S0091-679X(08)60307-6","volume":"36","author":"RM Harland","year":"1991","unstructured":"Harland, R. M. Meth. Cell Biol. 36, 685\u2013695 (1991).","journal-title":"Meth. Cell Biol."},{"key":"BF374617a0_CR50","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1101\/gad.8.12.1434","volume":"8","author":"DL Turner","year":"1994","unstructured":"Turner, D. L. & Weintraub, H. Genes Dev. 8, 1434\u20131447 (1994).","journal-title":"Genes Dev."}],"updated-by":[{"DOI":"10.1038\/375253a0","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[1995,5,18]],"date-time":"1995-05-18T00:00:00Z","timestamp":800755200000}}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/374617a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/374617a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/374617a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:48:37Z","timestamp":1684291717000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/374617a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,4,13]]},"references-count":50,"journal-issue":{"issue":"6523","published-print":{"date-parts":[[1995,4,13]]}},"alternative-id":["BF374617a0"],"URL":"https:\/\/doi.org\/10.1038\/374617a0","relation":{"correction":[{"id-type":"doi","id":"10.1038\/375253a0","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,4,13]]}}}