{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:23:57Z","timestamp":1789964637055,"version":"4.0.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"6542","license":[{"start":{"date-parts":[[1995,8,1]],"date-time":"1995-08-01T00:00:00Z","timestamp":807235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1995,8]]},"DOI":"10.1038\/376690a0","type":"journal-article","created":{"date-parts":[[2003,8,12]],"date-time":"2003-08-12T01:38:54Z","timestamp":1060652334000},"page":"690-695","source":"Crossref","is-referenced-by-count":353,"title":["A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem"],"prefix":"10.1038","volume":"376","author":[{"given":"Karen A.","family":"Ketchum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Joiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Sellers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard K.","family":"Kaczmarek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve A. N.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF376690a0_CR1","volume-title":"Ionic Channels of Excitable Membranes","author":"B Hille","year":"1992","unstructured":"Hille, B. Ionic Channels of Excitable Membranes (Sinauer, Sunderland, MA, 1992)."},{"key":"BF376690a0_CR2","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/S0006-3495(94)80887-2","volume":"66","author":"L Heginbotham","year":"1994","unstructured":"Heginbotham, L., Lu, Z., Abramson, T. & MacKinnon, R. Biophys. J. 66, 1061\u20131067 (1994).","journal-title":"Biophys. J."},{"key":"BF376690a0_CR3","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/325156a0","volume":"325","author":"H Matsuda","year":"1987","unstructured":"Matsuda, H., Saigusa, A. & Irisawa, H. Nature 325, 156\u2013159 (1987).","journal-title":"Nature"},{"key":"BF376690a0_CR4","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.1073\/pnas.84.8.2560","volume":"84","author":"CA Vandenberg","year":"1987","unstructured":"Vandenberg, C. A. Proc. natn. Acad. Sci. U.S.A. 84, 2560\u20132564 (1987).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF376690a0_CR5","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","volume":"215","author":"SF Altschul","year":"1990","unstructured":"Altschul, S. F., Gish, W., Miller, W., Myers, E. W. & Lipman, D. J. J. molec. Biol. 215, 403\u2013410 (1990).","journal-title":"J. molec. Biol."},{"key":"BF376690a0_CR6","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1002\/yea.320100712","volume":"10","author":"T Miosga","year":"1994","unstructured":"Miosga, T., Witzel, A. & Zimmermann, F. K. Yeast 10, 965\u2013973 (1994).","journal-title":"Yeast"},{"key":"BF376690a0_CR7","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/362127a0","volume":"362","author":"Y Kubo","year":"1993","unstructured":"Kubo, Y., Baldwin, T. J., Jan, Y. N. & Jan, L. Y. Nature 362, 127\u2013133 (1993).","journal-title":"Nature"},{"key":"BF376690a0_CR8","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/0896-6273(91)90292-8","volume":"7","author":"SA Goldstein","year":"1991","unstructured":"Goldstein, S. A. & Miller, C. Neuron 7, 403\u2013408 (1991).","journal-title":"Neuron"},{"key":"BF376690a0_CR9","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1016\/0896-6273(95)90277-5","volume":"14","author":"KW Wang","year":"1995","unstructured":"Wang, K. W. & Goldstein, S. A. N. Neuron 14, 1303\u20131309 (1995).","journal-title":"Neuron"},{"key":"BF376690a0_CR10","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1126\/science.7687074","volume":"261","author":"A Butler","year":"1993","unstructured":"Butler, A., Tsunoda, S., McCobb, D. P., Wei, A. & Salkoff, L. Science 261, 221\u2013224 (1993).","journal-title":"Science"},{"key":"BF376690a0_CR11","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/0896-6273(92)90160-F","volume":"9","author":"JP Adelman","year":"1992","unstructured":"Adelman, J. P. et al. Neuron 9, 209\u2013216 (1992).","journal-title":"Neuron"},{"key":"BF376690a0_CR12","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/372366a0","volume":"372","author":"AN Lopatin","year":"1994","unstructured":"Lopatin, A. N., Makhina, E. N. & Nichols, C. G. Nature 372, 366\u2013369 (1994).","journal-title":"Nature"},{"key":"BF376690a0_CR13","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1126\/science.7973666","volume":"266","author":"E Ficker","year":"1994","unstructured":"Ficker, E., Taglialatela, M., Wible, B. A., Henley, C. M. & Brown, A. M. Science 266, 1068\u20131072 (1994).","journal-title":"Science"},{"key":"BF376690a0_CR14","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/371243a0","volume":"371","author":"Z Lu","year":"1994","unstructured":"Lu, Z. & MacKinnon, R. Nature 371, 243\u2013246 (1994).","journal-title":"Nature"},{"key":"BF376690a0_CR15","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/371246a0","volume":"371","author":"BA Wible","year":"1994","unstructured":"Wible, B. A., Taglialatela, M., Ficker, E. & Brown, A. M. Nature 371, 246\u2013249 (1994).","journal-title":"Nature"},{"key":"BF376690a0_CR16","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1085\/jgp.103.2.153","volume":"103","author":"MJ Ackerman","year":"1994","unstructured":"Ackerman, M. J., Wickman, K. D. & Clapham, D. E. J. gen. Physiol. 103, 153\u2013179 (1994).","journal-title":"J. gen. Physiol."},{"key":"BF376690a0_CR17","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/BF00582635","volume":"407","author":"C Methfessel","year":"1986","unstructured":"Methfessel, C. et al. Pfl\u00fcgers Arch. 407, 577\u2013588 (1986).","journal-title":"Pfl\u00fcgers Arch."},{"key":"BF376690a0_CR18","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/365445a0","volume":"365","author":"A Bruggemann","year":"1993","unstructured":"Bruggemann, A., Pardo, L. A., Stuhmer, W. & Pongs, O. Nature 365, 445\u2013448 (1993).","journal-title":"Nature"},{"key":"BF376690a0_CR19","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/350232a0","volume":"350","author":"R MacKinnon","year":"1991","unstructured":"MacKinnon, R. Nature 350, 232\u2013235 (1991).","journal-title":"Nature"},{"key":"BF376690a0_CR20","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1007\/BF00388308","volume":"426","author":"KZ Shen","year":"1994","unstructured":"Shen, K. Z. et al. Pfl\u00fcgers Arch. 426, 440\u2013445 (1994).","journal-title":"Pfl\u00fcgers Arch."},{"key":"BF376690a0_CR21","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1146\/annurev.bb.15.060186.001541","volume":"15","author":"DM Engelman","year":"1986","unstructured":"Engelman, D. M., Steitz, T. A. & Goldman, A. A. Rev. Biophys. Chem. 15, 321\u2013353 (1986).","journal-title":"A. Rev. Biophys. Chem."},{"key":"BF376690a0_CR22","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/371119a0","volume":"371","author":"LY Jan","year":"1994","unstructured":"Jan, L. Y. & Jan, Y. N. Nature 371, 119\u2013122 (1994).","journal-title":"Nature"},{"key":"BF376690a0_CR23","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/0896-6273(90)90146-7","volume":"4","author":"R Swanson","year":"1990","unstructured":"Swanson, R. et al. Neuron 4, 929\u2013939 (1990).","journal-title":"Neuron"},{"key":"BF376690a0_CR24","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1016\/0896-6273(94)90452-9","volume":"12","author":"SA Goldstein","year":"1994","unstructured":"Goldstein, S. A., Pheasant, D. J. & Miller, C. Neuron 12, 1377\u20131388 (1994).","journal-title":"Neuron"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/376690a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/376690a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/376690a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T03:02:50Z","timestamp":1684292570000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/376690a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,8]]},"references-count":24,"journal-issue":{"issue":"6542","published-print":{"date-parts":[[1995,8]]}},"alternative-id":["BF376690a0"],"URL":"https:\/\/doi.org\/10.1038\/376690a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,8]]}}}