{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T20:06:54Z","timestamp":1778357214850,"version":"3.51.4"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"6544","license":[{"start":{"date-parts":[[1995,9,1]],"date-time":"1995-09-01T00:00:00Z","timestamp":809913600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1995,9]]},"DOI":"10.1038\/377065a0","type":"journal-article","created":{"date-parts":[[2004,11,24]],"date-time":"2004-11-24T03:09:04Z","timestamp":1101265744000},"page":"65-68","source":"Crossref","is-referenced-by-count":725,"title":["Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)"],"prefix":"10.1038","volume":"377","author":[{"given":"Paolo","family":"Macchi","sequence":"first","affiliation":[]},{"given":"Anna","family":"Villa","sequence":"additional","affiliation":[]},{"given":"Silvia","family":"Giliani","sequence":"additional","affiliation":[]},{"given":"Maria G.","family":"Sacco","sequence":"additional","affiliation":[]},{"given":"Annalisa","family":"Frattini","sequence":"additional","affiliation":[]},{"given":"Fulvio","family":"Porta","sequence":"additional","affiliation":[]},{"given":"Alberto G.","family":"Ugazio","sequence":"additional","affiliation":[]},{"given":"James A.","family":"Johnston","sequence":"additional","affiliation":[]},{"given":"Fabio","family":"Candotti","sequence":"additional","affiliation":[]},{"given":"John J.","family":"O'Sheai","sequence":"additional","affiliation":[]},{"given":"Paolo","family":"Vezzoni","sequence":"additional","affiliation":[]},{"given":"Luigi D.","family":"Notarangelo","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF377065a0_CR1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/0092-8674(93)90167-O","volume":"73","author":"M Noguchi","year":"1993","unstructured":"Noguchi, M. et al. Cell 73, 147\u2013157 (1993).","journal-title":"Cell"},{"key":"BF377065a0_CR2","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1172\/JCI117765","volume":"95","author":"FC Schmaistieg","year":"1995","unstructured":"Schmaistieg, F. C. et al. J. clin. Invest. 95, 1169\u20131173 (1995).","journal-title":"J. clin. Invest."},{"key":"BF377065a0_CR3","doi-asserted-by":"publisher","first-page":"6374","DOI":"10.1073\/pnas.91.14.6374","volume":"91","author":"M Kawamura","year":"1994","unstructured":"Kawamura, M. et al. Proc. natn. Acad. Sci. U.S.A. 91, 6374\u20136378 (1994).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF377065a0_CR4","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/370153a0","volume":"370","author":"BA Witthuhn","year":"1994","unstructured":"Witthuhn, B. A. et al. Nature 370, 153\u2013157 (1994).","journal-title":"Nature"},{"key":"BF377065a0_CR5","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/370151a0","volume":"370","author":"JA Johnston","year":"1994","unstructured":"Johnston, J. A. et al. Nature 370, 151\u2013153 (1994).","journal-title":"Nature"},{"key":"BF377065a0_CR6","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1126\/science.7973657","volume":"266","author":"VA Boussiotis","year":"1994","unstructured":"Boussiotis, V. A. et el. Science 266, 1039\u20131042 (1994).","journal-title":"Science"},{"key":"BF377065a0_CR7","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1126\/science.7973658","volume":"266","author":"SM Russell","year":"1994","unstructured":"Russell, S. M. Science 266, 1042\u20131045 (1994).","journal-title":"Science"},{"key":"BF377065a0_CR8","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1126\/science.7973659","volume":"266","author":"T Myazaki","year":"1994","unstructured":"Myazaki, T. et al. Science 266, 1045\u20131047 (1994).","journal-title":"Science"},{"key":"BF377065a0_CR9","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1084\/jem.181.4.1425","volume":"181","author":"T Musso","year":"1995","unstructured":"Musso, T. et al. J. exp. Med. 181, 1425\u20131431 (1995).","journal-title":"J. exp. Med."},{"key":"BF377065a0_CR10","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1126\/science.8197455","volume":"264","author":"JE Darnell","year":"1994","unstructured":"Darnell, J. E., Kerr, I. M. & Start, G. R. Science 264, 1415\u20131421 (1994).","journal-title":"Science"},{"key":"BF377065a0_CR11","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0168-9525(00)89000-9","volume":"11","author":"JN Ihle","year":"1995","unstructured":"Ihle, J. N. & Kerr, I. M. Trends Genet. 11, 69\u201374 (1995).","journal-title":"Trends Genet."},{"key":"BF377065a0_CR12","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/1074-7613(95)90047-0","volume":"2","author":"X Cao","year":"1995","unstructured":"Cao, X. et al. Immunity 2, 223\u2013238 (1995).","journal-title":"Immunity"},{"key":"BF377065a0_CR13","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1073\/pnas.92.2.377","volume":"93","author":"JP Di Santo","year":"1995","unstructured":"Di Santo, J. P., Muller, W., Guy-Grand, D., Fischer, A. & Rajewsky, K. Proc. natn. Acad. Sci. U.S.A. 93, 377\u2013381 (1995).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF377065a0_CR14","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.4049\/jimmunol.145.9.2873","volume":"145","author":"M-L Gougeon","year":"1990","unstructured":"Gougeon, M.-L. et al. J. Immun. 145, 2873\u20132877 (1990).","journal-title":"J. Immun."},{"key":"BF377065a0_CR15","doi-asserted-by":"crossref","first-page":"700","DOI":"10.4049\/jimmunol.150.2.700","volume":"150","author":"GS Wengler","year":"1993","unstructured":"Wengler, G. S., Allen, R. C., Parolini, O., Smith, H. & Conley, M. E. J. Immun. 150, 700\u2013704 (1993).","journal-title":"J. Immun."},{"key":"BF377065a0_CR16","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1172\/JCI112967","volume":"79","author":"JM Puck","year":"1987","unstructured":"Puck, J. M., Nussbaum, R. L. & Conley M. E. J. clin. Invest. 79, 1395\u20131400 (1987).","journal-title":"J. clin. Invest."},{"key":"BF377065a0_CR17","doi-asserted-by":"publisher","first-page":"3090","DOI":"10.1073\/pnas.85.9.3090","volume":"85","author":"ME Conley","year":"1988","unstructured":"Conley, M. E. et al. Proc. natn. Acad. Sci. U.S.A. 85, 3090\u20133094 (1988).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF377065a0_CR18","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","volume":"162","author":"P Chomczynski","year":"1987","unstructured":"Chomczynski, P. & Sacchi, N. Analyt. Biochem. 162, 156\u2013159 (1987).","journal-title":"Analyt. Biochem."},{"key":"BF377065a0_CR19","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/ng0495-414","volume":"9","author":"A Villa","year":"1995","unstructured":"Villa, A. et al. Nature Genet. 9, 414\u2013417 (1995).","journal-title":"Nature Genet."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/377065a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/377065a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/377065a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T03:04:49Z","timestamp":1684292689000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/377065a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9]]},"references-count":19,"journal-issue":{"issue":"6544","published-print":{"date-parts":[[1995,9]]}},"alternative-id":["BF377065a0"],"URL":"https:\/\/doi.org\/10.1038\/377065a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,9]]}}}