{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:31:58Z","timestamp":1777523518177,"version":"3.51.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"6545","license":[{"start":{"date-parts":[[1995,9,1]],"date-time":"1995-09-01T00:00:00Z","timestamp":809913600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1995,9]]},"DOI":"10.1038\/377173a0","type":"journal-article","created":{"date-parts":[[2003,6,12]],"date-time":"2003-06-12T23:55:46Z","timestamp":1055462146000},"page":"173-177","source":"Crossref","is-referenced-by-count":623,"title":["Role of IRS-2 in insulin and cytokine signalling"],"prefix":"10.1038","volume":"377","author":[{"given":"Xiao Jian","family":"Sun","sequence":"first","affiliation":[]},{"given":"Ling-Mei","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Yitao","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Lynne","family":"Yenush","sequence":"additional","affiliation":[]},{"given":"Martin G.","family":"Myers Jr","sequence":"additional","affiliation":[]},{"given":"Erin","family":"Glasheen","sequence":"additional","affiliation":[]},{"given":"William S.","family":"Lane","sequence":"additional","affiliation":[]},{"given":"Jacalyn H.","family":"Pierce","sequence":"additional","affiliation":[]},{"given":"Morris F.","family":"White","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF377173a0_CR1","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1210\/endo.132.4.8384986","volume":"132","author":"MG Myers Jr","year":"1993","unstructured":"Myers, M. G. Jr et al. Endocrinology 132, 1421\u20131430 (1993).","journal-title":"Endocrinology"},{"key":"BF377173a0_CR2","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1074\/jbc.270.8.3471","volume":"270","author":"M Ridderstale","year":"1995","unstructured":"Ridderstale, M., Degerman, E. & Tornqvist, H. J. biol. Chem. 270, 3471\u20133474 (1995).","journal-title":"J. biol. Chem."},{"key":"BF377173a0_CR3","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1002\/j.1460-2075.1992.tb05596.x","volume":"11","author":"LM Wang","year":"1992","unstructured":"Wang, L. M. et al. EMBO J. 11, 4899\u20134908 (1992).","journal-title":"EMBO J."},{"key":"BF377173a0_CR4","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.1073\/pnas.90.9.4032","volume":"90","author":"LM Wang","year":"1993","unstructured":"Wang, L. M. et al. Proc. natn. Acad. Sci. U.S.A. 90, 4032\u20134036 (1993).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF377173a0_CR5","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1126\/science.8372354","volume":"261","author":"LM Wang","year":"1993","unstructured":"Wang, L. M. et al. Science 261, 1591\u20131594 (1993).","journal-title":"Science"},{"key":"BF377173a0_CR6","doi-asserted-by":"crossref","first-page":"12286","DOI":"10.1074\/jbc.270.20.12286","volume":"270","author":"MJ Welham","year":"1995","unstructured":"Welham, M. J., Learmonth, L., Bone, H. & Schrader, J. W. J. biol. Chem. 270, 12286\u201312296 (1995).","journal-title":"J. biol. Chem."},{"key":"BF377173a0_CR7","doi-asserted-by":"crossref","first-page":"14685","DOI":"10.1074\/jbc.270.24.14685","volume":"270","author":"LS Argetsinger","year":"1995","unstructured":"Argetsinger, L. S. et al. J. biol. Chem. 270, 14685\u201314692 (1995).","journal-title":"J. biol. Chem."},{"key":"BF377173a0_CR8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0968-0004(94)90007-8","volume":"19","author":"MG Myers Jr","year":"1994","unstructured":"Myers, M. G. Jr, Sun, X. & White, M. F. Trends biochem. Sci. 19, 289\u2013294 (1994).","journal-title":"Trends biochem. Sci."},{"key":"BF377173a0_CR9","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/372186a0","volume":"372","author":"E Araki","year":"1994","unstructured":"Araki, E. et al. Nature 372, 186\u2013190 (1994).","journal-title":"Nature"},{"key":"BF377173a0_CR10","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/372182a0","volume":"372","author":"H Tamemoto","year":"1994","unstructured":"Tamemoto, H. et al. Nature 372, 182\u2013186 (1994).","journal-title":"Nature"},{"key":"BF377173a0_CR11","doi-asserted-by":"crossref","first-page":"31A","DOI":"10.2337\/diab.44.1.31","volume":"44","author":"ME Patti","year":"1995","unstructured":"Patti, M. E. et al. Diabetes (abstr.) 44, 31A (1995).","journal-title":"Diabetes"},{"key":"BF377173a0_CR12","unstructured":"Liu, X. J., Sorisky, A., Zhu, L. & Pawson, A. Molec cell. Biol. (in the press)."},{"key":"BF377173a0_CR13","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0167-4889(94)90261-5","volume":"1221","author":"E Araki","year":"1994","unstructured":"Araki, E., Haag, B. L. & Kahn, C. R. Biochim. biophys. Acta 1221, 353\u2013356 (1994).","journal-title":"Biochim. biophys. Acta"},{"key":"BF377173a0_CR14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/352073a0","volume":"352","author":"X Sun","year":"1991","unstructured":"Sun, X. et al. Nature 352, 73\u201377 (1991).","journal-title":"Nature"},{"key":"BF377173a0_CR15","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.2337\/diab.42.7.1041","volume":"42","author":"E Araki","year":"1993","unstructured":"Araki, E. et al. Diabetes 42, 1041\u20131054 (1993).","journal-title":"Diabetes"},{"key":"BF377173a0_CR16","doi-asserted-by":"crossref","first-page":"9031","DOI":"10.1021\/bi00152a046","volume":"31","author":"M Miralpeix","year":"1992","unstructured":"Miralpeix, M. et al. Biochemistry 31, 9031\u20139039 (1992).","journal-title":"Biochemistry"},{"key":"BF377173a0_CR17","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1128\/MCB.14.6.3577","volume":"14","author":"MG Myers Jr","year":"1994","unstructured":"Myers, M. G. Jr et al. Molec. cell. Biol. 14, 3577\u20133587 (1994).","journal-title":"Molec. cell. Biol."},{"key":"BF377173a0_CR18","doi-asserted-by":"crossref","first-page":"28783","DOI":"10.1016\/S0021-9258(19)61974-5","volume":"269","author":"MG Myers Jr","year":"1994","unstructured":"Myers, M. G. Jr et al. J. biol. Chem. 269, 28783\u201328789 (1994).","journal-title":"J. biol. Chem."},{"key":"BF377173a0_CR19","doi-asserted-by":"crossref","first-page":"12286","DOI":"10.1074\/jbc.270.20.12286","volume":"270","author":"MJ Welham","year":"1995","unstructured":"Welham, M. J. et al. J. biol. Chem. 270, 12286\u201312296 (1995).","journal-title":"J. biol. Chem."},{"key":"BF377173a0_CR20","doi-asserted-by":"crossref","first-page":"7418","DOI":"10.1128\/MCB.13.12.7418","volume":"13","author":"X Sun","year":"1993","unstructured":"Sun, X., Crimmins, D. L., Myers, M. G. Jr, Miralpeix, M. & White, M. F. Molec cell. Biol. 13, 7418\u20137428 (1993).","journal-title":"Molec cell. Biol."},{"key":"BF377173a0_CR21","doi-asserted-by":"crossref","first-page":"13614","DOI":"10.1016\/S0021-9258(17)36874-6","volume":"269","author":"S Sugimoto","year":"1994","unstructured":"Sugimoto, S., Wandless, T. J., Shoelson, S. E., Neel, B. G. & Walsh, C. T. J. biol. Chem. 269, 13614\u201313622 (1994).","journal-title":"J. biol. Chem."},{"key":"BF377173a0_CR22","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1074\/jbc.270.7.2897","volume":"270","author":"S Pluskey","year":"1995","unstructured":"Pluskey, S., Wandless, T. J., Walsh, C. T. & Shoelson, S. E. J. biol. Chem. 270, 2897\u20132900 (1995).","journal-title":"J. biol. Chem."},{"key":"BF377173a0_CR23","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0968-0004(93)90071-T","volume":"18","author":"A Musacchio","year":"1993","unstructured":"Musacchio, A., Gibson, T., Rice, P., Thompson, J. & Saraste, M. Trends biochem. Sci. 18, 343\u2013348 (1993).","journal-title":"Trends biochem. Sci."},{"key":"BF377173a0_CR24","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0968-0004(94)90108-2","volume":"19","author":"TJ Gibson","year":"1994","unstructured":"Gibson, T. J., Hyvonen, M., Musacchio, A. & Saraste, M. Trends biochem. Sci. 19, 349\u2013353 (1994).","journal-title":"Trends biochem. Sci."},{"key":"BF377173a0_CR25","doi-asserted-by":"crossref","first-page":"11715","DOI":"10.1074\/jbc.270.20.11715","volume":"270","author":"MG Myers Jr","year":"1995","unstructured":"Myers, M. G. Jr et al. J. biol. Chem. 270, 11715\u201311718 (1995).","journal-title":"J. biol. Chem."},{"key":"BF377173a0_CR26","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0092-8674(88)80008-4","volume":"54","author":"MF White","year":"1988","unstructured":"White, M. F. et al. Cell 54, 641\u2013649 (1988).","journal-title":"Cell"},{"key":"BF377173a0_CR27","doi-asserted-by":"crossref","first-page":"4634","DOI":"10.1016\/S0021-9258(17)41823-0","volume":"269","author":"K Yonezawa","year":"1994","unstructured":"Yonezawa, K. et al. J. biol. Chem. 269, 4634\u20134640 (1994).","journal-title":"J. biol. Chem."},{"key":"BF377173a0_CR28","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/0092-8674(94)90356-5","volume":"76","author":"AD Keegan","year":"1994","unstructured":"Keegan, A. D. et al. Cell 76, 811\u2013820 (1994).","journal-title":"Cell"},{"key":"BF377173a0_CR29","doi-asserted-by":"crossref","first-page":"32031","DOI":"10.1016\/S0021-9258(18)31593-X","volume":"269","author":"P Blaikie","year":"1994","unstructured":"Blaikie, P. et al. J. biol. Chem. 269, 32031\u201332034 (1994).","journal-title":"J. biol. Chem."},{"key":"BF377173a0_CR30","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1126\/science.7527937","volume":"266","author":"WM Kavanaugh","year":"1994","unstructured":"Kavanaugh, W. M. & Williams, L. T. Science 266, 1862\u20131865 (1994).","journal-title":"Science"},{"key":"BF377173a0_CR31","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0003-2697(92)90336-6","volume":"201","author":"J Fernandez","year":"1992","unstructured":"Fernandez, J., DeMott, M., Atherton, D. & Mische, S. M. Analyt. Biochem. 201, 255\u2013264 (1992).","journal-title":"Analyt. Biochem."},{"key":"BF377173a0_CR32","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF01024778","volume":"10","author":"WS Lane","year":"1991","unstructured":"Lane, W. S., Galat, A., Harding, M. W. & Schreiber, S. L. J. Pro. Chem. 10, 151\u2013160 (1991).","journal-title":"J. Pro. Chem."},{"key":"BF377173a0_CR33","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0092-8674(94)90200-3","volume":"79","author":"MS O'Reilly","year":"1994","unstructured":"O'Reilly, M. S. et al. Cell 79, 315\u2013328 (1994).","journal-title":"Cell"},{"key":"BF377173a0_CR34","doi-asserted-by":"crossref","first-page":"22662","DOI":"10.1016\/S0021-9258(18)41723-1","volume":"267","author":"X Sun","year":"1992","unstructured":"Sun, X. et al. J. biol. Chem. 267, 22662\u201322672 (1992).","journal-title":"J. biol. Chem."},{"key":"BF377173a0_CR35","doi-asserted-by":"crossref","first-page":"8946","DOI":"10.1016\/S0021-9258(18)81885-3","volume":"264","author":"R Perlman","year":"1989","unstructured":"Perlman, R., Bottaro, D., White, M. F. & Kahn, C. R. J. biol. Chem. 264, 8946\u20138950 (1989).","journal-title":"J. biol. Chem."},{"key":"BF377173a0_CR36","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0076-6879(91)01009-Q","volume":"7","author":"MF White","year":"1991","unstructured":"White, M. F. & Backer, J. M. Meth. Enzym. 7, 65\u201379 (1991).","journal-title":"Meth. Enzym."},{"key":"BF377173a0_CR37","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/0092-8674(95)90347-X","volume":"80","author":"P Bork","year":"1995","unstructured":"Bork, P. & Margolis, B. Cell 80, 693\u2013694 (1995).","journal-title":"Cell"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/377173a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/377173a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/377173a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T03:05:44Z","timestamp":1684292744000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/377173a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9]]},"references-count":37,"journal-issue":{"issue":"6545","published-print":{"date-parts":[[1995,9]]}},"alternative-id":["BF377173a0"],"URL":"https:\/\/doi.org\/10.1038\/377173a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,9]]}}}