{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:45:21Z","timestamp":1793072721697,"version":"4.5.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"6597","license":[{"start":{"date-parts":[[1996,9,1]],"date-time":"1996-09-01T00:00:00Z","timestamp":841536000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1996,9]]},"DOI":"10.1038\/383275a0","type":"journal-article","created":{"date-parts":[[2003,8,12]],"date-time":"2003-08-12T02:14:06Z","timestamp":1060654446000},"page":"275-279","source":"Crossref","is-referenced-by-count":129,"title":["Unique fold and active site in cytomegalovirus protease"],"prefix":"10.1038","volume":"383","author":[{"given":"Xiayang","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Culp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony G.","family":"DiLella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Hellmig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan S.","family":"Hoog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl A.","family":"Janson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ward W.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherin S.","family":"Abdel-Meguid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF383275a0_CR1","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.1128\/JVI.65.10.5149-5156.1991","volume":"65","author":"F Liu","year":"1991","unstructured":"Liu, F. & Roizman, B. J. Virol. 65, 5149\u20135156 (1991).","journal-title":"J. Virol."},{"key":"BF383275a0_CR2","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.1128\/JVI.68.6.3702-3712.1994","volume":"68","author":"M Gao","year":"1994","unstructured":"Gao, M. et al. J. Virol. 68, 3702\u20133712 (1994).","journal-title":"J. Virol."},{"key":"BF383275a0_CR3","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1128\/JVI.67.3.1300-1309.1993","volume":"67","author":"F Liu","year":"1993","unstructured":"Liu, F. & Roizman, B. J. Virol. 67, 1300\u20131309 (1993).","journal-title":"J. Virol."},{"key":"BF383275a0_CR4","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.1128\/JVI.67.10.5813-5822.1993","volume":"67","author":"Weinheimer","year":"1993","unstructured":"Weinheimer et al. J. Virol. 67, 5813\u20135822 (1993).","journal-title":"J. Virol."},{"key":"BF383275a0_CR5","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1073\/pnas.89.6.2076","volume":"89","author":"F Liu","year":"1992","unstructured":"Liu, F. & Roizman, B. Proc. Natl Acad. Sci. USA 89, 2076\u20132080 (1992).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF383275a0_CR6","doi-asserted-by":"crossref","first-page":"7360","DOI":"10.1128\/JVI.67.12.7360-7372.1993","volume":"67","author":"AR Welch","year":"1993","unstructured":"Welch, A. R., McNally, L. M., Hall, M. R. T. & Gibson, W. J. Virol. 67, 7360\u20137372 (1993).","journal-title":"J. Virol."},{"key":"BF383275a0_CR7","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1128\/JVI.69.7.4524-4528.1995","volume":"69","author":"GA Cox","year":"1995","unstructured":"Cox, G. A., Wakulchik, M., Sassmannshausen, L. M., Gibson, W. & Villarreal, E. C. J. Virol. 69, 4524\u20134528 (1995).","journal-title":"J. Virol."},{"key":"BF383275a0_CR8","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1432-1033.1994.tb20060.x","volume":"226","author":"JT Stevens","year":"1994","unstructured":"Stevens, J. T. et al. Eur. J. Biochem. 226, 361\u2013367 (1994).","journal-title":"Eur. J. Biochem."},{"key":"BF383275a0_CR9","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1128\/JVI.68.5.2937-2946.1994","volume":"68","author":"PJ Burck","year":"1994","unstructured":"Burck, P. J. et al. J. Virol. 68, 2937\u20132946 (1994).","journal-title":"J. Virol."},{"key":"BF383275a0_CR10","doi-asserted-by":"crossref","first-page":"25911","DOI":"10.1016\/S0021-9258(18)47332-2","volume":"269","author":"BC Holwerda","year":"1994","unstructured":"Holwerda, B. C. et al. J. Biol. Chem. 269, 25911\u201325915 (1994).","journal-title":"J. Biol. Chem."},{"key":"BF383275a0_CR11","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1128\/JVI.67.1.497-506.1993","volume":"67","author":"EZ Baum","year":"1993","unstructured":"Baum, E. Z. et al. J. Virol. 67, 497\u2013506 (1993).","journal-title":"J. Virol."},{"key":"BF383275a0_CR12","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1074\/jbc.270.9.4753","volume":"270","author":"DR O'Boyle II","year":"1993","unstructured":"O'Boyle II, D. R., Wager-Smith, K., Stevens III, J. T. & Weinheimer, S. P. J. Biol. Chem. 270, 4753\u20134758 (1993).","journal-title":"J. Biol. Chem."},{"key":"BF383275a0_CR13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1128\/JVI.69.1.341-347.1995","volume":"69","author":"AR Welch","year":"1993","unstructured":"Welch, A. R., Villarreal, E. C. & Gibson, W. J. Virol. 69, 341\u2013347 (1993).","journal-title":"J. Virol."},{"key":"BF383275a0_CR14","doi-asserted-by":"crossref","first-page":"25449","DOI":"10.1016\/S0021-9258(19)74412-3","volume":"268","author":"CL Dilanni","year":"1993","unstructured":"Dilanni, C. L. et al. J. Biol. Chem. 268, 25449\u201325454 (1993).","journal-title":"J. Biol. Chem."},{"key":"BF383275a0_CR15","first-page":"1981","volume-title":"Virology","author":"CA Alford","year":"1990","unstructured":"Alford, C. A. & Britt, W. J. in Virology 2nd edn (eds Knipe, D. M. and Fields, B. N.) 1981\u20132010 (Raven, New York, 1990)."},{"key":"BF383275a0_CR16","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1021\/bi00260a009","volume":"21","author":"C Chothia","year":"1982","unstructured":"Chothia, C. & Janin, J. Biochemistry 21, 3955\u20133965 (1982).","journal-title":"Biochemistry"},{"key":"BF383275a0_CR17","doi-asserted-by":"crossref","first-page":"5300","DOI":"10.1021\/bi952842u","volume":"35","author":"SA Margosiak","year":"1995","unstructured":"Margosiak, S. A., Vanderpool, D. L., Sisson, W., Pinko, C. & Kan, C. Biochemistry 35, 5300\u20135307 (1995).","journal-title":"Biochemistry"},{"key":"BF383275a0_CR18","doi-asserted-by":"crossref","first-page":"7445","DOI":"10.1074\/jbc.271.13.7445","volume":"271","author":"PL Darke","year":"1996","unstructured":"Darke, P. L. et al. J. Biol. Chem. 271, 7445\u20137449 (1996).","journal-title":"J. Biol. Chem."},{"key":"BF383275a0_CR19","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/pro.5560040301","volume":"4","author":"JJ Perona","year":"1995","unstructured":"Perona, J. J. & Craik, C. S. Protein Sci. 4, 337\u2013360 (1995).","journal-title":"Protein Sci."},{"key":"BF383275a0_CR20","first-page":"56","volume-title":"Data Collection and Processing","author":"Z Otwinowski","year":"1993","unstructured":"Otwinowski, Z. in Data Collection and Processing (eds Sawyer, L., Isaacs, N. & Bailey, S.) 56\u201362 (Daresbury Laboratory, Warrington, 1993)."},{"key":"BF383275a0_CR21","first-page":"110","volume":"47","author":"AJ Howard","year":"1994","unstructured":"Howard, A. J. et al. J. Appl. Crystallogr. A47, 110\u2013119 (1994).","journal-title":"J. Appl. Crystallogr."},{"key":"BF383275a0_CR22","doi-asserted-by":"crossref","unstructured":"Collaborative Computational Project Acta Crystallogr. D50, 760\u2013763 (1994).","DOI":"10.1107\/S0907444994003112"},{"key":"BF383275a0_CR23","first-page":"80","volume-title":"Isomorphous Replacement and Anomalous Scattering","author":"Z Otwinowski","year":"1991","unstructured":"Otwinowski, Z. in Isomorphous Replacement and Anomalous Scattering (eds Wolff, W., Evans, P. R. & Leslie, A. G. W.) 80\u201386 (Daresbury Laboratory, Warrington, 1991)."},{"key":"BF383275a0_CR24","volume-title":"Practical Protein Crystallography","author":"DE McKee","year":"1993","unstructured":"McKee, D. E. Practical Protein Crystallography (Academic, San Diego, 1993)."},{"key":"BF383275a0_CR25","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1126\/science.235.4787.458","volume":"235","author":"AT Brunger","year":"1987","unstructured":"Brunger, A. T., Kuriyan, J. & Karplus, M. Science 235, 458\u2013460 (1987).","journal-title":"Science"},{"key":"BF383275a0_CR26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"RA Laskowski","year":"1993","unstructured":"Laskowski, R. A., MacArthur, M. W., Morris, A. L. & Thornton, J. M. J. Appl. Crystallogr. 26, 283\u2013291 (1993).","journal-title":"J. Appl. Crystallogr."},{"key":"BF383275a0_CR27","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1107\/S0021889891004399","volume":"24","author":"P Kraulis","year":"1991","unstructured":"Kraulis, P. J. Appl. Crystallogr. 24, 946\u2013950 (1991).","journal-title":"J. Appl. Crystallogr."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/383275a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/383275a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/383275a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:48:41Z","timestamp":1684291721000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/383275a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,9]]},"references-count":27,"journal-issue":{"issue":"6597","published-print":{"date-parts":[[1996,9]]}},"alternative-id":["BF383275a0"],"URL":"https:\/\/doi.org\/10.1038\/383275a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,9]]}}}