{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:24:47Z","timestamp":1778732687755,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6619","license":[{"start":{"date-parts":[[1997,2,1]],"date-time":"1997-02-01T00:00:00Z","timestamp":854755200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1997,2]]},"DOI":"10.1038\/385820a0","type":"journal-article","created":{"date-parts":[[2003,8,12]],"date-time":"2003-08-12T15:21:34Z","timestamp":1060701694000},"page":"820-823","source":"Crossref","is-referenced-by-count":343,"title":["Insensitivity to anaesthetic agents conferred by a class of GABAA receptor subunit"],"prefix":"10.1038","volume":"385","author":[{"given":"Paul A.","family":"Davies","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike C.","family":"Hanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim G.","family":"Hales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewen F.","family":"Kirkness","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF385820a0_CR1","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/367607a0","volume":"367","author":"NP Franks","year":"1994","unstructured":"Franks, N. P. & Lieb, W. R. Nature 367, 607\u2013614 (1994).","journal-title":"Nature"},{"key":"BF385820a0_CR2","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1111\/j.1471-4159.1993.tb13643.x","volume":"61","author":"MN Bureau","year":"1993","unstructured":"Bureau, M. N. & Olsen, R. W. J. Neurochem. 61, 1479\u20131491 (1993).","journal-title":"J. Neurochem."},{"key":"BF385820a0_CR3","first-page":"263","volume":"37","author":"AL Morrow","year":"1990","unstructured":"Morrow, A. L., Pace, J. R., Purdy, R. H. & Paul, S. M. Mol. Pharmacol. 37, 263\u2013270 (1990).","journal-title":"Mol. Pharmacol."},{"key":"BF385820a0_CR4","first-page":"1392","volume":"265","author":"B Harris","year":"1993","unstructured":"Harris, B., Wong, G. & Skolnick, P. J. Pharmacol. Exp. Ther. 265, 1392\u20131398 (1993).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"BF385820a0_CR5","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1038\/338582a0","volume":"338","author":"DB Pritchett","year":"1989","unstructured":"Pritchett, D. B. et al. Nature 338, 582\u2013585 (1989).","journal-title":"Nature"},{"key":"BF385820a0_CR6","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1111\/j.1476-5381.1996.tb15221.x","volume":"117","author":"SA Thomson","year":"1996","unstructured":"Thomson, S. A., Whiting, P. J. & Wafford, K. A. Br. J. Pharmacol. 117, 521\u2013527 (1996).","journal-title":"Br. J. Pharmacol."},{"key":"BF385820a0_CR7","first-page":"1211","volume":"44","author":"KL Hadingham","year":"1993","unstructured":"Hadingham, K. L. et al. Mol. Pharmacol. 44, 1211\u20131218 (1993).","journal-title":"Mol. Pharmacol."},{"key":"BF385820a0_CR8","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/0896-6273(90)90202-Q","volume":"4","author":"G Puia","year":"1990","unstructured":"Puia, G. et al. Neuron 4, 759\u2013765 (1990).","journal-title":"Neuron"},{"key":"BF385820a0_CR9","first-page":"353","volume":"274","author":"E Sanna","year":"1995","unstructured":"Sanna, E. et al. J. Pharmacol. Exp. Ther. 274, 353\u2013360 (1995).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"BF385820a0_CR10","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/0922-4106(94)90190-2","volume":"268","author":"SJ Mihac","year":"1994","unstructured":"Mihac, S. J., Whiting, P. J. & Harris, R. A. Eur. J. Pharmacol. 268, 209\u2013214 (1994).","journal-title":"Eur. J. Pharmacol."},{"key":"BF385820a0_CR11","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0074-7742(08)60525-5","volume":"38","author":"PJ Whiting","year":"1995","unstructured":"Whiting, P. J., McKernan, R. M. & Wafford, K. A. Int. Rev. Neurobiol. 38, 95\u2013138 (1995).","journal-title":"Int. Rev. Neurobiol."},{"key":"BF385820a0_CR12","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/syn.890200103","volume":"20","author":"K Bell","year":"1995","unstructured":"Bell, K., Churchhill, L. & Kalivas, P. W. Synapse 20, 10\u201318 (1995).","journal-title":"Synapse"},{"key":"BF385820a0_CR13","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1523\/JNEUROSCI.12-03-01040.1992","volume":"12","author":"W Wisden","year":"1992","unstructured":"Wisden, W., Laurie, D. J., Monyer, H. & Seeburg, P. H. J. Neurosci. 12, 1040\u20131062 (1992).","journal-title":"J. Neurosci."},{"key":"BF385820a0_CR14","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1002\/j.1460-2075.1992.tb05259.x","volume":"11","author":"V Schmieden","year":"1992","unstructured":"Schmieden, V., Kuhse, J. & Betz, H. EMBO J. 11, 2025\u20132032 (1992).","journal-title":"EMBO J."},{"key":"BF385820a0_CR15","doi-asserted-by":"publisher","first-page":"7077","DOI":"10.1523\/JNEUROSCI.14-11-07077.1994","volume":"14","author":"NC Saxena","year":"1994","unstructured":"Saxena, N. C. & Macdonald, R. L. J. Neurosci. 14, 7077\u20137086 (1994).","journal-title":"J. Neurosci."},{"key":"BF385820a0_CR16","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/0896-6273(90)90145-6","volume":"4","author":"TA Verdoorn","year":"1992","unstructured":"Verdoorn, T. A., Draguhn, A., Ymer, S., Seeburg, P. H. & Sakmann, B. Neuron 4, 919\u2013928 (1992).","journal-title":"Neuron"},{"key":"BF385820a0_CR17","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1038\/sj.bjp.0700987","volume":"120","author":"PA Davies","year":"1997","unstructured":"Davies, P. A., Kirkness, E. F. & Hales, T. G. Br. J. Pharmacol. 120, 899\u2013909 (1997).","journal-title":"Br. J. Pharmacol."},{"key":"BF385820a0_CR18","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1152\/jn.1985.54.1.134","volume":"54","author":"R Gray","year":"1985","unstructured":"Gray, R. & Johnston, D. J. Neurophysiol. 54, 134\u2013142 (1985).","journal-title":"J. Neurophysiol."},{"key":"BF385820a0_CR19","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1152\/jn.1984.51.3.500","volume":"51","author":"M Segal","year":"1984","unstructured":"Segal, M. & Barker, J. L. J. Neurophysiol. 51, 500\u2013515 (1984).","journal-title":"J. Neurophysiol."},{"key":"BF385820a0_CR20","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1113\/jphysiol.1987.sp016493","volume":"385","author":"J Bormann","year":"1987","unstructured":"Bormann, J., Hamill, O. P. & Sakmann, B. J. Physiol. (Lond.) 385, 243\u2013286 (1987).","journal-title":"J. Physiol. (Lond.)"},{"key":"BF385820a0_CR21","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1098\/rspb.1994.0024","volume":"255","author":"PW Gage","year":"1994","unstructured":"Gage, P. W. & Chung, S. H. Proc. R. Soc. Lond. B 255, 167\u2013172 (1994).","journal-title":"Proc. R. Soc. Lond. B"},{"key":"BF385820a0_CR22","first-page":"87","volume":"44","author":"ER Korpi","year":"1993","unstructured":"Korpi, E. R. & Luddens, H. Mol. Pharmacol. 44, 87\u201392 (1993).","journal-title":"Mol. Pharmacol."},{"key":"BF385820a0_CR23","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1111\/j.1476-5381.1988.tb11646.x","volume":"94","author":"JA Peters","year":"1988","unstructured":"Peters, J. A., Kirkness, E. F., Callachan, H., Lambert, J. J. & Turner, A. J. Br. J. Pharmacol. 94, 1257\u20131269 (1988).","journal-title":"Br. J. Pharmacol."},{"key":"BF385820a0_CR24","doi-asserted-by":"publisher","first-page":"6648","DOI":"10.1523\/JNEUROSCI.16-21-06648.1996","volume":"16","author":"WJ Zhu","year":"1996","unstructured":"Zhu, W. J., Wang, J. F., Krueger, K. E. & Vicini, S. J. Neurosci. 16, 6648\u20136656 (1996).","journal-title":"J. Neurosci."},{"key":"BF385820a0_CR25","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1126\/science.2402638","volume":"249","author":"H Bergman","year":"1990","unstructured":"Bergman, H., Wichmann, T. & DeLong, M. R. Science 249, 1436\u20131438 (1990).","journal-title":"Science"},{"key":"BF385820a0_CR26","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1038\/nm0596-510","volume":"2","author":"CG Goetz","year":"1996","unstructured":"Goetz, C. G. & Diederich, N. J. Nature Med. 2, 510\u2013514 (1996).","journal-title":"Nature Med."},{"key":"BF385820a0_CR27","first-page":"3","volume":"377","author":"MD Adams","year":"1995","unstructured":"Adams, M. D. et al. Nature (suppl.) 377, 3\u2013174 (1995).","journal-title":"Nature"},{"key":"BF385820a0_CR28","first-page":"5616","volume":"47","author":"K Tokunaga","year":"1987","unstructured":"Tokunaga, K. et al. Cancer Res. 47, 5616\u20135619 (1987).","journal-title":"Cancer Res."},{"key":"BF385820a0_CR29","first-page":"858","volume":"46","author":"AL Buller","year":"1994","unstructured":"Buller, A. L., Hastings, G. A., Kirkness, E. F. & Fraser, C. M. Mol. Pharmacol. 46, 858\u2013865 (1994).","journal-title":"Mol. Pharmacol."},{"key":"BF385820a0_CR30","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1111\/j.1476-5381.1995.tb15903.x","volume":"115","author":"S Adodra","year":"1995","unstructured":"Adodra, S. & Hales, T. G. Br. J. Pharmacol. 115, 953\u2013960 (1995).","journal-title":"Br. J. Pharmacol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/385820a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/385820a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/385820a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T03:04:41Z","timestamp":1684292681000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/385820a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2]]},"references-count":30,"journal-issue":{"issue":"6619","published-print":{"date-parts":[[1997,2]]}},"alternative-id":["BF385820a0"],"URL":"https:\/\/doi.org\/10.1038\/385820a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,2]]}}}