{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:42:12Z","timestamp":1791549732261,"version":"4.3.4"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"6631","license":[{"start":{"date-parts":[[1997,5,1]],"date-time":"1997-05-01T00:00:00Z","timestamp":862444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1997,5]]},"DOI":"10.1038\/387406a0","type":"journal-article","created":{"date-parts":[[2003,8,11]],"date-time":"2003-08-11T22:29:01Z","timestamp":1060640941000},"page":"406-409","source":"Crossref","is-referenced-by-count":649,"title":["Pax6 is required for differentiation of glucagon-producing \u03b1-cells in mouse pancreas"],"prefix":"10.1038","volume":"387","author":[{"given":"Luc","family":"St-Onge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Sosa-Pineda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Mansouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Gruss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF387406a0_CR1","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1242\/dev.121.6.1569","volume":"121","author":"JM Slack","year":"1995","unstructured":"Slack, J. M. Developmental biology of the pancreas. Development 121, 1569\u20131580 (1995).","journal-title":"Development"},{"key":"BF387406a0_CR2","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/371606a0","volume":"371","author":"J Jonsson","year":"1994","unstructured":"Jonsson, J., Carlsson, L., Edlund, T. & Edlund, H. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371, 606\u2013609 (1994).","journal-title":"Nature"},{"key":"BF387406a0_CR3","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/386399a0","volume":"386","author":"B Sosa-Pineda","year":"1997","unstructured":"Sosa-Pineda, B., Chowdhury, K., Torres, M., Oliver, G. & Gruss, P. The Pax4 gene is essential for differentiation of insulin-producing \u03b2-cells in mammalian pancreas. Nature 386, 399\u2013402 (1997).","journal-title":"Nature"},{"key":"BF387406a0_CR4","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1242\/dev.113.4.1435","volume":"113","author":"C Walther","year":"1991","unstructured":"Walther, C. & Gruss, P. Pax-6, a murine paired box gene, is expressed in the developing CNS. Development 113, 1435\u20131449 (1991).","journal-title":"Development"},{"key":"BF387406a0_CR5","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1242\/dev.121.5.1433","volume":"121","author":"JC Grindley","year":"1995","unstructured":"Grindley, J. C., Davidson, D. R. & Hill, R. E. The role of Pax6 in eye and nasal development. Development 121, 1433\u20131442 (1995).","journal-title":"Development"},{"key":"BF387406a0_CR6","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1242\/dev.122.11.3453","volume":"122","author":"A Stoykova","year":"1996","unstructured":"Stoykova, A., Fritsch, R., Walter, C. & Gruss, P. Forebrain patterning defect in Small eye mutant mice. Development 122, 3453\u20133465 (1996).","journal-title":"Development"},{"key":"BF387406a0_CR7","first-page":"929","volume":"8","author":"N Turque","year":"1994","unstructured":"Turque, N., Plaza, S., Radvanyi, F., Carriere, C. & Saule, S. Pax-QNR\/PAX-6, a paired box- andhomeobox-containing gene expressed in neurons, is also expressed in pancreatic endocrine cells. Mol. Endocrinol. 8, 929\u2013938 (1994).","journal-title":"Mol. Endocrinol."},{"key":"BF387406a0_CR8","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1242\/dev.112.4.1115","volume":"112","author":"L Deltour","year":"1991","unstructured":"Deltour, L. et al. Polyclonal origin of pancreatic islets in aggregation mouse chimaeras. Development 112, 1115\u20131121 (1991).","journal-title":"Development"},{"key":"BF387406a0_CR9","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1242\/dev.113.4.1257","volume":"113","author":"PL Herrera","year":"1991","unstructured":"Herrera, P. L. et al. Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene. Development 113, 1257\u20131265 (1991).","journal-title":"Development"},{"key":"BF387406a0_CR10","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1242\/dev.122.9.2895","volume":"122","author":"U Dahl","year":"1996","unstructured":"Dahl, U., Sj\u00f6din, A. & Semb, H. Cadherins regulate aggregation of pancreatic \u03b2-cells in vivo. Development 122, 2895\u20132902 (1996).","journal-title":"Development"},{"key":"BF387406a0_CR11","first-page":"1332","volume":"6","author":"CJ M\u00f8ller","year":"1992","unstructured":"M\u00f811er, C. J. et al. Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas. Mol. Endocrinol. 6, 1332\u20131342 (1992).","journal-title":"Mol. Endocrinol."},{"key":"BF387406a0_CR12","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/0012-1606(91)90332-W","volume":"148","author":"DG Rouiller","year":"1991","unstructured":"Rouiller, D. G., Cirrulli, V. & Halban, P. Uvomorulin mediates calcium-dependent aggregation of islet cells, whereas calcium-independent cell adhesion molecules distinguish between islet cells types. Dev. Biol. 148, 233\u2013242 (1991).","journal-title":"Dev. Biol."},{"key":"BF387406a0_CR13","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1089\/dna.1994.13.891","volume":"13","author":"G Chalepakis","year":"1994","unstructured":"Chalepakis, G., Wijnholds, J., Giese, P., Schachner, M. & Gruss, P. Characterization of Pax-6 and Hoxa-1 binding to the promoter region of the neural cell adhesion molecule L1. DNA Cell Biol. 13, 891\u2013900 (1994).","journal-title":"DNA Cell Biol."},{"key":"BF387406a0_CR14","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1073\/pnas.89.3.1128","volume":"89","author":"GK Gittes","year":"1992","unstructured":"Gittes, G. K. & Rutter, W. J. Onset of cell-specific gene expression in the developing mouse pancreas. Proc. Natl Acad. Sci. USA 89, 1128\u20131132 (1992).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF387406a0_CR15","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1242\/dev.118.4.1031","volume":"118","author":"G Teitelman","year":"1993","unstructured":"Teitelman, G., Alpert, S., Polak, J. M., Martinez, A. & Hanahan, D. Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal protein tyrosine hydroxylase and neuropeptide Y, butnot pancreatic polypeptide. Development 118, 1031\u20131039 (1993).","journal-title":"Development"},{"key":"BF387406a0_CR16","doi-asserted-by":"publisher","first-page":"8424","DOI":"10.1073\/pnas.90.18.8424","volume":"90","author":"A Nagy","year":"1993","unstructured":"Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W. & Roder, J. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl Acad. Sci. USA 90, 8424\u20138428 (1993).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF387406a0_CR17","first-page":"33","volume-title":"Gene Targeting: A Practical Approach","author":"W Wurst","year":"1993","unstructured":"Wurst, W. & Joyner, A. L. in Gene Targeting: A Practical Approach (ed. Joyner, A. L.) 33\u201361 (Oxford University Press, Oxford, 1993)."},{"key":"BF387406a0_CR18","first-page":"145","volume-title":"Gene Targetting: A Practical Approach","author":"A Nagy","year":"1993","unstructured":"Nagy, A. & Rossant, J. in Gene Targetting: A Practical Approach (ed. Joyner, A. L.) 145\u2013179 (Oxford University Press, Oxford, 1993)."},{"key":"BF387406a0_CR19","doi-asserted-by":"publisher","first-page":"4251","DOI":"10.1002\/j.1460-2075.1993.tb06109.x","volume":"12","author":"H Ohlsson","year":"1993","unstructured":"Ohlsson, H., Karlsson, K. & Edlund, T. IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J. 12, 4251\u20134259 (1993).","journal-title":"EMBO J."},{"key":"BF387406a0_CR20","doi-asserted-by":"publisher","first-page":"4712","DOI":"10.1073\/pnas.87.12.4712","volume":"87","author":"H Le Mouellic","year":"1990","unstructured":"Le Mouellic, H., Lallemand, Y. & Br\u00fblet, P. Targeted replacement of the homeobox gene Hox-3.1 by the Escherichia coli LacZ in mouse chimeric embryos. Proc. Natl Acad. Sci. USA 87, 4712\u20134716 (1990).","journal-title":"Proc. Natl Acad. Sci. USA"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/387406a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/387406a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/387406a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T20:12:11Z","timestamp":1684354331000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/387406a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,5]]},"references-count":20,"journal-issue":{"issue":"6631","published-print":{"date-parts":[[1997,5]]}},"alternative-id":["BF387406a0"],"URL":"https:\/\/doi.org\/10.1038\/387406a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,5]]}}}