{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:24:28Z","timestamp":1783689868860,"version":"3.55.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"6651","license":[{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1997,10]]},"DOI":"10.1038\/39348","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:37:10Z","timestamp":1027672630000},"page":"618-622","source":"Crossref","is-referenced-by-count":736,"title":["Opposing BMP and EGF signalling pathways converge on the TGF-\u03b2 family mediator Smad1"],"prefix":"10.1038","volume":"389","author":[{"given":"Marcus","family":"Kretzschmar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Doody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Massagu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF39348_CR1","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/978-3-642-49295-2_8","volume-title":"Peptide Growth Factors and their Receptors","author":"AB Roberts","year":"1990","unstructured":"Roberts,A. B., Sporn,M. B. in Peptide Growth Factors and their Receptors (eds Sporn, M. B. &Roberts, A. B.) 419\u2013472 (Springer, Heidelberg, (1990))."},{"key":"BF39348_CR2","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1101\/gad.10.13.1580","volume":"10","author":"BLM Hogan","year":"1996","unstructured":"Hogan,B. L. M. Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev. 10, 1580\u20131594 (1996).","journal-title":"Genes Dev."},{"key":"BF39348_CR3","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/S0092-8674(00)80128-2","volume":"86","author":"K Eppert","year":"1996","unstructured":"Eppert,K. et al. MADR2 maps to 18q21 and encodes a TGF\u03b2-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell 86, 543\u2013552 (1996).","journal-title":"Cell"},{"key":"BF39348_CR4","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/S0092-8674(00)81249-0","volume":"85","author":"JM Graff","year":"1996","unstructured":"Graff,J. M., Bansal,A. & Melton,D. A. Xenopus Mad proteins transduce distinct subsets of signals for the TGF\u03b2 superfamily. Cell 85, 479\u2013487 (1996).","journal-title":"Cell"},{"key":"BF39348_CR5","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S0092-8674(00)81250-7","volume":"85","author":"PA Hoodless","year":"1996","unstructured":"Hoodless,P. A. et al. MADR1, a MAD-related protein that functions in BMP2 signalling pathways. Cell 85, 489\u2013500 (1996).","journal-title":"Cell"},{"key":"BF39348_CR6","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1101\/gad.11.8.984","volume":"11","author":"M Kretzschmar","year":"1997","unstructured":"Kretzschmar,M., Liu,F., Hata,A., Doody,J. & Massagu\u00e9,J. The TGF\u03b2 family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev. 11, 984\u2013995 (1997).","journal-title":"Genes Dev."},{"key":"BF39348_CR7","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1038\/383832a0","volume":"383","author":"G Lagna","year":"1996","unstructured":"Lagna,G., Hata,A., Hemmati-Brivanlou,A. & Massagu\u00e9,J. Partnership between DPC4 and SMAD proteins in TGF-\u03b2 signalling pathways. Nature 383, 832\u2013836 (1996).","journal-title":"Nature"},{"key":"BF39348_CR8","doi-asserted-by":"publisher","first-page":"17617","DOI":"10.1074\/jbc.271.30.17617","volume":"271","author":"RJ Lechleider","year":"1996","unstructured":"Lechleider,R. J., de Caestecker,M. P., Dehejia,A., Polymeropoulos,M. H. & Roberts,A. B. Serine phosphorylation, chromosomal localization and TGF\u03b2 signal transduction by human bsp-1. J. Biol. Chem. 271, 17617\u201317620 (1996).","journal-title":"J. Biol. Chem."},{"key":"BF39348_CR9","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1016\/S0092-8674(00)81817-6","volume":"87","author":"M Macias-Silva","year":"1996","unstructured":"Macias-Silva,M. et al. MADR2 is a substrate of the TGF\u03b2 receptor and phosphorylation is required for nuclear accumulation and signaling. Cell 87, 1215\u20131224 (1996).","journal-title":"Cell"},{"key":"BF39348_CR10","doi-asserted-by":"publisher","first-page":"8940","DOI":"10.1073\/pnas.93.17.8940","volume":"93","author":"JM Yingling","year":"1996","unstructured":"Yingling,J. M. et al. Mammalian Dwarfins are phosphorylated in response to TGF-\u03b2 and are implicated in control of cell growth. Proc. Natl Acad. Sci. USA 93, 8940\u20138944 (1996).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF39348_CR11","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1101\/gad.10.15.1880","volume":"10","author":"J Baker","year":"1996","unstructured":"Baker,J. & Harland,R. M. Anovel mesoderm inducer, mMadr-2, functions in the activin signal transduction pathway. Genes Dev. 10, 1880\u20131889 (1996).","journal-title":"Genes Dev."},{"key":"BF39348_CR12","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1038\/381620a0","volume":"381","author":"F Liu","year":"1996","unstructured":"Liu,F. et al. Ahuman Mad protein acting as a BMP-regulated transcriptional activator. Nature 381, 620\u2013623 (1996).","journal-title":"Nature"},{"key":"BF39348_CR13","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/383691a0","volume":"383","author":"X Chen","year":"1996","unstructured":"Chen,X., Rubock,M. J. & Whitman,M. Atranscriptional partner of MAD proteins in TGF-\u03b2 signalling. Nature 383, 691\u2013696 (1996).","journal-title":"Nature"},{"key":"BF39348_CR14","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/361068a0","volume":"361","author":"L Niswander","year":"1993","unstructured":"Niswander,L. & Martin,G. R. FGF-4 and BMP-2 have opposite effects on limb growth. Nature 361, 68\u201371 (1993).","journal-title":"Nature"},{"key":"BF39348_CR15","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1242\/dev.122.8.2349","volume":"122","author":"Y Ganan","year":"1996","unstructured":"Ganan,Y., Macias,D., Duterque-Coquillaud,M., Ros,M. A. & Hurle,J. M. Role of TGF\u03b2s and BMPs as signals controlling the position of the digits and the areas of interdigital cell death in the developing chick limb autopod. Development 122, 2349\u20132357 (1996).","journal-title":"Development"},{"key":"BF39348_CR16","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1002\/jcp.1041520213","volume":"152","author":"SM Bernier","year":"1992","unstructured":"Bernier,S. M. & Goltzman,D. Effect of protein and steroidal osteotropic agents on differentiation and epidermal growth factor-mediated growth of the CFK1 osseous cell line. J. Cell Physiol. 152, 317\u2013327 (1992).","journal-title":"J. Cell Physiol."},{"key":"BF39348_CR17","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/S0092-8674(00)80333-5","volume":"90","author":"A Neub\u00fcser","year":"1997","unstructured":"Neub\u00fcser,A., Peters,H., Balling,R. & Martin,G. R. Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Cell 90, 247\u2013255 (1997).","journal-title":"Cell"},{"key":"BF39348_CR18","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/40424","volume":"388","author":"A Hata","year":"1997","unstructured":"Hata,A., Lo,R. S., Wotton,D., Lagna,G. & Massagu\u00e9,J. Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature 388, 82\u201387 (1997).","journal-title":"Nature"},{"key":"BF39348_CR19","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/40906","volume":"388","author":"J Kim","year":"1997","unstructured":"Kim,J., Johnson,K., Chen,H. J., Carroll,S. & Laughon,A. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 388, 304\u2013308 (1997).","journal-title":"Nature"},{"key":"BF39348_CR20","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/383168a0","volume":"383","author":"Y Zhang","year":"1996","unstructured":"Zhang,Y., Feng,X.-, Wu,R.-Y. & Derynck,R. Receptor-associated Mad homologues synergize as effectors of the TGF-\u03b2 response. Nature 383, 168\u2013172 (1996).","journal-title":"Nature"},{"key":"BF39348_CR21","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1128\/MCB.17.5.2521","volume":"17","author":"R-Y Wu","year":"1997","unstructured":"Wu,R.-Y., Zhang,Y., Feng,X.-H. & Derynck,R. Heteromeric and homomeric interactions correlate with signalling activity and functional cooperativity of Smad3 and Smad4\/DPC4. Mol. Cell. Biol. 17, 2521\u20132528 (1997).","journal-title":"Mol. Cell. Biol."},{"key":"BF39348_CR22","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1126\/science.271.5247.350","volume":"271","author":"SA Hahn","year":"1996","unstructured":"Hahn,S. A. et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271, 350\u2013353 (1996).","journal-title":"Science"},{"key":"BF39348_CR23","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/40431","volume":"388","author":"Y Shi","year":"1997","unstructured":"Shi,Y., Hata,A., Lo,R. S., Massagu\u00e9,J. & Pavletich,N. P. Astructural basis for mutational inactivation of the tumour suppressor Smad4. Nature 388, 87\u201393 (1997).","journal-title":"Nature"},{"key":"BF39348_CR24","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/S0960-9822(06)00123-0","volume":"7","author":"Y Zhang","year":"1997","unstructured":"Zhang,Y., Musci,T. & Derynck,R. The tumor suppressor Smad4\/DPC4 as a central mediator of Smad function. Curr. Biol. 7, 270\u2013276 (1997).","journal-title":"Curr. Biol."},{"key":"BF39348_CR25","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/0092-8674(95)90403-4","volume":"80","author":"CS Hill","year":"1995","unstructured":"Hill,C. S. & Treisman,R. Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell 80, 199\u2013211 (1995).","journal-title":"Cell"},{"key":"BF39348_CR26","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/S0962-8924(00)89088-1","volume":"5","author":"P Vandenabeele","year":"1995","unstructured":"Vandenabeele,P., Declercg,W., Beyaert,R. & Fiers,W. Two tumour necrosis factor receptors: structure and function. Trends Cell Biol. 5, 392\u2013399 (1995).","journal-title":"Trends Cell Biol."},{"key":"BF39348_CR27","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/0092-8674(95)90401-8","volume":"80","author":"CJ Marshall","year":"1995","unstructured":"Marshall,C. J. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80, 179\u2013185 (1995).","journal-title":"Cell"},{"key":"BF39348_CR28","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/S0092-8674(00)81883-8","volume":"88","author":"TF Franke","year":"1997","unstructured":"Franke,T. F., Kaplan,D. R. & Cantley,L. C. PI3K: downstream AKTion blocks apoptosis. Cell 88, 435\u2013437 (1997).","journal-title":"Cell"},{"key":"BF39348_CR29","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/sj.onc.1200879","volume":"14","author":"D Besser","year":"1997","unstructured":"Besser,D. et al. Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2. Oncogene 14, 705\u2013711 (1997).","journal-title":"Oncogene"},{"key":"BF39348_CR30","doi-asserted-by":"publisher","first-page":"5889","DOI":"10.1073\/pnas.90.13.5889","volume":"90","author":"J Blenis","year":"1993","unstructured":"Blenis,J. Signal transduction via the MAP kinases: proceed at your own RSK. Proc. Natl Acad. Sci. USA 90, 5889\u20135892 (1993).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF39348_CR31","doi-asserted-by":"crossref","first-page":"16985","DOI":"10.1016\/S0021-9258(17)32506-1","volume":"269","author":"P ten Dijke","year":"1994","unstructured":"ten Dijke,P. et al. Identification of type I receptors for Osteogenic Protein-1 and Bone Morphogenetic Protein-4. J. Biol. Chem. 269, 16985\u201316988 (1994).","journal-title":"J. Biol. Chem."},{"key":"BF39348_CR32","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/0003-2697(87)90587-2","volume":"166","author":"H Schagger","year":"1987","unstructured":"Schagger,H. & von Jagow,G. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100\u2009kDa. Anal. Biochem. 166, 368\u2013379 (1987).","journal-title":"Anal. Biochem."},{"key":"BF39348_CR33","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1038\/42972","volume":"387","author":"W Gu","year":"1997","unstructured":"Gu,W., Shi,X.-L. & Roeder,R. G. Synergistic activation of transcription by CBP and p53. Nature 387, 819\u2013823 (1997).","journal-title":"Nature"},{"key":"BF39348_CR34","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S0962-8924(97)01036-2","volume":"7","author":"J Massagu\u00e9","year":"1997","unstructured":"Massagu\u00e9,J., Hata,A. & Liu,F. TGF-\u03b2 signalling through the Smad pathway. Trends Cell Biol. 7, 187\u2013192 (1997).","journal-title":"Trends Cell Biol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/39348.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/39348","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/39348.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:14:25Z","timestamp":1684368865000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/39348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":34,"journal-issue":{"issue":"6651","published-print":{"date-parts":[[1997,10]]}},"alternative-id":["BF39348"],"URL":"https:\/\/doi.org\/10.1038\/39348","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,10]]}}}