{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:02:14Z","timestamp":1791453734092,"version":"4.3.3"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"6654","license":[{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1997,10]]},"DOI":"10.1038\/40166","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:32:58Z","timestamp":1027672378000},"page":"978-981","source":"Crossref","is-referenced-by-count":463,"title":["Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells"],"prefix":"10.1038","volume":"389","author":[{"given":"Robert C.","family":"Fuhlbrigge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. David","family":"Kieffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Armerding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S.","family":"Kupper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF40166_CR1","first-page":"1053","volume":"136","author":"LJ Picker","year":"1990","unstructured":"Picker, L. J., Michie, S. A., Rott, L. S. & Butcher, E. C. Aunique phenotype of skin-associated lymphocytes in human. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites. Am. J. Pathol. 136, 1053\u20131068 (1990).","journal-title":"Am. J. Pathol."},{"key":"BF40166_CR2","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1002\/eji.1830240132","volume":"24","author":"H Rossiter","year":"1994","unstructured":"Rossiter, H. et al. Skin disease-related T cells bind to endothelial selectins: expression of cutaneous lymphocyte antigen (CLA) predicts E-selectin but not P-selectin binding. Eur. J. Immunol. 24, 205\u2013210 (1994).","journal-title":"Eur. J. Immunol."},{"key":"BF40166_CR3","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1002\/eji.1830240605","volume":"24","author":"LJ Picker","year":"1994","unstructured":"Picker, L. J. et al. Differential expression of lymphocyte homing receptors by human memory\/effector T cells in pulmonary versus cutaneous immune effector sites. Eur. J. Immunol. 24, 1269\u20131277 (1994).","journal-title":"Eur. J. Immunol."},{"key":"BF40166_CR4","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1172\/JCI117743","volume":"95","author":"KJ Abernathy-Carver","year":"1995","unstructured":"Abernathy-Carver, K. J., Sampson, H. A., Picker, L. J. & Leung, D. Y. Milk-induced eczema is associated with the expansion of T cell expression of cutaneous lymphotcyte antigen. J. Clin. Invest. 95, 913\u2013918 (1995).","journal-title":"J. Clin. Invest."},{"key":"BF40166_CR5","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1002\/art.1780390118","volume":"39","author":"C Pitzalis","year":"1996","unstructured":"Pitzalis, C. et al. Cutaneous lymphocyte antigen positive T lymphocytes preferentially migrate to skin but not to the joint in psoriatic arthritis. Arthritis Rheum. 39, 137\u2013145 (1996).","journal-title":"Arthritis Rheum."},{"key":"BF40166_CR6","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/S0889-8588(18)30054-6","volume":"9","author":"AH Rook","year":"1995","unstructured":"Rook, A. H. & Heald, P. The immunopathogenesis of cutaneous T-cell lymphoma. Hematol. Oncol. Clin. N. Am. 9, 997\u20131010 (1995).","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"BF40166_CR7","doi-asserted-by":"crossref","first-page":"14869","DOI":"10.1016\/S0021-9258(18)98555-8","volume":"266","author":"EL Berg","year":"1991","unstructured":"Berg, E. L., Robinson, M. K., Mansson, O., Butcher, E. C. & Magnani, J. L. Acarbohydrate domain common to both sialyl Le(a) and sialyl Le(x) is recognized by the endothelial cell leukocyte adhesion molecule ELAM-1. J. Biol. Chem. 266, 14869\u201314872 (1991).","journal-title":"J. Biol. Chem."},{"key":"BF40166_CR8","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.4049\/jimmunol.150.3.1122","volume":"150","author":"LJ Picker","year":"1993","unstructured":"Picker, L. J. et al. Control of lymphocyte recirculation in man. II. Differential regulation of the cutaneous lymphocyte-associated antigen, a tissue- selective homing receptor for skin-homing T cells. J. Immunol. 150, 1122\u20131136 (1993).","journal-title":"J. Immunol."},{"key":"BF40166_CR9","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1038\/349796a0","volume":"349","author":"LJ Picker","year":"1991","unstructured":"Picker, L. J., Kishimoto, T. K., Smith, C. W., Warnock, R. A. & Butcher, E. C. ELAM-1 is an adhesion molecule for skin-homing T cells. Nature 349, 796\u2013799 (1991).","journal-title":"Nature"},{"key":"BF40166_CR10","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1084\/jem.174.6.1461","volume":"174","author":"EL Berg","year":"1991","unstructured":"Berg, E. L. et al. The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1. J. Exp. Med. 174, 1461\u20131466 (1991).","journal-title":"J. Exp. Med."},{"key":"BF40166_CR11","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1083\/jcb.127.5.1485","volume":"127","author":"R Alon","year":"1994","unstructured":"Alon, R., Rossiter, H., Wang, X., Springer, T. A. & Kupper, T. S. Distinct cell surface ligands mediate T lymphocyte attachment and rolling on P- and E-selectin under physiological flow. J. Cell Biol. 127, 1485\u20131495 (1994).","journal-title":"J. Cell Biol."},{"key":"BF40166_CR12","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1126\/science.272.5258.60","volume":"272","author":"EC Butcher","year":"1996","unstructured":"Butcher, E. C. & Picker, L. J. Lymphotyte homing and homeostatis. Science 272, 60\u201366 (1996).","journal-title":"Science"},{"key":"BF40166_CR13","first-page":"H1637","volume":"267","author":"D Nolte","year":"1994","unstructured":"Nolte, D. et al. Leukocyte rolling in venules of striated muscle and skin is mediated by P-selectin, not by L-selectin. Am. J. Physiol. 267, H1637\u2013H1642 (1994).","journal-title":"Am. J. Physiol."},{"key":"BF40166_CR14","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1172\/JCI117612","volume":"94","author":"DA Jones","year":"1994","unstructured":"Jones, D. A., McIntire, L. V., Smith, C. W. & Picker, L. J. Atwo-step adhesion cascade for T cell\/endothelial cell interactions under flow conditions. J. Clin. Invest. 94, 2443\u20132450 (1994).","journal-title":"J. Clin. Invest."},{"key":"BF40166_CR15","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.4049\/jimmunol.154.4.1543","volume":"154","author":"LF Santamaria Babi","year":"1995","unstructured":"Santamaria Babi, L. F. et al. Migration of skin-homing T cells across cytokine-activated human endothelial cell layers involves interaction of the cutaneous lymphocyte-associated antigen (CLA), the very late antigen-4 (VLA-4), and the lymphocyte function-associated antigen-1 (LFA-1). J. Immunol. 154, 1543\u20131550 (1995).","journal-title":"J. Immunol."},{"key":"BF40166_CR16","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1084\/jem.183.3.1193","volume":"183","author":"TG Diacovo","year":"1996","unstructured":"Diacovo, T. G. et al. Interactions of human alpha\/beta and gamma\/delta T lymphocyte subsets in shear flow with E- and P-selectin. J. Exp. Med. 183, 1193\u20131203 (1996).","journal-title":"J. Exp. Med."},{"key":"BF40166_CR17","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1182\/blood.V88.9.3259.bloodjournal8893259","volume":"88","author":"GS Kansas","year":"1996","unstructured":"Kansas, G. S. Selectins and their ligands: current concepts and controversies. Blood 88, 3259\u20133287 (1996).","journal-title":"Blood"},{"key":"BF40166_CR18","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1084\/jem.181.2.747","volume":"181","author":"DY Leung","year":"1995","unstructured":"Leung, D. Y. et al. Bacterial superantigens induce T-cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production. J. Exp. Med. 181, 747\u2013753 (1995).","journal-title":"J. Exp. Med."},{"key":"BF40166_CR19","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1083\/jcb.133.4.911","volume":"133","author":"RN Knibbs","year":"1996","unstructured":"Knibbs, R. N. et al. The fucosyltransferase FucT-VII regulates E-selectin ligand synthesis in human T cells. J. Cell Biol. 133, 911\u2013920 (1996).","journal-title":"J. Cell Biol."},{"key":"BF40166_CR20","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1182\/blood.V88.6.2125.bloodjournal8862125","volume":"88","author":"AJ Wagers","year":"1996","unstructured":"Wagers, A. J., Lowe, J. B. & Kansas, G. S. An important role for the 1, 3 fucosyltransferase, FucT-VII, in leukocyte adhesion to E-selectin. Blood 88, 2125\u20132132 (1996).","journal-title":"Blood"},{"key":"BF40166_CR21","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1083\/jcb.118.2.445","volume":"118","author":"KL Moore","year":"1992","unstructured":"Moore, K. L. et al. Identification of a specific glycoprotein ligand for P-selectin (CD62) on myeloid cells. J. Cell Biol. 118, 445\u2013456 (1992).","journal-title":"J. Cell Biol."},{"key":"BF40166_CR22","doi-asserted-by":"crossref","first-page":"12764","DOI":"10.1016\/S0021-9258(18)31454-6","volume":"268","author":"KE Norgard","year":"1993","unstructured":"Norgard, K. E. et al. Characterization of a specific ligand for P-selectin on myeloid cells: A minor glycoprotein with sialylated O-linked oligosaccharides. J. Biol. Chem. 268, 12764\u201312774 (1993).","journal-title":"J. Biol. Chem."},{"key":"BF40166_CR23","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1016\/0092-8674(93)90327-M","volume":"75","author":"D Sako","year":"1993","unstructured":"Sako, D. et al. Expression cloning of a functional glycoprotein ligand for P-selectin. Cell 75, 1179\u20131186 (1993).","journal-title":"Cell"},{"key":"BF40166_CR24","first-page":"163","volume-title":"Frontiers in Molecular Biology","author":"JB Lowe","year":"1994","unstructured":"Lowe, J. B. in Frontiers in Molecular Biology (ed. Fukuda, M.) 163\u2013205 (Oxford Univ. Press, (1994))."},{"key":"BF40166_CR25","first-page":"5279","volume":"44","author":"K Fukushima","year":"1984","unstructured":"Fukushima, K. et al. Characterisation of sialosylated Lewisx as a new tumour-associated antigen. Cancer Res. 44, 5279\u20135285 (1984).","journal-title":"Cancer Res."},{"key":"BF40166_CR26","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1083\/jcb.135.3.837","volume":"135","author":"RC Fuhlbrigge","year":"1996","unstructured":"Fuhlbrigge, R. C., Alon, R., Puri, K. D., Lowe, J. B. & Springer, T. A. Sialylated, fucosylated ligands for L-selectin expressed on leukocytes mediate tethering and rolling adhesions in physiologic flow conditions. J. Cell Biol. 135, 837\u2013848 (1996).","journal-title":"J. Cell Biol."},{"key":"BF40166_CR27","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1006\/bbrc.1995.2799","volume":"217","author":"JD Kieffer","year":"1995","unstructured":"Kieffer, J. D., Plopper, G., Ingber, D. E., Hartwig, J. H. & Kupper, T. S. Direct binding of F actin to the cytoplasmic domain of the \u03b12 integrin chain in vitro. Biochem. Biophys. Res. Commun. 217, 466\u2013474 (1995).","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/40166.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/40166","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/40166.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:16:30Z","timestamp":1684368990000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/40166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":27,"journal-issue":{"issue":"6654","published-print":{"date-parts":[[1997,10]]}},"alternative-id":["BF40166"],"URL":"https:\/\/doi.org\/10.1038\/40166","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,10]]}}}