{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:47:40Z","timestamp":1791316060222,"version":"4.3.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[1998,12,1]],"date-time":"1998-12-01T00:00:00Z","timestamp":912470400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[1998,12]]},"DOI":"10.1038\/4033","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:43:54Z","timestamp":1027658634000},"page":"1441-1444","source":"Crossref","is-referenced-by-count":537,"title":["Expression of full-length utrophin prevents muscular dystrophy in mdx mice"],"prefix":"10.1038","volume":"4","author":[{"given":"Jonathon","family":"Tinsley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Deconinck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosie","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Phelps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Gillis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFnm1298_1441_CR1","volume-title":"Duchenne Muscular Dystrophy","author":"AEH Emery","year":"1993","unstructured":"Emery, A.E.H. in Duchenne Muscular Dystrophy (Oxford Medical Publications, Oxford, 1993)."},{"key":"BFnm1298_1441_CR2","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/360591a0","volume":"360","author":"JM Tinsley","year":"1992","unstructured":"Tinsley, J.M. et al. Primary structure of dystrophin-related protein. Nature 360, 591\u2013593 (1992).","journal-title":"Nature"},{"key":"BFnm1298_1441_CR3","doi-asserted-by":"publisher","first-page":"3243","DOI":"10.1073\/pnas.88.8.3243","volume":"88","author":"DR Love","year":"1991","unstructured":"Love, D.R. et al. Tissue distribution of the dystrophin-related gene product and expression in the mdx and dy mouse. Proc. Natl. Acad. Sci. USA 88, 3243\u20133247 (1991).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm1298_1441_CR4","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/0960-8966(91)90023-L","volume":"1","author":"TS Khurana","year":"1991","unstructured":"Khurana, T.S. et al. Immunolocalization and developmental expression of dystrophin related protein in skeletal muscle. Neuromuscul. Disord. 1, 185\u2013194 (1991).","journal-title":"Neuromuscul. Disord."},{"key":"BFnm1298_1441_CR5","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1038\/nm1197-1216","volume":"3","author":"N Deconinck","year":"1997","unstructured":"Deconinck, N. et al. Expression of truncated utrophin leads to major functional improvements in dystrophin-deficient muscles of mice. Nature Med. 3, 1216\u20131221 (1997).","journal-title":"Nature Med."},{"key":"BFnm1298_1441_CR6","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/384349a0","volume":"384","author":"JM Tinsley","year":"1996","unstructured":"Tinsley, J.M. et al. Amelioration of the dystrophic phenotype of mdx mice using a truncated utrophin transgene. Nature 384, 349\u2013353 (1996).","journal-title":"Nature"},{"key":"BFnm1298_1441_CR7","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0021-9258(18)54211-3","volume":"268","author":"KJ Brennan","year":"1993","unstructured":"Brennan, K.J. & Hardeman, E.C. Quantitative analysis of the human alpha-skeletal actin gene in transgenic mice. J. Biol. Chem. 268, 719\u2013725 (1993).","journal-title":"J. Biol. Chem."},{"key":"BFnm1298_1441_CR8","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1073\/pnas.81.4.1189","volume":"81","author":"G Bulfield","year":"1984","unstructured":"Bulfield, G., Siller, W.G., Wight, P.A. & Moore, K.J. X chromosome-linked muscular dystrophy (mdx) in the mouse. Proc. Natl. Acad. Sci. USA 81, 1189\u20131192 (1984).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm1298_1441_CR9","doi-asserted-by":"publisher","first-page":"3697","DOI":"10.1073\/pnas.92.9.3697","volume":"92","author":"DJ Blake","year":"1995","unstructured":"Blake, D.J. et al. G-utrophin, the autosomal homologue of dystrophin Dp116, is expressed in sensory ganglia and brain. Proc. Natl. Acad. Sc.i USA 92, 3697\u20133701 (1995).","journal-title":"Proc. Natl. Acad. Sc.i USA"},{"key":"BFnm1298_1441_CR10","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1097\/00019052-199704000-00016","volume":"10","author":"V Straub","year":"1997","unstructured":"Straub, V. & Campbell, K.P. Muscular dystrophies and the dystrophin-glycoprotein complex. Curr. Opin. Neurol. 10, 168\u2013175 (1997).","journal-title":"Curr. Opin. Neurol."},{"key":"BFnm1298_1441_CR11","doi-asserted-by":"publisher","first-page":"12413","DOI":"10.1073\/pnas.94.23.12413","volume":"94","author":"PH Sadoulet","year":"1997","unstructured":"Sadoulet, P.H., Rajala, M. & Kunkel, L.M. Dystrobrevin and dystrophin: an interaction through coiled-coil motifs. Proc. Natl. Acad. Sci. USA 94, 12413\u201312418 (1997).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm1298_1441_CR12","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1083\/jcb.128.3.373","volume":"128","author":"A Suzuki","year":"1995","unstructured":"Suzuki, A., Yoshida, M. & Ozawa, E. Mammalian alpha 1- and beta 1-syntrophin bind to the alternative splice-prone region of the dystrophin COOH terminus. J. Cell. Biol. 128, 373\u2013381 (1995).","journal-title":"J. Cell. Biol."},{"key":"BFnm1298_1441_CR13","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1073\/pnas.95.1.241","volume":"95","author":"DJ Blake","year":"1998","unstructured":"Blake, D.J., Nawrotzki, R., Loh, N.Y., Gorecki, D.C. & Davies, K.E. beta-dystrobrevin, a member of the dystrophin-related protein family. Proc. Natl. Acad. Sci. USA 95, 241\u2013246 (1998).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm1298_1441_CR14","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1007\/BF00121296","volume":"14","author":"P Moens","year":"1993","unstructured":"Moens, P., Baatsen, P.H. & Marechal, G. Increased susceptibility of EDL muscles from mdx mice to damage induced by contractions with stretch. J. Muscle Res. Cell. Motil. 14, 446\u2013451 (1993).","journal-title":"J. Muscle Res. Cell. Motil."},{"key":"BFnm1298_1441_CR15","doi-asserted-by":"publisher","first-page":"3710","DOI":"10.1073\/pnas.90.8.3710","volume":"90","author":"BJ Petrof","year":"1993","unstructured":"Petrof, B.J., Shrager, J.B., Stedman, H.H., Kelly, A.M. & Sweeney, H.L. Dystrophin protects the sarcolemma from stresses developed during muscle contraction. Proc. Natl. Acad. Sci. USA 90, 3710\u20133714 (1993).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm1298_1441_CR16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/0022-510X(90)90005-8","volume":"100","author":"B Weller","year":"1990","unstructured":"Weller, B., Karpati, G. & Carpenter, S. Dystrophin-deficient mdx muscle fibers are preferentially vulnerable to necrosis induced by experimental lengthening contractions. J. Neurol. Sci. 100, 9\u201313 (1990).","journal-title":"J. Neurol. Sci."},{"key":"BFnm1298_1441_CR17","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/352536a0","volume":"352","author":"HH Stedman","year":"1991","unstructured":"Stedman, H.H. et al. The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy. Nature 352, 536\u2013539 (1991).","journal-title":"Nature"},{"key":"BFnm1298_1441_CR18","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1083\/jcb.115.6.1695","volume":"115","author":"TM Nguyen","year":"1991","unstructured":"Nguyen, T.M. et al. Localization of the DMDL gene-encoded dystrophin-related protein using a panel of nineteen monoclonal antibodies: presence at neuromuscular junctions, in the sarcolemma of dystrophic skeletal muscle, in vascular and other smooth muscles, and in proliferating brain cell lines. J. Cell. Biol. 115, 1695\u20131700 (1991).","journal-title":"J. Cell. Biol."},{"key":"BFnm1298_1441_CR19","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1002\/mus.880130603","volume":"13","author":"CG Carlson","year":"1990","unstructured":"Carlson, C.G. & Makiejus, R.V. A non-invassive procedure to detect muscle weakness in the mdx mouse. Muscle Nerve 13, 480\u2013484 (1990).","journal-title":"Muscle Nerve"},{"key":"BFnm1298_1441_CR20","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1083\/jcb.136.4.883","volume":"136","author":"AE Deconinck","year":"1997","unstructured":"Deconinck, A.E. et al. Postsynaptic abnormalities at the neuromuscular junctions of utrophin-deficient mice. J. Cell. Biol. 136, 88\u2013894 (1997).","journal-title":"J. Cell. Biol."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm1298_1441.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm1298_1441","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm1298_1441.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:24:49Z","timestamp":1684434289000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm1298_1441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,12]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1998,12]]}},"alternative-id":["BFnm1298_1441"],"URL":"https:\/\/doi.org\/10.1038\/4033","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,12]]}}}