{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:09:17Z","timestamp":1780585757587,"version":"3.54.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"6865","license":[{"start":{"date-parts":[[2001,12,13]],"date-time":"2001-12-13T00:00:00Z","timestamp":1008201600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2001,12,13]],"date-time":"2001-12-13T00:00:00Z","timestamp":1008201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2001,12,13]]},"DOI":"10.1038\/414768a","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:34:56Z","timestamp":1027658096000},"page":"768-773","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":373,"title":["c-Myc regulates mammalian body size by controlling cell number but not cell size"],"prefix":"10.1038","volume":"414","author":[{"given":"Andreas","family":"Trumpp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosef","family":"Refaeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thordur","family":"Oskarsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Gasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail R.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Michael","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2001,12,13]]},"reference":[{"key":"BF414768a_CR1","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1146\/annurev.cellbio.16.1.653","volume":"16","author":"C Grandori","year":"2000","unstructured":"Grandori, C., Cowley, S. M., James, L. P. & Eisenman, R. N. The Myc\/Max\/Mad network and the transcriptional control of cell behavior. Annu. Rev. Cell Dev. Biol. 16, 653\u2013699 (2000).","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"BF414768a_CR2","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/S0092-8674(00)81512-3","volume":"98","author":"LA Johnston","year":"1999","unstructured":"Johnston, L. A., Prober, D. A., Edgar, B. A., Eisenman, R. N. & Gallant, P. Drosophila myc regulates cellular growth during development. Cell 98, 779\u2013790 (1999).","journal-title":"Cell"},{"key":"BF414768a_CR3","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1101\/gad.7.4.671","volume":"7","author":"AC Davis","year":"1993","unstructured":"Davis, A. C., Wims, M., Spotts, G. D., Hann, S. R. & Bradley, A. A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev. 7, 671\u2013682 (1993).","journal-title":"Genes Dev."},{"key":"BF414768a_CR4","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1146\/annurev.genet.31.1.33","volume":"31","author":"SH Orkin","year":"1997","unstructured":"Orkin, S. H. & Zon, L. I. Genetics of erythropoiesis: induced mutations in mice and zebrafish. Annu. Rev. Genet. 31, 33\u201360 (1997).","journal-title":"Annu. Rev. Genet."},{"key":"BF414768a_CR5","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/S1074-7613(00)80150-8","volume":"11","author":"L Van Parijs","year":"1999","unstructured":"Van Parijs, L., Refaeli, Y., Abbas, A. K. & Baltimore, D. Autoimmunity as a consequence of retrovirus-mediated expression of C-FLIP in lymphocytes. Immunity 11, 763\u2013770 (1999).","journal-title":"Immunity"},{"key":"BF414768a_CR6","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S1074-7613(01)00088-7","volume":"14","author":"IM de Alboran","year":"2001","unstructured":"de Alboran, I. M. et al. Analysis of c-myc function in normal cells via conditional gene-targeted mutation. Immunity 14, 45\u201355 (2001).","journal-title":"Immunity"},{"key":"BF414768a_CR7","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1083\/jcb.17.2.299","volume":"17","author":"GJ Todaro","year":"1963","unstructured":"Todaro, G. J. & Green, H. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J. Cell Biol. 17, 299\u2013313 (1963).","journal-title":"J. Cell Biol."},{"key":"BF414768a_CR8","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1126\/science.274.5292.1523","volume":"274","author":"P Gallant","year":"1996","unstructured":"Gallant, P., Shilo, Y., Cheng, P. F., Parkhurst, S. M. & Eisenman, R. N. Myc and Max homologs in Drosophila. Science 274, 1523\u20131527 (1996).","journal-title":"Science"},{"key":"BF414768a_CR9","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1126\/science.2783497","volume":"243","author":"GR Crabtree","year":"1989","unstructured":"Crabtree, G. R. Contingent genetic regulatory events in T lymphocyte activation. Science 243, 355\u2013361 (1989).","journal-title":"Science"},{"key":"BF414768a_CR10","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1126\/science.7660125","volume":"269","author":"R Kuhn","year":"1995","unstructured":"Kuhn, R., Schwenk, F., Aguet, M. & Rajewsky, K. Inducible gene targeting in mice. Science 269, 1427\u20131429 (1995).","journal-title":"Science"},{"key":"BF414768a_CR11","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/S1074-7613(00)80054-0","volume":"10","author":"F Radtke","year":"1999","unstructured":"Radtke, F. et al. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 10, 547\u2013558 (1999).","journal-title":"Immunity"},{"key":"BF414768a_CR12","doi-asserted-by":"publisher","first-page":"6595","DOI":"10.1002\/j.1460-2075.1996.tb01050.x","volume":"15","author":"J Vlach","year":"1996","unstructured":"Vlach, J., Hennecke, S., Alevizopoulos, K., Conti, D. & Amati, B. Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc. EMBO J. 15, 6595\u20136604 (1996).","journal-title":"EMBO J."},{"key":"BF414768a_CR13","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1101\/gad.827200","volume":"14","author":"RC O'Hagan","year":"2000","unstructured":"O'Hagan, R. C. et al. Myc-enhanced expression of cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression. Genes Dev. 14, 2185\u20132191 (2000).","journal-title":"Genes Dev."},{"key":"BF414768a_CR14","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/S0092-8674(00)81239-8","volume":"85","author":"ML Fero","year":"1996","unstructured":"Fero, M. L. et al. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell 85, 733\u2013744 (1996).","journal-title":"Cell"},{"key":"BF414768a_CR15","first-page":"1039","volume":"8","author":"MK Mateyak","year":"1997","unstructured":"Mateyak, M. K., Obaya, A. J., Adachi, S. & Sedivy, J. M. Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination. Cell Growth Differ. 8, 1039\u20131048 (1997).","journal-title":"Cell Growth Differ."},{"key":"BF414768a_CR16","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/j.1460-2075.1991.tb07929.x","volume":"10","author":"M Eilers","year":"1991","unstructured":"Eilers, M., Schirm, S. & Bishop, J. M. The myc protein activates transcription of the \u03b1-prothymosin gene. EMBO J. 10, 133\u2013141 (1991).","journal-title":"EMBO J."},{"key":"BF414768a_CR17","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0959-437X(05)80278-3","volume":"2","author":"EM Blackwood","year":"1992","unstructured":"Blackwood, E. M., Kretzner, L. & Eisenman, R. N. Myc and Max function as a nucleoprotein complex. Curr. Opin. Genet. Dev. 2, 227\u2013235 (1992).","journal-title":"Curr. Opin. Genet. Dev."},{"key":"BF414768a_CR18","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1073\/pnas.94.4.1235","volume":"94","author":"N Schreiber-Agus","year":"1997","unstructured":"Schreiber-Agus, N. et al. Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype. Proc. Natl Acad. Sci. USA 94, 1235\u20131240 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF414768a_CR19","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1098\/rspb.1995.0016","volume":"259","author":"RD Stevenson","year":"1995","unstructured":"Stevenson, R. D., Hill, M. F. & Bryant, P. J. Organ and cell allometry in Hawaiian Drosophila: how to make a big fly. Proc. R. Soc. Lond. B 259, 105\u2013110 (1995).","journal-title":"Proc. R. Soc. Lond. B"},{"key":"BF414768a_CR20","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S0092-8674(00)80563-2","volume":"96","author":"I Conlon","year":"1999","unstructured":"Conlon, I. & Raff, M. Size control in animal development. Cell 96, 235\u2013244 (1999).","journal-title":"Cell"},{"key":"BF414768a_CR21","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S0959-437X(00)00191-X","volume":"11","author":"CJ Potter","year":"2001","unstructured":"Potter, C. J. & Xu, T. Mechanisms of size control. Curr. Opin. Genet. Dev. 11, 279\u2013286 (2001).","journal-title":"Curr. Opin. Genet. Dev."},{"key":"BF414768a_CR22","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0959-437X(00)00123-4","volume":"10","author":"H Stocker","year":"2000","unstructured":"Stocker, H. & Hafen, E. Genetic control of cell size. Curr. Opin. Genet. Dev. 10, 529\u2013535 (2000).","journal-title":"Curr. Opin. Genet. Dev."},{"key":"BF414768a_CR23","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/BF01235756","volume":"18","author":"J Selfridge","year":"1992","unstructured":"Selfridge, J., Pow, A. M., McWhir, J., Magin, T. M. & Melton, D. W. Gene targeting using a mouse HPRT minigene\/HPRT-deficient embryonic stem cell system: inactivation of the mouse ERCC-1 gene. Somat. Cell Mol. Genet. 18, 325\u2013336 (1992).","journal-title":"Somat. Cell Mol. Genet."},{"key":"BF414768a_CR24","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1038\/373432a0","volume":"373","author":"RA Shivdasani","year":"1995","unstructured":"Shivdasani, R. A., Mayer, E. L. & Orkin, S. H. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1\/SCL. Nature 373, 432\u2013434 (1995).","journal-title":"Nature"},{"key":"BF414768a_CR25","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1101\/gad.6.1.14","volume":"6","author":"A Trumpp","year":"1992","unstructured":"Trumpp, A., Blundell, P. A., de la Pompa, J. L. & Zeller, R. The chicken limb deformity gene encodes nuclear proteins expressed in specific cell types during morphogenesis. Genes Dev. 6, 14\u201328 (1992).","journal-title":"Genes Dev."},{"key":"BF414768a_CR26","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/S1074-7613(00)80566-X","volume":"8","author":"Y Refaeli","year":"1998","unstructured":"Refaeli, Y., Van Parijs, L., London, C. A., Tschopp, J. & Abbas, A. K. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity 8, 615\u2013623 (1998).","journal-title":"Immunity"},{"key":"BF414768a_CR27","doi-asserted-by":"crossref","unstructured":"H\u00f6lzel, M., Kohlgruber, F., Schlosser, I., H\u00f6lzel, D., L\u00fcscher, B. & Eick, E. Myc\/Max\/Mad regulate the frequency but not the duration of productive cell cycles. EMBO Rep., 21 November 2001 (10.1093\/embo-reports\/kve251).","DOI":"10.1093\/embo-reports\/kve251"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/414768a.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/414768a","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/414768a.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T13:03:39Z","timestamp":1643807019000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/414768a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12,13]]},"references-count":27,"journal-issue":{"issue":"6865","published-print":{"date-parts":[[2001,12,13]]}},"alternative-id":["BF414768a"],"URL":"https:\/\/doi.org\/10.1038\/414768a","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1004191.70511","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1004191.29304","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1004191.32454","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12,13]]},"assertion":[{"value":"4 September 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2001","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2001","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}