{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T19:03:41Z","timestamp":1780599821260,"version":"3.54.1"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"6878","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2002,3]]},"DOI":"10.1038\/416279b","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:31:14Z","timestamp":1027672274000},"page":"279-280","source":"Crossref","is-referenced-by-count":479,"title":["Herceptin acts as an anti-angiogenic cocktail"],"prefix":"10.1038","volume":"416","author":[{"given":"Yotaro","family":"Izumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"di Tomaso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Fukumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh K.","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF416279b_CR1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/scientificamerican1201-38","volume":"285","author":"RK Jain","year":"2001","unstructured":"Jain, R. K. & Carmeliet, P. F. Sci. Am. 285, 38\u201345 (2001).","journal-title":"Sci. Am."},{"key":"BF416279b_CR2","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1093\/jnci\/93.14.1040","volume":"93","author":"IJ Fidler","year":"2001","unstructured":"Fidler, I. J. J. Natl Cancer Inst. 93, 1040\u20131041 (2001).","journal-title":"J. Natl Cancer Inst."},{"key":"BF416279b_CR3","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1056\/NEJM200103153441101","volume":"344","author":"DJ Slamon","year":"2001","unstructured":"Slamon, D. J. et al. N. Engl. J. Med. 344, 783\u2013792 (2001).","journal-title":"N. Engl. J. Med."},{"key":"BF416279b_CR4","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/35052073","volume":"2","author":"Y Yarden","year":"2001","unstructured":"Yarden, Y. & Sliwkowski, M. X. Nature Rev. Mol. Cell Biol. 2, 127\u2013137 (2001).","journal-title":"Nature Rev. Mol. Cell Biol."},{"key":"BF416279b_CR5","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1016\/S0959-8049(00)00092-7","volume":"36","author":"RS Kerbel","year":"2000","unstructured":"Kerbel, R. S., Viloria-Petit, A., Klement, G. & Rak, J. Eur. J. Cancer 36, 1248\u20131257 (2000).","journal-title":"Eur. J. Cancer"},{"key":"BF416279b_CR6","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1200\/JCO.2000.18.11.2201","volume":"18","author":"H Allgayer","year":"2000","unstructured":"Allgayer, H. et al. J. Clin. Oncol. 18, 2201\u20132209 (2000).","journal-title":"J. Clin. Oncol."},{"key":"BF416279b_CR7","doi-asserted-by":"publisher","first-page":"30290","DOI":"10.1074\/jbc.271.47.30290","volume":"271","author":"G Nicolini","year":"1996","unstructured":"Nicolini, G., Miloso, M., Moroni, M. C., Beguinot, L. & Scotto, L. J. Biol. Chem. 271, 30290\u201330296 (1996).","journal-title":"J. Biol. Chem."},{"key":"BF416279b_CR8","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1126\/science.286.5449.2511","volume":"286","author":"G Thurston","year":"1999","unstructured":"Thurston, G. et al. Science 286, 2511\u20132514 (1999).","journal-title":"Science"},{"key":"BF416279b_CR9","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1172\/JCI12749","volume":"107","author":"P Bornstein","year":"2001","unstructured":"Bornstein, P. J. Clin. Invest. 107, 929\u2013934 (2001).","journal-title":"J. Clin. Invest."},{"key":"BF416279b_CR10","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1038\/nm0901-987","volume":"7","author":"RK Jain","year":"2001","unstructured":"Jain, R. K. Nature Med. 7, 987\u2013989 (2001).","journal-title":"Nature Med."},{"key":"BF416279b_CR11","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/S0092-8674(00)81731-6","volume":"94","author":"D Fukumura","year":"1998","unstructured":"Fukumura, D. et al. Cell 94, 715\u2013725 (1998).","journal-title":"Cell"},{"key":"BF416279b_CR12","unstructured":"Jain, R. K., Munn, L. L. & Fukumura, D. Nature Rev. Cancer (in the press)."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/416279b.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/416279b","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/416279b.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:27:29Z","timestamp":1684369649000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/416279b"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":12,"journal-issue":{"issue":"6878","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["BF416279b"],"URL":"https:\/\/doi.org\/10.1038\/416279b","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3]]}}}