{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:38:09Z","timestamp":1778823489947,"version":"3.51.4"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"6762","license":[{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1999,12]]},"DOI":"10.1038\/45170","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:41:25Z","timestamp":1027672885000},"page":"623-631","source":"Crossref","is-referenced-by-count":201,"title":["Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand"],"prefix":"10.1038","volume":"402","author":[{"given":"Jos\u00e9","family":"Tormo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kannan","family":"Natarajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"Margulies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy A.","family":"Mariuzza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF45170_CR1","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1146\/annurev.immunol.16.1.359","volume":"16","author":"LL Lanier","year":"1998","unstructured":"Lanier,L. L. NK cell receptors. Annu. Rev. Immunol. 16, 359\u2013393 (1998).","journal-title":"Annu. Rev. Immunol."},{"key":"BF45170_CR2","first-page":"575","volume-title":"Fundamental Immunology","author":"WM Yokoyama","year":"1999","unstructured":"Yokoyama,W. M. in Fundamental Immunology (ed. Paul, W. E.) 575\u2013603 (Lippincott-Raven, Philadelphia, 1999)."},{"key":"BF45170_CR3","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1146\/annurev.immunol.17.1.875","volume":"17","author":"EO Long","year":"1999","unstructured":"Long,E. O. Regulation of immune responses through inhibitory receptors. Annu. Rev. Immunol. 17, 875\u2013904 (1999).","journal-title":"Annu. Rev. Immunol."},{"key":"BF45170_CR4","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/319675a0","volume":"319","author":"K K\u00e4rre","year":"1986","unstructured":"K\u00e4rre,K., Ljunggren,H. G., Piontek,G. & Kiessling,R. Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defense strategy. Nature 319, 675\u2013678 (1986).","journal-title":"Nature"},{"key":"BF45170_CR5","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0167-5699(90)90097-S","volume":"11","author":"HG Ljunggren","year":"1990","unstructured":"Ljunggren,H. G. & K\u00e4rre,K. In search of the \u201cmissing self\u201d: MHC molecules and NK cell recognition. Immunol. Today 11, 237\u2013244 (1990).","journal-title":"Immunol. Today"},{"key":"BF45170_CR6","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/38028","volume":"389","author":"QR Fan","year":"1997","unstructured":"Fan,Q. R. et al. Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors. Nature 389, 96\u2013100 (1997).","journal-title":"Nature"},{"key":"BF45170_CR7","doi-asserted-by":"publisher","first-page":"3864","DOI":"10.1073\/pnas.96.7.3864","volume":"96","author":"GA Snyder","year":"1999","unstructured":"Snyder,G. A., Brooks,A. G. & Sun,P. D. Crystal structure of the HLA-Cw3 allotype-specific killer cell inhibitory receptor KIR2DL2. Proc. Natl Acad. Sci. USA 96, 3864\u20133869 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF45170_CR8","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S0969-2126(99)80052-5","volume":"7","author":"K Maenaka","year":"1999","unstructured":"Maenaka,K., Juji,T., Stuart,D. I. & Jones,E. Y. Crystal structure of the human p58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I. Structure 7, 391\u2013398 (1999).","journal-title":"Structure"},{"key":"BF45170_CR9","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S1074-7613(00)80008-4","volume":"10","author":"JC Boyington","year":"1999","unstructured":"Boyington,J. C. et al. Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94\/NKG2 receptors. Immunity 10, 75\u201382 (1999).","journal-title":"Immunity"},{"key":"BF45170_CR10","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1146\/annurev.immunol.17.1.369","volume":"17","author":"KC Garcia","year":"1999","unstructured":"Garcia,K. C., Teyton,L. & Wilson,I. A. Structural basis of T cell recognition. Annu. Rev. Immunol. 17, 369\u2013397 (1999).","journal-title":"Annu. Rev. Immunol."},{"key":"BF45170_CR11","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/S1074-7613(00)80134-X","volume":"11","author":"K Natarajan","year":"1999","unstructured":"Natarajan,K. et al. Interaction of the NK cell inhibitory receptor Ly49A with H-2Dd: identification of a site distinct from the TCR site. Immunity 11, 591\u2013601 (1999).","journal-title":"Immunity"},{"key":"BF45170_CR12","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1006\/jmbi.1998.2091","volume":"283","author":"H Li","year":"1998","unstructured":"Li,H., Natarajan,K., Malchiodi,E. L., Margulies,D. H. & Mariuzza,R. A. Three-dimensional structure of H-2Dd complexed with an immunodominant peptide from human immunodeficiency virus envelope glycoprotein 120. J. Mol. Biol. 283, 179\u2013191 (1998).","journal-title":"J. Mol. Biol."},{"key":"BF45170_CR13","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1600-065X.1998.tb01185.x","volume":"163","author":"WI Weis","year":"1998","unstructured":"Weis,W. I., Taylor,M. E. & Drickamer,K. The C-type lectin superfamily in the immune system. Immunol. Rev. 163, 19\u201334 (1998).","journal-title":"Immunol. Rev."},{"key":"BF45170_CR14","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1126\/science.1721241","volume":"254","author":"WI Weis","year":"1991","unstructured":"Weis,W. I., Kahn,R., Fourme,R., Drickamer,K. & Hendrickson,W. A. Structure of the calcium-dependent lectin domain from a rat mannose-binding protein determined by MAD phasing. Science 254, 1608\u20131615 (1991).","journal-title":"Science"},{"key":"BF45170_CR15","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1006\/jmbi.1999.2910","volume":"290","author":"SF Poget","year":"1999","unstructured":"Poget,S. F. et al. The structure of a tunicate C-type lectin from Polyandrocarpa misakiensis complexed with D-galactose. J. Mol. Biol. 290, 867\u2013879 (1999).","journal-title":"J. Mol. Biol."},{"key":"BF45170_CR16","doi-asserted-by":"publisher","first-page":"17965","DOI":"10.1021\/bi981972a","volume":"37","author":"KK-S Ng","year":"1998","unstructured":"Ng,K. K.-S., Park-Snyder,S. & Weis,W. I. Ca2+-dependent structural changes in C-type mannose-binding proteins. Biochemistry 37, 17965\u201317976 (1998).","journal-title":"Biochemistry"},{"key":"BF45170_CR17","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1016\/S0969-2126(94)00124-3","volume":"2","author":"WI Weis","year":"1994","unstructured":"Weis,W. I. & Drickamer,K. Trimeric structure of a C-type mannose-binding protein. Structure 2, 1227\u20131240 (1994).","journal-title":"Structure"},{"key":"BF45170_CR18","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/nsb1194-789","volume":"1","author":"S Sheriff","year":"1994","unstructured":"Sheriff,S., Chan,C. Y. & Ezekowitz,R. A. B. Human mannose-binding protein carbohydrate recognition domain trimerizes through a triple \u03b1-helical coiled-coil. Nature Struct. Biol. 1, 789\u2013794 (1994).","journal-title":"Nature Struct. Biol."},{"key":"BF45170_CR19","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/367532a0","volume":"367","author":"BJ Graves","year":"1994","unstructured":"Graves,B. J. et al. Insight into E-selectin\/ligand interaction from the crystal structure and mutagenesis of the lec\/EGF domains. Nature 367, 532\u2013538 (1994).","journal-title":"Nature"},{"key":"BF45170_CR20","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1006\/jmbi.1998.2439","volume":"285","author":"L Lo Conte","year":"1999","unstructured":"Lo Conte,L., Chothia,C. & Janin,J. The atomic structure of protein\u2013protein recognition sites. J. Mol. Biol. 285, 2177\u20132198 (1999).","journal-title":"J. Mol. Biol."},{"key":"BF45170_CR21","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/S0092-8674(00)80790-4","volume":"97","author":"J-H Wang","year":"1999","unstructured":"Wang,J.-H. et al. Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors. Cell 97, 791\u2013803 (1999).","journal-title":"Cell"},{"key":"BF45170_CR22","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1006\/jmbi.1993.1648","volume":"234","author":"MC Lawrence","year":"1993","unstructured":"Lawrence,M. C. & Colman,P. M. Shape complementarity at protein\/protein interfaces. J. Mol. Biol. 234, 946\u2013950 (1993).","journal-title":"J. Mol. Biol."},{"key":"BF45170_CR23","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/358066a0","volume":"358","author":"FM Karlhofer","year":"1992","unstructured":"Karlhofer,F. M., Ribaudo,R. K. & Yokoyama,W. M. MHC class I alloantigen specificity of Ly-49+ IL-2 activated natural killer cells. Nature 358, 66\u201370 (1992).","journal-title":"Nature"},{"key":"BF45170_CR24","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/42523","volume":"387","author":"GF Gao","year":"1997","unstructured":"Gao,G. F. et al. Crystal structure of the complex between human CD8\u03b1\u03b1 and HLA-A2. Nature 387, 630\u2013634 (1997).","journal-title":"Nature"},{"key":"BF45170_CR25","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/S1074-7613(00)80635-4","volume":"9","author":"PS Kern","year":"1998","unstructured":"Kern,P. S. et al. Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8\u03b1\u03b1 ectodomain fragment in complex with H-2Kb. Immunity 9, 519\u2013530 (1998).","journal-title":"Immunity"},{"key":"BF45170_CR26","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S1074-7613(00)80602-0","volume":"9","author":"A Achour","year":"1998","unstructured":"Achour,A. et al. The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4\u2009\u00c5 resolution: implications for T cell and NK cell recognition. Immunity 9, 199\u2013208 (1998).","journal-title":"Immunity"},{"key":"BF45170_CR27","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/1074-7613(95)90079-9","volume":"2","author":"I Correa","year":"1995","unstructured":"Correa,I. & Raulet,D. H. Binding of diverse peptides to MHC class I molecules inhibits target cell lysis by activated natural killer cells. Immunity 2, 61\u201371 (1995).","journal-title":"Immunity"},{"key":"BF45170_CR28","doi-asserted-by":"publisher","first-page":"11792","DOI":"10.1073\/pnas.93.21.11792","volume":"93","author":"M Orihuela","year":"1996","unstructured":"Orihuela,M., Margulies,D. H. & Yokoyam,W. M. The natural killer cell receptor Ly49A recognizes a peptide-induced conformational determinant on its major histocompatibility complex class I ligand. Proc. Natl Acad. Sci. USA 93, 11792\u201311797 (1996).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF45170_CR29","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S1074-7613(00)80476-8","volume":"8","author":"N Matsumoto","year":"1998","unstructured":"Matsumoto,N., Ribaudo,R. K., Abastado,J. P., Margulies,D. H. & Yokoyama,W. M. The lectin-like NK cell receptor Ly-49A recognizes a carbohydrate-independent epitope on its MHC class I ligand. Immunity 8, 245\u2013254 (1998).","journal-title":"Immunity"},{"key":"BF45170_CR30","doi-asserted-by":"crossref","first-page":"5971","DOI":"10.4049\/jimmunol.160.12.5971","volume":"160","author":"J Sundb\u00e4ck","year":"1998","unstructured":"Sundb\u00e4ck,J. et al. The \u03b12 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A. J. Immunol. 160, 5971\u20135978 (1998).","journal-title":"J. Immunol."},{"key":"BF45170_CR31","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/358066a0","volume":"358","author":"FM Karlhofer","year":"1992","unstructured":"Karlhofer,F. M., Ribaudo,R. K. & Yokoyama,W. M. MHC class I alloantigen specificity of Ly-49+ IL-2 activated natural killer cells. Nature 358, 66\u201370 (1992).","journal-title":"Nature"},{"key":"BF45170_CR32","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1084\/jem.183.4.1553","volume":"183","author":"J Brennan","year":"1996","unstructured":"Brennan,J., Mahon,G., Mager,D. L., Jefferies,W. A. & Takei,F. Recognition of class I major histocompatibility complex molecules by Ly-49: specificities and domain interactions. J. Exp. Med. 183, 1553\u20131559 (1996).","journal-title":"J. Exp. Med."},{"key":"BF45170_CR33","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/S1074-7613(94)80020-0","volume":"1","author":"BF Daniels","year":"1994","unstructured":"Daniels,B. F., Nakamura,M. C., Rosen,S. D., Yokoyama,W. M. & Seaman,W. E. Ly49A, a receptor for H-2Dd, has a functional carbohydrate recognition domain. Immunity 1, 785\u2013792 (1994).","journal-title":"Immunity"},{"key":"BF45170_CR34","doi-asserted-by":"publisher","first-page":"9691","DOI":"10.1074\/jbc.270.17.9691","volume":"270","author":"J Brennan","year":"1995","unstructured":"Brennan,J., Takei,F., Wong,S. & Mager,D. L. Carbohydrate recognition by a natural killer cell receptor, Ly-49C. J. Biol. Chem. 270, 9691\u20139694 (1995).","journal-title":"J. Biol. Chem."},{"key":"BF45170_CR35","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.4049\/jimmunol.160.9.4367","volume":"160","author":"CS Chang","year":"1998","unstructured":"Chang,C. S. & Kane,K. P. Evidence for sulphate modification of H-2Dd on N-linked carbohydrate(s): possible involvement in Ly-49A interaction. J. Immunol. 160, 4367\u20134374 (1998).","journal-title":"J. Immunol."},{"key":"BF45170_CR36","first-page":"2031","volume":"161","author":"RH Lian","year":"1998","unstructured":"Lian,R. H., Freeman,J. D., Mager,D. L. & Takei,F. Role of conserved glycosylation site unique to murine class I MHC in recognition by Ly-49 NK cell receptor. J. Immunol. 161, 2031\u20132036 (1998).","journal-title":"J. Immunol."},{"key":"BF45170_CR37","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/S1074-7613(00)80082-5","volume":"11","author":"T Hanke","year":"1999","unstructured":"Hanke,T. et al. Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity 11, 67\u201377 (1999).","journal-title":"Immunity"},{"key":"BF45170_CR38","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1146\/annurev.iy.13.040195.003103","volume":"13","author":"DR Madden","year":"1995","unstructured":"Madden,D. R. The three-dimensional structure of peptide-MHC complexes. Annu. Rev. Immunol. 13, 587\u2013622 (1995).","journal-title":"Annu. Rev. Immunol."},{"key":"BF45170_CR39","doi-asserted-by":"crossref","first-page":"6133","DOI":"10.4049\/jimmunol.161.11.6133","volume":"161","author":"A K\u00e5se","year":"1998","unstructured":"K\u00e5se,A., Johansson,M. H., Olsson-Alheim,M. Y., K\u00e4rre,K. & H\u00f6glund,P. External and internal calibration of the MHC class I-specific receptor Ly49A on murine natural killer cells. J. Immunol. 161, 6133\u20136138 (1998).","journal-title":"J. Immunol."},{"key":"BF45170_CR40","doi-asserted-by":"crossref","first-page":"6475","DOI":"10.4049\/jimmunol.161.12.6475","volume":"161","author":"M Andersson","year":"1998","unstructured":"Andersson,M. et al. MHC class I mosaic mice reveal insights into control of Ly49C inhibitory receptor expression in NK cells. J. Immunol. 161, 6475\u20136479 (1998).","journal-title":"J. Immunol."},{"key":"BF45170_CR41","doi-asserted-by":"publisher","first-page":"2748","DOI":"10.1002\/(SICI)1521-4141(199909)29:09<2748::AID-IMMU2748>3.0.CO;2-C","volume":"29","author":"L Franksson","year":"1999","unstructured":"Franksson,L. et al. Peptide dependency and selectivity of the NK cell inhibitory receptor Ly-49C. Eur. J. Immunol. 29, 2748\u20132758 (1999).","journal-title":"Eur. J. Immunol."},{"key":"BF45170_CR42","doi-asserted-by":"publisher","first-page":"4250","DOI":"10.1093\/emboj\/18.15.4250","volume":"18","author":"M Val\u00e9s-G\u00f3mez","year":"1999","unstructured":"Val\u00e9s-G\u00f3mez,M., Reyburn,H. T., Erskine,R. A., L\u00f3pez-Botet,M. & Strominger,J. L. Kinetics and peptide dependency on the binding of the inhibitory NK receptor CD94\/NKG2-A and the activating receptor CD94\/NKG2-C to HLA-E. EMBO J. 18, 4250\u20134260 (1999).","journal-title":"EMBO J."},{"key":"BF45170_CR43","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.4049\/jimmunol.163.7.3699","volume":"163","author":"DH Chung","year":"1999","unstructured":"Chung,D. H. et al. NK and CTL recognition of a single chain H-2Dd molecule: distinct sites of H-2Dd interact with NK and T cell receptors. J. Immunol. 163, 3699\u20133708 (1999).","journal-title":"J. Immunol."},{"key":"BF45170_CR44","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1146\/annurev.immunol.15.1.535","volume":"15","author":"A Bendelac","year":"1997","unstructured":"Bendelac,A., Rivera,M. N., Park,S.-H. & Roark,J. H. Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu. Rev. Immunol. 15, 535\u2013562 (1997).","journal-title":"Annu. Rev. Immunol."},{"key":"BF45170_CR45","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Z Otwinowski","year":"1997","unstructured":"Otwinowski,Z. & Minor,W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307\u2013327 (1997).","journal-title":"Methods Enzymol."},{"key":"BF45170_CR46","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1107\/S0108767393007597","volume":"50","author":"J Navaza","year":"1994","unstructured":"Navaza,J. AMoRe: an automated package for molecular replacement. Acta Crystallogr. A 50, 157\u2013163 (1994).","journal-title":"Acta Crystallogr. A"},{"key":"BF45170_CR47","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1107\/S0907444998003254","volume":"54","author":"AT Br\u00fcnger","year":"1998","unstructured":"Br\u00fcnger,A. T. et al. Crystallography and NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr. D 54, 905\u2013921 (1998).","journal-title":"Acta Crystallogr. D"},{"key":"BF45170_CR48","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1107\/S0108767390010224","volume":"47","author":"TA Jones","year":"1991","unstructured":"Jones,T. A., Zou,J. Y., Cowan,S. W. & Kjeldgaard,M. Improved methods for building models in electron density maps and the location of errors in those models. Acta Crystallogr. A 47, 110\u2013119 (1991).","journal-title":"Acta Crystallogr. A"},{"key":"BF45170_CR49","first-page":"133","volume":"15","author":"RM Esnouf","year":"1997","unstructured":"Esnouf,R. M. An extensively modified version of Molscript that includes greatly enhanced colouring capabilities. J. Mol. Graph. 15, 133\u2013138 (1997).","journal-title":"J. Mol. Graph."},{"key":"BF45170_CR50","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/S0076-6879(97)77028-9","volume":"277","author":"EA Merrit","year":"1997","unstructured":"Merrit,E. A. & Bacon,D. J. Raster3D: photorealistic molecular graphics. Methods Enzymol. 277, 505\u2013524 (1997).","journal-title":"Methods Enzymol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/45170.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/45170","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/45170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/45170.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:21:18Z","timestamp":1684369278000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/45170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,12]]},"references-count":50,"journal-issue":{"issue":"6762","published-print":{"date-parts":[[1999,12]]}},"alternative-id":["BF45170"],"URL":"https:\/\/doi.org\/10.1038\/45170","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,12]]}}}