{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:23:21Z","timestamp":1791217401195,"version":"4.1.0"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"7502","license":[{"start":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T00:00:00Z","timestamp":1401235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T00:00:00Z","timestamp":1401235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2014,5,29]]},"DOI":"10.1038\/509s52a","type":"journal-article","created":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T16:46:51Z","timestamp":1401295611000},"page":"S52-S54","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Therapy: This time it's personal"],"prefix":"10.1038","volume":"509","author":[{"given":"Lauren","family":"Gravitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,5,28]]},"reference":[{"key":"BF509S52a_CR1","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1001\/jama.2011.497","volume":"305","author":"JS Welch","year":"2011","unstructured":"Welch, J. S. et al. J. Am. Med. Assoc. 305, 1577\u20131584 (2011).","journal-title":"J. Am. Med. Assoc."},{"key":"BF509S52a_CR2","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nature12065","volume":"497","author":"M Murtaza","year":"2013","unstructured":"Murtaza, M. et al. Nature 497, 108\u2013112 (2013).","journal-title":"Nature"},{"key":"BF509S52a_CR3","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nrc3237","volume":"12","author":"M Vanneman","year":"2012","unstructured":"Vanneman, M. & Dranoff, G. Nature Rev. Cancer 12, 237\u2013251 (2012).","journal-title":"Nature Rev. Cancer"},{"key":"BF509S52a_CR4","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1056\/NEJMoa1200690","volume":"366","author":"SL Topalian","year":"2012","unstructured":"Topalian, S. L. et al. N. Engl J. Med. 366, 2443\u20132454 (2012).","journal-title":"N. Engl J. Med."},{"key":"BF509S52a_CR5","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1084\/jem.20130590","volume":"211","author":"X Fan","year":"2014","unstructured":"Fan, X. Quezada, S. A., Sepulveda, M. A., Sharma, P. & Allison, J. P. J. Exp. Med. 211, 715\u201325 (2014).","journal-title":"J. Exp. Med."},{"key":"BF509S52a_CR6","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1038\/nature08956","volume":"464","author":"ME Davis","year":"2010","unstructured":"Davis, M. E. et al. Nature 464, 1067\u20131070 (2010).","journal-title":"Nature"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/509S52a.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/509S52a","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/509S52a.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T01:54:23Z","timestamp":1684374863000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/509S52a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,28]]},"references-count":6,"journal-issue":{"issue":"7502","published-print":{"date-parts":[[2014,5,29]]}},"alternative-id":["BF509S52a"],"URL":"https:\/\/doi.org\/10.1038\/509s52a","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,28]]},"assertion":[{"value":"28 May 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}