{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:42:15Z","timestamp":1791128535385,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[1999,12]]},"DOI":"10.1038\/70591","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:34:58Z","timestamp":1027658098000},"page":"466-470","source":"Crossref","is-referenced-by-count":456,"title":["Retinopathy and attenuated circadian entrainment in Crx-deficient mice"],"prefix":"10.1038","volume":"23","author":[{"given":"Takahisa","family":"Furukawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Morrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiansen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred C.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance L.","family":"Cepko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFng1299_466_CR1","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/S0092-8674(00)80439-0","volume":"91","author":"T Furukawa","year":"1997","unstructured":"Furukawa, T., Morrow, E.M. & Cepko, C.L. Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation. Cell 91, 531\u2013541 (1997).","journal-title":"Cell"},{"key":"BFng1299_466_CR2","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/S0896-6273(00)80394-3","volume":"19","author":"S Chen","year":"1997","unstructured":"Chen, S. et al. Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. Neuron 19, 1017\u20131030 (1997).","journal-title":"Neuron"},{"key":"BFng1299_466_CR3","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/S0092-8674(00)80440-7","volume":"91","author":"CL Freund","year":"1997","unstructured":"Freund, C.L. et al. Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor. Cell 91, 543\u2013553 ( 1997).","journal-title":"Cell"},{"key":"BFng1299_466_CR4","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/S0896-6273(00)80423-7","volume":"19","author":"PK Swain","year":"1997","unstructured":"Swain, P.K. et al. Mutations in the cone-rod homeobox gene are associated with the cone-rod dystrophy photoreceptor degeneration. Neuron 19, 1329\u20131336 (1997).","journal-title":"Neuron"},{"key":"BFng1299_466_CR5","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1086\/302101","volume":"63","author":"MM Sohocki","year":"1998","unstructured":"Sohocki, M.M. et al. A range of clinical phenotypes associated with mutations in CRX, a photoreceptor transcription-factor gene. Am. J. Hum. Genet. 63, 1307\u20131315 (1998).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng1299_466_CR6","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/ng0498-311","volume":"18","author":"CL Freund","year":"1998","unstructured":"Freund, C.L. et al. De novo mutations in the CRX homeobox gene associated with Leber congenital amaurosis. Nature Genet. 18, 311\u2013312 (1998).","journal-title":"Nature Genet."},{"key":"BFng1299_466_CR7","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1073\/pnas.95.4.1876","volume":"95","author":"X Li","year":"1998","unstructured":"Li, X. et al. A pineal regulatory element (PIRE) mediates transactivation by the pineal\/retina-specific transcription factor CRX. Proc. Natl Acad. Sci. USA 95, 1876\u20131881 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFng1299_466_CR8","doi-asserted-by":"publisher","first-page":"8074","DOI":"10.1523\/JNEUROSCI.17-21-08074.1997","volume":"17","author":"S Blackshaw","year":"1997","unstructured":"Blackshaw, S. & Snyder, S.H. Developmental expression pattern of phototransduction components in mammalian pineal implies a light-sensing function. J. Neurosci. 17, 8074\u2013 8082 (1997).","journal-title":"J. Neurosci."},{"key":"BFng1299_466_CR9","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/ng0297-216","volume":"15","author":"MH Humphries","year":"1997","unstructured":"Humphries, M.H. et al. Retinopathy induced in mice by targeted disruption of the rhodopsin gene. Nature Genet. 15, 216\u2013 219 (1997).","journal-title":"Nature Genet."},{"key":"BFng1299_466_CR10","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/0304-3940(81)90051-3","volume":"21","author":"S Sanyal","year":"1981","unstructured":"Sanyal, S. & Jansen, H.G. Absence of receptor outer segments in the retina of rds mutant mice. Neurosci Lett. 21 , 23\u201326 (1981).","journal-title":"Neurosci Lett."},{"key":"BFng1299_466_CR11","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/0304-3940(84)90024-7","volume":"48","author":"JH Reuter","year":"1984","unstructured":"Reuter, J.H. & Sanyal, S. Development and degeneration of retina in rds mutant mice: the electroretinogram. Neurosci. Lett. 48, 231\u2013237 (1984).","journal-title":"Neurosci. Lett."},{"key":"BFng1299_466_CR12","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0006-291X(05)81395-6","volume":"181","author":"GI Liou","year":"1991","unstructured":"Liou, G.I. et al. Retina-specific expression from the IRBP promoter in transgenic mice is conferred by 212 bp of the 5-'flanking region. Biochem. Biophys. Res. Commun. 181, 159\u2013165 (1991).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFng1299_466_CR13","first-page":"15","volume":"3","author":"JH Boatright","year":"1997","unstructured":"Boatright, J.H. et al. A major cis activator of the IRBP gene contains CRX-binding and Ret-1\/PCE-I elements. Mol. Vis. 3, 15 (1997).","journal-title":"Mol. Vis."},{"key":"BFng1299_466_CR14","doi-asserted-by":"publisher","first-page":"4243","DOI":"10.1523\/JNEUROSCI.17-11-04243.1997","volume":"17","author":"P Bovolenta","year":"1997","unstructured":"Bovolenta, P., Mallamaci, A., Briata, P., Corte, G. & Boncinelli, E. Implication of OTX2 in pigment epithelium determination and neural retina differentiation. J. Neurosci. 17, 4243\u20134252 (1997).","journal-title":"J. Neurosci."},{"key":"BFng1299_466_CR15","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1001\/archopht.1985.01050100078023","volume":"103","author":"SG Foxman","year":"1985","unstructured":"Foxman, S.G., Heckenlively, J.R., Bateman, J.B. & Wirtschafter, J.D. Classification of congenital and early onset retinitis pigmentosa. Arch. Ophthalmol. 103, 1502\u20131506 (1985).","journal-title":"Arch. Ophthalmol."},{"key":"BFng1299_466_CR16","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/S0896-6273(00)80464-X","volume":"20","author":"RG Foster","year":"1998","unstructured":"Foster, R.G. Shedding light on the biological clock. Neuron 20, 829\u2013832 (1998).","journal-title":"Neuron"},{"key":"BFng1299_466_CR17","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1073\/pnas.95.1.340","volume":"95","author":"I Provencio","year":"1998","unstructured":"Provencio, I., Jiang, G., De Grip, W.J., Hayes, W.P. & Rollag, M.D. Melanopsin: an opsin in melanophores, brain, and eye. Proc. Natl Acad. Sci. USA 95, 340\u2013 345 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFng1299_466_CR18","doi-asserted-by":"publisher","first-page":"9893","DOI":"10.1073\/pnas.94.18.9893","volume":"94","author":"H Sun","year":"1997","unstructured":"Sun, H., Gilbert, D.J., Copeland, N.G., Jenkins, N.A. & Nathans, J. Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium. Proc. Natl Acad. Sci. USA 94, 9893\u2013 9898 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFng1299_466_CR19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/27794","volume":"394","author":"BG Soni","year":"1998","unstructured":"Soni, B.G., Philp, A.R., Foster, R.G. & Knox, B.E. Novel retinal photoreceptors. Nature 394, 27\u201328 (1998).","journal-title":"Nature"},{"key":"BFng1299_466_CR20","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1126\/science.284.5413.505","volume":"284","author":"RJ Lucas","year":"1999","unstructured":"Lucas, R.J., Freedman, M.S., Munoz, M., Garcia-Fernandez, J.M. & Foster, R.G. Regulation of the mammalian pineal by non-rod, non-cone, ocular photoreceptors. Science 284, 505\u2013507 (1999).","journal-title":"Science"},{"key":"BFng1299_466_CR21","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1126\/science.284.5413.502","volume":"284","author":"MS Freedman","year":"1999","unstructured":"Freedman, M.S. et al. Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors. Science 284, 502\u2013 504 (1999).","journal-title":"Science"},{"key":"BFng1299_466_CR22","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/S0092-8674(00)81069-7","volume":"84","author":"C Deng","year":"1996","unstructured":"Deng, C., Wynshaw-Boris, A., Zhou, F., Kuo, A. & Leder, P. Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell 84, 911\u2013921 (1996).","journal-title":"Cell"},{"key":"BFng1299_466_CR23","doi-asserted-by":"publisher","first-page":"11933","DOI":"10.1073\/pnas.95.20.11933","volume":"95","author":"T Li","year":"1998","unstructured":"Li, T. et al. Effect of vitamin A supplementation on rhodopsin mutants threonine-17\u2192methionine and proline-347\u2192serine in transgenic mice and in cell cultures. Proc. Natl Acad. Sci. USA 95, 11933\u2013 11938 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFng1299_466_CR24","doi-asserted-by":"publisher","first-page":"8032","DOI":"10.1523\/JNEUROSCI.18-19-08032.1998","volume":"18","author":"J Grosse","year":"1998","unstructured":"Grosse, J. & Davis, F.C. Melatonin entrains the restored circadian activity rhuthms of syrian hamsters bearing fetal suprachiasmatic nucleus grafts. J. Neurosci. 18, 8032\u2013 8037 (1998).","journal-title":"J. Neurosci."},{"key":"BFng1299_466_CR25","doi-asserted-by":"publisher","first-page":"13726","DOI":"10.1073\/pnas.93.24.13726","volume":"93","author":"AF Goldberg","year":"1996","unstructured":"Goldberg, A.F. & Molday, R.S. Defective subunit assembly underlies a digenic form of retinitis pigmentosa linked to mutations in peripherin\/rds and rom-1. Proc. Natl Acad. Sci. USA 93, 13726\u201313730 (1996).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFng1299_466_CR26","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/ng0997-15","volume":"17","author":"H Sun","year":"1997","unstructured":"Sun, H. & Nathans, J. Stargardt's ABCR is localized to the disc membrane of retinal rod outer segments. Nature Genet. 17, 15\u201316 (1997).","journal-title":"Nature Genet."},{"key":"BFng1299_466_CR27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1242\/dev.126.1.23","volume":"126","author":"EM Morrow","year":"1999","unstructured":"Morrow, E.M., Furukawa, T., Lee, J.E. & Cepko, C.L. NeuroD regulates cell fate determination in the developing neural retina. Development 126, 23\u201336 (1999).","journal-title":"Development"}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng1299_466.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1299_466","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1299_466.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:05:27Z","timestamp":1684433127000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng1299_466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,12]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1999,12]]}},"alternative-id":["BFng1299_466"],"URL":"https:\/\/doi.org\/10.1038\/70591","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,12]]}}}