{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:04:39Z","timestamp":1791223479660,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[2000,3]]},"DOI":"10.1038\/73472","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:50:09Z","timestamp":1027673409000},"page":"262-265","source":"Crossref","is-referenced-by-count":189,"title":["Regulation of left-right patterning in mice by growth\/differentiation factor-1"],"prefix":"10.1038","volume":"24","author":[{"given":"Christopher T.","family":"Rankin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracie","family":"Bunton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Lawler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se-Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFng0300_262_CR1","first-page":"357","volume-title":"Growth Factors and Cytokines in Health and Disease","author":"AC McPherron","year":"1996","unstructured":"McPherron, A.C. & Lee, S.-J. The transforming growth factor \u03b2 superfamily. in Growth Factors and Cytokines in Health and Disease (ed. LeRoith, D.) 357\u2013393 (JAI, Greenwich, 1996)."},{"key":"BFng0300_262_CR2","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1210\/mend-4-7-1034","volume":"4","author":"S-J Lee","year":"1990","unstructured":"Lee, S.-J. Identification of a novel member of the transforming growth factor-\u03b2 superfamily. Mol. Endocrinol. 4, 1034\u2013 1040 (1990).","journal-title":"Mol. Endocrinol."},{"key":"BFng0300_262_CR3","doi-asserted-by":"publisher","first-page":"4250","DOI":"10.1073\/pnas.88.10.4250","volume":"88","author":"S-J Lee","year":"1991","unstructured":"Lee, S.-J. Expression of growth\/differentiation factor 1 in the nervous system: conservation of a bicistronic structure. Proc. Natl Acad. Sci. USA 88, 4250\u20134254 (1991).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFng0300_262_CR4","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1046\/j.1365-2443.1997.1400338.x","volume":"2","author":"C Meno","year":"1997","unstructured":"Meno, C. et al. Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos. Genes Cells 2, 513\u2013524 ( 1997).","journal-title":"Genes Cells"},{"key":"BFng0300_262_CR5","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/381151a0","volume":"381","author":"C Meno","year":"1996","unstructured":"Meno, C. et al. Left-right asymmetric expression of the TGF\u03b2-family member lefty in mouse embryos. Nature 381, 151\u2013 155 (1996).","journal-title":"Nature"},{"key":"BFng0300_262_CR6","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/381155a0","volume":"381","author":"J Collignon","year":"1996","unstructured":"Collignon, J., Varlet, I. & Robertson, E.J. Relationship between asymmetric nodal expression and the direction of embryonic turning. Nature 381, 155\u2013158 (1996).","journal-title":"Nature"},{"key":"BFng0300_262_CR7","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/381158a0","volume":"381","author":"LA Lowe","year":"1996","unstructured":"Lowe, L.A. et al. Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus. Nature 381, 158\u2013161 (1996).","journal-title":"Nature"},{"key":"BFng0300_262_CR8","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S0092-8674(00)81473-7","volume":"94","author":"H Yoshioka","year":"1998","unstructured":"Yoshioka, H. et al. Pitx2, a bicoid-type homeobox gene is involved in a lefty-signaling pathway in determination of left-right asymmetry. Cell 94, 299\u2013305 (1998).","journal-title":"Cell"},{"key":"BFng0300_262_CR9","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0092-8674(00)81475-0","volume":"94","author":"ME Piedra","year":"1998","unstructured":"Piedra, M.E., Icardo, J.M., Albajar, M., Rodriguez-Rey, J.C. & Ros, M.A. Pitx2 participates in the late phase of the pathway controlling left-right asymmetry. Cell 94, 319\u2013324 (1998).","journal-title":"Cell"},{"key":"BFng0300_262_CR10","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S0168-9525(98)01599-6","volume":"14","author":"AF Ramsdell","year":"1998","unstructured":"Ramsdell, A.F. & Yost, H.J. Molecular mechanisms of vertebrate left-right development. Trends Genet. 14, 459\u2013465 (1998).","journal-title":"Trends Genet."},{"key":"BFng0300_262_CR11","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/oxfordjournals.jhered.a106870","volume":"50","author":"KP Hummel","year":"1959","unstructured":"Hummel, K.P. & Chapman, D.B. Visceral inversion and associated anomalies in the mouse. J. Hered. 50, 9\u2013 13 (1959).","journal-title":"J. Hered."},{"key":"BFng0300_262_CR12","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1093\/oxfordjournals.jhered.a108749","volume":"67","author":"WM Layton","year":"1976","unstructured":"Layton, W.M. Random determination of a developmental process: reversal of normal visceral asymmetry in the mouse. J. Hered. 67, 336 \u2013338 (1976).","journal-title":"J. Hered."},{"key":"BFng0300_262_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1651-2227.1955.tb04287.x","volume":"44","author":"BI Ivemark","year":"1955","unstructured":"Ivemark, B.I. Implications of agenesis of the spleen on the pathogenesis of conco-truncus anomalies in childhood. Acta Paediatr. Scand. 44, 1\u2013110 (1955).","journal-title":"Acta Paediatr. Scand."},{"key":"BFng0300_262_CR14","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1006\/scdb.1997.0187","volume":"9","author":"K Kosaki","year":"1998","unstructured":"Kosaki, K. & Casey, B. Genetics of human left-right axis malformations. Semin. Cell Dev. Biol. 9, 89\u201399 (1998).","journal-title":"Semin. Cell Dev. Biol."},{"key":"BFng0300_262_CR15","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/S0092-8674(00)81705-5","volume":"95","author":"S Nonaka","year":"1998","unstructured":"Nonaka, S. et al. Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein. Cell 95, 829\u2013 837 (1998).","journal-title":"Cell"},{"key":"BFng0300_262_CR16","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S1097-2765(00)80197-5","volume":"4","author":"Y Okada","year":"1999","unstructured":"Okada, Y. et al. Abnormal nodal flow precedes situs inversus in iv and inv mice. Mol. Cell 4, 459\u2013 468 (1999).","journal-title":"Mol. Cell"},{"key":"BFng0300_262_CR17","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/361543a0","volume":"361","author":"X Zhou","year":"1993","unstructured":"Zhou, X., Sasaki, H., Lowe, L., Hogan, B.L.M. & Kuehn, M.R. Nodal is a novel TGF\u03b2-like gene expressed in the mouse node during gastrulation. Nature 361, 543\u2013547 (1993).","journal-title":"Nature"},{"key":"BFng0300_262_CR18","first-page":"163","volume-title":"In Situ Hybridization: A Practical Approach","author":"DG Wilkinson","year":"1992","unstructured":"Wilkinson, D.G. In Situ Hybridization: A Practical Approach 163 (Oxford University Press, New York, 1992)."},{"key":"BFng0300_262_CR19","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1242\/dev.121.6.1927","volume":"121","author":"AK Knecht","year":"1995","unstructured":"Knecht, A.K., Good, P.J., Dawid, I.B. & Harland, R.M. Dorsal-ventral patterning and differentiation of noggin-induced neural tissue in the absence of mesoderm. Development 121, 1927\u2013 1935 (1995).","journal-title":"Development"},{"key":"BFng0300_262_CR20","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/387083a0","volume":"387","author":"AC McPherron","year":"1997","unstructured":"McPherron, A.C., Lawler, A.M. & Lee, S.-J. Regulation of skeletal muscle mass in mice by a new TGF-\u03b2 superfamily member. Nature 387, 83\u2013 90 (1997).","journal-title":"Nature"},{"key":"BFng0300_262_CR21","doi-asserted-by":"crossref","unstructured":"Laird, P.W. et al. Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19, 4293 (1991).","DOI":"10.1093\/nar\/19.15.4293"},{"key":"BFng0300_262_CR22","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1101\/gad.11.14.1812","volume":"11","author":"SP Oh","year":"1997","unstructured":"Oh, S.P. & Li, E. The signalling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse. Genes Dev. 11, 1812\u2013 1826 (1997).","journal-title":"Genes Dev."}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng0300_262.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0300_262","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0300_262.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:23:17Z","timestamp":1684441397000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng0300_262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,3]]}},"alternative-id":["BFng0300_262"],"URL":"https:\/\/doi.org\/10.1038\/73472","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,3]]}}}