{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:14:10Z","timestamp":1779344050252,"version":"3.51.4"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[2000,7]]},"DOI":"10.1038\/77046","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:50:09Z","timestamp":1027673409000},"page":"294-297","source":"Crossref","is-referenced-by-count":876,"title":["Gene-expression profile of the ageing brain in mice"],"prefix":"10.1038","volume":"25","author":[{"given":"Cheol-Koo","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Weindruch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas A.","family":"Prolla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFng0700_294_CR1","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1126\/science.278.5337.412","volume":"278","author":"JH Morrison","year":"1997","unstructured":"Morrison, J.H. & Hof, P.R. Life and death of neurons in the aging brain. Science 278, 412\u2013419 (1997).","journal-title":"Science"},{"key":"BFng0700_294_CR2","first-page":"613","volume-title":"Basic Neurochemistry","author":"CE Finch","year":"1999","unstructured":"Finch, C.E. & Roth, G.S. in Basic Neurochemistry (eds Seigel, G., Agranoff, J.B., Albers, W.R.W., Fisher, S.K. & Uhler, M.D.) 613\u2013633 (Lippincott-Raven, Philadelphia, 1999)."},{"key":"BFng0700_294_CR3","first-page":"71","volume-title":"Molecular Basis of Aging","author":"JW Gaubatz","year":"1995","unstructured":"Gaubatz, J.W. in Molecular Basis of Aging (ed. Macieira-Coelho, A.) 71\u2013182 (CRC Press, Boca Raton, 1995)."},{"key":"BFng0700_294_CR4","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1006\/frne.1998.0173","volume":"20","author":"BS McEwen","year":"1998","unstructured":"McEwen, B.S. Stress and the aging hippocampus. Front. Neuroendocrinol. 20, 49\u201370 (1998).","journal-title":"Front. Neuroendocrinol."},{"key":"BFng0700_294_CR5","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1126\/science.273.5271.59","volume":"273","author":"RS Sohal","year":"1996","unstructured":"Sohal, R.S. & Weindruch, R. Oxidative stress, caloric restriction, and aging. Science 273, 59\u201363 (1996).","journal-title":"Science"},{"key":"BFng0700_294_CR6","volume-title":"Calcium Hypothesis of Aging and Dementia","author":"JF Disterhoft","year":"1994","unstructured":"Disterhoft, J.F., Gispen, W.H., Traber, J. & Khachaturian, Z.F. Calcium Hypothesis of Aging and Dementia (New York Academy of Sciences Press, New York, 1994)."},{"key":"BFng0700_294_CR7","doi-asserted-by":"publisher","first-page":"B1","DOI":"10.1093\/gerona\/52A.1.B1","volume":"52","author":"HT Blumenthal","year":"1997","unstructured":"Blumenthal, H.T. Fidelity assurance mechanisms of the brain with special reference to its immunogenic CNS compartment: their role in aging and aging-associated neurological disease. J. Gerontol. Biol. Sci. Med. Sci. 52, B1\u2013B9 (1997).","journal-title":"J. Gerontol. Biol. Sci. Med. Sci."},{"key":"BFng0700_294_CR8","volume-title":"The Retardation of Aging and Disease by Dietary Restriction","author":"R Weindruch","year":"1988","unstructured":"Weindruch, R. & Walford, R.L. The Retardation of Aging and Disease by Dietary Restriction (C.C. Thomas, Springfield, Illinois, 1988)."},{"key":"BFng0700_294_CR9","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1093\/geronj\/42.1.78","volume":"42","author":"DK Ingram","year":"1987","unstructured":"Ingram, D.K., Weindruch, R., Spangler, E.L., Freeman, J.R. & Walford, R.L. Dietary restriction benefits learning and motor performance of aged mice. J. Gerontol. 42, 78\u201381 (1987).","journal-title":"J. Gerontol."},{"key":"BFng0700_294_CR10","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/0197-4580(89)90042-0","volume":"10","author":"SE Moroi-Fetters","year":"1989","unstructured":"Moroi-Fetters, S.E., Mervis, R.F., London, E.D. & Ingram, D.K. Dietary restriction suppresses age-related changes in dendritic spines. Neurobiol. Aging 10, 317\u2013322 (1989).","journal-title":"Neurobiol. Aging"},{"key":"BFng0700_294_CR11","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1002\/(SICI)1097-4547(19990715)57:2<195::AID-JNR5>3.0.CO;2-P","volume":"57","author":"W Duan","year":"1999","unstructured":"Duan, W. & Mattson, M.P. Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease. J. Neurosci. Res. 57, 195\u2013206 (1999).","journal-title":"J. Neurosci. Res."},{"key":"BFng0700_294_CR12","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/S0006-8993(98)00780-X","volume":"807","author":"Z Suo","year":"1998","unstructured":"Suo, Z. et al. Alzheimer's \u03b2-amyloid peptides induce inflammatory cascade in human vascular cells: the roles of cytokines and CD40. Brain Res. 807, 110\u2013117 (1998).","journal-title":"Brain Res."},{"key":"BFng0700_294_CR13","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/BF00916410","volume":"6","author":"R Hallgren","year":"1982","unstructured":"Hallgren, R., Terent, A. & Venge, P. Lactoferrin, lysozyme, and \u03b2 2-microglobulin levels in cerebrospinal fluid: differential indices of CNS inflammation. Inflammation 6, 291\u2013304 (1982).","journal-title":"Inflammation"},{"key":"BFng0700_294_CR14","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1126\/science.285.5427.595","volume":"285","author":"J Huang","year":"1999","unstructured":"Huang, J. et al. Neuronal protection in stroke by an sLex-glycosylated complement inhibitory protein. Science 285, 595\u2013599 (1999).","journal-title":"Science"},{"key":"BFng0700_294_CR15","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1002\/(SICI)1098-2396(19990315)31:4<278::AID-SYN5>3.0.CO;2-0","volume":"31","author":"GM Pasinetti","year":"1999","unstructured":"Pasinetti, G.M., Hassler, M., Stone, D. & Finch, C.E. Glial gene expression during aging in rat striatum and in long-term responses to 6-OHDA lesions. Synapse 31, 278\u2013284 (1999).","journal-title":"Synapse"},{"key":"BFng0700_294_CR16","first-page":"848","volume":"146","author":"CA Lemere","year":"1995","unstructured":"Lemere, C.A. et al. The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study. Am. J. Pathol. 146, 848\u2013860 (1995).","journal-title":"Am. J. Pathol."},{"key":"BFng0700_294_CR17","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/S0306-4522(98)00249-8","volume":"88","author":"DM Hermann","year":"1999","unstructured":"Hermann, D.M., Mies, G. & Hossmann, K.A. Expression of c-Fos, JunB, c-Jun, MKP-1 and HSP72 following traumatic neocortical lesions in rats\u2014relation to spreading depression. Neuroscience 88, 599\u2013608 (1999).","journal-title":"Neuroscience"},{"key":"BFng0700_294_CR18","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/0197-4580(93)90100-P","volume":"14","author":"NR Nichols","year":"1993","unstructured":"Nichols, N.R., Day, J.R., Laping, N.J., Johnson, S.A. & Finch, C.E. GFAP mRNA increases with age in rat and human brain. Neurobiol. Aging 14, 421\u2013429 (1993).","journal-title":"Neurobiol. Aging"},{"key":"BFng0700_294_CR19","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1016\/S0896-6273(00)80651-0","volume":"21","author":"JW Fox","year":"1998","unstructured":"Fox, J.W. et al. Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia. Neuron 21, 1315\u20131325 (1998).","journal-title":"Neuron"},{"key":"BFng0700_294_CR20","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0165-0173(96)00014-8","volume":"23","author":"MP Mattson","year":"1997","unstructured":"Mattson, M.P. et al. Cellular signaling roles of TGF \u03b2, TNF\u03b1 and \u03b2 APP in brain injury responses and Alzheimer's disease. Brain Res. Rev. 23, 47\u201361 (1997).","journal-title":"Brain Res. Rev."},{"key":"BFng0700_294_CR21","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1089\/ars.1999.1.2-129","volume":"1","author":"B Kaltschmidt","year":"1999","unstructured":"Kaltschmidt, B., Sparna, T. & Kaltschmidt, C. Activation of NF\u2014B by reactive oxygen intermediates in the nervous system. Antioxidants Redox Signalling 1, 129\u2013144 (1999).","journal-title":"Antioxidants Redox Signalling"},{"key":"BFng0700_294_CR22","first-page":"895","volume":"29","author":"RP Ryseck","year":"1996","unstructured":"Ryseck, R.P., Weih, F., Carrasco, D. & Bravo, R. RELB, a member of the REL\/NF\u2014B family of transcription factors. Braz. J. Med. Biol. Res. 29, 895\u2013903 (1996).","journal-title":"Braz. J. Med. Biol. Res."},{"key":"BFng0700_294_CR23","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/0197-4580(96)00115-7","volume":"17","author":"J Rogers","year":"1996","unstructured":"Rogers, J. et al. Inflammation and Alzheimer's disease pathogenesis. Neurobiol. Aging 17, 681\u2013686 (1996).","journal-title":"Neurobiol. Aging"},{"key":"BFng0700_294_CR24","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1126\/science.285.5432.1390","volume":"285","author":"C-K Lee","year":"1999","unstructured":"Lee, C.-K., Klopp, R.G, Weindruch, R. & Prolla, T.A. Gene expression profile of aging and its retardation by caloric restriction. Science 285, 1390\u20131393 (1999).","journal-title":"Science"},{"key":"BFng0700_294_CR25","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1101\/gr.6.10.986","volume":"6","author":"CA Heid","year":"1996","unstructured":"Heid, C.A., Stevens, J., Livak, K.J. & Williams, P.M. Real time quantitative PCR. Genome Res. 6, 986\u2013994 (1996).","journal-title":"Genome Res."},{"key":"BFng0700_294_CR26","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/4447","volume":"21","author":"RJ Lipshutz","year":"1999","unstructured":"Lipshutz, R.J., Fodor, S.P., Gingeras, T.R. & Lockhart, D.J. High density synthetic oligonucleotide arrays. Nature Genet. 21, 20\u201324 (1999).","journal-title":"Nature Genet."}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng0700_294.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0700_294","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0700_294.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:42:51Z","timestamp":1684442571000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng0700_294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["BFng0700_294"],"URL":"https:\/\/doi.org\/10.1038\/77046","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}