{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T18:42:52Z","timestamp":1773427372978,"version":"3.50.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Biotechnol"],"published-print":{"date-parts":[[2000,8]]},"DOI":"10.1038\/78475","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:35:11Z","timestamp":1027672511000},"page":"862-867","source":"Crossref","is-referenced-by-count":210,"title":["Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis"],"prefix":"10.1038","volume":"18","author":[{"given":"Hong","family":"Zhang","sequence":"first","affiliation":[]},{"given":"Jesse","family":"Cook","sequence":"additional","affiliation":[]},{"given":"Jeffrey","family":"Nickel","sequence":"additional","affiliation":[]},{"given":"Rosie","family":"Yu","sequence":"additional","affiliation":[]},{"given":"Kimberly","family":"Stecker","sequence":"additional","affiliation":[]},{"given":"Kathleen","family":"Myers","sequence":"additional","affiliation":[]},{"given":"Nicholas M.","family":"Dean","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BFnbt0800_862_CR1","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1126\/science.7533326","volume":"267","author":"S Nagata","year":"1995","unstructured":"Nagata, S. & Golstein, P. The Fas death factor. Science 267, 1449\u20131455 (1995).","journal-title":"Science"},{"key":"BFnbt0800_862_CR2","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/978-3-642-79850-4_6","volume":"16","author":"S Nagata","year":"1996","unstructured":"Nagata, S. Apoptosis mediated by the Fas system. Prog. Mol. Subcell. Biol. 16, 87\u2013103 (1996).","journal-title":"Prog. Mol. Subcell. Biol."},{"key":"BFnbt0800_862_CR3","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1055\/s-2007-1007150","volume":"18","author":"PR Galle","year":"1998","unstructured":"Galle, P.R. & Krammer, P.H. CD95-induced apoptosis in human liver disease. Semin. Liver Dis. 18, 141\u2013151 (1998).","journal-title":"Semin. Liver Dis."},{"key":"BFnbt0800_862_CR4","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/nm0497-409","volume":"3","author":"T Kondo","year":"1997","unstructured":"Kondo, T., Suda, T., Fukuyama, H., Adachi, M. & Nagata, S. Essential roles of the fas ligand in the development of hepatitis. Nat. Med. 3, 409\u2013413 (1997).","journal-title":"Nat. Med."},{"key":"BFnbt0800_862_CR5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1172\/JCI5628","volume":"104","author":"K Kuwano","year":"1999","unstructured":"Kuwano, K. et al. Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis. J. Clin. Invest. 104, 13\u201319 (1999).","journal-title":"J. Clin. Invest."},{"key":"BFnbt0800_862_CR6","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1126\/science.282.5388.490","volume":"282","author":"I Viard","year":"1998","unstructured":"Viard, I. et al. Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin. Science 282, 490\u2013493 (1998).","journal-title":"Science"},{"key":"BFnbt0800_862_CR7","doi-asserted-by":"crossref","first-page":"6392","DOI":"10.4049\/jimmunol.162.11.6392","volume":"162","author":"BN Dittel","year":"1999","unstructured":"Dittel, B.N., Merchant, R.M. & Janeway, C.A.J. Evidence for Fas-dependent and Fas-independent mechanisms in the pathogenesis of experimental autoimmune encephalomyelitis. J. Immunol. 162, 6392\u20136400 (1999).","journal-title":"J. Immunol."},{"key":"BFnbt0800_862_CR8","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/S0016-5085(97)70091-X","volume":"113","author":"J Strater","year":"1997","unstructured":"Strater, J. et al. CD95 (APO-1\/Fas)-mediated apoptosis in colon epithelial cells: a possible role in ulcerative colitis. Gastroenterology 113, 160\u2013167 (1997).","journal-title":"Gastroenterology"},{"key":"BFnbt0800_862_CR9","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1002\/art.1780400113","volume":"40","author":"L Kong","year":"1997","unstructured":"Kong, L. et al. Fas and Fas ligand expression in the salivary glands of patients with primary Sj\u00f6gren's syndrome. Arthritis Rheum. 40, 87\u201397 (1997).","journal-title":"Arthritis Rheum."},{"key":"BFnbt0800_862_CR10","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1126\/science.275.5302.960","volume":"275","author":"C Giordano","year":"1997","unstructured":"Giordano, C. Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis. Science 275, 960\u2013963 (1997).","journal-title":"Science"},{"key":"BFnbt0800_862_CR11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.4049\/jimmunol.162.1.263","volume":"162","author":"G Stassi","year":"1999","unstructured":"Stassi, G. et al. Fas\/Fas ligand-driven T cell apoptosis as a consequence of ineffective thyroid immunoprivilege in Hashimoto's thyroiditis. J. Immunol. 162, 263\u2013267 (1999).","journal-title":"J. Immunol."},{"key":"BFnbt0800_862_CR12","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1097\/00007890-199810150-00013","volume":"66","author":"R Josien","year":"1998","unstructured":"Josien, R. et al. Fas ligand, tumor necrosis facter-a expression, and apoptosis during allograft rejection and tolerance. Transplantation 66, 887\u2013893 (1998).","journal-title":"Transplantation"},{"key":"BFnbt0800_862_CR13","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1172\/JCI2808","volume":"102","author":"J Rudi","year":"1998","unstructured":"Rudi, J. et al. Involvement of the CD95 (APO-1\/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis. J. Clin. Invest. 102, 1506\u20131514 (1998).","journal-title":"J. Clin. Invest."},{"key":"BFnbt0800_862_CR14","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1093\/intimm\/11.6.925","volume":"11","author":"K Miwa","year":"1999","unstructured":"Miwa, K. et al. Therapeutic effect of an anti-Fas ligand mAb on lethal graft-versus-host disease. Int. Immunol. 11, 925\u2013931 (1999).","journal-title":"Int. Immunol."},{"key":"BFnbt0800_862_CR15","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/S0163-7258(99)00002-9","volume":"82","author":"SR Cooper","year":"1999","unstructured":"Cooper, S.R., Taylor, J.K., Miraglia, L.J. & Dean, N.M. Pharmacology of antisense oligonucleotide inhibitors of protein expression. Pharmacol. Ther. 82, 427\u2013435 (1999).","journal-title":"Pharmacol. Ther."},{"key":"BFnbt0800_862_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-642-58785-6","volume-title":"Antisense research and application","author":"ST Crooke","year":"1998","unstructured":"Crooke, S.T. Basic principles of antisense therapeutics. In Antisense research and application. (ed. Crooke, S.T.) 1\u201350 (Springer-Verlag, Berlin; 1998)."},{"key":"BFnbt0800_862_CR17","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1038\/15079","volume":"17","author":"JK Taylor","year":"1999","unstructured":"Taylor, J.K., Zhang, Q.Q., Wyatt, J.R. & Dean, N.M. Induction of endogenous Bcl-xS through the control of Bcl-x pre-mRNA splicing by antisense oligonucleotides. Nat. Biotechnol. 17, 1097\u20131100 (1999).","journal-title":"Nat. Biotechnol."},{"key":"BFnbt0800_862_CR18","doi-asserted-by":"crossref","first-page":"231","DOI":"10.18388\/abp.1997_4418","volume":"44","author":"R Kole","year":"1997","unstructured":"Kole, R. Modification of pre-mRNA splicing by antisense oligonucleotides. Acta Biochimica Polonica 44, 231\u2013238 (1997).","journal-title":"Acta Biochimica Polonica"},{"key":"BFnbt0800_862_CR19","doi-asserted-by":"crossref","first-page":"16416","DOI":"10.1016\/S0021-9258(17)34023-1","volume":"269","author":"NM Dean","year":"1994","unstructured":"Dean, N.M., McKay, R., Condon, T.P. & Bennett, C.F. Inhibition of protein kinase C-alpha expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1 (ICAM-1) mRNA by phorbol esters. J. Biol. Chem. 269, 16416\u201316424 (1994).","journal-title":"J. Biol. Chem."},{"key":"BFnbt0800_862_CR20","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1128\/AAC.43.2.347","volume":"43","author":"H Zhang","year":"1999","unstructured":"Zhang, H. et al. Antisense oligonucleotide inhibition of hepatitis C virus (HCV) gene expression in livers of mice infected with an HCV\u2013vaccinia virus recombinant. Antimicrob. Agents Chemother. 43, 347\u2013353 (1999).","journal-title":"Antimicrob. Agents Chemother."},{"key":"BFnbt0800_862_CR21","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/9893","volume":"17","author":"T Mizuta","year":"1999","unstructured":"Mizuta, T. et al. Antisense oligonucleotides directed against the viral RNA polymerase gene enhance survival of mice infected with influenza A. Nat. Biotechnol. 17, 583\u2013587 (1999).","journal-title":"Nat. Biotechnol."},{"key":"BFnbt0800_862_CR22","first-page":"988","volume":"280","author":"CF Bennett","year":"1997","unstructured":"Bennett, C.F. et al. An ICAM-1 antisense oligonucleotide prevents and reverses dextran sulfate sodium-induced colitis in mice. J. Pharmacol. Exp. Ther. 280, 988\u20131000 (1997).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"BFnbt0800_862_CR23","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.1172\/JCI118681","volume":"97","author":"E Noiri","year":"1996","unstructured":"Noiri, E., Peresleni, T., Miller, F. & Goligorsky, M.S. In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia. J. Clin. Invest. 97, 2377\u20132383 (1996).","journal-title":"J. Clin. Invest."},{"key":"BFnbt0800_862_CR24","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1038\/70724","volume":"17","author":"SE Driver","year":"1999","unstructured":"Driver, S.E. et al. Oligonucleotide-based inhibition of embryonic gene expression. Nat. Biotechnol. 17, 1184\u20131187 (1999).","journal-title":"Nat. Biotechnol."},{"key":"BFnbt0800_862_CR25","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1089\/oli.1.1998.8.133","volume":"8","author":"ST Crooke","year":"1998","unstructured":"Crooke, S.T. Molecular mechanisms of antisense drugs: RNase H. Antisense Nucleic Acid Drug Dev. 8, 133\u2013134 (1998).","journal-title":"Antisense Nucleic Acid Drug Dev."},{"key":"BFnbt0800_862_CR26","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1074\/jbc.274.3.1715","volume":"274","author":"R McKay","year":"1999","unstructured":"McKay, R. et al. Characterization of a potent and specific class of antisense oligonucleotide inhibitors of human PKC-alpha expression. J. Biol. Chem. 274, 1715\u20131722 (1999).","journal-title":"J. Biol. Chem."},{"key":"BFnbt0800_862_CR27","doi-asserted-by":"crossref","first-page":"4082","DOI":"10.4049\/jimmunol.160.8.4082","volume":"160","author":"R Ksontini","year":"1998","unstructured":"Ksontini, R. et al. Disparate roles for TNF-\u03b1 and fas ligand in concanavalin A-induced hepatitis. J. Immunol. 160, 4082\u20134089 (1998).","journal-title":"J. Immunol."},{"key":"BFnbt0800_862_CR28","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1002\/hep.510240338","volume":"24","author":"Y Watanabe","year":"1996","unstructured":"Watanabe, Y., Morita, M. & Akaike, T. Concanavalin A induces perforin-mediated but not Fas-mediated hepatic injury. Hepatology 24, 702\u2013710 (1996).","journal-title":"Hepatology"},{"key":"BFnbt0800_862_CR29","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1038\/364806a0","volume":"364","author":"J Ogasawara","year":"1993","unstructured":"Ogasawara, J. et al. Lethal effect of the anti-Fas antibody in mice. Nature 364, 806\u2013809 (1993).","journal-title":"Nature"},{"key":"BFnbt0800_862_CR30","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1016\/S0140-6736(05)78614-1","volume":"351","author":"J Taieb","year":"1998","unstructured":"Taieb, J., Mathurin, P., Poynard, T., Gougerot-Pocidalo, M.A. & Collet-Martin, S. Raised plasma-soluble fas and fas-ligand in alcoholic liver disease. Lancet 351, 1930\u20131931 (1998).","journal-title":"Lancet"},{"key":"BFnbt0800_862_CR31","first-page":"1470","volume":"279","author":"SD Ray","year":"1996","unstructured":"Ray, S.D., Mumaw, V.R., Ravindra, R., Fariss, R. & Fariss, M.W. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. J. Pharmacol. Exp. Ther. 279, 1470\u20131483 (1996).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"BFnbt0800_862_CR32","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1177\/019262339602400206","volume":"24","author":"ME Blazka","year":"1996","unstructured":"Blazka, M.E., Elwell, M.R., Holladay, S.D., Wilson, R.E. & Luster, M.I. Histology of acetaminophen-induced liver changes: role of interleukin 1\u03b1 and tumor necrosis factor \u03b1. Toxicol. Pathol. 24, 181\u2013189 (1996).","journal-title":"Toxicol. Pathol."},{"key":"BFnbt0800_862_CR33","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1172\/JCI115836","volume":"90","author":"G Tiegs","year":"1992","unstructured":"Tiegs, G., Hentschel, J. & Wendel, A. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J. Clin. Invest. 90, 196\u2013203 (1992).","journal-title":"J. Clin. Invest."},{"key":"BFnbt0800_862_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0168-8278(96)80178-4","volume":"24","author":"K Mochizuki","year":"1996","unstructured":"Mochizuki, K. et al. Fas antigen expression in liver tissues of patients with chronic hepatitis B. J. Hepatol. 24, 1\u201317 (1996).","journal-title":"J. Hepatol."},{"key":"BFnbt0800_862_CR35","first-page":"9","volume":"12","author":"N Hayashi","year":"1997","unstructured":"Hayashi, N. & Mita, E. Fas system and apoptosis in viral hepatitis. J. Gastroenterol. Hepatol. 12, 9\u201310 (1997).","journal-title":"J. Gastroenterol. Hepatol."},{"key":"BFnbt0800_862_CR36","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1046\/j.1365-2893.1997.00053.x","volume":"4","author":"K-X Luo","year":"1997","unstructured":"Luo, K.-X et al. In situ investigation of Fas\/FasL expression in chronic hepatitis B infection and related liver diseases. J. Viral Hepatitis 4, 303\u2013307 (1997).","journal-title":"J. Viral Hepatitis"},{"key":"BFnbt0800_862_CR37","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1007\/BF02100142","volume":"41","author":"M Okazaki","year":"1996","unstructured":"Okazaki, M., Hino, K., Fujii, K., Kobayashi, N. & Okita, K. Hepatic Fas antigen expression before and after interferon therapy in patients with chronic hepatitis C. Dig. Dis. Sci. 41, 2453\u20132458 (1996).","journal-title":"Dig. Dis. Sci."},{"key":"BFnbt0800_862_CR38","first-page":"51","volume":"43","author":"K Sekine","year":"1997","unstructured":"Sekine, K., Nishimaki, T., Suzuki, T. & Kasukawa, R. Expression of Fas antigen on hepatocytes in viral hepatitis patients. Fukushima J. Med. Sci. 43, 51\u201359 (1997).","journal-title":"Fukushima J. Med. Sci."},{"key":"BFnbt0800_862_CR39","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1172\/JCI4765","volume":"103","author":"WA Faubion","year":"1999","unstructured":"Faubion, W.A. et al. Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of fas. J. Clin. Invest. 103, 137\u2013145 (1999).","journal-title":"J. Clin. Invest."},{"key":"BFnbt0800_862_CR40","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/nm0598-588","volume":"4","author":"S Strand","year":"1998","unstructured":"Strand, S. et al. Hepatic failure and liver cell damage in acute Wilson's disease involve CD95 (APO-1\/Fas) mediated apoptosis. Nat. Med. 4, 588\u2013593 (1998).","journal-title":"Nat. Med."},{"key":"BFnbt0800_862_CR41","first-page":"561","volume":"16","author":"R Matsumura","year":"1998","unstructured":"Matsumura, R. et al. Glandular and extraglandular expression of the Fas-Fas ligand and apoptosis in patients with Sjogren's syndrome. Clin. Exp. Rheumatol. 16, 561\u2013568 (1998).","journal-title":"Clin. Exp. Rheumatol."},{"key":"BFnbt0800_862_CR42","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1084\/jem.189.2.441","volume":"189","author":"SC Afford","year":"1999","unstructured":"Afford, S.C. et al. CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fas-mediated hepatocyte death during allograft rejection. J. Exp. Med. 189, 441\u2013446 (1999).","journal-title":"J. Exp. Med."},{"key":"BFnbt0800_862_CR43","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1053\/gast.1997.v113.pm9322527","volume":"113","author":"K-I Seino","year":"1997","unstructured":"Seino, K.-I. et al. Contribution of Fas ligand to T cell-mediated hepatic injury in mice. Gastroenterology 113, 1315\u20131322 (1997).","journal-title":"Gastroenterology"},{"key":"BFnbt0800_862_CR44","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.4049\/jimmunol.159.3.1418","volume":"159","author":"Y Tagawa","year":"1997","unstructured":"Tagawa, Y., Sekikawa, K. & Iwakure, Y. Suppression of concanavalin A-induced hepatitis in INF-r\u2212\/\u2212 mice, but not in TNF-a\u2212\/\u2212 mice. J. Immunol. 159, 1418\u20131428 (1997).","journal-title":"J. Immunol."},{"key":"BFnbt0800_862_CR45","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1074\/jbc.272.18.11994","volume":"272","author":"BF Baker","year":"1997","unstructured":"Baker, B.F. et al. 2\u2032-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells. J. Biol. Chem. 272, 1994\u20132000 (1997).","journal-title":"J. Biol. Chem."},{"key":"BFnbt0800_862_CR46","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1128\/JVI.70.8.5203-5212.1996","volume":"70","author":"R Hanecak","year":"1996","unstructured":"Hanecak, R. et al. Antisense oligonucleotide inhibition of hepatitis C virus gene expression in transformed hepatocytes. J. Virol. 70, 5203\u20135212 (1996).","journal-title":"J. Virol."},{"key":"BFnbt0800_862_CR47","first-page":"1272","volume":"25","author":"RS Geary","year":"1997","unstructured":"Geary, R.S. et al. Pharmacokinetics and metabolism in mice of a phosphorothioate oligonucleotide antisense inhibitor of C-raf-1 kinase expression. Drug Metab. Dispos. 25, 1272\u20131281 (1997).","journal-title":"Drug Metab. Dispos."},{"key":"BFnbt0800_862_CR48","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1006\/abio.1996.0088","volume":"235","author":"JM Leeds","year":"1996","unstructured":"Leeds, J.M., Graham, M.J., Truong, L. & Cummins, L.L. Quantitation of phosphorothioate oligonucleotides in human plasma. Anal. Biochem. 235, 36\u201343 (1996).","journal-title":"Anal. Biochem."}],"container-title":["Nature Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nbt0800_862.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nbt0800_862","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nbt0800_862.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T19:17:32Z","timestamp":1684437452000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nbt0800_862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["BFnbt0800_862"],"URL":"https:\/\/doi.org\/10.1038\/78475","relation":{},"ISSN":["1087-0156","1546-1696"],"issn-type":[{"value":"1087-0156","type":"print"},{"value":"1546-1696","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8]]}}}