{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:32:06Z","timestamp":1778657526173,"version":"3.51.4"},"update-to":[{"DOI":"10.1038\/82242","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000}}],"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2000,10]]},"DOI":"10.1038\/80516","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:34:58Z","timestamp":1027672498000},"page":"1167-1175","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":694,"title":["Encephalitogenic potential of the myelin basic protein peptide (amino acids 83\u201399) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand"],"prefix":"10.1038","volume":"6","author":[{"given":"Bibiana","family":"Bielekova","sequence":"first","affiliation":[]},{"given":"Bonnie","family":"Goodwin","sequence":"additional","affiliation":[]},{"given":"Nancy","family":"Richert","sequence":"additional","affiliation":[]},{"given":"Irene","family":"Cortese","sequence":"additional","affiliation":[]},{"given":"Takayuki","family":"Kondo","sequence":"additional","affiliation":[]},{"given":"Ghazaleh","family":"Afshar","sequence":"additional","affiliation":[]},{"given":"Bruno","family":"Gran","sequence":"additional","affiliation":[]},{"given":"Joan","family":"Eaton","sequence":"additional","affiliation":[]},{"given":"Jack","family":"Antel","sequence":"additional","affiliation":[]},{"given":"Joseph A.","family":"Frank","sequence":"additional","affiliation":[]},{"given":"Henry F.","family":"McFarland","sequence":"additional","affiliation":[]},{"given":"Roland","family":"Martin","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BFnm1000_1167_CR1","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1146\/annurev.iy.10.040192.001101","volume":"10","author":"R Martin","year":"1992","unstructured":"Martin, R., McFarland, H.F. & McFarlin, D.E. Immunological aspects of demyelinating diseases. Annu. Rev. Immunol. 10, 153\u2013187 (1992).","journal-title":"Annu. Rev. Immunol."},{"key":"BFnm1000_1167_CR2","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1177\/135245859800400301","volume":"4","author":"H Lassmann","year":"1998","unstructured":"Lassmann, H. Neuropathology in multiple sclerosis: new concepts. Mult. Scler. 4, 93\u201398 (1998 ).","journal-title":"Mult. Scler."},{"key":"BFnm1000_1167_CR3","first-page":"413","volume-title":"Multiple Sclerosis","author":"CS Raine","year":"1983","unstructured":"Raine, C.S. in Multiple Sclerosis (eds. Hallpike, J.F., Adams, C.W. & Tourtellotte, W.W.) 413\u2013478 (Williams & Wilkins, Baltimore, 1983)."},{"key":"BFnm1000_1167_CR4","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1056\/NEJM199801293380502","volume":"338","author":"BD Trapp","year":"1998","unstructured":"Trapp, B.D. et al. Axonal transection in the lesions of multiple sclerosis. N. Engl. J. Med. 338, 278\u2013285 (1998).","journal-title":"N. Engl. J. Med."},{"key":"BFnm1000_1167_CR5","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S0092-8674(00)81107-1","volume":"85","author":"L Steinman","year":"1996","unstructured":"Steinman, L. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 85, 299\u2013 302 (1996).","journal-title":"Cell"},{"key":"BFnm1000_1167_CR6","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/0167-5699(89)90236-3","volume":"10","author":"DA Hafler","year":"1989","unstructured":"Hafler, D.A. & Weiner, H.L. MS: a CNS and systemic autoimmune disease. Immunol. Today 10, 104\u2013 107 (1989).","journal-title":"Immunol. Today"},{"key":"BFnm1000_1167_CR7","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0166-2236(86)90077-9","volume":"9","author":"H Wekerle","year":"1986","unstructured":"Wekerle, H., Linington, C., Lassmann, H. & Meyermann, R. Cellular immune reactivity within the CNS. Trends. Neuro. Sci. 9, 271\u2013277 ( 1986).","journal-title":"Trends. Neuro. Sci."},{"key":"BFnm1000_1167_CR8","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/15525","volume":"23","author":"LS Madsen","year":"1999","unstructured":"Madsen, L.S. et al. A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. Nature Genet. 23, 343\u2013347 (1999).","journal-title":"Nature Genet."},{"key":"BFnm1000_1167_CR9","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S0165-5728(98)00031-9","volume":"86","author":"H Lassmann","year":"1998","unstructured":"Lassmann, H., Raine, C.S., Antel, J. & Prineas, J.W. Immunopathology of multiple sclerosis: report on an international meeting held at the Institute of Neurology of the University of Vienna. J. Neuroimmunol. 86, 213\u2013217 (1998).","journal-title":"J. Neuroimmunol."},{"key":"BFnm1000_1167_CR10","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1055\/s-2008-1040885","volume":"18","author":"CF Lucchinetti","year":"1998","unstructured":"Lucchinetti, C.F., Brueck, W., Rodriguez, M. & Lassmann, H. Multiple sclerosis: lessons from neuropathology. Semin. Neurol. 18, 337\u2013349 ( 1998).","journal-title":"Semin. Neurol."},{"key":"BFnm1000_1167_CR11","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1146\/annurev.iy.08.040190.003051","volume":"8","author":"SS Zamvil","year":"1990","unstructured":"Zamvil, S.S. & Steinman, L. The T lymphocyte in experimental allergic encephalomyelitis. Annu. Rev. Immunol. 8, 579\u2013621 (1990).","journal-title":"Annu. Rev. Immunol."},{"key":"BFnm1000_1167_CR12","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/346183a0","volume":"346","author":"K Ota","year":"1990","unstructured":"Ota, K. et al. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 346, 183\u2013 187 (1990).","journal-title":"Nature"},{"key":"BFnm1000_1167_CR13","doi-asserted-by":"crossref","first-page":"540","DOI":"10.4049\/jimmunol.145.2.540","volume":"145","author":"R Martin","year":"1990","unstructured":"Martin, R. et al. Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals . J. Immunol. 145, 540\u2013 548 (1990).","journal-title":"J. Immunol."},{"key":"BFnm1000_1167_CR14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000417289","volume-title":"Antigenic Determinants and Immune Response. Chem. Immunol.","author":"RB Fritz","year":"1989","unstructured":"Fritz, R.B. & McFarlin, D.E. in Antigenic Determinants and Immune Response. Chem. Immunol. Vol 46 (ed. Sercarz, E.E.) 101\u2013125 (Karger, Basel, 1989)."},{"key":"BFnm1000_1167_CR15","doi-asserted-by":"publisher","first-page":"7968","DOI":"10.1073\/pnas.87.20.7968","volume":"87","author":"M Pette","year":"1990","unstructured":"Pette, M. et al. Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple sclerosis patients and healthy donors. Proc. Natl. Acad. Sci. USA 87, 7968\u20137972 ( 1990).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm1000_1167_CR16","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1172\/JCI116242","volume":"91","author":"A Valli","year":"1993","unstructured":"Valli, A. et al. Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients. J. Clin. Invest. 91, 616\u2013628 (1993).","journal-title":"J. Clin. Invest."},{"key":"BFnm1000_1167_CR17","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1084\/jem.173.1.19","volume":"173","author":"R Martin","year":"1991","unstructured":"Martin, R. et al. A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis . J. Exp. Med. 173, 19\u2013 24 (1991).","journal-title":"J. Exp. Med."},{"key":"BFnm1000_1167_CR18","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1084\/jem.191.8.1395","volume":"191","author":"M Krogsgaard","year":"2000","unstructured":"Krogsgaard, M. et al. Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA)-DR2-MBP 85\u201399 complex . J. Exp. Med. 191, 1395\u2013 1412 (2000).","journal-title":"J. Exp. Med."},{"key":"BFnm1000_1167_CR19","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/341541a0","volume":"341","author":"AA Vandenbark","year":"1989","unstructured":"Vandenbark, A.A., Hashim, G. & Offner, H. Immunization with a synthetic T-cell receptor V-region peptide against experimental autoimmune encephalomyelitis. Nature 341, 541\u2013544 ( 1989).","journal-title":"Nature"},{"key":"BFnm1000_1167_CR20","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1126\/science.2814489","volume":"246","author":"MD Howell","year":"1989","unstructured":"Howell, M.D. et al. Vaccination against experimental allergic autoimmune encephalomyelitis with T cell receptor peptides. Science 246, 668\u2013670 (1989).","journal-title":"Science"},{"key":"BFnm1000_1167_CR21","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/0092-8674(89)90786-1","volume":"57","author":"DC Wraith","year":"1989","unstructured":"Wraith, D.C., McDevitt, H.O., Steinman, L. & Acha-Orbea, H. T cell recognition as the target for immune intervention in autoimmune disease . Cell 57, 709\u2013715 (1989).","journal-title":"Cell"},{"key":"BFnm1000_1167_CR22","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/0092-8674(88)90558-2","volume":"54","author":"H Acha-Orbea","year":"1988","unstructured":"Acha-Orbea, H. et al. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention . Cell 54, 263\u2013273 (1988).","journal-title":"Cell"},{"key":"BFnm1000_1167_CR23","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1093\/brain\/120.5.865","volume":"120","author":"R Hohlfeld","year":"1997","unstructured":"Hohlfeld, R. Biotechnological agents of the immunotherapy of multiple sclerosis. Principles, problems and perspectives. Brain 120, 865 \u2013916 (1997).","journal-title":"Brain"},{"key":"BFnm1000_1167_CR24","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/1074-7613(95)90169-8","volume":"3","author":"LB Nicholson","year":"1995","unstructured":"Nicholson, L.B., Greer, J.M., Sobel, R.A., Lees, M.B. & Kuchroo, V.K. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity 3, 397\u2013405 (1995).","journal-title":"Immunity"},{"key":"BFnm1000_1167_CR25","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1084\/jem.180.6.2227","volume":"180","author":"N Karin","year":"1994","unstructured":"Karin, N., Mitchell, D.J., Brocke, S., Ling, N. & Steinman, L. Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon \u03b3 and tumor necrosis factor \u03b1 production. J. Exp. Med. 180, 2227\u20132237 (1994).","journal-title":"J. Exp. Med."},{"key":"BFnm1000_1167_CR26","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/379343a0","volume":"379","author":"S Brocke","year":"1996","unstructured":"Brocke, S. et al. Dynamics of autoimmune T cell infiltration: reversal of paralysis and disappearance of inflammation following treatment of experimental encephalomyelitis with a myelin basic protein peptide analog. Nature 379, 343\u2013346 (1996).","journal-title":"Nature"},{"key":"BFnm1000_1167_CR27","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/0092-8674(92)90139-4","volume":"68","author":"MT De Magistris","year":"1992","unstructured":"De Magistris, M.T. et al. Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor. Cell 68, 625\u2013 634 (1992).","journal-title":"Cell"},{"key":"BFnm1000_1167_CR28","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/0092-8674(94)90080-9","volume":"79","author":"J Sloan-Lancaster","year":"1994","unstructured":"Sloan-Lancaster, J., Shaw, A.S., Rothbard, J.B. & Allen, P.M. Partial T cell signaling: Altered phospho-\u03b6 and lack of zap70 recruitment in APL-induced T cell anergy. Cell 79, 913 \u2013922 (1994).","journal-title":"Cell"},{"key":"BFnm1000_1167_CR29","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1126\/science.7824949","volume":"167","author":"J Madrenas","year":"1995","unstructured":"Madrenas, J. et al. \u03b6 phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 167, 515\u2013518 (1995).","journal-title":"Science"},{"key":"BFnm1000_1167_CR30","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/1074-7613(95)90145-0","volume":"2","author":"A Windhagen","year":"1995","unstructured":"Windhagen, A. et al. Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand. Immunity 2, 373\u2013380 ( 1995).","journal-title":"Immunity"},{"key":"BFnm1000_1167_CR31","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","volume":"33","author":"JF Kurtzke","year":"1983","unstructured":"Kurtzke, J.F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33, 1444\u2013 52 (1983).","journal-title":"Neurology"},{"key":"BFnm1000_1167_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0022-510X(95)00261-Y","volume":"135","author":"B Sharrack","year":"1996","unstructured":"Sharrack, B. & Hughes, R.A. Clinical scales for multiple sclerosis . J. Neurol. Sci. 135, 1\u2013 9 (1996).","journal-title":"J. Neurol. Sci."},{"key":"BFnm1000_1167_CR33","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1212\/WNL.49.3.862","volume":"49","author":"LA Stone","year":"1997","unstructured":"Stone, L.A. et al. Characterization of MRI response to treatment with interferon beta-1b: contrast-enhancing MRI lesion frequency as a primary outcome measure . Neurology 49, 862\u2013869 (1997).","journal-title":"Neurology"},{"key":"BFnm1000_1167_CR34","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0165-5728(99)00200-3","volume":"100","author":"B Bielekova","year":"1999","unstructured":"Bielekova, B. et al. Preferential expansion of autoreactive T lymphocytes from the memory T-cell pool by IL-7. J. Neuroimmunol. 100 , 115\u2013123 (1999).","journal-title":"J. Neuroimmunol."},{"key":"BFnm1000_1167_CR35","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1146\/annurev.immunol.17.1.467","volume":"17","author":"RN Germain","year":"1999","unstructured":"Germain, R.N. & Stefanova, I. The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation . Annu. Rev. Immunol. 17, 467\u2013 522 (1999).","journal-title":"Annu. Rev. Immunol."},{"key":"BFnm1000_1167_CR36","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.4049\/jimmunol.160.12.5807","volume":"160","author":"B Hemmer","year":"1998","unstructured":"Hemmer, B., Stefanova, I., Vergelli, M., Germain, R.N. & Martin, R. Relationships among TCR ligand potency, thresholds for effector function elicitation, and the quality of early signaling events in human T cells. J. Immunol. 160, 5807\u20135814 (1998).","journal-title":"J. Immunol."},{"key":"BFnm1000_1167_CR37","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/9858","volume":"17","author":"T Sturniolo","year":"1999","unstructured":"Sturniolo, T. et al. Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices. Nature Biotechnol. 17, 555\u2013561 (1999).","journal-title":"Nature Biotechnol."},{"key":"BFnm1000_1167_CR38","doi-asserted-by":"publisher","first-page":"2624","DOI":"10.1002\/eji.1830261113","volume":"26","author":"M Vergelli","year":"1996","unstructured":"Vergelli, M. et al. Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87-99) . Eur. J. Immunol. 26, 2624\u2013 2634 (1996).","journal-title":"Eur. J. Immunol."},{"key":"BFnm1000_1167_CR39","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/S0167-5699(98)01299-7","volume":"19","author":"D Mason","year":"1998","unstructured":"Mason, D. A very high level of crossreactivity is an essential feature of the T- cell receptor. Immunol. Today 19, 395\u2013 404 (1998).","journal-title":"Immunol. Today"},{"key":"BFnm1000_1167_CR40","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/S1074-7613(00)80036-9","volume":"10","author":"B Lucas","year":"1999","unstructured":"Lucas, B., Stefanova, I., Yasutomo, K., Dautigny, N. & Germain, R.N. Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire. Immunity 10, 367\u2013376 (1999).","journal-title":"Immunity"},{"key":"BFnm1000_1167_CR41","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1093\/intimm\/12.2.205","volume":"12","author":"LB Nicholson","year":"2000","unstructured":"Nicholson, L.B., Anderson, A.C. & Kuchroo, V.K. Tuning T cell activation threshold and effector function with cross-reactive peptide ligands. Int. Immunol. 12, 205\u2013213 (2000).","journal-title":"Int. Immunol."},{"key":"BFnm1000_1167_CR42","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1212\/WNL.49.4.1116","volume":"49","author":"B Hemmer","year":"1997","unstructured":"Hemmer, B. et al. Human T-cell response to myelin basic protein peptide (83\u201399): Extensive heterogeneity in antigen recognition, function, and phenotype. Neurology 49, 1116\u20131126 (1997).","journal-title":"Neurology"},{"key":"BFnm1000_1167_CR43","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1146\/annurev.immunol.15.1.297","volume":"15","author":"SL Constant","year":"1997","unstructured":"Constant, S.L. & Bottomly, K. Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu. Rev. Immunol. 15, 297\u2013322 (1997).","journal-title":"Annu. Rev. Immunol."},{"key":"BFnm1000_1167_CR44","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.4049\/jimmunol.140.6.1868","volume":"140","author":"VK Tuohy","year":"1988","unstructured":"Tuohy, V.K., Sobel, R.A. & Lees, M.B. Myelin proteolipid protein-induced experimental allergic encephalomyelitis. Variations of disease expression in different strains of mice. J. Immunol. 140, 1868\u2013 1873 (1988).","journal-title":"J. Immunol."},{"key":"BFnm1000_1167_CR45","first-page":"625","volume":"19","author":"J Remlinger","year":"1905","unstructured":"Remlinger, J. Accidents paralytiques au cours du traitment antirabique. Ann. Inst. Pasteur 19, 625\u2013646 (1905).","journal-title":"Ann. Inst. Pasteur"},{"key":"BFnm1000_1167_CR46","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1084\/jem.58.1.39","volume":"58","author":"TM Rivers","year":"1933","unstructured":"Rivers, T.M., Sprunt, D.H. & Berry, G.P. Observations on attempts to produce acute disseminated encephalomyelitis in monkeys. J. Exp. Med. 58, 39\u201353 (1933).","journal-title":"J. Exp. Med."},{"key":"BFnm1000_1167_CR47","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1084\/jem.111.1.119","volume":"111","author":"PY Paterson","year":"1960","unstructured":"Paterson, P.Y. Transfer of allergic encephalomyelitis in rats by means of lymph node cells . J. Exp. Med. 111, 119\u2013 133 (1960).","journal-title":"J. Exp. Med."},{"key":"BFnm1000_1167_CR48","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.4049\/jimmunol.127.4.1420","volume":"127","author":"CB Pettinelli","year":"1981","unstructured":"Pettinelli, C.B. & McFarlin, D.E. Adoptive transfer of experimental allergic encephalomyelitis in SJL\/J mice after in vivo activation of lymph node cells by myelin basic protein: requirement for Lyt-1+2- T lymphocytes . J. Immunol. 127, 1420\u2013 1423 (1981).","journal-title":"J. Immunol."},{"key":"BFnm1000_1167_CR49","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1126\/science.2414848","volume":"230","author":"RS Fujinami","year":"1985","unstructured":"Fujinami, R.S. & Oldstone, M.B.A. Amino Acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity. Science 230, 1043\u20131045 (1985).","journal-title":"Science"},{"key":"BFnm1000_1167_CR50","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1749-6632.1965.tb20235.x","volume":"112","author":"GA Schumacher","year":"1965","unstructured":"Schumacher, G.A. Problems of experimental trials of therapy in multiple sclerosis: Report by the panel on the evaluation of experimental trials in multiple sclerosis. Ann. New York Acad. Sci. 112, 552\u2013 568 (1965).","journal-title":"Ann. New York Acad. Sci."},{"key":"BFnm1000_1167_CR51","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1097\/00004728-199203000-00018","volume":"16","author":"C DeCarli","year":"1992","unstructured":"DeCarli, C. et al. Method for quantification of brain, ventricular, and subarachnoid CSF volumes from MR images. J. Comput. Assist. Tomogr. 16, 274\u2013284 (1992).","journal-title":"J. Comput. Assist. Tomogr."},{"key":"BFnm1000_1167_CR52","first-page":"139","volume":"2","author":"GE Deibler","year":"1972","unstructured":"Deibler, G.E., Martenson, R.E. & Kies, M.W. Large scale preparation of myelin basic protein from central nervous system tissue of several mammalian species. Prep. Biochem. 2, 139\u2013165 ( 1972).","journal-title":"Prep. Biochem."},{"key":"BFnm1000_1167_CR53","doi-asserted-by":"publisher","first-page":"4302","DOI":"10.1073\/pnas.81.14.4302","volume":"81","author":"N Ling","year":"1984","unstructured":"Ling, N. et al. Isolation, primary structure, and synthesis of human hypothalamic somatocrinin: growth hormone-releasing factor. Proc. Natl. Acad. Sci. USA 81, 4302\u20134306 ( 1984).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm1000_1167_CR54","doi-asserted-by":"publisher","first-page":"5131","DOI":"10.1073\/pnas.82.15.5131","volume":"82","author":"RA Houghten","year":"1985","unstructured":"Houghten, R.A. General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. Proc. Natl. Acad. Sci. USA 82, 5131 \u20135135 (1985).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm1000_1167_CR55","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/0167-5699(84)90137-3","volume":"5","author":"I Lefkovits","year":"1984","unstructured":"Lefkovits, I. & Waldmann, H. Limiting dilution analysis of the cells of immune system. The clonal basis of the immune response. Immunol. Today 5, 265\u2013277 (1984).","journal-title":"Immunol. Today"},{"key":"BFnm1000_1167_CR56","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1084\/jem.179.3.973","volume":"179","author":"J Zhang","year":"1994","unstructured":"Zhang, J. et al. Increased frequency of interleukin-2-responsive T cells specific for myelin basic protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J. Exp. Med. 179, 973\u2013984 (1994).","journal-title":"J. Exp. Med."},{"key":"BFnm1000_1167_CR57","doi-asserted-by":"publisher","first-page":"5474","DOI":"10.4049\/jimmunol.164.10.5474","volume":"164","author":"PA Muraro","year":"2000","unstructured":"Muraro, P.A., Pette, M., Bielekova, B., McFarland, H.F. & Martin, R. Human autoreactive CD4+ T cells from naive CD45RA+ and memory CD45RO+ subsets differ with respect to epitope specificity and functional antigen avidity. J. Immunol. 164, 5474\u2013 5481 (2000).","journal-title":"J. Immunol."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm1000_1167.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm1000_1167","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm1000_1167.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T11:26:12Z","timestamp":1704281172000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm1000_1167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["BFnm1000_1167"],"URL":"https:\/\/doi.org\/10.1038\/80516","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}