{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:05:53Z","timestamp":1792404353774,"version":"4.4.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2001,3,1]],"date-time":"2001-03-01T00:00:00Z","timestamp":983404800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[2001,3]]},"DOI":"10.1038\/85906","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:48:26Z","timestamp":1027658906000},"page":"327-331","source":"Crossref","is-referenced-by-count":1114,"title":["Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice"],"prefix":"10.1038","volume":"27","author":[{"given":"Richard Z.","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schahram","family":"Akbarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Tudor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Jaenisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFng0301_327_CR1","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/0092-8674(92)90610-O","volume":"69","author":"JD Lewis","year":"1992","unstructured":"Lewis, J.D. et al. Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell 69, 905\u2013914 (1992).","journal-title":"Cell"},{"key":"BFng0301_327_CR2","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1038\/30764","volume":"393","author":"X Nan","year":"1998","unstructured":"Nan, X. et al. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393, 386\u2013389 (1998).","journal-title":"Nature"},{"key":"BFng0301_327_CR3","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/561","volume":"19","author":"PL Jones","year":"1998","unstructured":"Jones, P.L. et al. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nature Genet. 19, 187\u2013191 (1998).","journal-title":"Nature Genet."},{"key":"BFng0301_327_CR4","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1093\/hmg\/8.7.1253","volume":"8","author":"JF Coy","year":"1999","unstructured":"Coy, J.F., Sedlacek, Z., Bachner, D., Delius, H. & Poustka, A. A complex pattern of evolutionary conservation and alternative polyadenylation within the long 3\"-untranslated region of the methyl-CpG-binding protein 2 gene (MeCP2) suggests a regulatory role in gene expression. Hum. Mol. Genet. 8, 1253\u20131262 (1999).","journal-title":"Hum. Mol. Genet."},{"key":"BFng0301_327_CR5","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/13810","volume":"23","author":"RE Amir","year":"1999","unstructured":"Amir, R.E. et al. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nature Genet. 23, 185\u2013188 (1999).","journal-title":"Nature Genet."},{"key":"BFng0301_327_CR6","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1086\/302690","volume":"65","author":"M Wan","year":"1999","unstructured":"Wan, M. et al. Rett syndrome and beyond: recurrent spontaneous and familial MECP2 mutations at CpG hotspots. Am. J. Hum. Genet. 65, 1520\u20131529 (1999).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng0301_327_CR7","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S0959-437X(00)00083-6","volume":"10","author":"IB Van den Veyver","year":"2000","unstructured":"Van den Veyver, I.B. & Zoghbi, H.Y. Methyl-CpG-binding protein 2 mutations in Rett syndrome. Curr. Opin. Genet. Dev. 10, 275\u2013279 (2000).","journal-title":"Curr. Opin. Genet. Dev."},{"key":"BFng0301_327_CR8","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1093\/hmg\/9.16.2365","volume":"9","author":"J Dragich","year":"2000","unstructured":"Dragich, J., Houwink-Manville, I. & Schanen, C. Rett syndrome: a surprising result of mutation in MECP2. Hum. Mol. Genet. 9, 2365\u20132375 (2000).","journal-title":"Hum. Mol. Genet."},{"key":"BFng0301_327_CR9","first-page":"723","volume":"116","author":"A Rett","year":"1966","unstructured":"Rett, A. Uber ein eigenartiges hirnatrophisches Syndrom bei Hyperammonamie im Kindersalter. Wien Med. Wochenschr. 116, 723\u2013726 (1966).","journal-title":"Wien Med. Wochenschr."},{"key":"BFng0301_327_CR10","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1002\/ana.410140412","volume":"14","author":"B Hagberg","year":"1983","unstructured":"Hagberg, B., Aicardi, J., Dias, K. & Ramos, O. A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome: report of 35 cases. Ann. Neurol. 14, 471\u2013479 (1983).","journal-title":"Ann. Neurol."},{"key":"BFng0301_327_CR11","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1097\/00005072-199708000-00001","volume":"56","author":"DD Armstrong","year":"1997","unstructured":"Armstrong, D.D. Review of Rett syndrome. J. Neuropathol. Exp. Neurol. 56, 843\u2013849 (1997).","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"BFng0301_327_CR12","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/ng0296-205","volume":"12","author":"P Tate","year":"1996","unstructured":"Tate, P., Skarnes, W. & Bird, A. The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse. Nature Genet. 12, 205\u2013208 (1996).","journal-title":"Nature Genet."},{"key":"BFng0301_327_CR13","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1046\/j.1440-1754.1999.355403.x","volume":"35","author":"C Ellaway","year":"1999","unstructured":"Ellaway, C. & Christodoulou, J. Rett syndrome: clinical update and review of recent genetic advances. J. Paediatr. Child Health 35, 419\u2013426 (1999).","journal-title":"J. Paediatr. Child Health"},{"key":"BFng0301_327_CR14","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1177\/088307389801300507","volume":"13","author":"NC Schanen","year":"1998","unstructured":"Schanen, N.C. et al. Neonatal encephalopathy in two boys in families with recurrent Rett syndrome. J. Child Neurol. 13, 229\u2013231 (1998).","journal-title":"J. Child Neurol."},{"key":"BFng0301_327_CR15","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1086\/301932","volume":"63","author":"C Schanen","year":"1998","unstructured":"Schanen, C. & Francke, U. A severely affected male born into a Rett syndrome kindred supports X-linked inheritance and allows extension of the exclusion map. Am. J. Hum. Genet. 63, 267\u2013269 (1998).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng0301_327_CR16","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1212\/WNL.55.8.1188","volume":"55","author":"L Villard","year":"2000","unstructured":"Villard, L., Cardoso, A.K., Chelly, P.J., Tardieu, P.M. & Fontes, M. Two affected boys in a Rett syndrome family: clinical and molecular findings. Neurology 55, 1188\u20131193 (2000).","journal-title":"Neurology"},{"key":"BFng0301_327_CR17","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1086\/303078","volume":"67","author":"I Meloni","year":"2000","unstructured":"Meloni, I. et al. A mutation in the rett syndrome gene, MECP2, causes X-linked mental retardation and progressive spasticity in males. Am. J. Hum. Genet. 67, 982\u2013985 (2000).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng0301_327_CR18","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/S0140-6736(00)02661-1","volume":"356","author":"J Clayton-Smith","year":"2000","unstructured":"Clayton-Smith, J., Watson, P., Ramsden, S. & Black, G.C. Somatic mutation in MECP2 as a non-fatal neurodevelopmental disorder in males. Lancet 356, 830\u2013832 (2000).","journal-title":"Lancet"},{"key":"BFng0301_327_CR19","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/S0014-5793(00)01994-3","volume":"481","author":"A Orrico","year":"2000","unstructured":"Orrico, A. et al. MECP2 mutation in male patients with non-specific X-linked mental retardation. FEBS Lett. 481, 285\u2013288 (2000).","journal-title":"FEBS Lett."},{"key":"BFng0301_327_CR20","doi-asserted-by":"publisher","first-page":"3136","DOI":"10.1101\/gad.13.23.3136","volume":"13","author":"A Trumpp","year":"1999","unstructured":"Trumpp, A., Depew, M.J., Rubenstein, J.L., Bishop, J.M. & Martin, G.R. Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev. 13, 3136\u20133148 (1999).","journal-title":"Genes Dev."},{"key":"BFng0301_327_CR21","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1523\/JNEUROSCI.21-03-00788.2001","volume":"21","author":"G Fan","year":"2001","unstructured":"Fan, G. et al. DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals. J. Neurosci. 21, 788\u2013797 (2001).","journal-title":"J. Neurosci."},{"key":"BFng0301_327_CR22","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/85899","volume":"27","author":"J Guy","year":"2001","unstructured":"Guy, J., Hendrich, B., Martin, J.E. & Bird, A. A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nature Genet. 27, 322\u2013326 (2001).","journal-title":"Nature Genet."},{"key":"BFng0301_327_CR23","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/BF00688098","volume":"76","author":"K Jellinger","year":"1988","unstructured":"Jellinger, K., Armstrong, D., Zoghbi, H.Y. & Percy, A.K. Neuropathology of Rett syndrome. Acta Neuropathol. 76, 142\u2013158 (1988).","journal-title":"Acta Neuropathol."},{"key":"BFng0301_327_CR24","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1111\/j.1651-2227.2000.tb01216.x","volume":"89","author":"G Hagberg","year":"2000","unstructured":"Hagberg, G., Stenbom, Y. & Witt Engerstrom, I. Head growth in Rett syndrome. Acta Paediatr. 89, 198\u2013202 (2000).","journal-title":"Acta Paediatr."},{"key":"BFng0301_327_CR25","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1055\/s-2007-979737","volume":"26","author":"ML Bauman","year":"1995","unstructured":"Bauman, M.L., Kemper, T.L. & Arin, D.M. Microscopic observations of the brain in Rett syndrome. Neuropediatrics 26, 105\u2013108 (1995).","journal-title":"Neuropediatrics"},{"key":"BFng0301_327_CR26","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1212\/WNL.45.8.1581","volume":"45","author":"ML Bauman","year":"1995","unstructured":"Bauman, M.L., Kemper, T.L. & Arin, D.M. Pervasive neuroanatomic abnormalities of the brain in three cases of Rett's syndrome. Neurology 45, 1581\u20131586 (1995).","journal-title":"Neurology"},{"key":"BFng0301_327_CR27","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/S0896-6273(00)80853-3","volume":"24","author":"L Minichiello","year":"1999","unstructured":"Minichiello, L. et al. Essential role for TrkB receptors in hippocampus-mediated learning. Neuron 24, 401\u2013414 (1999).","journal-title":"Neuron"},{"key":"BFng0301_327_CR28","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/5007","volume":"21","author":"P Soriano","year":"1999","unstructured":"Soriano, P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nature Genet. 21, 70\u201371 (1999).","journal-title":"Nature Genet."},{"key":"BFng0301_327_CR29","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<133::AID-GENE10>3.0.CO;2-V","volume":"26","author":"I Dragatsis","year":"2000","unstructured":"Dragatsis, I. & Zeitlin, S. CaMKII\u03b1-Cre transgene expression and recombination patterns in the mouse brain. Genesis 26, 133\u2013135 (2000).","journal-title":"Genesis"}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng0301_327.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0301_327","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0301_327.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T16:23:44Z","timestamp":1684427024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng0301_327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,3]]}},"alternative-id":["BFng0301_327"],"URL":"https:\/\/doi.org\/10.1038\/85906","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,3]]}}}