{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:16:22Z","timestamp":1789802182372,"version":"4.0.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Immunol"],"published-print":{"date-parts":[[2001,4]]},"DOI":"10.1038\/86365","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:41:29Z","timestamp":1027672889000},"page":"353-360","source":"Crossref","is-referenced-by-count":258,"title":["A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation"],"prefix":"10.1038","volume":"2","author":[{"given":"Simon P.","family":"Hogan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric B.","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Royalty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel M.","family":"Pope","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nives","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc E.","family":"Rothenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFni0401_353_CR1","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/S0091-6749(99)70411-2","volume":"103","author":"HA Sampson","year":"1999","unstructured":"Sampson, H. A. Food allergy. Part 1: immunopathogenesis and clinical disorders. J. Allergy Clin. Immunol. 103, 717\u2013728 (1999).","journal-title":"J. Allergy Clin. Immunol."},{"key":"BFni0401_353_CR2","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1097\/00001574-199511000-00013","volume":"11","author":"GT Furuta","year":"1995","unstructured":"Furuta, G. T., Ackerman, S. J. & Wershil, B. K. The role of the eosinophil in gastrointestinal diseases. Curr. Opin. Gastroenterol. 11, 541\u2013547 (1995).","journal-title":"Curr. Opin. Gastroenterol."},{"key":"BFni0401_353_CR3","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1001\/jama.1997.03550220094013","volume":"278","author":"HA Sampson","year":"1997","unstructured":"Sampson, H. A. Food allergy. J. Am. Med. Assoc. 278, 1888\u20131894 (1997).","journal-title":"J. Am. Med. Assoc."},{"key":"BFni0401_353_CR4","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1097\/00005176-200001001-00005","volume":"30","author":"KJ Kelly","year":"2000","unstructured":"Kelly, K. J. Eosinophilic gastroenteritis. J. Pediatr. Gastroenterol. Nutr. 30 Suppl 28\u201335 (2000).","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"BFni0401_353_CR5","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.4049\/jimmunol.123.6.2925","volume":"123","author":"GJ Gleich","year":"1979","unstructured":"Gleich, G. J., Frigas, E., Loegering, D. A., Wassom, D. L. & Steinmuller, D. Cytoxic properties of the eosinophil major basic protein. J. Immunol. 123, 2925\u20132927 (1979).","journal-title":"J. Immunol."},{"key":"BFni0401_353_CR6","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1097\/00005792-197007000-00003","volume":"49","author":"NC Klein","year":"1970","unstructured":"Klein, N. C., Hargrove, R. L., Sleisenger, M. H. & Jeffries, G. H. Eosinophilic gastroenteritis. Medicine (Baltimore) 49, 299\u2013319 (1970).","journal-title":"Medicine (Baltimore)"},{"key":"BFni0401_353_CR7","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/0002-9343(79)90652-1","volume":"67","author":"JP Cello","year":"1979","unstructured":"Cello, J. P. Eosinophilic gastroenteritis: a complex disease entity. Am. J. Med. 67, 1097\u20131114 (1979).","journal-title":"Am. J. Med."},{"key":"BFni0401_353_CR8","first-page":"404","volume":"74","author":"G Torpier","year":"1988","unstructured":"Torpier, G. et al. Eosinophilic gastroenteritis: ultrastructural evidence for a selective release of eosinophil major basic protein. Clin. Exp. Immunol. 74, 404\u2013408 (1988).","journal-title":"Clin. Exp. Immunol."},{"key":"BFni0401_353_CR9","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1046\/j.1365-2222.1999.00511.x","volume":"29","author":"LM Vandezande","year":"1999","unstructured":"Vandezande, L. M. et al. Interleukin-5 immunoreactivity and mRNA expression in gut mucosa from patients with food allergy. Clin. Exp. Allergy 29, 695\u2013702 (1999).","journal-title":"Clin. Exp. Allergy"},{"key":"BFni0401_353_CR10","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/S0016-5085(85)80026-3","volume":"88","author":"A Keshavarzian","year":"1985","unstructured":"Keshavarzian, A. et al. Activated eosinophils in familial eosinophilic gastroenteritis. Gastroenterology 88, 1041\u20131049 (1985).","journal-title":"Gastroenterology"},{"key":"BFni0401_353_CR11","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1136\/gut.31.1.54","volume":"31","author":"NJ Talley","year":"1990","unstructured":"Talley, N. J., Shorter, R. G., Phillips, S. F. & Zinsmeister, A. R. Eosinophilic gastroenteritis: a clinicopathological study of patients with disease of the mucosa, muscle layer, and subserosal tissues. Gut 31, 54\u201358 (1990).","journal-title":"Gut"},{"key":"BFni0401_353_CR12","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1053\/gast.1996.v110.pm8608886","volume":"110","author":"P Desreumaux","year":"1996","unstructured":"Desreumaux, P. et al. Interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 in eosinophilic gastroenteritis. Gastroenterology 110, 768\u2013774 (1996).","journal-title":"Gastroenterology"},{"key":"BFni0401_353_CR13","first-page":"110","volume":"9","author":"A Lowichik","year":"1996","unstructured":"Lowichik, A. & Weinberg, A. G. A quantitative evaluation of mucosal eosinophils in the pediatric gastrointestinal tract. Mod. Pathol. 9, 110\u2013114 (1996).","journal-title":"Mod. Pathol."},{"key":"BFni0401_353_CR14","first-page":"109s","volume":"22","author":"PF Weller","year":"1996","unstructured":"Weller, P. F. et al. Role of the eosinophil in allergic reactions. Eur. Respir. J. 22, 109s\u2013115s (1996).","journal-title":"Eur. Respir. J."},{"key":"BFni0401_353_CR15","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1073\/pnas.94.6.2101","volume":"94","author":"GJ Gleich","year":"1997","unstructured":"Gleich, G. J. & Kita, H. Bronchial asthma: lessons from murine models. Proc. Natl Acad. Sci. USA 94, 2101\u20132102 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"issue":"3","key":"BFni0401_353_CR16","first-page":"15","volume":"28","author":"RP Schleimer","year":"1998","unstructured":"Schleimer, R. P. & Bochner, B. S. The role of adhesion molecules in allergic inflammation and their suitability as targets of antiallergic therapy. Clin. Exp. Allergy 28 Suppl 3, 15\u201323 (1998).","journal-title":"Clin. Exp. Allergy"},{"key":"BFni0401_353_CR17","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1172\/JCI7010","volume":"104","author":"G Cieslewicz","year":"1999","unstructured":"Cieslewicz, G. et al. The late, but not early, asthmatic response is dependent on IL-5 and correlates with eosinophil infiltration. J. Clin. Invest. 104, 301\u2013308 (1999).","journal-title":"J. Clin. Invest."},{"key":"BFni0401_353_CR18","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1056\/NEJM199805283382206","volume":"338","author":"ME Rothenberg","year":"1998","unstructured":"Rothenberg, M. E. Eosinophilia. N. Engl. J. Med. 338, 1592\u20131600 (1998).","journal-title":"N. Engl. J. Med."},{"key":"BFni0401_353_CR19","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/S0167-5699(99)01522-4","volume":"20","author":"JC Gutierrez-Ramos","year":"1999","unstructured":"Gutierrez-Ramos, J. C., Lloyd, C. & Gonzalo, J. A. Eotaxin: from an eosinophilic chemokine to a major regulator of allergic reactions. Immunol. Today 20, 500\u2013504 (1999).","journal-title":"Immunol. Today"},{"key":"BFni0401_353_CR20","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/nm0496-449","volume":"2","author":"EA Garcia-Zepeda","year":"1996","unstructured":"Garcia-Zepeda, E. A. et al. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nature Med. 2, 449\u2013456 (1996).","journal-title":"Nature Med."},{"key":"BFni0401_353_CR21","doi-asserted-by":"publisher","first-page":"6681","DOI":"10.1073\/pnas.97.12.6681","volume":"97","author":"SP Hogan","year":"2000","unstructured":"Hogan, S. P., Mishra, A., Brandt, E. B., Foster, P. S. & Rothenberg, M. E. A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrointestinal allergy. Proc. Natl Acad. Sci. USA 97, 6681\u20136686 (2000).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFni0401_353_CR22","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1165\/ajrcmb.21.3.f160","volume":"21","author":"ME Rothenberg","year":"1999","unstructured":"Rothenberg, M. E. Eotaxin. An essential mediator of eosinophil trafficking into mucosal tissues. Am. J. Respir. Cell Mol. Biol. 21, 291\u2013295 (1999).","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"BFni0401_353_CR23","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1182\/blood.V96.4.1538","volume":"96","author":"A Mishra","year":"2000","unstructured":"Mishra, A., Hogan, S. P., Brandt, E. B. & Rothenberg, M. E. Peyer's patch eosinophils: identification, characterization, and regulation by mucosal allergen exposure, interleukin-5, and eotaxin. Blood 96, 1538\u20131544 (2000).","journal-title":"Blood"},{"key":"BFni0401_353_CR24","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1172\/JCI6560","volume":"103","author":"A Mishra","year":"1999","unstructured":"Mishra, A., Hogan, S. P., Lee, J. J., Foster, P. S. & Rothenberg, M. E. Fundamental signals regulate eosinophil homing to the gastrointestinal tract. J. Clin. Invest. 103, 1719\u20131727 (1999).","journal-title":"J. Clin. Invest."},{"key":"BFni0401_353_CR25","doi-asserted-by":"publisher","first-page":"261","DOI":"10.2165\/00063030-199809040-00001","volume":"9","author":"A Litwin","year":"1998","unstructured":"Litwin, A., Flanagan, M. & Michael, J. G. Microencapsulation. The future of oral immunotherapy? Biodrugs 9, 261\u2013270 (1998).","journal-title":"Biodrugs"},{"key":"BFni0401_353_CR26","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1159\/000236548","volume":"102","author":"AM Dvorak","year":"1993","unstructured":"Dvorak, A. M. et al. Ultrastructural identification of exocytosis of granules from human gut eosinophils in vivo. Int. Arch. Allergy Immunol. 102, 33\u201345 (1993).","journal-title":"Int. Arch. Allergy Immunol."},{"key":"BFni0401_353_CR27","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1084\/jem.191.2.265","volume":"191","author":"CM Lloyd","year":"2000","unstructured":"Lloyd, C. M. et al. CC chemokine receptor (CCR)3\/eotaxin is followed by CCR4\/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo. J. Exp. Med. 191, 265\u2013274 (2000).","journal-title":"J. Exp. Med."},{"key":"BFni0401_353_CR28","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1002\/jlb.65.6.846","volume":"65","author":"JC Grimaldi","year":"1999","unstructured":"Grimaldi, J. C. et al. Depletion of eosinophils in mice through the use of antibodies specific for C-C chemokine receptor 3 (CCR3). J. Leukoc. Biol. 65, 846\u2013853 (1999).","journal-title":"J. Leukoc. Biol."},{"key":"BFni0401_353_CR29","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1084\/jem.182.4.1169","volume":"182","author":"PD Collins","year":"1995","unstructured":"Collins, P. D., Marleau, S., Griffiths-Johnson, D. A., Jose, P. J. & Williams, T. J. Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo. J. Exp. Med. 182, 1169\u20131174 (1995).","journal-title":"J. Exp. Med."},{"key":"BFni0401_353_CR30","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1172\/JCI108986","volume":"61","author":"J Mestecky","year":"1978","unstructured":"Mestecky, J. et al. Selective induction of an immune response in human external secretions by ingestion of bacterial antigen. J. Clin. Invest. 61, 731\u2013737 (1978).","journal-title":"J. Clin. Invest."},{"key":"BFni0401_353_CR31","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.3109\/08820138909030606","volume":"18","author":"JG Michael","year":"1989","unstructured":"Michael, J. G. The role of digestive enzymes in orally induced immune tolerance. Immunol. Invest. 18, 1049\u20131054 (1989).","journal-title":"Immunol. Invest."},{"key":"BFni0401_353_CR32","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/BF01540983","volume":"14","author":"JS Jaffe","year":"1994","unstructured":"Jaffe, J. S. et al. Evidence for an abnormal profile of interleukin-4 (IL-4), IL-5, and gamma-interferon (gamma-IFN) in peripheral blood T cells from patients with allergic eosinophilic gastroenteritis. J. Clin. Immunol. 14, 299\u2013309 (1994).","journal-title":"J. Clin. Immunol."},{"key":"BFni0401_353_CR33","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1146\/annurev.me.44.020193.000505","volume":"44","author":"GJ Gleich","year":"1993","unstructured":"Gleich, G. J., Adolphson, C. R. & Leiferman, K. M. The biology of the eosinophilic leukocyte. Annu. Rev. Med. 44, 85\u2013101 (1993).","journal-title":"Annu. Rev. Med."},{"key":"BFni0401_353_CR34","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.4049\/jimmunol.142.7.2393","volume":"142","author":"RI Abu-Ghazaleh","year":"1989","unstructured":"Abu-Ghazaleh, R. I., Fujisawa, T., Mestecky, J., Kyle, R. A. & Gleich, G. J. IgA-induced eosinophil degranulation. J. Immunol. 142, 2393\u20132400 (1989).","journal-title":"J. Immunol."},{"key":"BFni0401_353_CR35","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1172\/JCI119763","volume":"100","author":"CM Evans","year":"1997","unstructured":"Evans, C. M., Fryer, A. D., Jacoby, D. B., Gleich, G. J. & Costello, R. W. Pretreatment with antibody to eosinophil major basic protein prevents hyperresponsiveness by protecting neuronal M2 muscarinic receptors in antigen-challenged guinea pigs. J. Clin. Invest. 100, 2254\u20132262 (1997).","journal-title":"J. Clin. Invest."},{"key":"BFni0401_353_CR36","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1084\/jem.190.10.1465","volume":"190","author":"DJ Adamko","year":"1999","unstructured":"Adamko, D. J., Yost, B. L., Gleich, G. J., Fryer, A. D. & Jacoby, D. B. Ovalbumin sensitization changes the inflammatory response to subsequent parainfluenza infection. Eosinophils mediate airway hyperresponsiveness, m(2) muscarinic receptor dysfunction, and antiviral effects. J. Exp. Med. 190, 1465\u20131478 (1999).","journal-title":"J. Exp. Med."},{"key":"BFni0401_353_CR37","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1023\/A:1018808329603","volume":"42","author":"S Lin","year":"1997","unstructured":"Lin, S. et al. Expression of muscarinic receptor subtypes in rat gastric smooth muscle: effect of M3 selective antagonist on gastric motility and emptying. Dig. Dis. Sci. 42, 907\u2013914 (1997).","journal-title":"Dig. Dis. Sci."},{"key":"BFni0401_353_CR38","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0016-5085(92)91106-E","volume":"103","author":"NJ Talley","year":"1992","unstructured":"Talley, N. J., Kephart, G. M., McGovern, T. W., Carpenter, H. A. & Gleich, G. J. Deposition of eosinophil granule major basic protein in eosinophilic gastroenteritis and celiac disease. Gastroenterology 103, 137\u2013145 (1992).","journal-title":"Gastroenterology"},{"key":"BFni0401_353_CR39","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1165\/ajrcmb.18.4.2957","volume":"18","author":"D Stelts","year":"1998","unstructured":"Stelts, D. et al. Eosinophils retain their granule major basic protein in a murine model of allergic pulmonary inflammation. Am. J. Respir. Cell Mol. Biol. 18, 463\u2013470 (1998).","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"BFni0401_353_CR40","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1164\/ajrccm.161.6.9906085","volume":"161","author":"JS Erjefalt","year":"2000","unstructured":"Erjefalt, J. S. & Persson, C. G. New aspects of degranulation and fates of airway mucosal eosinophils. Am. J. Respir. Crit. Care Med. 161, 2074\u20132085 (2000).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"BFni0401_353_CR41","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1172\/JCI10224","volume":"107","author":"A Mishra","year":"2001","unstructured":"Mishra, A., Hogan, S. P., Brandt, E. B. & Rothenberg, M. E. An etiological role for aeroallergens and eosinophils in experimental esophagitis. J. Clin. Invest. 107, 83\u201390 (2001).","journal-title":"J. Clin. Invest."},{"key":"BFni0401_353_CR42","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1097\/00000478-198507000-00002","volume":"9","author":"RG Lee","year":"1985","unstructured":"Lee, R. G. Marked eosinophilia in esophageal mucosal biopsies. Am. J. Surg. Pathol. 9, 475\u2013479 (1985).","journal-title":"Am. J. Surg. Pathol."},{"key":"BFni0401_353_CR43","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/S0016-5085(77)80034-6","volume":"72","author":"JW Dobbins","year":"1977","unstructured":"Dobbins, J. W., Sheahan, D. G. & Behar, J. Eosinophilic gastroenteritis with esophageal involvement. Gastroenterology 72, 1312 (1977).","journal-title":"Gastroenterology"},{"key":"BFni0401_353_CR44","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1016\/0016-5085(95)90637-1","volume":"109","author":"KJ Kelly","year":"1995","unstructured":"Kelly, K. J. et al. Eosinophilic esophagitis attributed to gastroesophageal reflux: improvement with an amino acid-based formula. Gastroenterology 109, 1503\u20131512 (1995).","journal-title":"Gastroenterology"},{"key":"BFni0401_353_CR45","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1084\/jem.190.4.487","volume":"190","author":"G Woerly","year":"1999","unstructured":"Woerly, G. et al. Expression of CD28 and CD86 by human eosinophils and role in the secretion of type 1 cytokines (interleukin 2 and interferon gamma). Inhibition by immunoglobulin A complexes. J. Exp. Med. 190, 487\u2013496 (1999).","journal-title":"J. Exp. Med."},{"key":"BFni0401_353_CR46","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1172\/JCI8945","volume":"105","author":"HZ Shi","year":"2000","unstructured":"Shi, H. Z., Humbles, A., Gerard, C., Jin, Z. & Weller, P. F. Lymph node trafficking and antigen presentation by endobronchial eosinophils. J. Clin. Invest. 105, 945\u2013953 (2000).","journal-title":"J. Clin. Invest."},{"key":"BFni0401_353_CR47","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1084\/jem.185.4.785","volume":"185","author":"ME Rothenberg","year":"1997","unstructured":"Rothenberg, M. E., MacLean, J. A., Pearlman, E., Luster, A. D. & Leder, P. Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. J. Exp. Med. 185, 785\u2013790 (1997).","journal-title":"J. Exp. Med."}],"container-title":["Nature Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ni0401_353.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ni0401_353","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ni0401_353.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T22:20:24Z","timestamp":1684448424000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ni0401_353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["BFni0401_353"],"URL":"https:\/\/doi.org\/10.1038\/86365","relation":{},"ISSN":["1529-2908","1529-2916"],"issn-type":[{"value":"1529-2908","type":"print"},{"value":"1529-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}