{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:27:45Z","timestamp":1790922465227,"version":"4.1.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Biotechnol"],"published-print":{"date-parts":[[2001,4]]},"DOI":"10.1038\/86664","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:41:29Z","timestamp":1027672889000},"page":"305-306","source":"Crossref","is-referenced-by-count":61,"title":["Persistent failures in gene repair"],"prefix":"10.1038","volume":"19","author":[{"given":"Gerrit","family":"van der Steege","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra H.L.","family":"Schuilenga-Hut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.C.M.","family":"Buys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Scheffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendri H.","family":"Pas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel F.","family":"Jonkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFnbt0401_305_CR1","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1073\/pnas.93.5.2071","volume":"93","author":"K Yoon","year":"1996","unstructured":"Yoon, K., Cole-Strauss, A. & Kmiec, E.B. Proc. Natl. Acad. Sci. USA 93, 2071\u20132076 (1996).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnbt0401_305_CR2","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1126\/science.273.5280.1386","volume":"273","author":"A Cole-Strauss","year":"1996","unstructured":"Cole-Strauss, A. et al. Science 273, 1386\u20131389 (1996).","journal-title":"Science"},{"key":"BFnbt0401_305_CR3","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1002\/hep.510250626","volume":"25","author":"BT Kren","year":"1997","unstructured":"Kren, B.T., Cole-Strauss, A., Kmiec, E.B. & Steer, C.J. Hepatology 25, 1462\u20131468 (1997).","journal-title":"Hepatology"},{"key":"BFnbt0401_305_CR4","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nm0398-285","volume":"4","author":"BT Kren","year":"1998","unstructured":"Kren, B.T., Bandyopadhyay, P. & Steer, C.J. Nat. Med. 4, 285\u2013290 (1998).","journal-title":"Nat. Med."},{"key":"BFnbt0401_305_CR5","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1038\/4322","volume":"16","author":"V Alexeev","year":"1998","unstructured":"Alexeev, V. & Yoon, K. Nat. Biotechnol. 16, 1343\u20131346 (1998).","journal-title":"Nat. Biotechnol."},{"key":"BFnbt0401_305_CR6","doi-asserted-by":"publisher","first-page":"8768","DOI":"10.1073\/pnas.96.15.8768","volume":"96","author":"T Zhu","year":"1999","unstructured":"Zhu, T. et al. Proc. Natl. Acad. Sci. USA 96, 8768\u20138773 (1999).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnbt0401_305_CR7","doi-asserted-by":"publisher","first-page":"8774","DOI":"10.1073\/pnas.96.15.8774","volume":"96","author":"PR Beetham","year":"1999","unstructured":"Beetham, P.R., Kipp, P.B., Sawycky, X.L., Arntzen, C.J. & May, G.D. Proc. Natl. Acad. Sci. USA 96, 8774\u20138778 (1999).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnbt0401_305_CR8","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1093\/nar\/27.5.1323","volume":"27","author":"A Cole-Strauss","year":"1999","unstructured":"Cole-Strauss, A. et al. Nucleic Acids Res. 27, 1323\u20131330 (1999).","journal-title":"Nucleic Acids Res."},{"key":"BFnbt0401_305_CR9","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1038\/sj.gt.3301042","volume":"6","author":"O Igoucheva","year":"1999","unstructured":"Igoucheva, O., Peritz, A.E., Levy, D. & Yoon, K. Gene Ther. 6, 1960\u20131971 (1999).","journal-title":"Gene Ther."},{"key":"BFnbt0401_305_CR10","doi-asserted-by":"publisher","first-page":"5808","DOI":"10.1021\/bi9921891","volume":"39","author":"HB Gamper Jr","year":"2000","unstructured":"Gamper, H.B. Jr . et al. Biochemistry 39, 5808\u20135816 (2000).","journal-title":"Biochemistry"},{"key":"BFnbt0401_305_CR11","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1163\/156855800744593","volume":"1","author":"O Igoucheva","year":"2000","unstructured":"Igoucheva, O. & Yoon, K. Gene Ther. Reg. 1, 165\u2013175 (2000).","journal-title":"Gene Ther. Reg."},{"key":"BFnbt0401_305_CR12","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/71901","volume":"18","author":"V Alexeev","year":"2000","unstructured":"Alexeev, V., Igoucheva, O., Domashenko, A., Cotsarelis, G. & Yoon, K. Nat. Biotechnol. 18, 43\u201347 (2000).","journal-title":"Nat. Biotechnol."},{"key":"BFnbt0401_305_CR13","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1046\/j.1523-1747.1998.00403.x","volume":"111","author":"E Santana","year":"1998","unstructured":"Santana, E., Peritz, A.E., Iyer, S., Uitto, J. & Yoon, K. J. Invest. Dermatol. 111, 1172\u20131177 (1998).","journal-title":"J. Invest. Dermatol."},{"key":"BFnbt0401_305_CR14","doi-asserted-by":"publisher","first-page":"10349","DOI":"10.1073\/pnas.96.18.10349","volume":"96","author":"BT Kren","year":"1999","unstructured":"Kren, B.T. et al. Proc. Natl. Acad. Sci. USA 96, 10349\u201310354 (1999).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnbt0401_305_CR15","doi-asserted-by":"publisher","first-page":"5363","DOI":"10.1073\/pnas.97.10.5363","volume":"97","author":"TA Rando","year":"2000","unstructured":"Rando, T.A., Disatnik, M.H. & Zhou, L.Z. Proc. Natl. Acad. Sci. USA 97, 5363\u20135368 (2000).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnbt0401_305_CR16","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/76448","volume":"18","author":"RJ Bartlett","year":"2000","unstructured":"Bartlett, R.J. et al. Nat. Biotechnol. 18, 615\u2013622 (2000).","journal-title":"Nat. Biotechnol."}],"container-title":["Nature Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nbt0401_305.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nbt0401_305","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nbt0401_305.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T19:39:24Z","timestamp":1684438764000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nbt0401_305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["BFnbt0401_305"],"URL":"https:\/\/doi.org\/10.1038\/86664","relation":{},"ISSN":["1087-0156","1546-1696"],"issn-type":[{"value":"1087-0156","type":"print"},{"value":"1546-1696","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}