{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:28:38Z","timestamp":1787002118296,"version":"build-2736575974"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1999,5,1]],"date-time":"1999-05-01T00:00:00Z","timestamp":925516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[1999,5]]},"DOI":"10.1038\/8760","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:50:09Z","timestamp":1027659009000},"page":"59-62","source":"Crossref","is-referenced-by-count":344,"title":["Sequence variation in the human angiotensin converting enzyme"],"prefix":"10.1038","volume":"22","author":[{"given":"Mark J.","family":"Rieder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott L.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah A.","family":"Nickerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFng0599_59_CR1","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1172\/JCI114844","volume":"86","author":"B Rigat","year":"1990","unstructured":"Rigat, B. et al. An insertion\/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J. Clin. Invest. 86, 1343\u20131346 (1990).","journal-title":"J. Clin. Invest."},{"key":"BFng0599_59_CR2","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1007\/s001090050178","volume":"75","author":"H Schunkert","year":"1997","unstructured":"Schunkert, H. Polymorphism of the angiotensin-converting enzyme gene and cardiovascular disease. J. Mol. Med. 75, 867\u2013 875 (1997).","journal-title":"J. Mol. Med."},{"key":"BFng0599_59_CR3","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1093\/eurheartj\/15.suppl_D.24","volume":"15","author":"F Soubrier","year":"1994","unstructured":"Soubrier, F., Nadaud, S. & Williams, T.A. Angiotensin I converting enzyme gene: regulation, polymorphism and implications in cardiovascular diseases. Eur. Heart J. 15, 24\u201329 ( 1994).","journal-title":"Eur. Heart J."},{"key":"BFng0599_59_CR4","first-page":"211","volume":"87","author":"AE Evans","year":"1994","unstructured":"Evans, A.E. et al. Polymorphisms of the angiotensin-converting-enzyme gene in subjects who die from coronary heart disease. Q. J. Med. 87, 211\u2013214 (1994).","journal-title":"Q. J. Med."},{"key":"BFng0599_59_CR5","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1161\/01.CIR.97.18.1780","volume":"97","author":"JP O'Malley","year":"1998","unstructured":"O'Malley, J.P., Maslen, C.L. & Illingworth, D.R. Angiotensin-converting enzyme DD genotype and cardiovascular disease in heterozygous familial hypercholesterolemia. Circulation 97, 1780\u20131783 ( 1998).","journal-title":"Circulation"},{"key":"BFng0599_59_CR6","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1161\/01.CIR.97.18.1766","volume":"97","author":"CJ O'Donnell","year":"1998","unstructured":"O'Donnell, C.J. et al. Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation 97, 1766\u20131772 (1998).","journal-title":"Circulation"},{"key":"BFng0599_59_CR7","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/ng0194-29","volume":"6","author":"F Sch\u00e4chter","year":"1994","unstructured":"Sch\u00e4chter, F. et al. Genetic associations with human longevity at the APOE and ACE loci. Nature Genet. 6, 29\u2013 32 (1994).","journal-title":"Nature Genet."},{"key":"BFng0599_59_CR8","first-page":"772","volume":"60","author":"R Harding","year":"1997","unstructured":"Harding, R. et al. Archaic African and Asian lineages in the genetic ancestry of modern humans. Am. J. Hum. Genet. 60, 772\u2013789 (1997).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng0599_59_CR9","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1126\/science.280.5366.1077","volume":"280","author":"DG Wang","year":"1998","unstructured":"Wang, D.G. et al. Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science 280, 1077\u20131082 (1998).","journal-title":"Science"},{"key":"BFng0599_59_CR10","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1126\/science.278.5343.1580","volume":"278","author":"FS Collins","year":"1997","unstructured":"Collins, F.S., Guyer, M.S. & Charkravarti, A. Variations on a theme: cataloging human DNA sequence variation. Science 278, 1580\u2013 1581 (1997).","journal-title":"Science"},{"key":"BFng0599_59_CR11","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/genetics\/150.3.1133","volume":"150","author":"MW Nachman","year":"1998","unstructured":"Nachman, M.W., Bauer, V.L., Crowell, S.L. & Aquadro, C.F. DNA variability and recombination rates at X-linked loci in humans. Genetics 150,1133\u20131141 ( 1998).","journal-title":"Genetics"},{"key":"BFng0599_59_CR12","doi-asserted-by":"crossref","first-page":"15377","DOI":"10.1016\/S0021-9258(18)98626-6","volume":"266","author":"C Hubert","year":"1991","unstructured":"Hubert, C., Houot, A., Corvol, P. & Soubrier, P. Structure of the angiotensin I-converting enzyme gene. Two alternate promoters correspond to evolutionary steps of a duplicated gene. J. Biol. Chem. 266, 15377\u201315383 (1991).","journal-title":"J. Biol. Chem."},{"key":"BFng0599_59_CR13","first-page":"111","volume":"7","author":"AG Clark","year":"1990","unstructured":"Clark, A.G. Inference of haplotypes from PCR-amplified samples of diploid populations. Mol. Biol. Evol. 7, 111\u2013 122 (1990).","journal-title":"Mol. Biol. Evol."},{"key":"BFng0599_59_CR14","doi-asserted-by":"publisher","first-page":"12288","DOI":"10.1073\/pnas.91.25.12288","volume":"91","author":"MA Batzer","year":"1994","unstructured":"Batzer, M.A. et al. African origin of human-specific polymorphic Alu insertions. Proc. Natl Acad. Sci. USA 91, 12288\u2013 12292 (1994).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFng0599_59_CR15","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/oxfordjournals.molbev.a025749","volume":"14","author":"J Hey","year":"1997","unstructured":"Hey, J. Mitochondrial and nuclear genes present conflicting portraits of human origins. Mol. Biol. Evol. 14, 166\u2013172 (1997).","journal-title":"Mol. Biol. Evol."},{"key":"BFng0599_59_CR16","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1086\/301977","volume":"63","author":"AG Clark","year":"1998","unstructured":"Clark, A.G. et al. Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase. Am. J. Hum. Genet. 63, 595\u2013612 (1998).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng0599_59_CR17","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1146\/annurev.ge.29.120195.004021","volume":"29","author":"J Zielenski","year":"1995","unstructured":"Zielenski, J. & Tsui, L.C. Cystic fibrosis: genotypic and phenotypic variations. Annu. Rev. Genet. 29, 777\u2013 807 (1995).","journal-title":"Annu. Rev. Genet."},{"key":"BFng0599_59_CR18","first-page":"73","volume-title":"Variation in the Human Genome","author":"CR Scrivner","year":"1996","unstructured":"Scrivner, C.R., Byck, S., Prevost, L. & Hoang, L. in Variation in the Human Genome (ed. Weiss, K.M.) 73\u201390 (John Wiley & Sons, Chichester, 1996)."},{"key":"BFng0599_59_CR19","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1093\/genetics\/149.2.999","volume":"149","author":"AD Long","year":"1998","unstructured":"Long, A.D., Lyman, R.F., Langley, C.H. & Mackay, T.F. Two sites in the Delta gene region contribute to naturally occurring variation in bristle number in Drosophila melanogaster. Genetics 149, 999\u20131017 (1998).","journal-title":"Genetics"},{"key":"BFng0599_59_CR20","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/30374","volume":"393","author":"HE Montgomery","year":"1998","unstructured":"Montgomery, H.E. et al. Human gene for physical performance. Nature 393, 221\u2013222 (1998).","journal-title":"Nature"},{"key":"BFng0599_59_CR21","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/BF00145343","volume":"8","author":"CF Sing","year":"1992","unstructured":"Sing, C.F., Haviland, M.B., Zerba, K.E. & Templeton, A.R. Application of cladistics to the analysis of genotype-phenotype relationships. Eur. J. Epidemiol. 8 (suppl. 1), 3\u2013 9 (1992).","journal-title":"Eur. J. Epidemiol"},{"key":"BFng0599_59_CR22","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1093\/hmg\/7.11.1745","volume":"7","author":"B Keavney","year":"1998","unstructured":"Keavney, B. et al. Measured haplotype analysis of the angiotensin-I converting enzyme gene. Hum. Mol. Genet. 7, 1745\u2013 1751 (1998).","journal-title":"Hum. Mol. Genet."},{"key":"BFng0599_59_CR23","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/907","volume":"19","author":"DA Nickerson","year":"1998","unstructured":"Nickerson, D.A. et al. DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene. Nature Genet. 19, 233\u2013 240 (1998).","journal-title":"Nature Genet."},{"key":"BFng0599_59_CR24","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1093\/nar\/25.14.2745","volume":"25","author":"DA Nickerson","year":"1997","unstructured":"Nickerson, D.A., Tobe, V.O. & Taylor, S.L. PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing. Nucleic Acids Res. 25, 2745\u2013 2751 (1997).","journal-title":"Nucleic Acids Res."},{"key":"BFng0599_59_CR25","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1101\/gr.8.3.175","volume":"8","author":"B Ewing","year":"1998","unstructured":"Ewing, B., Hillier, L., Wendl, M.C. & Green, P. Base-calling of automated sequencer traces using phred. I. Accuracy assessment. Genome Res. 8,175\u2013185 ( 1998).","journal-title":"Genome Res."},{"key":"BFng0599_59_CR26","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1093\/genetics\/105.2.437","volume":"105","author":"F Tajima","year":"1983","unstructured":"Tajima, F. Evolutionary relationship of DNA sequences in finite populations. Genetics 105, 437\u2013460 ( 1983).","journal-title":"Genetics"},{"key":"BFng0599_59_CR27","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/genetics\/123.3.585","volume":"123","author":"F Tajima","year":"1989","unstructured":"Tajima, F. Statistical method for testing the neutral mutation hypothesis by DNA polymorphisms. Genetics 123, 585\u2013595 (1989).","journal-title":"Genetics"},{"key":"BFng0599_59_CR28","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1214\/ss\/1177010378","volume":"9","author":"RC Griffiths","year":"1994","unstructured":"Griffiths, R.C. & Tavar\u00e9, S. Ancestral inference in population genetics. Stat. Sci. 9, 307\u2013319 (1994).","journal-title":"Stat. Sci."},{"key":"BFng0599_59_CR29","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/genetics\/145.2.505","volume":"145","author":"S Tavar\u00e9","year":"1997","unstructured":"Tavar\u00e9, S., Griffiths, R.C. & Donnelly, P. Inferring coalescence times from DNA sequence data. Genetics 145, 505\u2013518 (1997).","journal-title":"Genetics"},{"key":"BFng0599_59_CR30","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/genetics\/111.1.147","volume":"111","author":"RR Hudson","year":"1985","unstructured":"Hudson, R.R. & Kaplan, N.L. Statistical properties of the number of recombination events in the history of a sample of DNA sequences. Genetics 111, 147\u2013164 ( 1985).","journal-title":"Genetics"}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng0599_59.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0599_59","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0599_59.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T16:37:37Z","timestamp":1684427857000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng0599_59"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,5]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,5]]}},"alternative-id":["BFng0599_59"],"URL":"https:\/\/doi.org\/10.1038\/8760","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,5]]}}}