{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:05:56Z","timestamp":1790856356958,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2001,5,1]],"date-time":"2001-05-01T00:00:00Z","timestamp":988675200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Immunol"],"published-print":{"date-parts":[[2001,5]]},"DOI":"10.1038\/87713","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T21:13:11Z","timestamp":1517346791000},"page":"410-414","source":"Crossref","is-referenced-by-count":127,"title":["SAP controls T cell responses to virus and terminal differentiation of TH2 cells"],"prefix":"10.1038","volume":"2","author":[{"given":"Chengbin","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khuong B.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary C.","family":"Pien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninghai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Gullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan","family":"Howie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam Rodriguez","family":"Sosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Persephone","family":"Borrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay R.","family":"Satoskar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene H.","family":"Sharpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine A.","family":"Biron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cox","family":"Terhorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2001,5,1]]},"reference":[{"key":"BFni0501410_CR1","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/26683","volume":"395","author":"J Sayos","year":"1998","unstructured":"Sayos, J. et al. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature 395, 462\u2013469 (1998).","journal-title":"Nature"},{"key":"BFni0501410_CR2","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/2424","volume":"20","author":"AJ Coffey","year":"1998","unstructured":"Coffey, A. J. et al. Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene. Nature Genet. 20, 129\u2013135 (1998).","journal-title":"Nature Genet."},{"key":"BFni0501410_CR3","doi-asserted-by":"publisher","first-page":"13765","DOI":"10.1073\/pnas.95.23.13765","volume":"95","author":"KE Nichols","year":"1998","unstructured":"Nichols, K. E. et al. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc. Natl Acad. Sci. USA 95, 13765\u201313770 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFni0501410_CR4","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1007\/s002510000215","volume":"51","author":"C Wu","year":"2000","unstructured":"Wu, C. et al. Genomic organization and characterization of mouse SAP, the gene that is altered in X-linked lymphoproliferative disease. Immunogenetics 51, 805\u2013815 (2000).","journal-title":"Immunogenetics"},{"key":"BFni0501410_CR5","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1084\/jem.192.3.337","volume":"192","author":"S Parolini","year":"2000","unstructured":"Parolini, S. et al. X-linked Lymphoproliferative Disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill epstein-barr virus-infected cells. J. Exp. Med. 192, 337\u2013346 (2000).","journal-title":"J. Exp. Med."},{"key":"BFni0501410_CR6","doi-asserted-by":"crossref","first-page":"6981","DOI":"10.4049\/jimmunol.162.12.6981","volume":"162","author":"SG Tangye","year":"1999","unstructured":"Tangye, S. G. et al. Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP. J. Immunol. 162, 6981\u20136985 (1999).","journal-title":"J. Immunol."},{"key":"BFni0501410_CR7","doi-asserted-by":"publisher","first-page":"3549","DOI":"10.4049\/jimmunol.165.7.3549","volume":"165","author":"L Benoit","year":"2000","unstructured":"Benoit, L., Wang, X., Pabst, H.F., Dutz, J. & Tan, R. Defective natural killer cell activation in X-linked lymphoproliferative disease. J. Immunol. 165, 3549\u20133553 (2000).","journal-title":"J. Immunol."},{"key":"BFni0501410_CR8","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1093\/intimm\/12.12.1749","volume":"12","author":"J Sayos","year":"2000","unstructured":"Sayos, J. et al. Potential pathways for regulation of NK and T cell responses: differential X-linked lymphoproliferative syndrome gene product SAP interactions with SLAM and 2B4. Int. Immunol. 12, 1749\u20131757 (2000).","journal-title":"Int. Immunol."},{"key":"BFni0501410_CR9","unstructured":"Sayos, J. et al. The cell surface receptors Ly-9 and CD84 recruit the XLP gene product SAP. Blood (in the press, 2001)."},{"key":"BFni0501410_CR10","doi-asserted-by":"publisher","first-page":"685","DOI":"10.3109\/15513819109065466","volume":"11","author":"DT Purtilo","year":"1991","unstructured":"Purtilo, D. T., Grierson, H. L., Davis, J. R. & Okano, M. The X-linked lymphoproliferative disease: from autopsy toward cloning the gene 1975\u20131990. Pediatr. Pathol. 11, 685\u2013710 (1991).","journal-title":"Pediatr. Pathol."},{"key":"BFni0501410_CR11","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1203\/00006450-199510000-00001","volume":"38","author":"T Seemayer","year":"1995","unstructured":"Seemayer, T. A.et al. X-linked lymphoproliferative disease: twenty-five years after the discovery. Pediatr. Res. 38, 471\u2013478 (1995).","journal-title":"Pediatr. Res."},{"key":"BFni0501410_CR12","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s100249900093","volume":"2","author":"DM Maia","year":"1999","unstructured":"Maia, D. M. & Garwacki, C. P. X-linked lymphoproliferative disease: pathology and diagnosis. Pediatr. Dev. Pathol. 2, 72\u201377 (1999).","journal-title":"Pediatr. Dev. Pathol."},{"key":"BFni0501410_CR13","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1146\/annurev.immunol.19.1.657","volume":"19","author":"M Morra","year":"2001","unstructured":"Morra, M. et al. X-linked lymphoproliferation disease: a progressive immunodeficiency. Annu. Rev. Immunol. 19, 657\u2013682 (2001).","journal-title":"Annu. Rev. Immunol."},{"key":"BFni0501410_CR14","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1084\/jem.164.4.1075","volume":"164","author":"RM Zinkernagel","year":"1986","unstructured":"Zinkernagel, R. M. et al. T cell-mediated hepatitis in mice infected with lymphocytic choriomeningitis virus. Liver cell destruction by H-2 class I-restricted virus-specific cytotoxic T cells as a physiological correlate of the 51Cr-release assay? J. Exp. Med. 164, 1075\u20131092 (1986).","journal-title":"J. Exp. Med."},{"key":"BFni0501410_CR15","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1084\/jem.164.5.1667","volume":"164","author":"KW McIntyre","year":"1986","unstructured":"McIntyre, K. W. & Welsh, R. M. Accumulation of natural killer and cytotoxic T large granular lymphocytes in the liver during virus infection. J. Exp. Med. 164, 1667\u20131681 (1986).","journal-title":"J. Exp. Med."},{"key":"BFni0501410_CR16","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1084\/jem.179.4.1285","volume":"179","author":"T Yoshimoto","year":"1994","unstructured":"Yoshimoto, T. & Paul, W. E. CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179, 1285\u20131295 (1994).","journal-title":"J. Exp. Med."},{"key":"BFni0501410_CR17","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1126\/science.270.5243.1845","volume":"270","author":"T Yoshimoto","year":"1995","unstructured":"Yoshimoto, T., Bendelac, A., Watson, C., Hu-Li, J. & Paul, W. E. Role of NK1.1+ T cells in a TH2 response and in immunoglobulin E production. Science 270, 1845\u20131847 (1995).","journal-title":"Science"},{"key":"BFni0501410_CR18","doi-asserted-by":"publisher","first-page":"11931","DOI":"10.1073\/pnas.92.25.11931","volume":"92","author":"T Yoshimoto","year":"1995","unstructured":"Yoshimoto, T., Bendelac, A., Hu-Li, J. & Paul, W. E. Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+ T cells that promptly produce interleukin 4. Proc. Natl Acad. Sci. USA 92, 11931\u201311934 (1995).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFni0501410_CR19","doi-asserted-by":"crossref","first-page":"6156","DOI":"10.4049\/jimmunol.161.11.6156","volume":"161","author":"H Himmelrich","year":"1998","unstructured":"Himmelrich, H., Parra-Lopez, C., Tacchini-Cottier, F., Louis, J. A. & Launois, P. The IL-4 rapidly produced in BALB\/c mice after infection with Leishmania major down-regulates IL-12 receptor \u03b22-chain expression on CD4+ T cells resulting in a state of unresponsiveness to IL-12. J. Immunol. 161, 6156\u20136163 (1998).","journal-title":"J. Immunol."},{"key":"BFni0501410_CR20","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/S1074-7613(00)80342-8","volume":"6","author":"P Launois","year":"1997","unstructured":"Launois, P. et al. IL-4 rapidly produced by V\u03b2 4V\u03b1 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB\/c mice. Immunity 6, 541\u2013549 (1997).","journal-title":"Immunity"},{"key":"BFni0501410_CR21","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.4049\/jimmunol.148.4.1182","volume":"148","author":"R Chatelain","year":"1992","unstructured":"Chatelain, R., Varkila, K. & Coffman, R. L. IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol. 148, 1182\u20131187 (1992).","journal-title":"J. Immunol."},{"key":"BFni0501410_CR22","doi-asserted-by":"crossref","first-page":"5298","DOI":"10.4049\/jimmunol.163.10.5298","volume":"163","author":"AR Satoskar","year":"1999","unstructured":"Satoskar, A. R. et al. NK cell-deficient mice develop a Th1-like response but fail to mount an efficient antigen-specific IgG2a antibody response. J. Immunol. 163, 5298\u20135302 (1999).","journal-title":"J. Immunol."},{"key":"BFni0501410_CR23","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/376260a0","volume":"376","author":"BG Cocks","year":"1995","unstructured":"Cocks, B. G. et al. A novel receptor involved in T-cell activation. Nature 376, 260\u2013263 (1995).","journal-title":"Nature"},{"key":"BFni0501410_CR24","doi-asserted-by":"publisher","first-page":"2932","DOI":"10.4049\/jimmunol.165.6.2932","volume":"165","author":"SG Tangye","year":"2000","unstructured":"Tangye, S. G., Phillips, J. H., Lanier, L. L. & Nichols, K. E. Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome. J. Immunol. 165, 2932\u20132936 (2000).","journal-title":"J. Immunol."},{"key":"BFni0501410_CR25","unstructured":"Morra, M. et al. Missense mutations that affect non-phospho tyrosine interactions and stability of the SAP SH2-domain in X-linked proliferative disease patients. J. Exp. Med. (submitted, 2001)."},{"key":"BFni0501410_CR26","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1084\/jem.189.8.1315","volume":"189","author":"LP Cousens","year":"1999","unstructured":"Cousens, L. P. et al. Two roads diverged: interferon \u03b1\/\u03b2- and interleukin 12-mediated pathways in promoting T cell interferon \u03b3 responses during viral infection. J. Exp. Med. 189, 1315\u20131328 (1999).","journal-title":"J. Exp. Med."},{"key":"BFni0501410_CR27","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S1074-7613(00)80470-7","volume":"8","author":"K Murali-Krishna","year":"1998","unstructured":"Murali-Krishna, K. et al. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8, 177\u2013187 (1998).","journal-title":"Immunity"},{"key":"BFni0501410_CR28","doi-asserted-by":"publisher","first-page":"994","DOI":"10.4049\/jimmunol.164.2.994","volume":"164","author":"GC Pien","year":"2000","unstructured":"Pien, G. C. & Biron, C. A. Compartmental differences in NK cell responsiveness to IL-12 during lymphocytic choriomeningitis virus infection. J. Immunol. 164, 994\u20131001 (2000).","journal-title":"J. Immunol."},{"key":"BFni0501410_CR29","doi-asserted-by":"crossref","first-page":"6747","DOI":"10.4049\/jimmunol.162.11.6747","volume":"162","author":"AR Satoskar","year":"1999","unstructured":"Satoskar, A. R. et al. Mice lacking NK cells develop an efficient TH1 response and control cutaneous Leishmania major infection. J. Immunol. 162, 6747\u20136754 (1999).","journal-title":"J. Immunol."}],"container-title":["Nature Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ni0501_410.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ni0501_410","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ni0501_410.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T04:59:14Z","timestamp":1751259554000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ni0501_410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,5]]}},"alternative-id":["BFni0501410"],"URL":"https:\/\/doi.org\/10.1038\/87713","relation":{},"ISSN":["1529-2908","1529-2916"],"issn-type":[{"value":"1529-2908","type":"print"},{"value":"1529-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,5]]}}}