{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:50:54Z","timestamp":1775281854448,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2001,6,1]],"date-time":"2001-06-01T00:00:00Z","timestamp":991353600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[2001,6]]},"DOI":"10.1038\/88859","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:43:34Z","timestamp":1027673014000},"page":"147-150","source":"Crossref","is-referenced-by-count":239,"title":["High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection"],"prefix":"10.1038","volume":"28","author":[{"given":"Hilary A.","family":"Coller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin","family":"Khrapko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalya D.","family":"Bodyak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina","family":"Nekhaeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Herrero-Jimenez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William G.","family":"Thilly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFng0601_147_CR1","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1126\/science.287.5460.2017","volume":"287","author":"MS Fliss","year":"2000","unstructured":"Fliss, M.S. et al. Facile detection of mitochondrial DNA mutations in tumors and bodily fluids. Science 287, 2017\u20132019 (2000).","journal-title":"Science"},{"key":"BFng0601_147_CR2","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/3108","volume":"20","author":"K Polyak","year":"1998","unstructured":"Polyak, K. et al. Somatic mutations of the mitochondrial genome in human colorectal tumours. Nature Genet. 20, 291\u2013293 (1998).","journal-title":"Nature Genet."},{"key":"BFng0601_147_CR3","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1002\/elps.1150180504","volume":"18","author":"A Alonso","year":"1997","unstructured":"Alonso, A. et al. Detection of somatic mutations in the mitochondrial DNA control region of colorectal and gastric tumors by heteroduplex and single-strand conformation analysis. Electrophoresis 18, 682\u2013685 (1997).","journal-title":"Electrophoresis"},{"key":"BFng0601_147_CR4","first-page":"4231","volume":"60","author":"SM Richard","year":"2000","unstructured":"Richard, S.M. et al. Nuclear and mitochondrial genome instability in human breast cancer. Cancer Res. 60, 4231\u20134237 (2000).","journal-title":"Cancer Res."},{"key":"BFng0601_147_CR5","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1038\/sj.onc.1202112","volume":"17","author":"W Habano","year":"1998","unstructured":"Habano, W., Nakamura, S. & Sugai, T. Microsatellite instability in the mitochondrial DNA of colorectal carcinomas: Evidence for mismatch repair systems in mitochondrial genome. Oncogene 17, 1931\u20131937 (1998).","journal-title":"Oncogene"},{"key":"BFng0601_147_CR6","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/S0016-5085(00)70169-7","volume":"118","author":"W Habano","year":"2000","unstructured":"Habano, W. et al. Microsatellite instability and mutation of mitochondrial and nuclear DNA in gastric carcinoma. Gastroenterology 118, 835\u2013841 (2000).","journal-title":"Gastroenterology"},{"key":"BFng0601_147_CR7","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1126\/science.123.3191.309","volume":"123","author":"O Warburg","year":"1956","unstructured":"Warburg, O. On the origin of cancer cells. Science 123, 309\u2013314 (1956).","journal-title":"Science"},{"key":"BFng0601_147_CR8","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/0165-1110(87)90028-5","volume":"186","author":"JW Shay","year":"1987","unstructured":"Shay, J.W. & Werbin, H. Are mitochondrial DNA mutations involved in the carcinogenic process? Mutat. Res. 186, 149\u2013160 (1987).","journal-title":"Mutat. Res."},{"key":"BFng0601_147_CR9","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1146\/annurev.es.18.110187.002421","volume":"18","author":"JC Avise","year":"1987","unstructured":"Avise, J.C. et al. Intraspecific phylogeography: The mitochondrial DNA bridge between population genetics and systematics. Annu. Rev. Ecol. Syst . 18, 489\u2013522 (1987).","journal-title":"Annu. Rev. Ecol. Syst"},{"key":"BFng0601_147_CR10","doi-asserted-by":"publisher","first-page":"2895","DOI":"10.1073\/pnas.82.9.2895","volume":"82","author":"RJ Monnat Jr.","year":"1985","unstructured":"Monnat, R.J. Jr. & Loeb, L.A. Nucleotide sequence preservation of human mitochondrial DNA. Proc. Natl. Acad. Sci. USA 82, 2895\u20132899 (1985).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng0601_147_CR11","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/0378-1119(91)90451-G","volume":"108","author":"A Bodenteich","year":"1991","unstructured":"Bodenteich, A., Mitchell, L.G. & Merril, C.R. A lifetime of retinal light exposure does not appear to increase mitochondrial mutations. Gene 108, 305\u2013309 (1991).","journal-title":"Gene"},{"key":"BFng0601_147_CR12","first-page":"1268","volume":"58","author":"HA Coller","year":"1998","unstructured":"Coller, H.A. et al. Mutational spectra of a 100-base pair mitochondrial DNA target sequence in bronchial epithelial cells: a comparison of smoking and nonsmoking twins. Cancer Res. 58, 1268\u20131277 (1998).","journal-title":"Cancer Res."},{"key":"BFng0601_147_CR13","first-page":"591","volume":"59","author":"F Pallotti","year":"1996","unstructured":"Pallotti, F., Chen, X., Bonilla, E. & Schon, E.A. Evidence that specific mtDNA point mutations may not accumulate in skeletal muscle during normal human aging. Am. J. Hum. Genet. 59, 591\u2013602 (1996).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng0601_147_CR14","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1126\/science.286.5440.774","volume":"286","author":"Y Michikawa","year":"1999","unstructured":"Michikawa, Y., Mazzucchelli, F., Bresolin, N., Scarlato, G. & Attardi, G. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science 286, 774\u2013779 (1999).","journal-title":"Science"},{"key":"BFng0601_147_CR15","first-page":"3912","volume":"54","author":"BG Heerdt","year":"1994","unstructured":"Heerdt, B.G., Chen, J., Stewart, L.R. & Augenlicht, L.H. Polymorphisms, but lack of mutations or instability, in the promotor region of the mitochondrial genome in human colonic tumors. Cancer Res . 54, 3912\u20133915 (1994).","journal-title":"Cancer Res"},{"key":"BFng0601_147_CR16","first-page":"279","volume":"10","author":"JW Shay","year":"1990","unstructured":"Shay, J.W. & Ishii, S. Unexpected nonrandom mitochondrial DNA segregation in human cell hybrids. Anticancer Res. 10, 279\u2013284 (1990).","journal-title":"Anticancer Res."},{"key":"BFng0601_147_CR17","doi-asserted-by":"publisher","first-page":"11164","DOI":"10.1073\/pnas.89.23.11164","volume":"89","author":"M Yoneda","year":"1992","unstructured":"Yoneda, M., Chomyn, A., Martinuzzi, A., Hurko, O. & Attardi, G. Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy. Proc. Natl Acad. Sci. USA 89, 11164\u201311168 (1992).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFng0601_147_CR18","doi-asserted-by":"publisher","first-page":"6562","DOI":"10.1073\/pnas.92.14.6562","volume":"92","author":"DR Dunbar","year":"1995","unstructured":"Dunbar, D.R., Moonie, P.A., Jacobs, H.T. & Holt, I.J. Different cellular backgrounds confer a marked advantage to either mutant or wild-type mitochondrial genomes. Proc. Natl Acad. Sci. USA 92, 6562\u20136566 (1995).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFng0601_147_CR19","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/S0027-5107(98)00067-0","volume":"400","author":"P Herrero-Jimenez","year":"1998","unstructured":"Herrero-Jimenez, P. et al. Mutation, cell kinetics, and subpopulations at risk for colon cancer in the United States. Mutat. Res. 400, 553\u2013578 (1998).","journal-title":"Mutat. Res."},{"key":"BFng0601_147_CR20","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0027-5107(99)00201-8","volume":"447","author":"P Herrero-Jimenez","year":"2000","unstructured":"Herrero-Jimenez, P., Tomita-Mitchell, A., Furth, E.E., Morgenthaler, S. & Thilly, W.G. Population risk and physiological rate parameters for colon cancer. The union of an explicit model for carcinogenesis with the public health records of the United States. Mutat. Res. 447, 73\u2013116 (2000).","journal-title":"Mutat. Res."},{"key":"BFng0601_147_CR21","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1002\/ijc.2910040113","volume":"4","author":"PJ Cook","year":"1969","unstructured":"Cook, P.J., Doll, R. & Fillingham, S.A. A mathematical model for the age distribution of cancer in man. Int. J. Cancer 4, 93\u2013112 (1969).","journal-title":"Int. J. Cancer"},{"key":"BFng0601_147_CR22","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nm0696-676","volume":"2","author":"D Shibata","year":"1996","unstructured":"Shibata, D., Navidi, W., Salovaara, R., Li, Z.-H. & Aaltonen, L.A. Somatic microsatellite mutations as molecular tumor clocks. Nature Med . 2, 676\u2013681 (1996).","journal-title":"Nature Med"},{"key":"BFng0601_147_CR23","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1006\/excr.2000.4949","volume":"259","author":"L Cavelier","year":"2000","unstructured":"Cavelier, L., Johannisson, A. & Gyllensten, U. Analysis of mtDNA copy number and composition of single mitochondrial particles using flow cytometry and PCR. Exp. Cell Res. 259, 79\u201385 (2000).","journal-title":"Exp. Cell Res."},{"key":"BFng0601_147_CR24","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1093\/hmg\/10.1.17","volume":"10","author":"ND Bodyak","year":"2001","unstructured":"Bodyak, N.D., Nekhaeva, E., Wei, J.Y. & Khrapko, K. Quantification and sequencing of somatic deleted mtDNA in single cells: evidence for partially duplicated mtDNA in aged human tissues. Hum. Mol. Genet. 10, 17\u201324 (2001).","journal-title":"Hum. Mol. Genet."},{"key":"BFng0601_147_CR25","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/0925-4439(95)00034-2","volume":"1271","author":"G Attardi","year":"1995","unstructured":"Attardi, G., Yoneda, M. & Chomyn, A. Complementation and segregation behavior of disease-causing mitochondrial DNA mutations in cellular model systems. Biochim. Biophys. Acta 1271, 241\u2013248 (1995).","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng0601_147.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0601_147","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0601_147.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:38:28Z","timestamp":1684442308000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng0601_147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["BFng0601_147"],"URL":"https:\/\/doi.org\/10.1038\/88859","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6]]}}}