{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T18:33:36Z","timestamp":1776710016832,"version":"3.51.2"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2001,7,1]],"date-time":"2001-07-01T00:00:00Z","timestamp":993945600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Immunol"],"published-print":{"date-parts":[[2001,7]]},"DOI":"10.1038\/89775","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:50:09Z","timestamp":1027659009000},"page":"625-631","source":"Crossref","is-referenced-by-count":175,"title":["IgA production without \u03bc or \u03b4 chain expression in developing B cells"],"prefix":"10.1038","volume":"2","author":[{"given":"Andrew J. S.","family":"Macpherson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Lamarre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"McCoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory R.","family":"Harriman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Odermatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon","family":"Dougan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Hengartner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf M.","family":"Zinkernagel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFni0701_625_CR1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/j.1600-065X.2000.imr017510.x","volume":"175","author":"F Melchers","year":"2000","unstructured":"Melchers, F. et al. Repertoire selection by pre-B-cell receptors and B-cell receptors, and genetic control of B-cell development from immature to mature B cells. Immunol. Rev. 175, 33\u201346 (2000).","journal-title":"Immunol. Rev."},{"key":"BFni0701_625_CR2","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/j.1600-065X.2000.imr017517.x","volume":"175","author":"RR Hardy","year":"2000","unstructured":"Hardy, R. R. et al. B-cell commitment, development and selection. Immunol. Rev. 175, 23\u201332 (2000).","journal-title":"Immunol. Rev."},{"key":"BFni0701_625_CR3","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/S1074-7613(00)80049-7","volume":"10","author":"S Pillai","year":"1999","unstructured":"Pillai, S. The chosen few? Positive selection and the generation of naive B lymphocytes. Immunity 10, 493\u2013502 (1999).","journal-title":"Immunity"},{"key":"BFni0701_625_CR4","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1093\/intimm\/6.8.1257","volume":"6","author":"A Rolink","year":"1994","unstructured":"Rolink, A., Grawunder, U., Winkler, T. H., Karasuyama, H. & Melchers, F. IL-2 receptor-\u03b1 chain (Cd25,Tac) expression defines a crucial stage in pre-B-cell Development. Int. Immunol. 6, 1257\u20131264 (1994).","journal-title":"Int. Immunol."},{"key":"BFni0701_625_CR5","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/350423a0","volume":"350","author":"D Kitamura","year":"1991","unstructured":"Kitamura, D., Roes, J., Kuhn, R. & Rajewsky, K. A. B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin \u03bc chain gene. Nature 350, 423\u2013426 (1991).","journal-title":"Nature"},{"key":"BFni0701_625_CR6","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.4049\/jimmunol.157.5.2073","volume":"157","author":"D Yuan","year":"1996","unstructured":"Yuan, D., Witte, P. L., Tan, J., Hawley, J. & Dang, T. Regulation of IgM and IgD heavy chain gene expression: effect of abrogation of intergenic transcriptional termination. J. Immunol. 157, 2073\u20132081 (1996).","journal-title":"J. Immunol."},{"key":"BFni0701_625_CR7","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.4049\/jimmunol.140.8.2808","volume":"140","author":"D Yuan","year":"1988","unstructured":"Yuan, D. & Witte, P. L. Transcriptional regulation of \u03bc and \u03b4 gene expression in bone marrow pre-B and B lymphocytes. J. Immunol. 140, 2808\u20132814 (1988).","journal-title":"J. Immunol."},{"key":"BFni0701_625_CR8","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1093\/intimm\/11.5.813","volume":"11","author":"M Kim","year":"1999","unstructured":"Kim, M., Qiu, P., Abuodeh, R., Chen, J. & Yuan, D. Differential regulation of transcription termination occurring at two different sites on the microdelta gene complex. Int. Immunol. 11, 813\u2013824 (1999).","journal-title":"Int. Immunol."},{"key":"BFni0701_625_CR9","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1093\/intimm\/3.12.1367","volume":"3","author":"J Roes","year":"1991","unstructured":"Roes, J. & Rajewsky, K. Cell autonomous expression of IgD is not essential for the maturation of conventional B-cells. Int. Immunol. 3, 1367\u20131371 (1991).","journal-title":"Int. Immunol."},{"key":"BFni0701_625_CR10","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/31716","volume":"393","author":"C Lutz","year":"1998","unstructured":"Lutz, C. et al. IgD can largely substitute for loss of IgM function in B cells. Nature 393, 797\u2013801 (1998).","journal-title":"Nature"},{"key":"BFni0701_625_CR11","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1093\/intimm\/9.10.1481","volume":"9","author":"DM Tarlinton","year":"1997","unstructured":"Tarlinton, D. M., Corcoran, L. M. & Strasser, A. Continued differentiation during B lymphopoiesis requires signals in addition to cell survival. Int. Immunol. 9, 1481\u20131494 (1997).","journal-title":"Int. Immunol."},{"key":"BFni0701_625_CR12","doi-asserted-by":"publisher","first-page":"4353","DOI":"10.4049\/jimmunol.165.8.4353","volume":"165","author":"D Melamed","year":"2000","unstructured":"Melamed, D., Miri, E., Leider, N. & Nemazee, D. Unexpected autoantibody production in membrane Ig\u03bc-deficient\/lpr mice. J. Immunol. 165, 4353\u20134358 (2000).","journal-title":"J. Immunol."},{"key":"BFni0701_625_CR13","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/296325a0","volume":"296","author":"FW Alt","year":"1982","unstructured":"Alt, F. W., Rosenberg, N., Casanova, R. J., Thomas, E. & Baltimore, D. Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line. Nature 296, 325\u2013331 (1982).","journal-title":"Nature"},{"key":"BFni0701_625_CR14","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/306243a0","volume":"306","author":"PD Burrows","year":"1983","unstructured":"Burrows, P. D., Beck-Engeser, G. B. & Wabl, M. R. Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement. Nature 306, 243\u2013246 (1983).","journal-title":"Nature"},{"key":"BFni0701_625_CR15","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/290339a0","volume":"290","author":"LB Vogler","year":"1981","unstructured":"Vogler, L. B. et al. Diversity of immunoglobulin expression in leukaemic cells resembling B-lymphocyte precursors. Nature 290, 339\u2013341 (1981).","journal-title":"Nature"},{"key":"BFni0701_625_CR16","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.4049\/jimmunol.162.5.2521","volume":"162","author":"GR Harriman","year":"1999","unstructured":"Harriman, G. R. et al. Targeted deletion of the IgA constant region in mice leads to IgA deficiency with alterations in expression of other immunoglobulin isotypes. J. Immunol. 162, 2521\u20132529 (1999).","journal-title":"J. Immunol."},{"key":"BFni0701_625_CR17","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1002\/j.1460-2075.1993.tb05722.x","volume":"12","author":"JZ Chen","year":"1993","unstructured":"Chen, J. Z. et al. B-cell development in mice that lack one or both immunoglobulin \u03ba-light chain genes. EMBO J. 12, 821\u2013830 (1993).","journal-title":"EMBO J."},{"key":"BFni0701_625_CR18","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.1126\/science.288.5474.2222","volume":"288","author":"AJ Macpherson","year":"2000","unstructured":"Macpherson, A. J. et al. A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 288, 2222\u20132226 (2000).","journal-title":"Science"},{"key":"BFni0701_625_CR19","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1126\/science.286.5446.1965","volume":"286","author":"TV Golovkina","year":"1999","unstructured":"Golovkina, T. V., Shlomchik, M., Hannum, L. & Chervonsky, A. Organogenic role of B lymphocytes in mucosal immunity. Science 286, 1965\u20131968 (1999).","journal-title":"Science"},{"key":"BFni0701_625_CR20","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1093\/ajcn\/69.5.1035s","volume":"69","author":"R Mackie","year":"1999","unstructured":"Mackie, R., Sghir, A. & Gaskins, H. R. Developmental microbial ecology of the neonatal gastrointestinal tract. Am. J. Clin. Nutr. 69, 1035\u20131045 (1999).","journal-title":"Am. J. Clin. Nutr."},{"key":"BFni0701_625_CR21","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/0264-410X(95)00216-N","volume":"14","author":"LP Londono","year":"1996","unstructured":"Londono, L. P. et al. Immunisation of mice using Salmonella typhimurium expressing human papillomavirus inserted into hepatitis B virus core antigen. Vaccine 14, 545\u2013552 (1996).","journal-title":"Vaccine"},{"key":"BFni0701_625_CR22","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1093\/intimm\/1.1.75","volume":"1","author":"F Kroese","year":"1988","unstructured":"Kroese, F. G. M. et al. Many of the IgA producing plasma cells in the murine gut are derived from self-replenishing precursors in the peritoneal cavity. Int. Immunol. 1, 75\u201384 (1988).","journal-title":"Int. Immunol."},{"key":"BFni0701_625_CR23","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/8780","volume":"22","author":"R Shinkura","year":"1999","unstructured":"Shinkura, R. et al. Alymphoplasia is caused by a point mutation in the mouse gene encoding NF-\u03baB-inducing kinase. Nature Genet. 22, 74\u201377 (1999).","journal-title":"Nature Genet."},{"key":"BFni0701_625_CR24","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.4049\/jimmunol.153.5.2014","volume":"153","author":"M Nanno","year":"1994","unstructured":"Nanno, M. et al. Development of intestinal intraepithelial T lymphocytes is independent of Peyer's patches and lymph nodes in aly mutant mice. J. Immunol. 153, 2014\u20132020 (1994).","journal-title":"J. Immunol."},{"key":"BFni0701_625_CR25","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.4049\/jimmunol.163.3.1584","volume":"163","author":"M Matsumoto","year":"1999","unstructured":"Matsumoto, M. et al. Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-\u03b1-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysis. J. Immunol. 163, 1584\u20131591 (1999).","journal-title":"J. Immunol."},{"key":"BFni0701_625_CR26","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/0167-5699(95)80008-5","volume":"16","author":"GW Warr","year":"1995","unstructured":"Warr, G. W., Magor, K. E. & Higgins, D. A. IgY: clues to the origins of modern antibodies. Immunol. Today 16, 392\u2013398 (1995).","journal-title":"Immunol. Today"},{"key":"BFni0701_625_CR27","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/B978-0-12-524730-6.50015-4","volume-title":"Handbook of Mucosal Immunology","author":"P Brandzaeg","year":"1994","unstructured":"Brandzaeg, P., Krajci, P., Lamm, M. E. & Kaetzel, C. S. in Handbook of Mucosal Immunology (ed. Ogra, P. L.) 113\u2013126 (Academic Press, San Diego, 1994)."},{"key":"BFni0701_625_CR28","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1128\/IAI.64.2.616-623.1996","volume":"64","author":"NA Bos","year":"1996","unstructured":"Bos, N. A. et al. Monoclonal immunoglobulin A derived from peritoneal B cells is encoded by both germ line and somatically mutated VH genes and is reactive with commensal bacteria. Infect. Immun. 64, 616\u2013623 (1996).","journal-title":"Infect. Immun."},{"key":"BFni0701_625_CR29","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1093\/intimm\/4.2.243","volume":"4","author":"NM Bhat","year":"1992","unstructured":"Bhat, N. M. et al. The ontogeny and functional characteristics of human B-1 (CD5+ B) cells. Int. Immunol. 4, 243\u2013252 (1992).","journal-title":"Int. Immunol."},{"key":"BFni0701_625_CR30","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/0092-8674(91)90323-Q","volume":"64","author":"CA Reynaud","year":"1991","unstructured":"Reynaud, C. A., Mackay, C. R., Muller, R. G. & Weill, J. C. Somatic generation of diversity in a mammalian primary lymphoid organ: the sheep ileal Peyer's patches. Cell 64, 995\u20131005 (1991).","journal-title":"Cell"},{"key":"BFni0701_625_CR31","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/0092-8674(95)90456-5","volume":"80","author":"CA Reynaud","year":"1995","unstructured":"Reynaud, C. A., Garcia, C., Hein, W. R. & Weill, J. C. Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process. Cell 80, 115\u2013125 (1995).","journal-title":"Cell"},{"key":"BFni0701_625_CR32","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1093\/intimm\/5.6.647","volume":"5","author":"JZ Chen","year":"1993","unstructured":"Chen, J. Z. et al. Immunoglobulin gene rearrangement in B-cell deficient mice generated by targeted deletion of the J(H) locus. Int. Immunol. 5, 647\u2013656 (1993).","journal-title":"Int. Immunol."},{"key":"BFni0701_625_CR33","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/0092-8674(92)90030-G","volume":"68","author":"P Mombaerts","year":"1992","unstructured":"Mombaerts, P. et al. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68, 869\u2013877 (1992).","journal-title":"Cell"},{"key":"BFni0701_625_CR34","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1099\/0022-1317-71-5-1109","volume":"71","author":"BE Clarke","year":"1990","unstructured":"Clarke, B. E., Brown, A. L. & Grace, K. G. Presentation and immunogenicity of viral epitopes on the surface of hybrid hepatitis B core particles produced in bacteria. J. Gen. Virol. 71, 1109\u20131117 (1990).","journal-title":"J. Gen. Virol."},{"key":"BFni0701_625_CR35","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/S0076-6879(86)25033-8","volume":"125","author":"PJ Henderson","year":"1986","unstructured":"Henderson, P. J. & Macpherson, A. J. Assay, genetics, proteins, and reconstitution of proton-linked galactose, arabinose, and xylose transport systems of Escherichia coli. Methods Enzymol. 125, 387\u2013429 (1986).","journal-title":"Methods Enzymol."},{"key":"BFni0701_625_CR36","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0022-1759(96)00208-6","volume":"201","author":"A Krebber","year":"1997","unstructured":"Krebber, A. et al. Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires employing a reengineered phage display system. J. Immunol. Methods 201, 35\u201355 (1997).","journal-title":"J. Immunol. Methods"}],"container-title":["Nature Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ni0701_625.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ni0701_625","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ni0701_625.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:25:54Z","timestamp":1684434354000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ni0701_625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2001,7]]}},"alternative-id":["BFni0701_625"],"URL":"https:\/\/doi.org\/10.1038\/89775","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.722723772.793564881","asserted-by":"object"}]},"ISSN":["1529-2908","1529-2916"],"issn-type":[{"value":"1529-2908","type":"print"},{"value":"1529-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7]]}}}