{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T12:44:02Z","timestamp":1768481042937,"version":"3.49.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2009,12,18]],"date-time":"2009-12-18T00:00:00Z","timestamp":1261094400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1038\/cdd.2009.202","type":"journal-article","created":{"date-parts":[[2009,12,18]],"date-time":"2009-12-18T12:57:34Z","timestamp":1261141054000},"page":"633-641","source":"Crossref","is-referenced-by-count":135,"title":["Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo"],"prefix":"10.1038","volume":"17","author":[{"given":"I","family":"Lambertz","sequence":"first","affiliation":[]},{"given":"D","family":"Nittner","sequence":"additional","affiliation":[]},{"given":"P","family":"Mestdagh","sequence":"additional","affiliation":[]},{"given":"G","family":"Denecker","sequence":"additional","affiliation":[]},{"given":"J","family":"Vandesompele","sequence":"additional","affiliation":[]},{"given":"M A","family":"Dyer","sequence":"additional","affiliation":[]},{"given":"J-C","family":"Marine","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2009,12,18]]},"reference":[{"key":"BFcdd2009202_CR1","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/nrg2634","volume":"10","author":"CM Croce","year":"2009","unstructured":"Croce CM . Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet 2009; 10: 704\u2013714.","journal-title":"Nat Rev Genet"},{"key":"BFcdd2009202_CR2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","volume":"136","author":"DP Bartel","year":"2009","unstructured":"Bartel DP . MicroRNAs: target recognition and regulatory functions. Cell 2009; 136: 215\u2013233.","journal-title":"Cell"},{"key":"BFcdd2009202_CR3","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.cell.2009.02.005","volume":"136","author":"A Ventura","year":"2009","unstructured":"Ventura A, Jacks T . MicroRNAs and cancer: short RNAs go a long way. Cell 2009; 136: 586\u2013591.","journal-title":"Cell"},{"key":"BFcdd2009202_CR4","doi-asserted-by":"publisher","first-page":"759","DOI":"10.4161\/cc.7.6.5834","volume":"7","author":"A Esquela-Kerscher","year":"2008","unstructured":"Esquela-Kerscher A, Trang P, Wiggins JF, Patrawala L, Cheng A, Ford L et al. The let-7 microRNA reduces tumor growth in mouse models of lung cancer. Cell Cycle 2008; 7: 759\u2013764.","journal-title":"Cell Cycle"},{"key":"BFcdd2009202_CR5","doi-asserted-by":"publisher","first-page":"3903","DOI":"10.1073\/pnas.0712321105","volume":"105","author":"MS Kumar","year":"2008","unstructured":"Kumar MS, Erkeland SJ, Pester RE, Chen CY, Ebert MS, Sharp PA et al. Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc Natl Acad Sci USA 2008; 105: 3903\u20133908.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2009202_CR6","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nrc1840","volume":"6","author":"A Esquela-Kerscher","year":"2006","unstructured":"Esquela-Kerscher A, Slack FJ . Oncomirs \u2013 microRNAs with a role in cancer. Nat Rev Cancer 2006; 6: 259\u2013269.","journal-title":"Nat Rev Cancer"},{"key":"BFcdd2009202_CR7","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/nature03702","volume":"435","author":"J Lu","year":"2005","unstructured":"Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D et al. MicroRNA expression profiles classify human cancers. Nature 2005; 435: 834\u2013838.","journal-title":"Nature"},{"key":"BFcdd2009202_CR8","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/ng2003","volume":"39","author":"MS Kumar","year":"2007","unstructured":"Kumar MS, Lu J, Mercer KL, Golub TR, Jacks T . Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet 2007; 39: 673\u2013677.","journal-title":"Nat Genet"},{"key":"BFcdd2009202_CR9","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/ng.2007.30","volume":"40","author":"TC Chang","year":"2008","unstructured":"Chang TC, Yu D, Lee YS, Wentzel EA, Arking DE, West KM et al. Widespread microRNA repression by Myc contributes to tumorigenesis. Nat Genet 2008; 40: 43\u201350.","journal-title":"Nat Genet"},{"key":"BFcdd2009202_CR10","unstructured":"Pampalakis G, Diamandis EP, Katsaros D, Sotiropoulou G . Down-regulation of dicer expression in ovarian cancer tissues. Clin Biochem 2009; e-pub ahead of print 25 September 2009."},{"key":"BFcdd2009202_CR11","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/j.1349-7006.2005.00015.x","volume":"96","author":"Y Karube","year":"2005","unstructured":"Karube Y, Tanaka H, Osada H, Tomida S, Tatematsu Y, Yanagisawa K et al. Reduced expression of Dicer associated with poor prognosis in lung cancer patients. Cancer Sci 2005; 96: 111\u2013115.","journal-title":"Cancer Sci"},{"key":"BFcdd2009202_CR12","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/ng.317","volume":"41","author":"SA Melo","year":"2009","unstructured":"Melo SA, Ropero S, Moutinho C, Aaltonen LA, Yamamoto H, Calin GA et al. A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat Genet 2009; 41: 365\u2013370.","journal-title":"Nat Genet"},{"key":"BFcdd2009202_CR13","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/ng1253","volume":"35","author":"E Bernstein","year":"2003","unstructured":"Bernstein E, Kim SY, Carmell MA, Murchison EP, Alcorn H, Li MZ et al. Dicer is essential for mouse development. Nat Genet 2003; 35: 215\u2013217.","journal-title":"Nat Genet"},{"key":"BFcdd2009202_CR14","doi-asserted-by":"publisher","first-page":"12135","DOI":"10.1073\/pnas.0505479102","volume":"102","author":"EP Murchison","year":"2005","unstructured":"Murchison EP, Partridge JF, Tam OH, Cheloufi S, Hannon GJ . Characterization of Dicer-deficient murine embryonic stem cells. Proc Natl Acad Sci USA 2005; 102: 12135\u201312140.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2009202_CR15","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.ydbio.2004.03.039","volume":"271","author":"S Rowan","year":"2004","unstructured":"Rowan S, Cepko CL . Genetic analysis of the homeodomain transcription factor Chx10 in the retina using a novel multifunctional BAC transgenic mouse reporter. Dev Biol 2004; 271: 388\u2013402.","journal-title":"Dev Biol"},{"key":"BFcdd2009202_CR16","doi-asserted-by":"publisher","first-page":"4878","DOI":"10.1523\/JNEUROSCI.0828-08.2008","volume":"28","author":"D Damiani","year":"2008","unstructured":"Damiani D, Alexander JJ, O\u2019Rourke JR, McManus M, Jadhav AP, Cepko CL et al. Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci 2008; 28: 4878\u20134887.","journal-title":"J Neurosci"},{"key":"BFcdd2009202_CR17","first-page":"952","volume":"3","author":"J Zhang","year":"2004","unstructured":"Zhang J, Schweers B, Dyer MA . The first knockout mouse model of retinoblastoma. Cell Cycle 2004; 3: 952\u2013959.","journal-title":"Cell Cycle"},{"key":"BFcdd2009202_CR18","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1741-7007-4-14","volume":"4","author":"SL Donovan","year":"2006","unstructured":"Donovan SL, Schweers B, Martins R, Johnson D, Dyer MA . Compensation by tumor suppressor genes during retinal development in mice and humans. BMC Biol 2006; 4: 14.","journal-title":"BMC Biol"},{"key":"BFcdd2009202_CR19","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/ng1318","volume":"36","author":"J Zhang","year":"2004","unstructured":"Zhang J, Gray J, Wu L, Leone G, Rowan S, Cepko CL et al. Rb regulates proliferation and rod photoreceptor development in the mouse retina. Nat Genet 2004; 36: 351\u2013360.","journal-title":"Nat Genet"},{"key":"BFcdd2009202_CR20","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1006\/scbi.2000.0326","volume":"10","author":"D DiCiommo","year":"2000","unstructured":"DiCiommo D, Gallie BL, Bremner R . Retinoblastoma: the disease, gene and protein provide critical leads to understand cancer. Semin Cancer Biol 2000; 10: 255\u2013269.","journal-title":"Semin Cancer Biol"},{"key":"BFcdd2009202_CR21","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/nature05194","volume":"444","author":"NA Laurie","year":"2006","unstructured":"Laurie NA, Donovan SL, Shih CS, Zhang J, Mills N, Fuller C et al. Inactivation of the p53 pathway in retinoblastoma. Nature 2006; 444: 61\u201366.","journal-title":"Nature"},{"issue":"Pt 3","key":"BFcdd2009202_CR22","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1242\/jcs.03362","volume":"120","author":"JC Marine","year":"2007","unstructured":"Marine JC, Dyer MA, Jochemsen AG . MDMX: from bench to bedside. J Cell Sci 2007; 120 (Pt 3): 371\u2013378.","journal-title":"J Cell Sci"},{"key":"BFcdd2009202_CR23","doi-asserted-by":"publisher","first-page":"4259","DOI":"10.1523\/JNEUROSCI.21-12-04259.2001","volume":"21","author":"MA Dyer","year":"2001","unstructured":"Dyer MA, Cepko CL . p27Kip1 and p57Kip2 regulate proliferation in distinct retinal progenitor cell populations. J Neurosci 2001; 21: 4259\u20134271.","journal-title":"J Neurosci"},{"key":"BFcdd2009202_CR24","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/BF00192111","volume":"426","author":"K Yuge","year":"1995","unstructured":"Yuge K, Nakajima M, Uemura Y, Miki H, Uyama M, Tsubura A . Immunohistochemical features of the human retina and retinoblastoma. Virchows Arch 1995; 426: 571\u2013575.","journal-title":"Virchows Arch"},{"key":"BFcdd2009202_CR25","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1242\/dev.124.6.1119","volume":"124","author":"MR Alexiades","year":"1997","unstructured":"Alexiades MR, Cepko CL . Subsets of retinal progenitors display temporally regulated and distinct biases in the fates of their progeny. Development 1997; 124: 1119\u20131131.","journal-title":"Development"},{"key":"BFcdd2009202_CR26","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/0896-6273(94)90354-9","volume":"13","author":"IS Liu","year":"1994","unstructured":"Liu IS, Chen JD, Ploder L, Vidgen D, van der Kooy D, Kalnins VI et al. Developmental expression of a novel murine homeobox gene (Chx10): evidence for roles in determination of the neuroretina and inner nuclear layer. Neuron 1994; 13: 377\u2013393.","journal-title":"Neuron"},{"key":"BFcdd2009202_CR27","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/ng0496-376","volume":"12","author":"M Burmeister","year":"1996","unstructured":"Burmeister M, Novak J, Liang MY, Basu S, Ploder L, Hawes NL et al. Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation. Nat Genet 1996; 12: 376\u2013384.","journal-title":"Nat Genet"},{"key":"BFcdd2009202_CR28","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.molmed.2008.07.001","volume":"14","author":"I Bussing","year":"2008","unstructured":"Bussing I, Slack FJ, Grosshans H . let-7 microRNAs in development, stem cells and cancer. Trends Mol Med 2008; 14: 400\u2013409.","journal-title":"Trends Mol Med"},{"key":"BFcdd2009202_CR29","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1038\/nrc2232","volume":"7","author":"L He","year":"2007","unstructured":"He L, He X, Lowe SW, Hannon GJ . microRNAs join the p53 network\u2014another piece in the tumour-suppression puzzle. Nat Rev Cancer 2007; 7: 819\u2013822.","journal-title":"Nat Rev Cancer"},{"key":"BFcdd2009202_CR30","doi-asserted-by":"crossref","unstructured":"Forbes SA, Bhamra G, Bamford S, Dawson E, Kok C, Clements J et al. The catalogue of somatic mutations in cancer (COSMIC). Curr Protoc Hum Genet 2008; Chapter 10 Unit 10 11.","DOI":"10.1002\/0471142905.hg1011s57"},{"key":"BFcdd2009202_CR31","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1126\/science.1174334","volume":"325","author":"DA Hill","year":"2009","unstructured":"Hill DA, Ivanovich J, Priest JR, Gurnett CA, Dehner LP, Desruisseau D et al. DICER1 mutations in familial pleuropulmonary blastoma. Science 2009; 325: 965.","journal-title":"Science"},{"key":"BFcdd2009202_CR32","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.1101\/gad.1848209","volume":"23","author":"MS Kumar","year":"2009","unstructured":"Kumar MS, Pester RE, Chen CY, Lane K, Chin C, Lu J et al. Dicer1 functions as a haploinsufficient tumor suppressor. Genes Dev 2009; 23: 2700\u20132704.","journal-title":"Genes Dev"},{"key":"BFcdd2009202_CR33","first-page":"105","volume":"1654","author":"M Santarosa","year":"2004","unstructured":"Santarosa M, Ashworth A . Haploinsufficiency for tumour suppressor genes: when you don\u2019t need to go all the way. Biochim Biophys Acta 2004; 1654: 105\u2013122.","journal-title":"Biochim Biophys Acta"},{"key":"BFcdd2009202_CR34","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1038\/nmeth1130","volume":"4","author":"JC Huang","year":"2007","unstructured":"Huang JC, Babak T, Corson TW, Chua G, Khan S, Gallie BL et al. Using expression profiling data to identify human microRNA targets. Nat Methods 2007; 4: 1045\u20131049.","journal-title":"Nat Methods"},{"key":"BFcdd2009202_CR35","doi-asserted-by":"publisher","first-page":"4542","DOI":"10.1167\/iovs.09-3520","volume":"50","author":"CL Dalgard","year":"2009","unstructured":"Dalgard CL, Gonzalez M, deNiro JE, O\u2019Brien JM . Differential microRNA-34a expression and tumor suppressor function in retinoblastoma cells. Invest Ophthalmol Vis Sci 2009; 50: 4542\u20134551.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFcdd2009202_CR36","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1038\/sj.emboj.7601515","volume":"26","author":"D MacPherson","year":"2007","unstructured":"MacPherson D, Conkrite K, Tam M, Mukai S, Mu D, Jacks T . Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification. EMBO J 2007; 26: 784\u2013794.","journal-title":"EMBO J"},{"key":"BFcdd2009202_CR37","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/309458a0","volume":"309","author":"WH Lee","year":"1984","unstructured":"Lee WH, Murphree AL, Benedict WF . Expression and amplification of the N-myc gene in primary retinoblastoma. Nature 1984; 309: 458\u2013460.","journal-title":"Nature"},{"key":"BFcdd2009202_CR38","doi-asserted-by":"publisher","first-page":"R64","DOI":"10.1186\/gb-2009-10-6-r64","volume":"10","author":"P Mestdagh","year":"2009","unstructured":"Mestdagh P, Van Vlierberghe P, De Weer A, Muth D, Westermann F, Speleman F et al. A novel and universal method for microRNA RT-qPCR data normalization. Genome Biol 2009; 10: R64.","journal-title":"Genome Biol"},{"key":"BFcdd2009202_CR39","doi-asserted-by":"publisher","first-page":"e143","DOI":"10.1093\/nar\/gkn725","volume":"36","author":"P Mestdagh","year":"2008","unstructured":"Mestdagh P, Feys T, Bernard N, Guenther S, Chen C, Speleman F et al. High-throughput stem-loop RT-qPCR miRNA expression profiling using minute amounts of input RNA. Nucleic Acids Res 2008; 36: e143.","journal-title":"Nucleic Acids Res"}],"container-title":["Cell Death & Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd2009202.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd2009202","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd2009202.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:46:34Z","timestamp":1684417594000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd2009202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,18]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["BFcdd2009202"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2009.202","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,18]]}}}