{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:35:40Z","timestamp":1771644940539,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[1989,11,1]],"date-time":"1989-11-01T00:00:00Z","timestamp":625881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":9532,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[1989,11]]},"DOI":"10.1038\/ki.1989.266","type":"journal-article","created":{"date-parts":[[2007,5,29]],"date-time":"2007-05-29T11:40:23Z","timestamp":1180438823000},"page":"810-815","source":"Crossref","is-referenced-by-count":86,"title":["Reduced renal prepro-epidermal growth factor mRNA and decreased EGF excretion in ARF"],"prefix":"10.1016","volume":"36","author":[{"given":"Robert","family":"Safirstein","sequence":"first","affiliation":[]},{"given":"Arthur Z.","family":"Zelent","sequence":"additional","affiliation":[]},{"given":"Peter M.","family":"Price","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1038\/ki.1989.266_bb0010","series-title":"Nephrology","first-page":"748","article-title":"Control of renal regeneration after acute tubule necrosis","author":"Toback","year":"1984"},{"key":"10.1038\/ki.1989.266_bb0015","first-page":"5215","article-title":"The biologic role of oncogenes-insights from platelet-derived growth factor. Roads Memorial Award Lecture","volume":"45","author":"Stiles","year":"1985","journal-title":"Cancer Res"},{"key":"10.1038\/ki.1989.266_bb0020","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev.bi.48.070179.001205","article-title":"Epidermal growth factor","volume":"48","author":"Carpenter","year":"1979","journal-title":"Ann Rev Biochem"},{"key":"10.1038\/ki.1989.266_bb0025","doi-asserted-by":"crossref","first-page":"8427","DOI":"10.1093\/nar\/14.21.8427","article-title":"Human epidermal growth factor precursor:cDNA sequence, expression in vitro and gene organization","volume":"14","author":"Bell","year":"1986","journal-title":"Nucleic Acids Res"},{"key":"10.1038\/ki.1989.266_bb0030","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/313228a0","article-title":"Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues","volume":"313","author":"Rall","year":"1985","journal-title":"Nature"},{"key":"10.1038\/ki.1989.266_bb0035","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1177\/34.9.2426343","article-title":"Immunocytochemical localization of epidermal growth factor in mouse kidney","volume":"34","author":"Salido","year":"1986","journal-title":"J Histochem Cytochem"},{"key":"10.1038\/ki.1989.266_bb0040","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0167-0115(84)90051-X","article-title":"Renal origin of rat urinary epidermal growth factor","volume":"10","author":"Olsen","year":"1984","journal-title":"Reg Peptides"},{"key":"10.1038\/ki.1989.266_bb0045","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1172\/JCI113659","article-title":"Evidence for glomerular actions of epidermal growth factor in the rat","volume":"82","author":"Harris","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1989.266_bb0050","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1042\/bj2490587","article-title":"Epidermal growth factor is synergistic with phorbol esters and vasopressin in stimulating arachidonate release and prostaglandin production in renal glomerular mesangial cells","volume":"249","author":"Margolis","year":"1988","journal-title":"Biochem J"},{"key":"10.1038\/ki.1989.266_bb0055","doi-asserted-by":"crossref","first-page":"C267","DOI":"10.1152\/ajpcell.1988.254.2.C267","article-title":"Epidermal growth factor stimulates growth, Na+\/H+ exchange and hexose monophosphate shunt activity in rat proximal tubule cells in primary culture","volume":"253","author":"Stanton","year":"1988","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1989.266_bb0060","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1172\/JCI113732","article-title":"Epidermal growth factor inhibits both chlorophenylthio-cyclic AMP and vasopressin stimulated hydraulic conductivity in the rabbit cortical collecting tubule","volume":"82","author":"Breyer","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1989.266_bb0065","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1172\/JCI113051","article-title":"Transepithelial transport of epidermal growth factor by absorptive cells of suckling rat ileum","volume":"80","author":"Gonnella","year":"1987","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1989.266_bb0070","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1083\/jcb.99.4.1259","article-title":"Transport of epidermal growth factor by rat liver: Evidence for a nonlysosomal pathway","volume":"99","author":"Burwen","year":"1984","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.1989.266_bb0075","first-page":"161a","article-title":"Growth rate of inner medullary collecting duct cells is stimulated by low potassium and by epidermal growth factor, and determines expression of Na+\/H+exchange and H+ATPase","volume":"31","author":"Boxer","year":"1987","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1989.266_bb0080","first-page":"167a","article-title":"Potential role for egf in proliferative glomerulonephritis","volume":"31","author":"Goodyer","year":"1987","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1989.266_bb0085","first-page":"184a","article-title":"Effect of epidermal growth factor on cultured mesangial cells","volume":"31","author":"Tsivists","year":"1987","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1989.266_bb0090","first-page":"547a","article-title":"Rat renal papillary collecting duct cells possess receptors specific for epidermal growth factor","volume":"35","author":"Harris","year":"1987","journal-title":"Clin Res"},{"key":"10.1038\/ki.1989.266_bb0095","first-page":"F175","article-title":"Cisplatin nephrotoxicity: Defect in medullary hypertonicity","volume":"241","author":"Safirstein","year":"1981","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1989.266_bb0100","doi-asserted-by":"crossref","first-page":"5294","DOI":"10.1021\/bi00591a005","article-title":"Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease","volume":"18","author":"Chirgwin","year":"1979","journal-title":"Biochemstry"},{"key":"10.1038\/ki.1989.266_bb0105","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1073\/pnas.69.6.1408","article-title":"Purification of biologically active globin messenger RNA by chromotography on oligthymidylic acid-cellulose","volume":"69","author":"Aviv","year":"1972","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.1989.266_bb0110","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1021\/bi00640a033","article-title":"RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination","volume":"16","author":"Lehrach","year":"1977","journal-title":"Biochemistry"},{"key":"10.1038\/ki.1989.266_bb0115","series-title":"Molecular Cloning Manual","first-page":"383","author":"Maniatis","year":"1982"},{"key":"10.1038\/ki.1989.266_bb0120","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0022-2836(77)90052-3","article-title":"Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I","volume":"113","author":"Rigby","year":"1977","journal-title":"J Mol Biol"},{"key":"10.1038\/ki.1989.266_bb0125","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1128\/jvi.61.4.1108-1115.1987","article-title":"Murine cells carrying integrated genomes of hepatitis B virus DNA transcribe RNA from endogenous promoters on both viral strands and express middle and major viral envelope proteins","volume":"61","author":"Zelent","year":"1987","journal-title":"J Virol"},{"key":"10.1038\/ki.1989.266_bb0130","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1126\/science.6602382","article-title":"Structure of a mouse submaxillary messenger RNA encoding epidermal growth factor and seven related proteins","volume":"221","author":"Scott","year":"1983","journal-title":"Science"},{"key":"10.1038\/ki.1989.266_bb0135","first-page":"787","article-title":"Isolation and characterization of full length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: Skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed","volume":"3","author":"Gunning","year":"1983","journal-title":"Mol Cell Biol"},{"key":"10.1038\/ki.1989.266_bb0140","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1128\/jvi.44.2.674-682.1982","article-title":"FBJ murine osteosarcoma virus: Identification and molecular cloning of biologically active pro viral DNA","volume":"44","author":"Curran","year":"1982","journal-title":"J Virol"},{"key":"10.1038\/ki.1989.266_bb0145","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/292506a0","article-title":"The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes","volume":"292","author":"Ellis","year":"1981","journal-title":"Nature"},{"key":"10.1038\/ki.1989.266_bb0150","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1016\/S0021-9258(17)38511-3","article-title":"The murine transforming growth factor precursor","volume":"261","author":"Derynck","year":"1986","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1989.266_bb0155","first-page":"1428","article-title":"Variant forms of rat epidermal growth factor present in the urine of nude rats bearing human tumors","volume":"48","author":"Hudgens","year":"1988","journal-title":"Cancer Res"},{"key":"10.1038\/ki.1989.266_bb0160","series-title":"Clinical Chemistry: Principles and Technics","first-page":"514","article-title":"Non-protein nitrogenous constituents","author":"Di Giorgio","year":"1974"},{"key":"10.1038\/ki.1989.266_bb0165","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/ki.1978.31","article-title":"Tubular leakage and obstruction after renal ischemia: structural-functional correlations","volume":"13","author":"Donohoe","year":"1978","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1989.266_bb0170","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF00622899","article-title":"The early phase of experimental acute renal failure IV. The diluting ability of the short loops of Henle","volume":"379","author":"Mason","year":"1979","journal-title":"Pfl\u00fcgers Arch"},{"key":"10.1038\/ki.1989.266_bb0175","first-page":"F17","article-title":"Isolated nephron segments in a rabbit model of ischemic acute renal failure","volume":"239","author":"Hanley","year":"1980","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1989.266_bb0180","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1172\/JCI111189","article-title":"Selective vulnerability of the medullary thick ascending limb to anoxia in the isolated perfused rat kidney","volume":"73","author":"Brezis","year":"1983","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1989.266_bb0185","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/ki.1982.65","article-title":"with the technical assistance of V, VanPutten, M. Ellis: Renal concentration defect following nonoliguric acute renal failure in the rat","volume":"21","author":"Anderson","year":"1982","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1989.266_bb0190","first-page":"629","article-title":"Epidermal growth factor (urogastrone) in human fluids: Size heterogeneity","volume":"48","author":"Hirata","year":"1979","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1038\/ki.1989.266_bb0195","first-page":"1934","article-title":"Comparison of growth factors functionally related to epidermal growth factor in the urine of normal and human tumor-bearing athymic mice","volume":"45","author":"Twardzik","year":"1985","journal-title":"Cancer Res"},{"key":"10.1038\/ki.1989.266_bb0200","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-2605.1987.tb00200.x","article-title":"Cisplatin nephrotoxicity: Insights into mechanism","volume":"10","author":"Safirstein","year":"1987","journal-title":"Int J Androl"},{"key":"10.1038\/ki.1989.266_bb0205","first-page":"2140","article-title":"Complexicity of the early genetic response to growth factors in mouse fibroblasts","volume":"8","author":"Almendral","year":"1988","journal-title":"Mol Cell Biol"},{"key":"10.1038\/ki.1989.266_bb0210","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/311433a0","article-title":"Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene","volume":"311","author":"Greenberg","year":"1984","journal-title":"Nature"},{"key":"10.1038\/ki.1989.266_bb0215","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/312711a0","article-title":"Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein","volume":"312","author":"Kruijer","year":"1984","journal-title":"Nature"},{"key":"10.1038\/ki.1989.266_bb0220","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/312716a0","article-title":"Induction of c-fos gene and protein by growth factors precedes activation of c-myc","volume":"312","author":"Muller","year":"1984","journal-title":"Nature"},{"key":"10.1038\/ki.1989.266_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1083\/jcb.93.1.1","article-title":"EGF inhibits growth of A431 human epidermoid cells in serum-free cell culture","volume":"93","author":"Barnes","year":"1982","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.1989.266_bb0230","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/293305a0","article-title":"Increased phosphotyrosine content and inhibition of proliferation in EGF-treated A431 cells","volume":"293","author":"Gill","year":"1981","journal-title":"Nature"},{"key":"10.1038\/ki.1989.266_bb0235","first-page":"1648","article-title":"Growth inhibitory effects of EGF and overexpression of its receptors on human squamous cell carcinomas in culture","volume":"46","author":"Kamata","year":"1986","journal-title":"Cancer Res"},{"key":"10.1038\/ki.1989.266_bb0240","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1203\/00006450-198605000-00017","article-title":"Treatment of the neonatal rat with epidermal growth factor: Differences in time and organ response","volume":"20","author":"Hoath","year":"1986","journal-title":"Pediatr Res"},{"key":"10.1038\/ki.1989.266_bb0245","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1203\/00006450-198612000-00012","article-title":"Effect of epidermal growth factor and artificial feeding in suckling rats","volume":"20","author":"Moors","year":"1986","journal-title":"Pediatr Res"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815347074?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815347074?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T19:57:39Z","timestamp":1635537459000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815347074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,11]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1989,11]]}},"alternative-id":["S0085253815347074"],"URL":"https:\/\/doi.org\/10.1038\/ki.1989.266","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[1989,11]]}}}