{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:58:15Z","timestamp":1772895495040,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":8167,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2000,9]]},"DOI":"10.1038\/labinvest.3780143","type":"journal-article","created":{"date-parts":[[2011,6,16]],"date-time":"2011-06-16T17:53:18Z","timestamp":1308246798000},"page":"1347-1359","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Distribution of Tsc1 Protein Detected by Immunohistochemistry in Various Normal Rat Tissues and the Renal Carcinomas of Eker Rat: Detection of Limited Colocalization with Tsc1 and Tsc2 Gene Products In Vivo"],"prefix":"10.1016","volume":"80","author":[{"given":"Tomokazu","family":"Fukuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Momose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Yasui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Okio","family":"Hino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.3780143_bib1","first-page":"1201","article-title":"Tuberous sclerosis-associated renal cell carcinoma. Clinical, pathological, and genetic features","volume":"149","author":"Bjornsson","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.3780143_bib2","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1083\/jcb.129.3.673","article-title":"Immunolocalization of sarcolemmal dihydropyridine receptor and sarcoplasmic reticular triadin and ryanodine receptor in rabbit ventricle and atrium","volume":"129","author":"Carl","year":"1995","journal-title":"J Cell Biol"},{"key":"10.1038\/labinvest.3780143_bib3","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1136\/jmg.33.6.480","article-title":"A cross sectional study of renal involvement in tuberous sclerosis","volume":"33","author":"Cook","year":"1996","journal-title":"J Med Genet"},{"key":"10.1038\/labinvest.3780143_bib4","doi-asserted-by":"crossref","unstructured":"European chromosome 16 tuberous sclerosis consortium (1993). Identification and characterization of the tuberous sclerosis gene on chromosome 16. The European Chromosome 16 Tuberous Sclerosis Consortium. Cell75: 1305\u20131315.","DOI":"10.1016\/0092-8674(93)90618-Z"},{"key":"10.1038\/labinvest.3780143_bib5","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s004280050350","article-title":"Distribution of Tsc2 protein in various normal rat tissues and renal tumours of Tsc2 mutant (Eker) rat detected by immunohistochemistry","volume":"434","author":"Fukuda","year":"1999","journal-title":"Virchows Arch"},{"issue":"Suppl","key":"10.1038\/labinvest.3780143_bib6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0387-7604(94)00130-8","article-title":"History of the tuberous sclerosis complex","volume":"17","author":"Gomez","year":"1995","journal-title":"Brain Dev"},{"key":"10.1038\/labinvest.3780143_bib7","doi-asserted-by":"crossref","first-page":"20535","DOI":"10.1074\/jbc.273.32.20535","article-title":"Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members","volume":"273","author":"Henry","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.3780143_bib8","first-page":"665","article-title":"Frequent progesterone receptor immunoreactivity in tuberous sclerosis- associated renal angiomyolipomas","volume":"11","author":"Henske","year":"1998","journal-title":"Mod Pathol"},{"key":"10.1038\/labinvest.3780143_bib9","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1073\/pnas.90.1.327","article-title":"Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer","volume":"90","author":"Hino","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1038\/labinvest.3780143_bib10","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1007\/BF01197777","article-title":"Renal carcinogenesis in the Eker rat","volume":"121","author":"Hino","year":"1995","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1038\/labinvest.3780143_bib11","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1006\/bbrc.1994.2324","article-title":"The predisposing gene of the Eker rat inherited cancer syndrome is tightly linked to the tuberous sclerosis (TSC2) gene","volume":"203","author":"Hino","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/labinvest.3780143_bib12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1750-3639.1999.tb00209.x","article-title":"Co-localization of TSC1 and TSC2 gene products in tubers of patients with tuberous sclerosis","volume":"9","author":"Johnson","year":"1999","journal-title":"Brain Pathol"},{"key":"10.1038\/labinvest.3780143_bib13","first-page":"1543","article-title":"The association between tuberous sclerosis and insulinoma","volume":"16","author":"Kim","year":"1995","journal-title":"Am J Neuroradiol"},{"key":"10.1038\/labinvest.3780143_bib14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/ng0195-70","article-title":"A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer","volume":"9","author":"Kobayashi","year":"1995","journal-title":"Nat Genet"},{"key":"10.1038\/labinvest.3780143_bib15","first-page":"1206","article-title":"Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice","volume":"59","author":"Kobayashi","year":"1999","journal-title":"Cancer Res"},{"key":"10.1038\/labinvest.3780143_bib16","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.1073\/pnas.94.8.3990","article-title":"Transgenic rescue from embryonic lethality and renal carcinogenesis in the Eker rat model by introduction of a wild-type Tsc2 gene","volume":"94","author":"Kobayashi","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1038\/labinvest.3780143_bib17","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/j.1349-7006.1995.tb03092.x","article-title":"Allelic loss at the tuberous sclerosis (Tsc2) gene locus in spontaneous uterine leiomyosarcomas and pituitary adenomas in the Eker rat model","volume":"86","author":"Kubo","year":"1995","journal-title":"Jpn J Cancer Res"},{"key":"10.1038\/labinvest.3780143_bib18","first-page":"989","article-title":"Early detection of Knudson's two-hits in preneoplastic renal cells of the Eker rat model by the laser microdissection procedure","volume":"55","author":"Kubo","year":"1995","journal-title":"Cancer Res"},{"key":"10.1038\/labinvest.3780143_bib19","first-page":"2633","article-title":"Allelic loss at the predisposing gene locus in spontaneous and chemically induced renal cell carcinomas in the Eker rat","volume":"54","author":"Kubo","year":"1994","journal-title":"Cancer Res"},{"key":"10.1038\/labinvest.3780143_bib20","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1177\/43.1.7822770","article-title":"A novel, simple, reliable, and sensitive method for multiple immunoenzyme staining: Use of microwave oven heating to block antibody crossreactivity and retrieve antigens","volume":"43","author":"Lan","year":"1995","journal-title":"J Histochem Cytochem"},{"key":"10.1038\/labinvest.3780143_bib21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1378\/chest.117.1.25","article-title":"Frequent estrogen and progesterone receptor immunoreactivity in renal angiomyolipomas from women with pulmonary lymphangioleiomyomatosis","volume":"117","author":"Logginidou","year":"2000","journal-title":"Chest"},{"key":"10.1038\/labinvest.3780143_bib22","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/ana.410400621","article-title":"Loss of tuberin from cerebral tissues with tuberous sclerosis and astrocytoma","volume":"40","author":"Mizuguchi","year":"1996","journal-title":"Ann Neurol"},{"key":"10.1038\/labinvest.3780143_bib23","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s003359900057","article-title":"Expression and differential splicing of the mouse TSC2 homolog","volume":"7","author":"Olsson","year":"1996","journal-title":"Mamm Genome"},{"key":"10.1038\/labinvest.3780143_bib24","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1172\/JCI7319","article-title":"Tsc2(+\/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background","volume":"104","author":"Onda","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.3780143_bib25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/bbrc.1996.0183","article-title":"Suppression of the neoplastic phenotype by replacement of the Tsc2 gene in Eker rat renal carcinoma cells","volume":"219","author":"Orimoto","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/labinvest.3780143_bib26","first-page":"H1619","article-title":"Sustained cardiomyocyte DNA synthesis in whole embryo cultures lacking the TSC2 gene product","volume":"273","author":"Pajak","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1038\/labinvest.3780143_bib27","first-page":"539","article-title":"The expression of hamartin, the product of the TSC1 gene, in normal human tissues and in TSC1- and TSC2-linked angiomyolipomas","volume":"12","author":"Plank","year":"1999","journal-title":"Mod Pathol"},{"key":"10.1038\/labinvest.3780143_bib28","first-page":"4766","article-title":"Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles","volume":"58","author":"Plank","year":"1998","journal-title":"Cancer Res"},{"key":"10.1038\/labinvest.3780143_bib29","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/(SICI)1097-0215(19980911)77:6<895::AID-IJC16>3.0.CO;2-0","article-title":"Biallelic mutations of the Tsc2 gene in chemically induced rat renal cell carcinoma","volume":"77","author":"Satake","year":"1998","journal-title":"Int J Cancer"},{"key":"10.1038\/labinvest.3780143_bib30","doi-asserted-by":"crossref","first-page":"29301","DOI":"10.1074\/jbc.272.46.29301","article-title":"Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase","volume":"272","author":"Soucek","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.3780143_bib31","first-page":"429","article-title":"Presence of potent transcriptional activation domains in the predisposing tuberous sclerosis (Tsc2) gene product of the Eker rat model","volume":"56","author":"Tsuchiya","year":"1996","journal-title":"Cancer Res"},{"key":"10.1038\/labinvest.3780143_bib32","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.277.5327.805","article-title":"Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34","volume":"277","author":"van Slegtenhorst","year":"1997","journal-title":"Science"},{"key":"10.1038\/labinvest.3780143_bib33","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/hmg\/7.6.1053","article-title":"Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products","volume":"7","author":"van Slegtenhorst","year":"1998","journal-title":"Hum Mol Genet"},{"key":"10.1038\/labinvest.3780143_bib34","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1159\/000017404","article-title":"Cortical dysplasia, genetic abnormalities and neurocutaneous syndromes","volume":"21","author":"Vinters","year":"1999","journal-title":"Dev Neurosci"},{"key":"10.1038\/labinvest.3780143_bib35","doi-asserted-by":"crossref","first-page":"16409","DOI":"10.1074\/jbc.270.27.16409","article-title":"Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity","volume":"270","author":"Wienecke","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.3780143_bib36","first-page":"913","article-title":"Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus","volume":"13","author":"Wienecke","year":"1996","journal-title":"Oncogene"},{"key":"10.1038\/labinvest.3780143_bib37","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1093\/carcin\/19.11.2043","article-title":"Estrogen treatment enhances hereditary renal tumor development in Eker rats","volume":"19","author":"Wolf","year":"1998","journal-title":"Carcinogenesis"},{"key":"10.1038\/labinvest.3780143_bib38","first-page":"81","article-title":"Germ-line Tsc2 mutation in a dominantly inherited cancer model defines a novel family of rat intracisternal-A particle elements","volume":"11","author":"Xiao","year":"1995","journal-title":"Oncogene"},{"key":"10.1038\/labinvest.3780143_bib39","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1074\/jbc.272.10.6097","article-title":"The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis","volume":"272","author":"Xiao","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.3780143_bib40","first-page":"1477","article-title":"Subependymal astrocytic hamartomas in the Eker rat model of tuberous sclerosis","volume":"151","author":"Yeung","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.3780143_bib41","doi-asserted-by":"crossref","first-page":"11413","DOI":"10.1073\/pnas.91.24.11413","article-title":"Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene","volume":"91","author":"Yeung","year":"1994","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3780143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3780143","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002368372202089X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002368372202089X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3780143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:44:51Z","timestamp":1758397491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002368372202089X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["S002368372202089X"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.3780143","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2000,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distribution of Tsc1 Protein Detected by Immunohistochemistry in Various Normal Rat Tissues and the Renal Carcinomas of Eker Rat: Detection of Limited Colocalization with Tsc1 and Tsc2 Gene Products In Vivo","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.3780143","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2000 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}