{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T14:12:23Z","timestamp":1772201543724,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":5611,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1038\/modpathol.3800903","type":"journal-article","created":{"date-parts":[[2007,7,13]],"date-time":"2007-07-13T08:41:51Z","timestamp":1184316111000},"page":"921-928","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":135,"title":["Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues"],"prefix":"10.1016","volume":"20","author":[{"given":"Jiangling J","family":"Tu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Rohan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Kao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Kitabayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Mathew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Tseng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.3800903_bib1","series-title":"Pathology and Genetics of Tumors of Hematopietic and Lymphoid Tissue","author":"Jaffe","year":"2001"},{"key":"10.1038\/modpathol.3800903_bib2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-2559.2005.02285.x","article-title":"The role of genetic testing in soft tissue sarcoma","volume":"48","author":"Antonescu","year":"2006","journal-title":"Histopathology"},{"key":"10.1038\/modpathol.3800903_bib3","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1158\/1078-0432.CCR-05-2376","article-title":"MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma","volume":"12","author":"Okabe","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1038\/modpathol.3800903_bib4","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cll.2005.01.008","article-title":"Translocation carcinomas of the kidney","volume":"25","author":"Argani","year":"2005","journal-title":"Clin Lab Med"},{"key":"10.1038\/modpathol.3800903_bib5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0002-9440(10)64536-1","article-title":"Recurrent genetic aberrations in thymoma and thymic carcinoma","volume":"157","author":"Zettl","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.3800903_bib6","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1126\/science.1117679","article-title":"Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer","volume":"310","author":"Tomlins","year":"2005","journal-title":"Science"},{"key":"10.1038\/modpathol.3800903_bib7","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1158\/0008-5472.CAN-06-0168","article-title":"TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer","volume":"66","author":"Tomlins","year":"2006","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.3800903_bib8","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/00019606-199509000-00003","article-title":"The emerging molecular genetics of sarcoma translocations","volume":"4","author":"Ladanyi","year":"1995","journal-title":"Diagn Mol Pathol"},{"key":"10.1038\/modpathol.3800903_bib9","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.leukres.2005.10.014","article-title":"ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22)","volume":"30","author":"Moore","year":"2006","journal-title":"Leuk Res"},{"key":"10.1038\/modpathol.3800903_bib10","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH743>3.0.CO;2-T","article-title":"Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues","volume":"193","author":"Vaarala","year":"2001","journal-title":"J Pathol"},{"key":"10.1038\/modpathol.3800903_bib11","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/geno.1997.4845","article-title":"Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3","volume":"44","author":"Paoloni-Giacobino","year":"1997","journal-title":"Genomics"},{"key":"10.1038\/modpathol.3800903_bib12","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1038\/sj.onc.1210070","article-title":"Diversity of TMPRSS2-ERG fusion transcripts in the human prostate","volume":"26","author":"Clark","year":"2007","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.3800903_bib13","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/gcc.20329","article-title":"Confirmation of the high frequency of the TMPRSS2\/ERG fusion gene in prostate cancer","volume":"45","author":"Soller","year":"2006","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/modpathol.3800903_bib14","doi-asserted-by":"crossref","first-page":"8347","DOI":"10.1158\/0008-5472.CAN-06-1966","article-title":"Expression of variant TMPRSS2\/ERG fusion messenger RNAs is associated with aggressive prostate cancer","volume":"66","author":"Wang","year":"2006","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.3800903_bib15","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1593\/neo.06283","article-title":"Three-color FISH analysis of TMPRSS2\/ERG fusions in prostate cancer indicates that genomic microdeletion of chromosome 21 is associated with rearrangement","volume":"8","author":"Yoshimoto","year":"2006","journal-title":"Neoplasia"},{"key":"10.1038\/modpathol.3800903_bib16","doi-asserted-by":"crossref","first-page":"8337","DOI":"10.1158\/0008-5472.CAN-06-1482","article-title":"TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer","volume":"66","author":"Perner","year":"2006","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.3800903_bib17","doi-asserted-by":"crossref","first-page":"10242","DOI":"10.1158\/0008-5472.CAN-06-1986","article-title":"TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming","volume":"66","author":"Iljin","year":"2006","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.3800903_bib18","doi-asserted-by":"crossref","first-page":"6558","DOI":"10.1158\/1078-0432.CCR-05-0647","article-title":"Messenger RNA expression ratios among four genes predict subtypes of renal cell carcinoma and distinguish oncocytoma from carcinoma","volume":"11","author":"Chen","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1038\/modpathol.3800903_bib19","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4161\/cbt.5.3.2603","article-title":"ETS-TMPRSS2 fusion gene products in prostate cancer","volume":"5","author":"Ahlers","year":"2006","journal-title":"Cancer Biol Ther"},{"key":"10.1038\/modpathol.3800903_bib20","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1038\/sj.onc.1208518","article-title":"Frequent overexpression of ETS-related gene-1 (ERG1) in prostate cancer transcriptome","volume":"24","author":"Petrovics","year":"2005","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.3800903_bib21","doi-asserted-by":"crossref","unstructured":"Demichelis F, Fall K, Perner S, et al. TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort. Oncogene 2007 (in press).","DOI":"10.1038\/sj.onc.1210630"},{"key":"10.1038\/modpathol.3800903_bib22","doi-asserted-by":"crossref","first-page":"10658","DOI":"10.1158\/0008-5472.CAN-06-1871","article-title":"TMPRSS2:ERG fusion by translocation or interstitial deletion is highly relevant in androgen-dependent prostate cancer, but is bypassed in late-stage androgen receptor-negative prostate cancer","volume":"66","author":"Hermans","year":"2006","journal-title":"Cancer Res"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3800903.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3800903","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222032653?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222032653?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3800903.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:08:22Z","timestamp":1760231302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222032653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S0893395222032653"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.3800903","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.3800903","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2007 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}