{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:48:36Z","timestamp":1778856516142,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6927","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2003,3]]},"DOI":"10.1038\/nature01457","type":"journal-article","created":{"date-parts":[[2003,3,5]],"date-time":"2003-03-05T17:43:17Z","timestamp":1046886197000},"page":"80-83","source":"Crossref","is-referenced-by-count":410,"title":["Monoclonal antibodies inhibit prion replication and delay the development of prion disease"],"prefix":"10.1038","volume":"422","author":[{"given":"Anthony R.","family":"White","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perry","family":"Enever","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mourad","family":"Tayebi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosey","family":"Mushens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackie","family":"Linehan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Brandner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Anstee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Collinge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Hawke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2003,3,6]]},"reference":[{"key":"BFnature01457_CR1","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/383685a0","volume":"383","author":"J Collinge","year":"1996","unstructured":"Collinge, J., Sidle, K. C., Meads, J., Ironside, J. & Hill, A. F. Molecular analysis of prion strain variation and the aetiology of \u2018new variant\u2019 CJD. Nature 383, 685\u2013690 (1996)","journal-title":"Nature"},{"key":"BFnature01457_CR2","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/39057","volume":"389","author":"ME Bruce","year":"1997","unstructured":"Bruce, M. E. et al. Transmissions to mice indicate that \u2018new variant\u2019 CJD is caused by the BSE agent. Nature 389, 498\u2013501 (1997)","journal-title":"Nature"},{"key":"BFnature01457_CR3","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/38925","volume":"389","author":"AF Hill","year":"1997","unstructured":"Hill, A. F. et al. The same prion strain causes vCJD and BSE. Nature 389, 448\u2013450 (1997)","journal-title":"Nature"},{"key":"BFnature01457_CR4","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/S0140-6736(96)91412-9","volume":"347","author":"RG Will","year":"1996","unstructured":"Will, R. G. et al. A new variant of Creutzfeldt-Jakob disease in the UK. Lancet 347, 921\u2013925 (1996)","journal-title":"Lancet"},{"key":"BFnature01457_CR5","doi-asserted-by":"publisher","first-page":"13363","DOI":"10.1073\/pnas.95.23.13363","volume":"95","author":"SB Prusiner","year":"1998","unstructured":"Prusiner, S. B. Prions. Proc. Natl Acad. Sci. USA 95, 13363\u201313383 (1998)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature01457_CR6","doi-asserted-by":"publisher","first-page":"9295","DOI":"10.1073\/pnas.151242598","volume":"98","author":"M Enari","year":"2001","unstructured":"Enari, M., Flechsig, E. & Weissmann, C. Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody. Proc. Natl. Acad. Sci. USA 98, 9295\u20139299 (2001)","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnature01457_CR7","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/35089090","volume":"412","author":"D Peretz","year":"2001","unstructured":"Peretz, D. et al. Antibodies inhibit prion propagation and clear cell cultures of prion infectivity. Nature 412, 739\u2013743 (2001)","journal-title":"Nature"},{"key":"BFnature01457_CR8","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1126\/science.283.5409.1935","volume":"283","author":"GS Jackson","year":"1999","unstructured":"Jackson, G. S. et al. Reversible conversion of monomeric human prion protein between native and fibrilogenic conformations. Science 283, 1935\u20131937 (1999)","journal-title":"Science"},{"key":"BFnature01457_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0167-4838(99)00038-2","volume":"1431","author":"GS Jackson","year":"1999","unstructured":"Jackson, G. S. et al. Multiple folding pathways for heterologously expressed human prion protein. Biochim. Biophys. Acta 1431, 1\u201313 (1999)","journal-title":"Biochim. Biophys. Acta"},{"key":"BFnature01457_CR10","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/356577a0","volume":"356","author":"H Bueler","year":"1992","unstructured":"Bueler, H. et al. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature 356, 577\u2013582 (1992)","journal-title":"Nature"},{"key":"BFnature01457_CR11","doi-asserted-by":"crossref","unstructured":"Beringue, V. et al. Regional heterogeneity of cellular prion protein isoforms in the brain. Brain (submitted).","DOI":"10.1093\/brain\/awg205"},{"key":"BFnature01457_CR12","doi-asserted-by":"publisher","first-page":"5432","DOI":"10.1128\/JVI.74.12.5432-5440.2000","volume":"74","author":"V Beringue","year":"2000","unstructured":"Beringue, V. et al. Opposite effects of dextran sulfate 500, the polyene antibiotic MS-8209 and Congo red on accumulation of the protease-resistant isoform of PrP in the spleens of mice inoculated intraperitoneally with the scrapie agent. J. Virol. 74, 5432\u20135440 (2000)","journal-title":"J. Virol."},{"key":"BFnature01457_CR13","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1002\/1521-4141(200108)31:8<2338::AID-IMMU2338>3.0.CO;2-V","volume":"31","author":"L Souan","year":"2001","unstructured":"Souan, L. et al. Modulation of proteinase-K resistant prion protein by prion peptide immunisation. Eur. J. Immunol. 31, 2338\u20132346 (2001)","journal-title":"Eur. J. Immunol."},{"key":"BFnature01457_CR14","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1126\/science.1063093","volume":"294","author":"FL Heppner","year":"2001","unstructured":"Heppner, F. L. et al. Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies. Science 294, 178\u2013182 (2001)","journal-title":"Science"},{"key":"BFnature01457_CR15","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/S0968-0004(02)02106-0","volume":"27","author":"D Westaway","year":"2002","unstructured":"Westaway, D. & Carlson, G. A. Mammalian prion proteins: enigma, variation and vaccination. Trends Biochem. Sci. 27, 301\u2013307 (2002)","journal-title":"Trends Biochem. Sci."},{"key":"BFnature01457_CR16","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1038\/4022","volume":"4","author":"MA Klein","year":"1998","unstructured":"Klein, M. A. et al. PrP expression in B lymphocytes is not required for prion neuroinvasion. Nature Med. 4, 1429\u20131433 (1998)","journal-title":"Nature Med."},{"key":"BFnature01457_CR17","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1126\/science.288.5469.1257","volume":"288","author":"F Montrasio","year":"2000","unstructured":"Montrasio, F. et al. Impaired prion replication in spleens of mice lacking functional follicular dendritic cells. Science 288, 1257\u20131259 (2000)","journal-title":"Science"},{"key":"BFnature01457_CR18","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1038\/15264","volume":"5","author":"KL Brown","year":"1999","unstructured":"Brown, K. L. et al. Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells. Nature Med. 5, 1308\u20131312 (1999)","journal-title":"Nature Med."},{"key":"BFnature01457_CR19","doi-asserted-by":"crossref","first-page":"7534","DOI":"10.1128\/JVI.68.11.7534-7536.1994","volume":"68","author":"D McKenzie","year":"1994","unstructured":"McKenzie, D., Kaczkowski, J., Marsh, R. & Aiken, J. Amphotericin B delays both scrapie agent replication and PrP-res accumulation early in infection. J. Virol. 68, 7534\u20137536 (1994)","journal-title":"J. Virol."},{"key":"BFnature01457_CR20","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1128\/JVI.69.1.506-508.1995","volume":"69","author":"L Ingrosso","year":"1995","unstructured":"Ingrosso, L., Ladogana, A. & Pocchiari, M. Congo red prolongs the incubation period in scrapie-infected hamsters. J. Virol. 69, 506\u2013508 (1995)","journal-title":"J. Virol."},{"key":"BFnature01457_CR21","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0140-6736(98)05395-1","volume":"353","author":"C Farquhar","year":"1999","unstructured":"Farquhar, C., Dickinson, A. & Bruce, M. Prophylactic potential of pentosan polysulphate in transmissible spongiform encephalopathies. Lancet 353, 117 (1999)","journal-title":"Lancet"},{"key":"BFnature01457_CR22","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1212\/WNL.58.12.1720","volume":"58","author":"P Brown","year":"2002","unstructured":"Brown, P. Drug therapy in human and experimental transmissible spongiform encephalopathy. Neurology 58, 1720\u20131725 (2002)","journal-title":"Neurology"},{"key":"BFnature01457_CR23","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0140-6736(02)09513-2","volume":"360","author":"S Sethi","year":"2002","unstructured":"Sethi, S., Lipford, G., Wagner, H. & Kretzschmar, H. Postexposure prophylaxis against prion disease with a stimulator of innate immunity. Lancet 360, 229\u2013230 (2002)","journal-title":"Lancet"},{"key":"BFnature01457_CR24","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0002-9440(10)64151-X","volume":"161","author":"EM Sigurdsson","year":"2002","unstructured":"Sigurdsson, E. M. et al. Immunisation delays the onset of prion disease in mice. Am. J. Pathol. 161, 13\u201317 (2002)","journal-title":"Am. J. Pathol."},{"key":"BFnature01457_CR25","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1038\/78682","volume":"6","author":"F Bard","year":"2000","unstructured":"Bard, F. et al. Peripherally administered antibodies against amyloid \u03b2-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nature Med. 6, 916\u2013919 (2000)","journal-title":"Nature Med."},{"key":"BFnature01457_CR26","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/379339a0","volume":"379","author":"S Brandner","year":"1996","unstructured":"Brandner, S. et al. Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature 379, 339\u2013343 (1996)","journal-title":"Nature"},{"key":"BFnature01457_CR27","first-page":"197","volume":"74","author":"DJ Anstee","year":"1991","unstructured":"Anstee, D. J. et al. New monoclonal antibodies in CD44 and CD58: their use to quantify CD44 and CD58 on normal human erythrocytes and to compare the distribution of CD44 and CD58 in human tissues. Immunology 74, 197\u2013205 (1991)","journal-title":"Immunology"},{"key":"BFnature01457_CR28","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1042\/bj2561043","volume":"256","author":"ND Avent","year":"1988","unstructured":"Avent, N. D. et al. Protein-sequence studies on Rh-related polypeptides suggest the presence of at least two groups of proteins which associate in the human red-cell membrane. Biochem. J. 256, 1043\u20131046 (1988)","journal-title":"Biochem. J."},{"key":"BFnature01457_CR29","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/0021-9975(68)90005-4","volume":"78","author":"AG Dickinson","year":"1968","unstructured":"Dickinson, A. G., Meikle, V. M. & Fraser, H. Identification of a gene which controls the incubation period of some strains of scrapie agent in mice. J. Comp. Pathol. 78, 293\u2013299 (1968)","journal-title":"J. Comp. Pathol."},{"key":"BFnature01457_CR30","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S0140-6736(01)05403-4","volume":"358","author":"JD Wadsworth","year":"2001","unstructured":"Wadsworth, J. D. et al. Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay. Lancet 358, 171\u2013180 (2001)","journal-title":"Lancet"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature01457.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature01457","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature01457.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:13:25Z","timestamp":1684433605000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature01457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":30,"journal-issue":{"issue":"6927","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["BFnature01457"],"URL":"https:\/\/doi.org\/10.1038\/nature01457","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3]]}}}