{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:07:05Z","timestamp":1769634425231,"version":"3.49.0"},"reference-count":99,"publisher":"Springer Science and Business Media LLC","issue":"6928","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2003,3]]},"DOI":"10.1038\/nature01513","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T21:40:57Z","timestamp":1047505257000},"page":"216-225","source":"Crossref","is-referenced-by-count":401,"title":["From words to literature in structural proteomics"],"prefix":"10.1038","volume":"422","author":[{"given":"Andrej","family":"Sali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Glaeser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Earnest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Baumeister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFnature01513_CR1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0092-8674(00)80922-8","volume":"92","author":"B Alberts","year":"1998","unstructured":"Alberts, B. The cell as a collection of protein machines \u2014 preparing the next generation of molecular biologists. Cell 92, 291\u2013294 (1998).","journal-title":"Cell"},{"key":"BFnature01513_CR2","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/S0968-0004(00)01720-5","volume":"25","author":"W Baumeister","year":"2000","unstructured":"Baumeister, W. & Steven, A. C. Macromolecular electron microscopy in the era of structural genomics. Trends Biochem. Sci. 25, 624\u2013631 (2000).","journal-title":"Trends Biochem. Sci."},{"key":"BFnature01513_CR3","doi-asserted-by":"crossref","first-page":"M20","DOI":"10.1016\/S0968-0004(99)01494-2","volume":"24","author":"A Sali","year":"1999","unstructured":"Sali, A. & Kuriyan, J. Challenges at the frontiers of structural biology. Trends Biochem. Sci. 24, M20\u2013M24 (1999).","journal-title":"Trends Biochem. Sci."},{"key":"BFnature01513_CR4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/1615-9861(200201)2:1<11::AID-PROT11>3.0.CO;2-T","volume":"2","author":"CA Orengo","year":"2002","unstructured":"Orengo, C. A. et al. The CATH protein family database: a resource for structural and functional annotation of genomes. Proteomics 2, 11\u201321 (2002).","journal-title":"Proteomics"},{"key":"BFnature01513_CR5","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/(SICI)1097-0134(19990601)35:4<408::AID-PROT4>3.0.CO;2-A","volume":"35","author":"S Govindarajan","year":"1999","unstructured":"Govindarajan, S., Recabarren, R. & Goldstein, R. A. Estimating the total number of protein folds. Proteins 35, 408\u2013414 (1999).","journal-title":"Proteins"},{"key":"BFnature01513_CR6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/47048","volume":"402","author":"EM Marcotte","year":"1999","unstructured":"Marcotte, E. M., Pellegrini, M., Thompson, M. J., Yeates, T. O. & Eisenberg, D. A combined algorithm for genome-wide prediction of protein function. Nature 402, 83\u201386 (1999).","journal-title":"Nature"},{"key":"BFnature01513_CR7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/nar\/30.1.31","volume":"30","author":"HW Mewes","year":"2002","unstructured":"Mewes, H. W. et al. MIPS: a database for genomes and protein sequences. Nucleic Acids Res. 30, 31\u201334 (2002).","journal-title":"Nucleic Acids Res."},{"key":"BFnature01513_CR8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/nar\/29.1.75","volume":"29","author":"MC Costanzo","year":"2001","unstructured":"Costanzo, M. C. et al. YPD, PombePD and WormPD: model org anism volumes of the BioKnowledge library, an integrated resource for protein information. Nucleic Acids Res. 29, 75\u201379 (2001).","journal-title":"Nucleic Acids Res."},{"key":"BFnature01513_CR9","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nature750","volume":"417","author":"C von Mering","year":"2002","unstructured":"von Mering, C. et al. Comparative assessment of large-scale data sets of protein\u2013protein interactions. Nature 417, 399\u2013403 (2002).","journal-title":"Nature"},{"key":"BFnature01513_CR10","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1073\/pnas.061034498","volume":"98","author":"T Ito","year":"2001","unstructured":"Ito, T. et al. A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc. Natl Acad. Sci. USA 98, 4569\u20134574 (2001).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature01513_CR11","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/35001009","volume":"403","author":"P Uetz","year":"2000","unstructured":"Uetz, P. et al. A comprehensive analysis of protein\u2013protein interactions in Saccharomyces cerevisiae. Nature 403, 623\u2013627 (2000).","journal-title":"Nature"},{"key":"BFnature01513_CR12","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0014-5793(02)03427-0","volume":"530","author":"P Aloy","year":"2002","unstructured":"Aloy, P. & Russell, R. B. Potential artefacts in protein-interaction networks. FEBS Lett. 530, 253\u2013254 (2002).","journal-title":"FEBS Lett."},{"key":"BFnature01513_CR13","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/415141a","volume":"415","author":"AC Gavin","year":"2002","unstructured":"Gavin, A. C. et al. Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature 415, 141\u2013147 (2002).","journal-title":"Nature"},{"key":"BFnature01513_CR14","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0968-0004(02)02204-1","volume":"27","author":"P Aloy","year":"2002","unstructured":"Aloy, P. & Russell, R. B. The third dimension for protein interactions and complexes. Trends Biochem. Sci. 27, 633\u2013638 (2002).","journal-title":"Trends Biochem. Sci."},{"key":"BFnature01513_CR15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1101\/gr.205602","volume":"2","author":"R Jansen","year":"2002","unstructured":"Jansen, R., Greenbaum, D. & Gerstein, M. Relating whole-genome expression data with protein-protein interactions. Genome Res. 2, 37\u201346 (2002).","journal-title":"Genome Res."},{"key":"BFnature01513_CR16","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/ng776","volume":"4","author":"H Ge","year":"2001","unstructured":"Ge, H., Liu, Z., Church, G. M. & Vidal, M. Correlation between transcriptome and interactome mapping data from Saccharomyces cerevisiae. Nature Genet. 4, 482\u2013486 (2001).","journal-title":"Nature Genet."},{"key":"BFnature01513_CR17","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0168-9525(02)02763-4","volume":"10","author":"AM Edwards","year":"2002","unstructured":"Edwards, A. M. et al. Bridging structural biology and genomics: assessing protein interaction data with known complexes. Trends Genet. 10, 529\u2013536 (2002).","journal-title":"Trends Genet."},{"key":"BFnature01513_CR18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/415123a","volume":"415","author":"A Kumar","year":"2002","unstructured":"Kumar, A. & Snyder, M. Protein complexes take the bait. Nature 415, 123\u2013124 (2002).","journal-title":"Nature"},{"key":"BFnature01513_CR19","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/417894a","volume":"417","author":"A Abbott","year":"2002","unstructured":"Abbott, A. The society of proteins. Nature 417, 894\u2013896 (2002).","journal-title":"Nature"},{"key":"BFnature01513_CR20","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/nar\/30.1.245","volume":"30","author":"J Westbrook","year":"2002","unstructured":"Westbrook, J. et al. The Protein Data Bank: unifying the archive. Nucleic Acids Res. 30, 245\u2013248 (2002).","journal-title":"Nucleic Acids Res."},{"key":"BFnature01513_CR21","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1126\/science.1059493","volume":"292","author":"P Cramer","year":"2001","unstructured":"Cramer, P., Bushnell, D. A. & Kornberg, R. D. Structural basis of transcription: RNA polymerase II at 2.8 \u00c5ngstrom resolution. Science 292, 1863\u20131876 (2001).","journal-title":"Science"},{"key":"BFnature01513_CR22","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1126\/science.289.5481.905","volume":"289","author":"N Ban","year":"2000","unstructured":"Ban, N., Nissen, P., Hansen, J., Moore, P. B. & Steitz, T. A. The complete atomic structure of the large ribosomal subunit at 2.4 \u00c5 resolution. Science 289, 905\u2013920 (2000).","journal-title":"Science"},{"key":"BFnature01513_CR23","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0092-8674(01)00546-3","volume":"107","author":"J Harms","year":"2001","unstructured":"Harms, J. et al. High resolution structure of the large ribosomal subunit from a mesophilic eubacterium. Cell 107, 679\u2013688 (2001).","journal-title":"Cell"},{"key":"BFnature01513_CR24","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/35030006","volume":"407","author":"BT Wimberly","year":"2000","unstructured":"Wimberly, B. T. et al. Structure of the 30S ribosomal subunit. Nature 407, 327\u2013339 (2000).","journal-title":"Nature"},{"key":"BFnature01513_CR25","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1126\/science.1060089","volume":"292","author":"MM Yusupov","year":"2001","unstructured":"Yusupov, M. M. et al. Crystal structure of the ribosome at 5.5 \u00c5 resolution. Science 292, 883\u2013896 (2001).","journal-title":"Science"},{"key":"BFnature01513_CR26","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/80754","volume":"7","author":"E Abola","year":"2000","unstructured":"Abola, E., Kuhn, P., Earnest, T. & Stevens, R. C. Automation of X-ray crystallography. Nature Struct. Biol. 7, 973\u2013977 (2000).","journal-title":"Nature Struct. Biol."},{"key":"BFnature01513_CR27","unstructured":"Snell, G. et al. Automatic sample mounting and alignment system for biological crystallography. J. Synchrotron Radiat. (in the press)."},{"key":"BFnature01513_CR28","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/13783","volume":"23","author":"SK Burley","year":"1999","unstructured":"Burley, S. K. et al. Structural genomics: beyond the Human Genome Project. Nature Genet. 23, 151\u2013157 (1999).","journal-title":"Nature Genet."},{"key":"BFnature01513_CR29","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/88640","volume":"8","author":"D Vitkup","year":"2001","unstructured":"Vitkup, D., Melamud, E., Moult, J. & Sander, C. Completeness in structural genomics. Nature Struct. Biol. 8, 559\u2013566 (2001).","journal-title":"Nature Struct. Biol."},{"key":"BFnature01513_CR30","doi-asserted-by":"crossref","unstructured":"Structural genomics. Nature Struct. Biol. 7 (Suppl.), 927\u2013994 (2000).","DOI":"10.1038\/80689"},{"key":"BFnature01513_CR31","volume-title":"Three-dimensional Electron Microscopy of Macromolecular Assemblies","author":"J Frank","year":"1996","unstructured":"Frank, J. Three-dimensional Electron Microscopy of Macromolecular Assemblies (Academic, London, 1996)."},{"key":"BFnature01513_CR32","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0022-2836(05)80271-2","volume":"213","author":"R Henderson","year":"1990","unstructured":"Henderson, R., Baldwin, J. M. & Ceska, T. A. Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy. J. Mol. Biol. 213, 899\u2013929 (1990).","journal-title":"J. Mol. Biol."},{"key":"BFnature01513_CR33","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/367614a0","volume":"367","author":"W Kuhlbrandt","year":"1994","unstructured":"Kuhlbrandt, W., Wang, D. N. & Fujiyoshi, Y. Atomic model of plant light-harvesting complex by electron crystallography. Nature 367, 614\u2013621 (1994).","journal-title":"Nature"},{"key":"BFnature01513_CR34","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1006\/jmbi.1996.0328","volume":"259","author":"N Grigorieff","year":"1996","unstructured":"Grigorieff, N., Ceska, T. A., Downing, K. H., Baldwin, J. M. & Henderson, R. Electron-crystallographic refinement of the structure of bacteriorhodopsin. J. Mol. Biol. 259, 393\u2013421 (1996).","journal-title":"J. Mol. Biol."},{"key":"BFnature01513_CR35","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/34465","volume":"391","author":"E Nogales","year":"1998","unstructured":"Nogales, E., Wolf, S. G. & Downing, K. H. Structure of the \u03b1\u03b2 tubulin dimer by electron crystallography. Nature 391, 199\u2013203 (1998).","journal-title":"Nature"},{"key":"BFnature01513_CR36","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1006\/jmbi.1998.2529","volume":"286","author":"K Mitsuoka","year":"1999","unstructured":"Mitsuoka, K. et al. The structure of bacteriorhodopsin at 3.0 \u00c5 resolution based on electron crystallography: implication of the charge distribution. J. Mol. Biol. 286, 861\u2013882 (1999).","journal-title":"J. Mol. Biol."},{"key":"BFnature01513_CR37","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35036519","volume":"407","author":"K Murata","year":"2000","unstructured":"Murata, K. et al. Structural determinants of water permeation through aquaporin-1. Nature 407, 599\u2013605 (2000).","journal-title":"Nature"},{"key":"BFnature01513_CR38","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1006\/jmbi.2001.5077","volume":"313","author":"J Lowe","year":"2001","unstructured":"Lowe, J., Li, H., Downing, K. H. & Nogales, E. Refined structure of \u03b1\u03b2-tubulin at 3.5 \u00c5 resolution. J. Mol. Biol. 313, 1045\u20131057 (2001).","journal-title":"J. Mol. Biol."},{"key":"BFnature01513_CR39","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/386091a0","volume":"386","author":"JF Conway","year":"1997","unstructured":"Conway, J. F. et al. Visualization of a 4-helix bundle in the hepatitis B virus capsid by cryo-electron microscopy. Nature 386, 91\u201394 (1997).","journal-title":"Nature"},{"key":"BFnature01513_CR40","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/386088a0","volume":"386","author":"B Bottcher","year":"1997","unstructured":"Bottcher, B., Wynne, S. A. & Crowther, R. A. Determination of the fold of the core protein of hepatitis B virus by cryo-electron microscopy. Nature 386, 88\u201391 (1997).","journal-title":"Nature"},{"key":"BFnature01513_CR41","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/S0969-2126(02)00827-4","volume":"10","author":"HL Li","year":"2002","unstructured":"Li, H. L., DeRosier, D. J., Nicholson, W. V., Nogales, E. & Downing, K. H. Microtubule structure at 8 \u00c5 resolution. Structure 10, 1317\u20131328 (2002).","journal-title":"Structure"},{"key":"BFnature01513_CR42","doi-asserted-by":"crossref","first-page":"5979","DOI":"10.1093\/emboj\/cdf601","volume":"21","author":"B Rockel","year":"2002","unstructured":"Rockel, B., Peters, J., Kuhlmorgen, B., Glaeser, R. M. & Baumeister, W. A giant protease with a twist: the TPP II complex from Drosophila studied by electron microscopy. EMBO J. 21, 5979\u20135984 (2002).","journal-title":"EMBO J."},{"key":"BFnature01513_CR43","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1017\/S003358350000305X","volume":"28","author":"R Henderson","year":"1995","unstructured":"Henderson, R. The potential and limitations of neutrons, electrons and X-rays for atomic resolution microscopy of unstained biological molecules. Q. Rev. Biophys. 28, 171\u2013193 (1995).","journal-title":"Q. Rev. Biophys."},{"key":"BFnature01513_CR44","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/jsbi.2000.4314","volume":"132","author":"B Carragher","year":"2000","unstructured":"Carragher, B. et al. Leginon: an automated system for acquisition of images from vitreous ice specimens. J. Struct. Biol 132, 33\u201345 (2000).","journal-title":"J. Struct. Biol"},{"key":"BFnature01513_CR45","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1006\/jsbi.2001.4404","volume":"135","author":"PJ Zhang","year":"2001","unstructured":"Zhang, P. J., Beatty, A., Milne, J. L. S. & Subramaniam, S. Automated data collection with a Tecnai 12 electron microscope: applications for molecular imaging by cryomicroscopy. J. Struct. Biol. 135, 251\u2013261 (2001).","journal-title":"J. Struct. Biol."},{"key":"BFnature01513_CR46","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1006\/jsbi.2001.4415","volume":"135","author":"YX Zhu","year":"2001","unstructured":"Zhu, Y. X., Carragher, B., Kriegman, D. J., Milligan, R. A. & Potter, C. S. Automated identification of filaments in cryoelectron microscopy images. J. Struct. Biol. 135, 302\u2013312 (2001).","journal-title":"J. Struct. Biol."},{"key":"BFnature01513_CR47","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/jsbi.2002.4435","volume":"136","author":"MG Rossmann","year":"2001","unstructured":"Rossmann, M. G., Bernal, R. & Pletnev, S. V. Combining electron microscopic with X-ray crystallographic structures. J. Struct. Biol. 136, 190\u2013200 (2001).","journal-title":"J. Struct. Biol."},{"key":"BFnature01513_CR48","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1006\/jsbi.2000.4350","volume":"133","author":"W Wriggers","year":"2001","unstructured":"Wriggers, W. & Birmanns, S. Using Situs for flexible and rigid-body fitting of multiresolution single-molecule data. J. Struct. Biol. 133, 193\u2013202 (2001).","journal-title":"J. Struct. Biol."},{"key":"BFnature01513_CR49","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1006\/jsbi.1998.4074","volume":"125","author":"N Volkmann","year":"1999","unstructured":"Volkmann, N. & Hanein, D. Quantitative fitting of atomic models into observed densities derived by electron microscopy. J. Struct. Biol. 125, 176\u2013184 (1999).","journal-title":"J. Struct. Biol."},{"key":"BFnature01513_CR50","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1006\/jmbi.2002.5438","volume":"317","author":"P Chacon","year":"2002","unstructured":"Chacon, P. & Wriggers, W. Multi-resolution contour-based fitting of macromolecular structures. J. Mol. Biol. 317, 375\u2013384 (2002).","journal-title":"J. Mol. Biol."},{"key":"BFnature01513_CR51","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1073\/pnas.87.5.1950","volume":"87","author":"A Malhotra","year":"1990","unstructured":"Malhotra, A., Tan, R. K. & Harvey, S. C. Prediction of the three-dimensional structure of Escherichia coli 30S ribosomal subunit: a molecular mechanics approach. Proc. Natl Acad. Sci. USA 87, 1950\u20131954 (1990).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature01513_CR52","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1093\/embo-reports\/kvf135","volume":"3","author":"P Aloy","year":"2002","unstructured":"Aloy, P. et al. A complex prediction: three-dimensional model of the yeast exosome. EMBO Rep. 3, 628\u2013635 (2002).","journal-title":"EMBO Rep."},{"key":"BFnature01513_CR53","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0092-8674(01)00539-6","volume":"107","author":"CM Spahn","year":"2001","unstructured":"Spahn, C. M. et al. Structure of the 80S ribosome from Saccharomyces cerevisiae\u2013tRNA-ribosome and subunit-subunit interactions. Cell 107, 373\u2013386 (2001).","journal-title":"Cell"},{"key":"BFnature01513_CR54","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0959-440X(02)00378-0","volume":"12","author":"W Baumeister","year":"2002","unstructured":"Baumeister, W. Electron tomography: towards visualizing the molecular organization of the cytoplasm. Curr. Opin. Struct. Biol. 12, 679\u2013684 (2002).","journal-title":"Curr. Opin. Struct. Biol."},{"key":"BFnature01513_CR55","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0962-8924(98)01423-8","volume":"9","author":"W Baumeister","year":"1999","unstructured":"Baumeister, W., Grimm, R. & Walz, J. Electron tomography of molecules and cells. Trends Cell Biol. 9, 81\u201385 (1999).","journal-title":"Trends Cell Biol."},{"key":"BFnature01513_CR56","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1126\/science.1076184","volume":"298","author":"O Medalia","year":"2002","unstructured":"Medalia, O. et al. Macromolecular architecture in eukaryotic cells visualized by cryoelectron tomography. Science 298, 1209\u20131213 (2002).","journal-title":"Science"},{"key":"BFnature01513_CR57","doi-asserted-by":"crossref","unstructured":"Grunewald, K., Medalia, O., Gross, A., Steven, A. & Baumeister, W. Prospects of electron cryotomography to visualize macromolecular complexes inside cellular compartments: implications of crowding. Biophys. Chem. (in press).","DOI":"10.1016\/S0301-4622(02)00307-1"},{"key":"BFnature01513_CR58","doi-asserted-by":"crossref","first-page":"14245","DOI":"10.1073\/pnas.230282097","volume":"97","author":"J Bohm","year":"2000","unstructured":"Bohm, J. et al. Toward detecting and identifying macromolecules in a cellular context: template matching applied to electron tomograms. Proc. Natl Acad. Sci. USA 97, 14245\u201314250 (2000).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature01513_CR59","doi-asserted-by":"crossref","first-page":"14153","DOI":"10.1073\/pnas.172520299","volume":"99","author":"AS Frangakis","year":"2002","unstructured":"Frangakis, A. S. et al. Identification of macromolecular complexes in electron cryotomograms of phantom cells. Proc. Natl Acad. Sci. USA 99, 14153\u201314158 (2002).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature01513_CR60","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0006-3495(98)74028-7","volume":"74","author":"R Grimm","year":"1998","unstructured":"Grimm, R. et al. Electron tomography of ice-embedded prokaryotic cells. Biophys. J. 74, 1031\u20131042 (1998).","journal-title":"Biophys. J."},{"key":"BFnature01513_CR61","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1016\/S0167-7799(02)02017-6","volume":"20","author":"J Plitzko","year":"2002","unstructured":"Plitzko, J. et al. In vivo veritas: electron cryotomography of cells. Trends Biotechnol. 20, S40\u2013S44 (2002).","journal-title":"Trends Biotechnol."},{"key":"BFnature01513_CR62","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1006\/jsbi.1997.3933","volume":"120","author":"AJ Koster","year":"1997","unstructured":"Koster, A. J. et al. Perspectives of molecular and cellular electron tomography. J. Struct. Biol. 120, 276\u2013308 (1997).","journal-title":"J. Struct. Biol."},{"key":"BFnature01513_CR63","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1006\/jsbi.1999.4172","volume":"128","author":"RM Glaeser","year":"1999","unstructured":"Glaeser, R. M. Electron crystallography: present excitement, a nod to the past, anticipating the future. J. Struct. Biol. 128, 3\u201314 (1999).","journal-title":"J. Struct. Biol."},{"key":"BFnature01513_CR64","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0092-8674(00)81515-9","volume":"98","author":"GY Zhang","year":"1999","unstructured":"Zhang, G. Y. et al. Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 \u00c5 resolution. Cell 98, 811\u2013824 (1999).","journal-title":"Cell"},{"key":"BFnature01513_CR65","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature00860","volume":"418","author":"J Fiaux","year":"2002","unstructured":"Fiaux, J., Bertelsen, E. B., Horwich, A. L. & Wuthrich, K. NMR analysis of a 900K GroEL\u2013GroES complex. Nature 418, 207\u2013211 (2002).","journal-title":"Nature"},{"key":"BFnature01513_CR66","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1073\/pnas.042684599","volume":"99","author":"A Yee","year":"2002","unstructured":"Yee, A. et al. An NMR approach to structural proteomics. Proc. Natl Acad. Sci. USA 99, 1825\u20131830 (2002).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature01513_CR67","doi-asserted-by":"crossref","first-page":"10225","DOI":"10.1021\/bi990897g","volume":"38","author":"D Fushman","year":"1999","unstructured":"Fushman, D., Xu, R. & Cowburn, D. Direct determination of changes of interdomain orientation on ligation: use of the orientational dependence of 15N NMR relaxation in Abl SH(32). Biochemistry 38, 10225\u201310230 (1999).","journal-title":"Biochemistry"},{"key":"BFnature01513_CR68","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0022-2836(02)00018-9","volume":"318","author":"T Nakanishi","year":"2002","unstructured":"Nakanishi, T. et al. Determination of the interface of a large protein complex by transferred cross-saturation measurements. J. Mol. Biol. 318, 245\u2013249 (2002).","journal-title":"J. Mol. Biol."},{"key":"BFnature01513_CR69","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nrd748","volume":"1","author":"M Pellecchia","year":"2002","unstructured":"Pellecchia, M., Sem, D. S. & Wuthrich, K. NMR in drug discovery. Nature Rev. Drug Discov. 1, 211\u2013219 (2002).","journal-title":"Nature Rev. Drug Discov."},{"key":"BFnature01513_CR70","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev.biophys.31.082901.134202","volume":"31","author":"J Frank","year":"2002","unstructured":"Frank, J. Single-particle imaging of macromolecules by cryo-electron microscopy. Annu. Rev. Biophys. Biomol. Struct. 31, 303\u2013319 (2002).","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"BFnature01513_CR71","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S1047-8477(02)00009-6","volume":"138","author":"N Volkmann","year":"2002","unstructured":"Volkmann, N. A novel three-dimensional variant of the watershed transform for segmentation of electron density maps. J. Struct. Biol. 138, 123\u2013129 (2002).","journal-title":"J. Struct. Biol."},{"key":"BFnature01513_CR72","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1083\/jcb.148.4.635","volume":"148","author":"MP Rout","year":"2000","unstructured":"Rout, M. P. et al. The yeast nuclear pore complex: composition, architecture, and transport mechanism. J. Cell Biol. 148, 635\u2013651 (2000).","journal-title":"J. Cell Biol."},{"key":"BFnature01513_CR73","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1021\/ac991081o","volume":"72","author":"J Rappsilber","year":"2000","unstructured":"Rappsilber, J., Siniossoglou, S., Hurt, E. C. & Mann, M. A generic strategy to analyze the spatial organization of multi-protein complexes by cross-linking and mass spectrometry. Anal. Chem. 72, 267\u2013275 (2000).","journal-title":"Anal. Chem."},{"key":"BFnature01513_CR74","doi-asserted-by":"crossref","first-page":"5802","DOI":"10.1073\/pnas.090099097","volume":"97","author":"MM Young","year":"2000","unstructured":"Young, M. M. et al. High throughput protein fold identification by using experimental constraints derived from intramolecular cross-links and mass spectrometry. Proc. Natl Acad. Sci. USA 97, 5802\u20135806 (2000).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature01513_CR75","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1073\/pnas.94.2.385","volume":"94","author":"G Neubauer","year":"1997","unstructured":"Neubauer, G. et al. Identification of the proteins of the yeast U1 small nuclear ribonucleoprotein complex by mass spectrometry. Proc. Natl Acad. Sci. USA 94, 385\u2013390 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature01513_CR76","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/1700","volume":"20","author":"G Neubauer","year":"1998","unstructured":"Neubauer, G. et al. Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. Nature Genet. 20, 46\u201350 (1998).","journal-title":"Nature Genet."},{"key":"BFnature01513_CR77","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/45977","volume":"402","author":"WA Houry","year":"1999","unstructured":"Houry, W. A., Frishman, D., Eckerskorn, C., Lottspeich, F. & Hartl, F. U. Identification of in vivo substrates of the chaperonin GroEL. Nature 402, 147\u2013154 (1999).","journal-title":"Nature"},{"key":"BFnature01513_CR78","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/415180a","volume":"415","author":"Y Ho","year":"2002","unstructured":"Ho, Y. et al. Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature 415, 180\u2013183 (2002).","journal-title":"Nature"},{"key":"BFnature01513_CR79","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1021\/bi011854e","volume":"41","author":"I Miras","year":"2002","unstructured":"Miras, I., Schaeffer, F., Beguin, P. & Alzari, P. M. Mapping by site-directed mutagenesis of the region responsible for cohesin-dockerin interaction on the surface of the seventh cohesin domain of Clostridium thermocellum CipA. Biochemistry 41, 2115\u20132119 (2002).","journal-title":"Biochemistry"},{"key":"BFnature01513_CR80","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/0076-6879(91)02020-A","volume":"202","author":"JA Wells","year":"1991","unstructured":"Wells, J. A. Systematic mutational analyses of protein-protein interfaces. Methods Enzymol. 202, 390\u2013411 (1991).","journal-title":"Methods Enzymol."},{"key":"BFnature01513_CR81","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1073\/pnas.91.1.113","volume":"91","author":"L Jin","year":"1994","unstructured":"Jin, L., Cohen, F. E. & Wells, J. A. Structure from function: screening structural models with functional data. Proc. Natl Acad. Sci. USA 91, 113\u2013117 (1994).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature01513_CR82","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1126\/science.270.5235.467","volume":"270","author":"M Schena","year":"1995","unstructured":"Schena, M., Shalon, D., Davis, R. W. & Brown, P. O. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 270, 467\u2013470 (1995).","journal-title":"Science"},{"key":"BFnature01513_CR83","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/35015701","volume":"405","author":"DJ Lockhart","year":"2000","unstructured":"Lockhart, D. J. & Winzeler, E. A. Genomics, gene expression and DNA arrays. Nature 405, 827\u2013836 (2000).","journal-title":"Nature"},{"key":"BFnature01513_CR84","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1126\/science.1065659","volume":"294","author":"D Baker","year":"2001","unstructured":"Baker, D. & Sali, A. Protein structure prediction and structural genomics. Science 294, 93\u201396 (2001).","journal-title":"Science"},{"key":"BFnature01513_CR85","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev.biophys.30.1.173","volume":"30","author":"R Bonneau","year":"2001","unstructured":"Bonneau, R. & Baker, D. Ab initio protein structure prediction: progress and prospects. Annu. Rev. Biophys. Biomol. Struct. 30, 173\u2013189 (2001).","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"BFnature01513_CR86","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0022-2836(02)00698-8","volume":"322","author":"R Bonneau","year":"2002","unstructured":"Bonneau, R. et al. De novo prediction of three-dimensional structures for major protein families. J. Mol. Biol. 322, 65\u201378 (2002).","journal-title":"J. Mol. Biol."},{"key":"BFnature01513_CR87","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev.biophys.29.1.291","volume":"29","author":"MA Marti-Renom","year":"2000","unstructured":"Marti-Renom, M. A. et al. Comparative protein structure modeling of genes and genomes. Annu. Rev. Biophys. Biomol. Struct. 29, 291\u2013325 (2000).","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"BFnature01513_CR88","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1006\/jmbi.2000.3615","volume":"297","author":"FS Domingues","year":"2000","unstructured":"Domingues, F. S., Lackner, P., Andreeva, A. & Sippl, M. J. Structure-based evaluation of sequence comparison and fold recognition alignment accuracy. J. Mol. Biol 297, 1003\u20131013 (2000).","journal-title":"J. Mol. Biol"},{"key":"BFnature01513_CR89","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/nar\/30.1.255","volume":"30","author":"U Pieper","year":"2002","unstructured":"Pieper, U., Eswar, N., Stuart, A. C., Ilyin, V. A. & Sali, A. MODBASE, a database of annotated comparative protein structure models. Nucleic Acids Res. 30, 255\u2013259 (2002).","journal-title":"Nucleic Acids Res."},{"key":"BFnature01513_CR90","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0959-440X(02)00285-3","volume":"12","author":"GR Smith","year":"2002","unstructured":"Smith, G. R. & Sternberg, M. J. E. Prediction of protein-protein interactions by docking methods. Curr. Opin. Struct. Biol. 12, 28\u201335 (2002).","journal-title":"Curr. Opin. Struct. Biol."},{"key":"BFnature01513_CR91","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nsb0396-233","volume":"3","author":"NCJ Strynadka","year":"1996","unstructured":"Strynadka, N. C. J. et al. Molecular docking programs successfully predict the binding of a \u03b2-lactamase inhibitory protein to TEM-1 \u03b2-lactamase. Nature Struct. Biol. 3, 233\u2013239 (1996).","journal-title":"Nature Struct. Biol."},{"key":"BFnature01513_CR92","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/47056","volume":"402","author":"AJ Enright","year":"1999","unstructured":"Enright, A. J., Iliopoulos, I., Kyrpides, N. C. & Ouzounis, C. A. Protein interaction maps for complete genomes based on gene fusion events. Nature 402, 86\u201390 (1999).","journal-title":"Nature"},{"key":"BFnature01513_CR93","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1073\/pnas.96.6.2896","volume":"96","author":"R Overbeek","year":"1999","unstructured":"Overbeek, R., Fonstein, M., D'Souza, M., Pusch, G. D. & Maltsev, N. The use of gene clusters to infer functional coupling. Proc. Natl Acad. Sci. USA 96, 2896\u20132901 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature01513_CR94","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1006\/jmbi.2000.3732","volume":"299","author":"CS Goh","year":"2000","unstructured":"Goh, C. S., Bogan, A. A., Joachimiak, M., Walther, D. & Cohen, F. E. Co-evolution of proteins with their interaction partners. J. Mol. Biol. 299, 283\u2013293 (2000).","journal-title":"J. Mol. Biol."},{"key":"BFnature01513_CR95","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/protein\/14.9.609","volume":"14","author":"F Pazos","year":"2001","unstructured":"Pazos, F. & Valencia, A. Similarity of phylogenetic trees as indicator of protein-protein interaction. Protein Eng. 14, 609\u2013614 (2001).","journal-title":"Protein Eng."},{"key":"BFnature01513_CR96","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/prot.10074","volume":"47","author":"F Pazos","year":"2002","unstructured":"Pazos, F. & Valencia, A. In silico two-hybrid system for the selection of physically interacting protein pairs. Proteins 47, 219\u2013227 (2002).","journal-title":"Proteins"},{"key":"BFnature01513_CR97","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1006\/jmbi.1996.0167","volume":"257","author":"O Lichtarge","year":"1996","unstructured":"Lichtarge, O., Bourne, H. R. & Cohen, F. E. An evolutionary trace method defines binding surfaces common to protein families. J. Mol. Biol. 257, 342\u2013358 (1996).","journal-title":"J. Mol. Biol."},{"key":"BFnature01513_CR98","doi-asserted-by":"crossref","first-page":"S149","DOI":"10.1093\/bioinformatics\/17.suppl_1.S149","volume":"17","author":"M Lappe","year":"2001","unstructured":"Lappe, M., Park, J., Niggemann, O. & Holm, L. Generating protein interaction maps from incomplete data: application to fold assignment. Bioinformatics 17, S149\u2013S156 (2001).","journal-title":"Bioinformatics"},{"key":"BFnature01513_CR99","doi-asserted-by":"crossref","first-page":"5896","DOI":"10.1073\/pnas.092147999","volume":"99","author":"P Aloy","year":"2002","unstructured":"Aloy, P. & Russell, R. B. Interrogating protein interaction networks through structural biology. Proc. Natl Acad. Sci. USA 99, 5896\u20135901 (2002).","journal-title":"Proc. Natl Acad. Sci. USA"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature01513.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature01513","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature01513.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:13:56Z","timestamp":1684433636000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature01513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":99,"journal-issue":{"issue":"6928","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["BFnature01513"],"URL":"https:\/\/doi.org\/10.1038\/nature01513","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3]]}}}