{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:47:07Z","timestamp":1778586427748,"version":"3.51.4"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"6939","license":[{"start":{"date-parts":[[2003,5,18]],"date-time":"2003-05-18T00:00:00Z","timestamp":1053216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2003,5,18]],"date-time":"2003-05-18T00:00:00Z","timestamp":1053216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2003,5,29]]},"DOI":"10.1038\/nature01667","type":"journal-article","created":{"date-parts":[[2003,5,18]],"date-time":"2003-05-18T22:19:56Z","timestamp":1053296396000},"page":"550-555","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1272,"title":["Insulin-regulated hepatic gluconeogenesis through FOXO1\u2013PGC-1\u03b1 interaction"],"prefix":"10.1038","volume":"423","author":[{"given":"Pere","family":"Puigserver","sequence":"first","affiliation":[]},{"given":"James","family":"Rhee","sequence":"additional","affiliation":[]},{"given":"Jerry","family":"Donovan","sequence":"additional","affiliation":[]},{"given":"Christopher J.","family":"Walkey","sequence":"additional","affiliation":[]},{"given":"J. Cliff","family":"Yoon","sequence":"additional","affiliation":[]},{"given":"Francesco","family":"Oriente","sequence":"additional","affiliation":[]},{"given":"Yukari","family":"Kitamura","sequence":"additional","affiliation":[]},{"given":"Jennifer","family":"Altomonte","sequence":"additional","affiliation":[]},{"given":"Hengjiang","family":"Dong","sequence":"additional","affiliation":[]},{"given":"Domenico","family":"Accili","sequence":"additional","affiliation":[]},{"given":"Bruce M.","family":"Spiegelman","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2003,5,18]]},"reference":[{"key":"BFnature01667_CR1","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1007\/BF00281991","volume":"28","author":"RH Unger","year":"1985","unstructured":"Unger, R. H. Glucagon physiology and pathophysiology in the light of new advances. Diabetologia 28, 574\u2013578 (1985)","journal-title":"Diabetologia"},{"key":"BFnature01667_CR2","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1146\/annurev.biochem.66.1.581","volume":"66","author":"RW Hanson","year":"1997","unstructured":"Hanson, R. W. & Reshef, L. Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Annu. Rev. Biochem. 66, 581\u2013611 (1997)","journal-title":"Annu. Rev. Biochem."},{"key":"BFnature01667_CR3","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1515\/JBCPP.1999.10.2.119","volume":"10","author":"RK Hall","year":"1999","unstructured":"Hall, R. K. & Granner, D. K. Insulin regulates expression of metabolic genes through divergent signaling pathways. J. Basic Clin. Physiol. Pharmacol. 10, 119\u2013133 (1999)","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"BFnature01667_CR4","doi-asserted-by":"publisher","first-page":"30169","DOI":"10.1074\/jbc.M004898200","volume":"275","author":"RK Hall","year":"2000","unstructured":"Hall, R. K. et al. Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix\/forkhead proteins. J. Biol. Chem. 275, 30169\u201330175 (2000)","journal-title":"J. Biol. Chem."},{"key":"BFnature01667_CR5","doi-asserted-by":"publisher","first-page":"36324","DOI":"10.1074\/jbc.M003616200","volume":"275","author":"D Schmoll","year":"2000","unstructured":"Schmoll, D. et al. Regulation of glucose-6-phosphatase gene expression by protein kinase B\u03b1 and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity. J. Biol. Chem. 275, 36324\u201336333 (2000)","journal-title":"J. Biol. Chem."},{"key":"BFnature01667_CR6","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/ng890","volume":"32","author":"J Nakae","year":"2002","unstructured":"Nakae, J. et al. Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nature Genet. 32, 245\u2013253 (2002)","journal-title":"Nature Genet."},{"key":"BFnature01667_CR7","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/S0092-8674(00)80595-4","volume":"96","author":"A Brunet","year":"1999","unstructured":"Brunet, A. et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857\u2013868 (1999)","journal-title":"Cell"},{"key":"BFnature01667_CR8","doi-asserted-by":"publisher","first-page":"15982","DOI":"10.1074\/jbc.274.23.15982","volume":"274","author":"J Nakae","year":"1999","unstructured":"Nakae, J., Park, B. C. & Accili, D. Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. J. Biol. Chem. 274, 15982\u201315985 (1999)","journal-title":"J. Biol. Chem."},{"key":"BFnature01667_CR9","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/35093050","volume":"413","author":"JC Yoon","year":"2001","unstructured":"Yoon, J. C. et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413, 131\u2013138 (2001)","journal-title":"Nature"},{"key":"BFnature01667_CR10","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/35093131","volume":"413","author":"S Herzig","year":"2001","unstructured":"Herzig, S. et al. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 413, 179\u2013183 (2001)","journal-title":"Nature"},{"key":"BFnature01667_CR11","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/S0092-8674(00)81410-5","volume":"92","author":"P Puigserver","year":"1998","unstructured":"Puigserver, P. et al. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829\u2013839 (1998)","journal-title":"Cell"},{"key":"BFnature01667_CR12","doi-asserted-by":"publisher","first-page":"17179","DOI":"10.1074\/jbc.274.24.17179","volume":"274","author":"G Rena","year":"1999","unstructured":"Rena, G., Guo, S., Cichy, S. C., Unterman, T. G. & Cohen, P. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J. Biol. Chem. 274, 17179\u201317183 (1999)","journal-title":"J. Biol. Chem."},{"key":"BFnature01667_CR13","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1172\/JCI200112876","volume":"108","author":"J Nakae","year":"2001","unstructured":"Nakae, J., Kitamura, T., Silver, D. L. & Accili, D. The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J. Clin. Invest. 108, 1359\u20131367 (2001)","journal-title":"J. Clin. Invest."},{"key":"BFnature01667_CR14","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1210\/endo.140.7.6856","volume":"140","author":"SK Durham","year":"1999","unstructured":"Durham, S. K. et al. FKHR binds the insulin response element in the insulin-like growth factor binding protein-1 promoter. Endocrinology 140, 3140\u20133146 (1999)","journal-title":"Endocrinology"},{"key":"BFnature01667_CR15","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1128\/MCB.20.7.2411-2422.2000","volume":"20","author":"D Knutti","year":"2000","unstructured":"Knutti, D., Kaul, A. & Kralli, A. A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen. Mol. Cell. Biol. 20, 2411\u20132422 (2000)","journal-title":"Mol. Cell. Biol."},{"key":"BFnature01667_CR16","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/0959-437X(95)80024-7","volume":"5","author":"GJ Darlington","year":"1995","unstructured":"Darlington, G. J., Wang, N. & Hanson, R. W. C\/EBP alpha: a critical regulator of genes governing integrative metabolic processes. Curr. Opin. Genet. Dev. 5, 565\u2013570 (1995)","journal-title":"Curr. Opin. Genet. Dev."},{"key":"BFnature01667_CR17","doi-asserted-by":"publisher","first-page":"13033","DOI":"10.1074\/jbc.274.19.13033","volume":"274","author":"C Arizmendi","year":"1999","unstructured":"Arizmendi, C., Liu, S., Croniger, C., Poli, V. & Friedman, J. E. The transcription factor CCAAT\/enhancer-binding protein beta regulates gluconeogenesis and phosphoenolpyruvate carboxykinase (GTP) gene transcription during diabetes. J. Biol. Chem. 274, 13033\u201313040 (1999)","journal-title":"J. Biol. Chem."},{"key":"BFnature01667_CR18","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.2337\/diabetes.50.11.2425","volume":"50","author":"D Becard","year":"2001","unstructured":"Becard, D. et al. Adenovirus-mediated overexpression of sterol regulatory element binding protein-1c mimics insulin effects on hepatic gene expression and glucose homeostasis in diabetic mice. Diabetes 50, 2425\u20132430 (2001)","journal-title":"Diabetes"},{"key":"BFnature01667_CR19","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1124\/mol.54.2.313","volume":"54","author":"H Zaher","year":"1998","unstructured":"Zaher, H. et al. The involvement of aryl hydrocarbon receptor in the activation of transforming growth factor-beta and apoptosis. Mol. Pharmacol. 54, 313\u2013321 (1998)","journal-title":"Mol. Pharmacol."},{"key":"BFnature01667_CR20","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1126\/science.286.5443.1368","volume":"286","author":"P Puigserver","year":"1999","unstructured":"Puigserver, P. et al. Activation of PPAR\u03b3 coactivator-1 through transcription factor docking. Science 286, 1368\u20131371 (1999)","journal-title":"Science"},{"key":"BFnature01667_CR21","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S1534-5807(02)00401-X","volume":"4","author":"J Nakae","year":"2003","unstructured":"Nakae, J. et al. The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev. Cell 4, 119\u2013129 (2003)","journal-title":"Dev. Cell"},{"key":"BFnature01667_CR22","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1074\/jbc.271.1.203","volume":"271","author":"L Rossetti","year":"1996","unstructured":"Rossetti, L. et al. Hepatic overexpression of insulin-like growth factor-II in adulthood increases basal and insulin-stimulated glucose disposal in conscious mice. J. Biol. Chem. 271, 203\u2013208 (1996)","journal-title":"J. Biol. Chem."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/nature01667.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nature01667","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/nature01667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.nature.com\/articles\/nature01667.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T18:25:59Z","timestamp":1708971959000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature01667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5,18]]},"references-count":22,"journal-issue":{"issue":"6939","published-print":{"date-parts":[[2003,5,29]]}},"alternative-id":["BFnature01667"],"URL":"https:\/\/doi.org\/10.1038\/nature01667","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,5,18]]},"assertion":[{"value":"8 January 2003","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2003","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2003","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}