{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:35:46Z","timestamp":1779363346129,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6970","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1038\/nature02238","type":"journal-article","created":{"date-parts":[[2004,1,7]],"date-time":"2004-01-07T08:23:55Z","timestamp":1073463835000},"page":"154-159","source":"Crossref","is-referenced-by-count":1416,"title":["T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases"],"prefix":"10.1038","volume":"427","author":[{"given":"Thorsten R.","family":"Mempel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah E.","family":"Henrickson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich H.","family":"von Andrian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFnature02238_CR1","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1126\/science.1071065","volume":"296","author":"S Stoll","year":"2002","unstructured":"Stoll, S., Delon, J., Brotz, T. M. & Germain, R. N. Dynamic imaging of T cell\u2013dendritic cell interactions in lymph nodes. Science 296, 1873\u20131876 (2002)","journal-title":"Science"},{"key":"BFnature02238_CR2","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1126\/science.1070051","volume":"296","author":"MJ Miller","year":"2002","unstructured":"Miller, M. J., Wei, S. H., Parker, I. & Cahalan, M. D. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 296, 1869\u20131873 (2002)","journal-title":"Science"},{"key":"BFnature02238_CR3","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/ni928","volume":"4","author":"P Bousso","year":"2003","unstructured":"Bousso, P. & Robey, E. Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes. Nature Immunol. 4, 579\u2013585 (2003)","journal-title":"Nature Immunol."},{"key":"BFnature02238_CR4","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1098\/rspb.1964.0001","volume":"159","author":"JL Gowans","year":"1964","unstructured":"Gowans, J. L. & Knight, E. J. The route of re-circulation of lymphocytes in the rat. Proc. R. Soc. Lond. B 159, 257\u2013282 (1964)","journal-title":"Proc. R. Soc. Lond. B"},{"key":"BFnature02238_CR5","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1126\/science.296.5574.1815","volume":"296","author":"UH von Andrian","year":"2002","unstructured":"von Andrian, U. H. Immunology. T cell activation in six dimensions. Science 296, 1815\u20131817 (2002)","journal-title":"Science"},{"key":"BFnature02238_CR6","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/nri935","volume":"2","author":"MD Cahalan","year":"2002","unstructured":"Cahalan, M. D., Parker, I., Wei, S. H. & Miller, M. J. Two-photon tissue imaging: seeing the immune system in a fresh light. Nature Rev. Immunol. 2, 872\u2013880 (2002)","journal-title":"Nature Rev. Immunol."},{"key":"BFnature02238_CR7","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1038\/nri1222","volume":"3","author":"UH von Andrian","year":"2003","unstructured":"von Andrian, U. H. & Mempel, T. R. Homing and cellular traffic in lymph nodes. Nature Rev. Immunol. 3, 867\u2013878 (2003)","journal-title":"Nature Rev. Immunol."},{"key":"BFnature02238_CR8","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3109\/10739689609148303","volume":"3","author":"UH von Andrian","year":"1996","unstructured":"von Andrian, U. H. Intravital microscopy of the peripheral lymph node microcirculation in mice. Microcirculation 3, 287\u2013300 (1996)","journal-title":"Microcirculation"},{"key":"BFnature02238_CR9","doi-asserted-by":"publisher","first-page":"2604","DOI":"10.1073\/pnas.2628040100","volume":"100","author":"MJ Miller","year":"2003","unstructured":"Miller, M. J., Wei, S. H., Cahalan, M. D. & Parker, I. Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proc. Natl Acad. Sci. USA 100, 2604\u20132609 (2003)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature02238_CR10","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/304030a0","volume":"304","author":"WM Gallatin","year":"1983","unstructured":"Gallatin, W. M., Weissman, I. L. & Butcher, E. C. A cell-surface molecule involved in organ-specific homing of lymphocytes. Nature 304, 30\u201334 (1983)","journal-title":"Nature"},{"key":"BFnature02238_CR11","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1084\/jem.189.3.451","volume":"189","author":"MD Gunn","year":"1999","unstructured":"Gunn, M. D. et al. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J. Exp. Med. 189, 451\u2013460 (1999)","journal-title":"J. Exp. Med."},{"key":"BFnature02238_CR12","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.1002\/(SICI)1521-4141(199809)28:09<2760::AID-IMMU2760>3.0.CO;2-N","volume":"28","author":"F Sallusto","year":"1998","unstructured":"Sallusto, F. et al. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur. J. Immunol. 28, 2760\u20132769 (1998)","journal-title":"Eur. J. Immunol."},{"key":"BFnature02238_CR13","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1084\/jem.20030167","volume":"198","author":"M Bajenoff","year":"2003","unstructured":"Bajenoff, M., Granjeaud, S. & Guerder, S. The strategy of T cell antigen-presenting cell encounter in antigen-draining lymph nodes revealed by imaging of initial T cell activation. J. Exp. Med. 198, 715\u2013724 (2003)","journal-title":"J. Exp. Med."},{"key":"BFnature02238_CR14","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/79758","volume":"1","author":"A Langenkamp","year":"2000","unstructured":"Langenkamp, A., Messi, M., Lanzavecchia, A. & Sallusto, F. Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nature Immunol. 1, 311\u2013316 (2000)","journal-title":"Nature Immunol."},{"key":"BFnature02238_CR15","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1146\/annurev.biophys.26.1.373","volume":"26","author":"MJ Saxton","year":"1997","unstructured":"Saxton, M. J. & Jacobson, K. Single-particle tracking: applications to membrane dynamics. Annu. Rev. Biophys. Biomol. Struct. 26, 373\u2013399 (1997)","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"BFnature02238_CR16","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1126\/science.284.5415.819","volume":"284","author":"HL Tang","year":"1999","unstructured":"Tang, H. L. & Cyster, J. G. Chemokine up-regulation and activated T cell attraction by maturing dendritic cells. Science 284, 819\u2013822 (1999)","journal-title":"Science"},{"key":"BFnature02238_CR17","doi-asserted-by":"publisher","first-page":"3909","DOI":"10.1073\/pnas.94.8.3909","volume":"94","author":"ML Dustin","year":"1997","unstructured":"Dustin, M. L., Bromley, S. K., Zhengyan, K., Peterson, D. A. & Unanue, E. R. Antigen receptor engagement delivers a stop signal to migrating T lymphocytes. Proc. Natl Acad. Sci. USA 94, 3909\u20133913 (1997)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature02238_CR18","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/25764","volume":"394","author":"CRF Monks","year":"1998","unstructured":"Monks, C. R. F., Freiberg, B. A., Kupfer, H., Sciaky, N. & Kupfer, A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 394, 82\u201386 (1998)","journal-title":"Nature"},{"key":"BFnature02238_CR19","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1126\/science.285.5425.221","volume":"285","author":"A Grakoui","year":"1999","unstructured":"Grakoui, A. et al. The immunological synapse: a molecular machine controlling T cell activation. Science 285, 221\u2013227 (1999)","journal-title":"Science"},{"key":"BFnature02238_CR20","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1126\/science.1067710","volume":"295","author":"KH Lee","year":"2002","unstructured":"Lee, K. H. et al. T cell receptor signaling precedes immunological synapse formation. Science 295, 1539\u20131542 (2002)","journal-title":"Science"},{"key":"BFnature02238_CR21","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S1074-7613(00)00032-7","volume":"13","author":"M Gunzer","year":"2000","unstructured":"Gunzer, M. et al. Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity 13, 323\u2013332 (2000)","journal-title":"Immunity"},{"key":"BFnature02238_CR22","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1084\/jem.185.12.2133","volume":"185","author":"E Ingulli","year":"1997","unstructured":"Ingulli, E., Mondino, A., Khoruts, A. & Jenkins, M. K. In vivo detection of dendritic cell antigen presentation to CD4+ T cells. J. Exp. Med. 185, 2133\u20132141 (1997)","journal-title":"J. Exp. Med."},{"key":"BFnature02238_CR23","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/ni762","volume":"3","author":"CC Norbury","year":"2002","unstructured":"Norbury, C. C., Malide, D., Gibbs, J. S., Bennink, J. R. & Yewdell, J. W. Visualizing priming of virus-specific CD8+ T cells by infected dendritic cells in vivo. Nature Immunol. 3, 265\u2013271 (2002)","journal-title":"Nature Immunol."},{"key":"BFnature02238_CR24","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1126\/science.2125367","volume":"250","author":"KM Murphy","year":"1990","unstructured":"Murphy, K. M., Heimberger, A. B. & Loh, D. Y. Induction by antigen of intrathymic apoptosis of CD4+ CD8+ TCRlo thymocytes in vivo. Science 250, 1720\u20131723 (1990)","journal-title":"Science"},{"key":"BFnature02238_CR25","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/nature01146","volume":"420","author":"I Stefanova","year":"2002","unstructured":"Stefanova, I., Dorfman, J. R. & Germain, R. N. Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes. Nature 420, 429\u2013434 (2002)","journal-title":"Nature"},{"key":"BFnature02238_CR26","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.4049\/jimmunol.171.3.1128","volume":"171","author":"M Faroudi","year":"2003","unstructured":"Faroudi, M., Zaru, R., Paulet, P., Muller, S. & Valitutti, S. Cutting edge: T lymphocyte activation by repeated immunological synapse formation and intermittent signaling. J. Immunol. 171, 1128\u20131132 (2003)","journal-title":"J. Immunol."},{"key":"BFnature02238_CR27","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/ni912","volume":"4","author":"MJ van Stipdonk","year":"2003","unstructured":"van Stipdonk, M. J. et al. Dynamic programming of CD8+ T lymphocyte responses. Nature Immunol. 4, 361\u2013365 (2003)","journal-title":"Nature Immunol."},{"key":"BFnature02238_CR28","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1084\/jem.20022230","volume":"198","author":"V Hurez","year":"2003","unstructured":"Hurez, V. et al. Restricted clonal expression of IL-2 by naive T cells reflects differential dynamic interactions with dendritic cells. J. Exp. Med. 198, 123\u2013132 (2003)","journal-title":"J. Exp. Med."},{"key":"BFnature02238_CR29","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/342559a0","volume":"342","author":"H Pircher","year":"1989","unstructured":"Pircher, H., Burki, K., Lang, R., Hengartner, H. & Zinkernagel, R. M. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 342, 559\u2013561 (1989)","journal-title":"Nature"},{"key":"BFnature02238_CR30","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature01726","volume":"424","author":"JR Mora","year":"2003","unstructured":"Mora, J. R. et al. Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells. Nature 424, 88\u201393 (2003)","journal-title":"Nature"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature02238.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature02238","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature02238.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:20:25Z","timestamp":1684419625000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature02238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":30,"journal-issue":{"issue":"6970","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["BFnature02238"],"URL":"https:\/\/doi.org\/10.1038\/nature02238","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1016942.201704","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1016942.202093","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1016942.201653","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1016942.202108","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1016942.204259","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1]]}}}