{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T05:36:33Z","timestamp":1783748193701,"version":"3.55.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"6968","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2003,12]]},"DOI":"10.1038\/nature02255","type":"journal-article","created":{"date-parts":[[2003,12,18]],"date-time":"2003-12-18T09:47:45Z","timestamp":1071740865000},"page":"845-849","source":"Crossref","is-referenced-by-count":602,"title":["A microRNA controlling left\/right neuronal asymmetry in Caenorhabditis elegans"],"prefix":"10.1038","volume":"426","author":[{"suffix":"Jr","given":"Robert J.","family":"Johnston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Hobert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2003,12,14]]},"reference":[{"key":"BFnature02255_CR1","doi-asserted-by":"publisher","first-page":"3384","DOI":"10.1073\/pnas.94.7.3384","volume":"94","author":"S Yu","year":"1997","unstructured":"Yu, S., Avery, L., Baude, E. & Garbers, D. L. Guanylyl cyclase expression in specific sensory neurons: a new family of chemosensory receptors. Proc. Natl Acad. Sci. USA 94, 3384\u20133387 (1997)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature02255_CR2","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1038\/35070575","volume":"410","author":"JT Pierce-Shimomura","year":"2001","unstructured":"Pierce-Shimomura, J. T., Faumont, S., Gaston, M. R., Pearson, B. J. & Lockery, S. R. The homeobox gene lim-6 is required for distinct chemosensory representations in C. elegans. Nature 410, 694\u2013698 (2001)","journal-title":"Nature"},{"key":"BFnature02255_CR3","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1101\/gad.1117903","volume":"17","author":"S Chang","year":"2003","unstructured":"Chang, S., Johnston, R. J. Jr & Hobert, O. A transcriptional regulatory cascade that controls left\/right asymmetry in chemosensory neurons of C. elegans. Genes Dev. 17, 2123\u20132137 (2003)","journal-title":"Genes Dev."},{"key":"BFnature02255_CR4","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/S0166-2236(03)00129-2","volume":"26","author":"ME Halpern","year":"2003","unstructured":"Halpern, M. E., Liang, J. O. & Gamse, J. T. Leaning to the left: laterality in the zebrafish forebrain. Trends Neurosci. 26, 308\u2013313 (2003)","journal-title":"Trends Neurosci."},{"key":"BFnature02255_CR5","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1002\/(SICI)1520-6408(1998)23:3<159::AID-DVG1>3.0.CO;2-1","volume":"23","author":"HJ Yost","year":"1998","unstructured":"Yost, H. J. Left-right development from embryos to brains. Dev. Genet. 23, 159\u2013163 (1998)","journal-title":"Dev. Genet."},{"key":"BFnature02255_CR6","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/nrn897","volume":"3","author":"O Hobert","year":"2002","unstructured":"Hobert, O., Johnston, R. J. Jr & Chang, S. Left-right asymmetry in the nervous system: the Caenorhabditis elegans model. Nature Rev. Neurosci. 3, 629\u2013640 (2002)","journal-title":"Nature Rev. Neurosci."},{"key":"BFnature02255_CR7","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/0896-6273(91)90276-6","volume":"7","author":"CI Bargmann","year":"1991","unstructured":"Bargmann, C. I. & Horvitz, H. R. Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans. Neuron 7, 729\u2013742 (1991)","journal-title":"Neuron"},{"key":"BFnature02255_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1098\/rstb.1986.0056","volume":"314","author":"JG White","year":"1986","unstructured":"White, J. G., Southgate, E., Thomson, J. N. & Brenner, S. The structure of the nervous system of the nematode Caenorhabditis elegans. Phil. Trans. R. Soc. Lond. B 314, 1\u2013340 (1986)","journal-title":"Phil. Trans. R. Soc. Lond. B"},{"key":"BFnature02255_CR9","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1242\/dev.126.7.1547","volume":"126","author":"O Hobert","year":"1999","unstructured":"Hobert, O., Tessmar, K. & Ruvkun, G. The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons. Development 126, 1547\u20131562 (1999)","journal-title":"Development"},{"key":"BFnature02255_CR10","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/S0092-8674(00)81525-1","volume":"99","author":"ER Troemel","year":"1999","unstructured":"Troemel, E. R., Sagasti, A. & Bargmann, C. I. Lateral signaling mediated by axon contact and calcium entry regulates asymmetric odorant receptor expression in C. elegans. Cell 99, 387\u2013398 (1999)","journal-title":"Cell"},{"key":"BFnature02255_CR11","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1038\/88878","volume":"28","author":"SR Wicks","year":"2001","unstructured":"Wicks, S. R., Yeh, R. T., Gish, W. R., Waterston, R. H. & Plasterk, R. H. Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map. Nature Genet. 28, 160\u2013164 (2001)","journal-title":"Nature Genet."},{"key":"BFnature02255_CR12","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","volume":"75","author":"RC Lee","year":"1993","unstructured":"Lee, R. C., Feinbaum, R. L. & Ambros, V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75, 843\u2013854 (1993)","journal-title":"Cell"},{"key":"BFnature02255_CR13","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1006\/dbio.1999.9523","volume":"216","author":"PH Olsen","year":"1999","unstructured":"Olsen, P. H. & Ambros, V. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev. Biol. 216, 671\u2013680 (1999)","journal-title":"Dev. Biol."},{"key":"BFnature02255_CR14","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/S0960-9822(03)00287-2","volume":"13","author":"V Ambros","year":"2003","unstructured":"Ambros, V., Lee, R. C., Lavanway, A., Williams, P. T. & Jewell, D. MicroRNAs and other tiny endogenous RNAs in C. elegans. Curr. Biol. 13, 807\u2013818 (2003)","journal-title":"Curr. Biol."},{"key":"BFnature02255_CR15","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1101\/gad.1074403","volume":"17","author":"LP Lim","year":"2003","unstructured":"Lim, L. P. et al. The microRNAs of Caenorhabditis elegans. Genes Dev. 17, 991\u20131008 (2003)","journal-title":"Genes Dev."},{"key":"BFnature02255_CR16","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/S1097-2765(03)00153-9","volume":"11","author":"Y Grad","year":"2003","unstructured":"Grad, Y. et al. Computational and experimental identification of C. elegans microRNAs. Mol. Cell 11, 1253\u20131263 (2003)","journal-title":"Mol. Cell"},{"key":"BFnature02255_CR17","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1126\/science.1065062","volume":"294","author":"NC Lau","year":"2001","unstructured":"Lau, N. C., Lim, L. P., Weinstein, E. G. & Bartel, D. P. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 294, 858\u2013862 (2001)","journal-title":"Science"},{"key":"BFnature02255_CR18","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/S0012-1606(03)00202-1","volume":"259","author":"SM Johnson","year":"2003","unstructured":"Johnson, S. M., Lin, S. Y. & Slack, F. J. The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter. Dev. Biol. 259, 364\u2013379 (2003)","journal-title":"Dev. Biol."},{"key":"BFnature02255_CR19","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/S1534-5807(03)00293-4","volume":"5","author":"A Lanjuin","year":"2003","unstructured":"Lanjuin, A., VanHoven, M. K., Bargmann, C. I., Thompson, J. K. & Sengupta, P. Otx\/otd homeobox genes specify distinct sensory neuron identities in C. elegans. Dev. Cell 5, 621\u2013633 (2003)","journal-title":"Dev. Cell"},{"key":"BFnature02255_CR20","unstructured":"Stark, A., Brennecke, J., Russell, R. B. & Cohen, S. M. Identification of Drosphila MicroRNA targets. PLOS Biol. Online publication 13 October 2003 (doi:10.1371\/journal.pbio.0000060)"},{"key":"BFnature02255_CR21","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1006\/dbio.2002.0850","volume":"252","author":"RE Palmer","year":"2002","unstructured":"Palmer, R. E., Inoue, T., Sherwood, D. R., Jiang, L. I. & Sternberg, P. W. Caenorhabditis elegans cog-1 locus encodes GTX\/Nkx6.1 homeodomain proteins and regulates multiple aspects of reproductive system development. Dev. Biol. 252, 202\u2013213 (2002)","journal-title":"Dev. Biol."},{"key":"BFnature02255_CR22","doi-asserted-by":"publisher","first-page":"728","DOI":"10.2144\/02324bm01","volume":"32","author":"O Hobert","year":"2002","unstructured":"Hobert, O. PCR fusion-based approach to create reporter gene constructs for expression analysis in transgenic C. elegans. Biotechniques 32, 728\u2013730 (2002)","journal-title":"Biotechniques"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature02255.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature02255","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature02255.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:20:34Z","timestamp":1684419634000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature02255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":22,"journal-issue":{"issue":"6968","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["BFnature02255"],"URL":"https:\/\/doi.org\/10.1038\/nature02255","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1016817.201346","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12]]}}}