{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:32:45Z","timestamp":1773657165379,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6994","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2004,6]]},"DOI":"10.1038\/nature02618","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T18:04:35Z","timestamp":1088013875000},"page":"878-883","source":"Crossref","is-referenced-by-count":92,"title":["Rapid BDNF-induced retrograde synaptic modification in a developing retinotectal system"],"prefix":"10.1038","volume":"429","author":[{"given":"Jiu-lin","family":"Du","sequence":"first","affiliation":[]},{"given":"Mu-ming","family":"Poo","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BFnature02618_CR1","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/41267","volume":"388","author":"RM Fitzsimonds","year":"1997","unstructured":"Fitzsimonds, R. M., Song, H. J. & Poo, M. M. Propagation of activity-dependent synaptic depression in simple neural networks. Nature 388, 439\u2013448 (1997)","journal-title":"Nature"},{"key":"BFnature02618_CR2","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.1523\/JNEUROSCI.20-09-03233.2000","volume":"20","author":"HW Tao","year":"2000","unstructured":"Tao, H. W., Zhang, L. I., Bi, G. Q. & Poo, M. Selective presynaptic propagation of long-term potentiation in defined neural networks. J. Neurosci. 20, 3233\u20133243 (2000)","journal-title":"J. Neurosci."},{"key":"BFnature02618_CR3","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/323533a0","volume":"323","author":"DE Rumelhart","year":"1986","unstructured":"Rumelhart, D. E., Hinton, G. E. & Williams, R. J. Learning representations by back-propagation errors. Nature 323, 533\u2013536 (1986)","journal-title":"Nature"},{"key":"BFnature02618_CR4","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/0896-6273(94)90328-X","volume":"12","author":"S Cohen-cory","year":"1994","unstructured":"Cohen-cory, S. & Fraser, S. E. BDNF in the development of the visual system of Xenopus. Neuron 12, 747\u2013761 (1994)","journal-title":"Neuron"},{"key":"BFnature02618_CR5","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1146\/annurev.neuro.24.1.677","volume":"24","author":"EJ Huang","year":"2001","unstructured":"Huang, E. J. & Reichardt, L. F. Neurotrophins: roles in neuronal development and function. Annu. Rev. Neurosci. 24, 677\u2013736 (2001)","journal-title":"Annu. Rev. Neurosci."},{"key":"BFnature02618_CR6","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/363350a0","volume":"363","author":"AM Lohof","year":"1993","unstructured":"Lohof, A. M. & Poo, M. M. Potentiation of developing neuromuscular synapses by the neurotrophins NT3 and BDNF. Nature 363, 350\u2013353 (1993)","journal-title":"Nature"},{"key":"BFnature02618_CR7","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/00001756-199412300-00007","volume":"6","author":"V Lessmann","year":"1994","unstructured":"Lessmann, V., Gottmann, K. & Heumann, R. BDNF and NT-4\/5 enhance glutamatergic synaptic transmission in cultured hippocampal neurones. Neuroreport 6, 21\u201325 (1994)","journal-title":"Neuroreport"},{"key":"BFnature02618_CR8","doi-asserted-by":"publisher","first-page":"10884","DOI":"10.1073\/pnas.95.18.10884","volume":"95","author":"YX Li","year":"1998","unstructured":"Li, Y. X. et al. Expression of a dominant negative TrkB receptor, T1, reveals a requirement for presynaptic signaling in BDNF-induced synaptic potentiation in cultured hippocampal neurons. Proc. Natl Acad. Sci. USA 95, 10884\u201310889 (1998)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature02618_CR9","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0896-6273(00)80879-X","volume":"25","author":"AF Schinder","year":"2000","unstructured":"Schinder, A. F., Berninger, B. & Poo, M. M. Postsynaptic target specificity of neurotrophin-induced presynaptic potentiation. Neuron 25, 151\u2013163 (2000)","journal-title":"Neuron"},{"key":"BFnature02618_CR10","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/35049004","volume":"2","author":"MM Poo","year":"2001","unstructured":"Poo, M. M. Neurotrophins as synaptic modulators. Nature Rev. Neurosci. 2, 24\u201332 (2001)","journal-title":"Nature Rev. Neurosci."},{"key":"BFnature02618_CR11","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/0896-6273(95)90046-2","volume":"15","author":"JT Isaac","year":"1995","unstructured":"Isaac, J. T., Nicoll, R. A. & Malenka, R. C. Evidence for silent synapses: implications for the expression of LTP. Neuron 15, 427\u2013434 (1995)","journal-title":"Neuron"},{"key":"BFnature02618_CR12","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/381071a0","volume":"381","author":"GM Durand","year":"1996","unstructured":"Durand, G. M., Kovalchuk, Y. & Konnerth, A. Long-term potentiation and functional synapse induction in developing hippocampus. Nature 381, 71\u201375 (1996)","journal-title":"Nature"},{"key":"BFnature02618_CR13","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1126\/science.274.5289.972","volume":"274","author":"GY Wu","year":"1996","unstructured":"Wu, G. Y., Malinow, R. & Cline, H. T. Maturation of a central glutamatergic synapse. Science 274, 972\u2013976 (1996)","journal-title":"Science"},{"key":"BFnature02618_CR14","doi-asserted-by":"publisher","first-page":"7889","DOI":"10.1523\/JNEUROSCI.19-18-07889.1999","volume":"19","author":"FL Watson","year":"1999","unstructured":"Watson, F. L. et al. Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complex. J. Neurosci. 19, 7889\u20137900 (1999)","journal-title":"J. Neurosci."},{"key":"BFnature02618_CR15","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1038\/379830a0","volume":"379","author":"CS von Bartheld","year":"1996","unstructured":"von Bartheld, C. S., Byers, M. R., Williams, R. & Bothwell, M. Anterograde transport of neurotrophins and axodendritic transfer in the developing visual system. Nature 379, 830\u2013833 (1996)","journal-title":"Nature"},{"key":"BFnature02618_CR16","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/S0959-4388(02)00326-4","volume":"12","author":"DD Ginty","year":"2002","unstructured":"Ginty, D. D. & Segal, R. A. Retrograde neurotrophin signaling: Trk-ing along the axon. Curr. Opin. Neurobiol. 12, 268\u2013274 (2002)","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnature02618_CR17","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1113\/jphysiol.1975.sp011151","volume":"252","author":"D Purves","year":"1975","unstructured":"Purves, D. Functional and structural changes in mammalian sympathetic neurons following interruption of their axons. J. Physiol. (Lond.) 252, 429\u2013463 (1975)","journal-title":"J. Physiol. (Lond.)"},{"key":"BFnature02618_CR18","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/260535a0","volume":"260","author":"D Purves","year":"1976","unstructured":"Purves, D. Effects of nerve growth factor on synaptic depression after axotomy. Nature 260, 535\u2013536 (1976)","journal-title":"Nature"},{"key":"BFnature02618_CR19","doi-asserted-by":"publisher","first-page":"5024","DOI":"10.1523\/JNEUROSCI.20-13-05024.2000","volume":"20","author":"WT Wong","year":"2000","unstructured":"Wong, W. T., Faulkner-Jones, B. E., Sanes, J. R. & Wong, R. O. Rapid dendritic remodeling in the developing retina: dependence on neurotransmission and reciprocal regulation by Rac and Rho. J. Neurosci. 20, 5024\u20135036 (2000)","journal-title":"J. Neurosci."},{"key":"BFnature02618_CR20","doi-asserted-by":"publisher","first-page":"7639","DOI":"10.1523\/JNEUROSCI.22-17-07639.2002","volume":"22","author":"B Lom","year":"2002","unstructured":"Lom, B., Cogen, J., Sanchez, A. L., Vu, T. & Cohen-cory, S. Local and target-derived brain-derived neurotrophic factor exert opposing effects on the dendritic arborization of retinal ganglion cells in vivo. J. Neurosci. 22, 7639\u20137649 (2002)","journal-title":"J. Neurosci."},{"key":"BFnature02618_CR21","doi-asserted-by":"publisher","first-page":"5887","DOI":"10.1093\/emboj\/20.21.5887","volume":"20","author":"M Hartmann","year":"2001","unstructured":"Hartmann, M., Heumann, R. & Lessmann, V. Synaptic secretion of BDNF after high-frequency stimulation of glutamatergic synapses. EMBO J. 20, 5887\u20135897 (2001)","journal-title":"EMBO J."},{"key":"BFnature02618_CR22","doi-asserted-by":"publisher","first-page":"10399","DOI":"10.1523\/JNEUROSCI.22-23-10399.2002","volume":"22","author":"A Balkowiec","year":"2002","unstructured":"Balkowiec, A. & Katz, D. M. Cellular mechanisms regulating activity-dependent release of native brain-derived neurotrophic factor from hippocampal neurons. J. Neurosci. 22, 10399\u201310407 (2002)","journal-title":"J. Neurosci."},{"key":"BFnature02618_CR23","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.mcn.2003.11.009","volume":"25","author":"G Chytrova","year":"2004","unstructured":"Chytrova, G. & Johnson, J. E. Spontaneous retinal activity modulates BDNF trafficking in the developing chick visual system. Mol. Cell. Neurosci. 25, 549\u2013557 (2004)","journal-title":"Mol. Cell. Neurosci."},{"key":"BFnature02618_CR24","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1146\/annurev.ne.13.030190.001021","volume":"13","author":"M Constantine-Paton","year":"1990","unstructured":"Constantine-Paton, M., Cline, H. T. & Debski, E. Patterned activity, synaptic convergence, and the NMDA receptor in developing visual pathways. Annu. Rev. Neurosci. 13, 129\u2013154 (1990)","journal-title":"Annu. Rev. Neurosci."},{"key":"BFnature02618_CR25","doi-asserted-by":"publisher","first-page":"6621","DOI":"10.1523\/JNEUROSCI.14-11-06621.1994","volume":"14","author":"RJ Wingate","year":"1994","unstructured":"Wingate, R. J. & Thompson, I. D. Targeting and activity-related dendritic modification in mammalian retinal ganglion cells. J. Neurosci. 14, 6621\u20136637 (1994)","journal-title":"J. Neurosci."},{"key":"BFnature02618_CR26","doi-asserted-by":"crossref","DOI":"10.7551\/mitpress\/2010.001.0001","volume-title":"The Computational Brain","author":"PS Churchland","year":"1992","unstructured":"Churchland, P. S. & Sejnowski, T. J. The Computational Brain (MIT Press, Cambridge, Massachusetts, 1992)"},{"key":"BFnature02618_CR27","volume-title":"Normal table of Xenopus laevis","author":"PD Nieuwkoop","year":"1967","unstructured":"Nieuwkoop, P. D. & Faber, J. Normal table of Xenopus laevis, 2nd edn (North Holland, Amsterdam, 1967)"},{"key":"BFnature02618_CR28","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/25665","volume":"395","author":"LI Zhang","year":"1998","unstructured":"Zhang, L. I., Tao, H. W., Holt, C. E., Harris, W. A. & Poo, M. M. A critical window for cooperation and competition among developing retinotectal synapses. Nature 395, 37\u201344 (1998)","journal-title":"Nature"},{"key":"BFnature02618_CR29","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/0896-6273(93)90184-S","volume":"11","author":"SF Traynelis","year":"1993","unstructured":"Traynelis, S. F., Silver, R. A. & Cull-Candy, S. G. Estimated conductance of glutamate receptor channels activated during EPSCs at the cerebellar mossy fiber-granule cell synapse. Neuron 11, 279\u2013289 (1993)","journal-title":"Neuron"},{"key":"BFnature02618_CR30","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/31709","volume":"393","author":"TA Benke","year":"1998","unstructured":"Benke, T. A., L\u00fcthi, A., Isaac, J. T. R. & Collingridge, G. L. Modulation of AMPA receptor unitary conductance by synaptic activity. Nature 393, 793\u2013797 (1998)","journal-title":"Nature"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature02618.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature02618","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature02618.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:24:02Z","timestamp":1684434242000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature02618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":30,"journal-issue":{"issue":"6994","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["BFnature02618"],"URL":"https:\/\/doi.org\/10.1038\/nature02618","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6]]}}}