{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T08:02:20Z","timestamp":1781078540334,"version":"3.54.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"6995","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1038\/nature02698","type":"journal-article","created":{"date-parts":[[2004,6,30]],"date-time":"2004-06-30T13:33:07Z","timestamp":1088602387000},"page":"85-88","source":"Crossref","is-referenced-by-count":789,"title":["Evolutionary changes in cis and trans gene regulation"],"prefix":"10.1038","volume":"430","author":[{"given":"Patricia J.","family":"Wittkopp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda K.","family":"Haerum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFnature02698_CR1","volume-title":"Genomic Regulatory Systems: Development and Evolution","author":"EH Davidson","year":"2001","unstructured":"Davidson, E. H. Genomic Regulatory Systems: Development and Evolution (Academic, San Diego, 2001)"},{"key":"BFnature02698_CR2","volume-title":"From DNA to Diversity: Molecular Genetics and the Evolution of Animal Design","author":"SB Carroll","year":"2001","unstructured":"Carroll, S. B., Grenier, J. K. & Weatherbee, S. D. From DNA to Diversity: Molecular Genetics and the Evolution of Animal Design (Blackwell Science, Oxford, 2001)"},{"key":"BFnature02698_CR3","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1093\/molbev\/msg140","volume":"20","author":"GA Wray","year":"2003","unstructured":"Wray, G. A. et al. The evolution of transcriptional regulation in eukaryotes. Mol. Biol. Evol. 20, 1377\u20131419 (2003)","journal-title":"Mol. Biol. Evol."},{"key":"BFnature02698_CR4","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1038\/ng992","volume":"32","author":"CR Cowles","year":"2002","unstructured":"Cowles, C. R., Hirschhorn, J. N., Altshuler, D. & Lander, E. S. Detection of regulatory variation in mouse genes. Nature Genet. 32, 432\u2013437 (2002)","journal-title":"Nature Genet."},{"key":"BFnature02698_CR5","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1126\/science.1072545","volume":"297","author":"H Yan","year":"2002","unstructured":"Yan, H., Yuan, W., Velculescu, V. E., Vogelstein, B. & Kinzler, K. W. Allelic variation in human gene expression. Science 297, 1143 (2002)","journal-title":"Science"},{"key":"BFnature02698_CR6","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195076912.001.0001","volume-title":"Progress and Prospects in Evolutionary Biology: The Drosophila Model","author":"JR Powell","year":"1997","unstructured":"Powell, J. R. Progress and Prospects in Evolutionary Biology: The Drosophila Model (Oxford Univ. Press, New York, 1997)"},{"key":"BFnature02698_CR7","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1152\/physiolgenomics.00163.2003","volume":"16","author":"T Pastinen","year":"2004","unstructured":"Pastinen, T. et al. A survey of genetic and epigenetic variation affecting human gene expression. Physiol. Genomics 16, 184\u2013193 (2004)","journal-title":"Physiol. Genomics"},{"key":"BFnature02698_CR8","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1006\/abio.2000.4493","volume":"280","author":"A Ahmadian","year":"2000","unstructured":"Ahmadian, A. et al. Single-nucleotide polymorphism analysis by pyrosequencing. Anal. Biochem. 280, 103\u2013110 (2000)","journal-title":"Anal. Biochem."},{"key":"BFnature02698_CR9","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.2144\/02325dd03","volume":"32","author":"B Neve","year":"2002","unstructured":"Neve, B. et al. Rapid SNP allele frequency determination in genomic DNA pools by pyrosequencing. Biotechniques 32, 1138\u20131142 (2002)","journal-title":"Biotechniques"},{"key":"BFnature02698_CR10","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/ng1086","volume":"33","author":"SA Rifkin","year":"2003","unstructured":"Rifkin, S. A., Kim, J. & White, K. P. Evolution of gene expression in the Drosophila melanogaster subgroup. Nature Genet. 33, 138\u2013144 (2003)","journal-title":"Nature Genet."},{"key":"BFnature02698_CR11","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1126\/science.1085881","volume":"300","author":"JM Ranz","year":"2003","unstructured":"Ranz, J. M., Castillo-Davis, C. I., Meiklejohn, C. D. & Hartl, D. L. Sex-dependent gene expression and evolution of the Drosophila transcriptome. Science 300, 1742\u20131745 (2003)","journal-title":"Science"},{"key":"BFnature02698_CR12","doi-asserted-by":"crossref","unstructured":"Davidson, E. H., McClay, D. R. & Hood, L. Regulatory gene networks and the properties of the developmental process. Proc. Natl Acad. Sci. USA 100, 1475\u20131480","DOI":"10.1073\/pnas.0437746100"},{"key":"BFnature02698_CR13","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner, M. et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nature Genet. 25, 25\u201329 (2000)","journal-title":"Nature Genet."},{"key":"BFnature02698_CR14","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1093\/nar\/gkg094","volume":"31","author":"The FlyBase Consortium","year":"2003","unstructured":"The FlyBase Consortium, The FlyBase database of the Drosophila genome projects and community literature. Nucleic Acids Res. 31, 172\u2013175 (2003)","journal-title":"Nucleic Acids Res."},{"key":"BFnature02698_CR15","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/ng1222","volume":"35","author":"G Yvert","year":"2003","unstructured":"Yvert, G. et al. Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Nature Genet. 35, 57\u201364 (2003)","journal-title":"Nature Genet."},{"key":"BFnature02698_CR16","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1126\/science.1069516","volume":"296","author":"RB Brem","year":"2002","unstructured":"Brem, R. B., Yvert, G., Clinton, R. & Kruglyak, L. Genetic dissection of transcriptional regulation in budding yeast. Science 296, 752\u2013755 (2002)","journal-title":"Science"},{"key":"BFnature02698_CR17","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/nature01434","volume":"422","author":"EE Schadt","year":"2003","unstructured":"Schadt, E. E. et al. Genetics of gene expression surveyed in maize, mouse and man. Nature 422, 297\u2013302 (2003)","journal-title":"Nature"},{"key":"BFnature02698_CR18","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/genetics\/165.2.623","volume":"165","author":"KL Montooth","year":"2003","unstructured":"Montooth, K. L., Marden, J. H. & Clark, A. G. Mapping determinants of variation in energy metabolism, respiration and flight in Drosophila. Genetics 165, 623\u2013635 (2003)","journal-title":"Genetics"},{"key":"BFnature02698_CR19","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/380157a0","volume":"380","author":"AW Davis","year":"1996","unstructured":"Davis, A. W. et al. Rescue of hybrid sterility in crosses between D. melanogaster and D. simulans. Nature 380, 157\u2013159 (1996)","journal-title":"Nature"},{"key":"BFnature02698_CR20","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/genetics\/133.2.307","volume":"133","author":"K Sawamura","year":"1993","unstructured":"Sawamura, K., Yamamoto, M. T. & Watanabe, T. K. Hybrid lethal systems in the Drosophila melanogaster species complex. II. The Zygotic hybrid rescue (Zhr) gene of D. melanogaster. Genetics 133, 307\u2013313 (1993)","journal-title":"Genetics"},{"key":"BFnature02698_CR21","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1002\/1097-010X(20001015)288:3<205::AID-JEZ2>3.0.CO;2-S","volume":"288","author":"H Hollocher","year":"2000","unstructured":"Hollocher, H., Agopian, K., Waterbury, J., O'Neill, R. W. & Davis, A. W. Characterization of defects in adult germline development and oogenesis of sterile and rescued female hybrids in crosses between Drosophila simulans and Drosophila melanogaster. J. Exp. Zool. 288, 205\u2013218 (2000)","journal-title":"J. Exp. Zool."},{"key":"BFnature02698_CR22","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1093\/genetics\/154.4.1747","volume":"154","author":"DA Barbash","year":"2000","unstructured":"Barbash, D. A., Roote, J. & Ashburner, M. The Drosophila melanogaster hybrid male rescue gene causes inviability in male and female species hybrids. Genetics 154, 1747\u20131771 (2000)","journal-title":"Genetics"},{"key":"BFnature02698_CR23","first-page":"19","volume":"69","author":"P Otto","year":"1998","unstructured":"Otto, P., Kephart, D., Bitner, R., Huber, S. & Volkerding, K. Separate isolation of genomic DNA and total RNA from single samples using the SV Total RNA Isolation System. Promega Notes 69, 19\u201324 (1998)","journal-title":"Promega Notes"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature02698.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature02698","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature02698.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T14:54:27Z","timestamp":1705157667000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature02698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":23,"journal-issue":{"issue":"6995","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["BFnature02698"],"URL":"https:\/\/doi.org\/10.1038\/nature02698","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1020138.292772","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1020138.229456","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}