{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T07:50:59Z","timestamp":1779349859265,"version":"3.51.4"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"7017","license":[{"start":{"date-parts":[[2004,11,21]],"date-time":"2004-11-21T00:00:00Z","timestamp":1100995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1038\/nature03023","type":"journal-article","created":{"date-parts":[[2004,11,22]],"date-time":"2004-11-22T10:10:08Z","timestamp":1101118208000},"page":"588-595","source":"Crossref","is-referenced-by-count":246,"title":["Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry"],"prefix":"10.1038","volume":"432","author":[{"given":"Michael","family":"Rape","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc W.","family":"Kirschner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,11,21]]},"reference":[{"key":"BFnature03023_CR1","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/S0092-8674(03)00645-7","volume":"114","author":"Y Geng","year":"2003","unstructured":"Geng, Y. et al. Cyclin E ablation in the mouse. Cell 114, 431\u2013443 (2003)","journal-title":"Cell"},{"key":"BFnature03023_CR2","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/ng1232","volume":"35","author":"S Ortega","year":"2003","unstructured":"Ortega, S. et al. Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nature Genet. 35, 25\u201331 (2003)","journal-title":"Nature Genet."},{"key":"BFnature03023_CR3","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1002\/j.1460-2075.1992.tb05135.x","volume":"11","author":"M Pagano","year":"1992","unstructured":"Pagano, M., Pepperkok, R., Verde, F., Ansorge, W. & Draetta, G. Cyclin A is required at two points in the human cell cycle. EMBO J. 11, 961\u2013971 (1992)","journal-title":"EMBO J."},{"key":"BFnature03023_CR4","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1006\/excr.2000.4889","volume":"259","author":"F Erlandsson","year":"2000","unstructured":"Erlandsson, F., Linnman, C., Ekholm, S., Bengtsson, E. & Zetterberg, A. A detailed analysis of cyclin A accumulation at the G1\/S border in normal and transformed cells. Exp. Cell Res. 259, 86\u201395 (2000)","journal-title":"Exp. Cell Res."},{"key":"BFnature03023_CR5","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/S1097-2765(02)00540-3","volume":"9","author":"JM Peters","year":"2002","unstructured":"Peters, J. M. The anaphase-promoting complex: proteolysis in mitosis and beyond. Mol. Cell 9, 931\u2013943 (2002)","journal-title":"Mol. Cell"},{"key":"BFnature03023_CR6","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1101\/gad.832500","volume":"14","author":"BO Petersen","year":"2000","unstructured":"Petersen, B. O. et al. Cell-cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1. Genes Dev. 14, 2330\u20132343 (2000)","journal-title":"Genes Dev."},{"key":"BFnature03023_CR7","doi-asserted-by":"publisher","first-page":"6115","DOI":"10.1093\/emboj\/cdg573","volume":"22","author":"M Araki","year":"2003","unstructured":"Araki, M., Wharton, R. P., Tang, Z., Yu, H. & Asano, M. Degradation of origin recognition complex large subunit by the anaphase-promoting complex in Drosophila. EMBO J. 22, 6115\u20136126 (2003)","journal-title":"EMBO J."},{"key":"BFnature03023_CR8","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/ncb785","volume":"4","author":"JY Hsu","year":"2002","unstructured":"Hsu, J. Y., Reimann, J. D. R., Sorensen, C. S., Lukas, J. & Jackson, P. K. E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APCCdh1. Nature Cell Biol. 4, 358\u2013366 (2002)","journal-title":"Nature Cell Biol."},{"key":"BFnature03023_CR9","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1038\/44611","volume":"401","author":"C Lukas","year":"1999","unstructured":"Lukas, C. et al. Accumulation of cyclin B1 requires E2F and cyclin A-dependent rearrangement of the anaphase-promoting complex. Nature 401, 815\u2013818 (1999)","journal-title":"Nature"},{"key":"BFnature03023_CR10","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1091\/mbc.11.5.1555","volume":"11","author":"ER Kramer","year":"2000","unstructured":"Kramer, E. R., Scheuringer, N., Podtelejnikov, A. V., Mann, M. & Peters, J. M. Mitotic regulation of APC activator proteins CDC20 and CDH1. Mol. Biol. Cell 11, 1555\u20131569 (2000)","journal-title":"Mol. Biol. Cell"},{"key":"BFnature03023_CR11","doi-asserted-by":"publisher","first-page":"3692","DOI":"10.1128\/MCB.21.11.3692-3703.2001","volume":"21","author":"CS Sorensen","year":"2001","unstructured":"Sorensen, C. S. et al. A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression. Mol. Cell. Biol. 21, 3692\u20133703 (2001)","journal-title":"Mol. Cell. Biol."},{"key":"BFnature03023_CR12","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1083\/jcb.153.1.137","volume":"153","author":"S Geley","year":"2001","unstructured":"Geley, S. et al. Anaphase-promoting complex\/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint. J. Cell Biol. 153, 137\u2013148 (2001)","journal-title":"J. Cell Biol."},{"key":"BFnature03023_CR13","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1083\/jcb.153.1.121","volume":"153","author":"N den Elzen","year":"2001","unstructured":"den Elzen, N. & Pines, J. Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase. J. Cell Biol. 153, 121\u2013136 (2001)","journal-title":"J. Cell Biol."},{"key":"BFnature03023_CR14","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1093\/emboj\/20.10.2376","volume":"20","author":"HW Jacobs","year":"2001","unstructured":"Jacobs, H. W., Keidel, E. & Lehner, C. F. A complex degradation signal in Cyclin A required for G1 arrest, and a C-terminal region for mitosis. EMBO J. 20, 2376\u20132386 (2001)","journal-title":"EMBO J."},{"key":"BFnature03023_CR15","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/S0092-8674(00)80528-0","volume":"90","author":"SJ Sigrist","year":"1997","unstructured":"Sigrist, S. J. & Lehner, C. F. Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles. Cell 90, 671\u2013681 (1997)","journal-title":"Cell"},{"key":"BFnature03023_CR16","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/S1534-5807(03)00153-9","volume":"4","author":"F Margottin-Goguet","year":"2003","unstructured":"Margottin-Goguet, F. et al. Prophase destruction of Emi1 by the SCF(\u03b2TrCP\/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond metaphase. Dev. Cell 4, 813\u2013826 (2003)","journal-title":"Dev. Cell"},{"key":"BFnature03023_CR17","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/S0960-9822(06)00220-X","volume":"7","author":"F Sprenger","year":"1997","unstructured":"Sprenger, F., Yakubovich, N. & O'Farrell, P. H. S-phase function of Drosophila cyclin A and its downregulation in G1 phase. Curr. Biol. 7, 488\u2013499 (1997)","journal-title":"Curr. Biol."},{"key":"BFnature03023_CR18","doi-asserted-by":"publisher","first-page":"3839","DOI":"10.1091\/mbc.12.12.3839","volume":"12","author":"Z Tang","year":"2001","unstructured":"Tang, Z. et al. APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. Mol. Biol. Cell 12, 3839\u20133851 (2001)","journal-title":"Mol. Biol. Cell"},{"key":"BFnature03023_CR19","doi-asserted-by":"publisher","first-page":"2821","DOI":"10.1091\/mbc.11.8.2821","volume":"11","author":"A Yamanaka","year":"2000","unstructured":"Yamanaka, A. et al. Cell cycle-dependent expression of mammalian E2-C regulated by the anaphase-promoting complex\/cyclosome. Mol. Biol. Cell 11, 2821\u20132831 (2000)","journal-title":"Mol. Biol. Cell"},{"key":"BFnature03023_CR20","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1038\/sj.emboj.7600149","volume":"23","author":"T Listovsky","year":"2004","unstructured":"Listovsky, T. et al. Mammalian Cdh1\/Fzr mediates its own degradation. EMBO J. 23, 1619\u20131626 (2004)","journal-title":"EMBO J."},{"key":"BFnature03023_CR21","doi-asserted-by":"publisher","first-page":"6598","DOI":"10.1093\/emboj\/cdg627","volume":"22","author":"C Kraft","year":"2003","unstructured":"Kraft, C. et al. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. EMBO J. 22, 6598\u20136609 (2003)","journal-title":"EMBO J."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature03023.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature03023","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature03023.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:27:50Z","timestamp":1684434470000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature03023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,21]]},"references-count":21,"journal-issue":{"issue":"7017","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["BFnature03023"],"URL":"https:\/\/doi.org\/10.1038\/nature03023","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,21]]}}}