{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T12:59:42Z","timestamp":1775134782401,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"7045","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1038\/nature03648","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T14:13:03Z","timestamp":1119449583000},"page":"1113-1116","source":"Crossref","is-referenced-by-count":233,"title":["Early developmental arrest of mammalian limbs lacking HoxA\/HoxD gene function"],"prefix":"10.1038","volume":"435","author":[{"given":"Marie","family":"Kmita","sequence":"first","affiliation":[]},{"given":"Basile","family":"Tarchini","sequence":"additional","affiliation":[]},{"given":"Jozsef","family":"Z\u00e0k\u00e0ny","sequence":"additional","affiliation":[]},{"given":"Malcolm","family":"Logan","sequence":"additional","affiliation":[]},{"given":"Clifford J.","family":"Tabin","sequence":"additional","affiliation":[]},{"given":"Denis","family":"Duboule","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BFnature03648_CR1","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1126\/science.1096049","volume":"304","author":"J Zakany","year":"2004","unstructured":"Zakany, J., Kmita, M. & Duboule, D. A dual role for Hox genes in limb anterior\u2013posterior asymmetry. Science 304, 1669\u20131672 (2004)","journal-title":"Science"},{"key":"BFnature03648_CR2","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/375791a0","volume":"375","author":"AP Davis","year":"1995","unstructured":"Davis, A. P., Witte, D. P., Hsieh-Li, H. M., Potter, S. S. & Capecchi, M. R. Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Nature 375, 791\u2013795 (1995)","journal-title":"Nature"},{"key":"BFnature03648_CR3","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1242\/dev.122.10.2997","volume":"122","author":"C Fromental-Ramain","year":"1996","unstructured":"Fromental-Ramain, C. et al. Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod. Development 122, 2997\u20133011 (1996)","journal-title":"Development"},{"key":"BFnature03648_CR4","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1242\/dev.122.2.449","volume":"122","author":"B Favier","year":"1996","unstructured":"Favier, B. et al. Functional cooperation between the non-paralogous genes Hoxa-10 and Hoxd-11 in the developing forelimb and axial skeleton. Development 122, 449\u2013460 (1996)","journal-title":"Development"},{"key":"BFnature03648_CR5","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1126\/science.1085672","volume":"301","author":"DM Wellik","year":"2003","unstructured":"Wellik, D. M. & Capecchi, M. R. Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton. Science 301, 363\u2013367 (2003)","journal-title":"Science"},{"key":"BFnature03648_CR6","volume-title":"Principles of Insect Morphology","author":"RE Snodgrass","year":"1935","unstructured":"Snodgrass, R. E. Principles of Insect Morphology (McGraw-Hill, New York, 1935)"},{"key":"BFnature03648_CR7","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/0092-8674(93)90626-2","volume":"75","author":"RD Riddle","year":"1993","unstructured":"Riddle, R. D., Johnson, R. L., Laufer, E. & Tabin, C. Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401\u20131416 (1993)","journal-title":"Cell"},{"key":"BFnature03648_CR8","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1006\/dbio.2000.9651","volume":"220","author":"H Suemori","year":"2000","unstructured":"Suemori, H. & Noguchi, S. Hox C cluster genes are dispensable for overall body plan of mouse embryonic development. Dev. Biol. 220, 333\u2013342 (2000)","journal-title":"Dev. Biol."},{"key":"BFnature03648_CR9","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1006\/dbio.2000.9683","volume":"222","author":"O Medina-Martinez","year":"2000","unstructured":"Medina-Martinez, O., Bradley, A. & Ramirez-Solis, R. A large targeted deletion of Hoxb1\u2013Hoxb9 produces a series of single-segment anterior homeotic transformations. Dev. Biol. 222, 71\u201383 (2000)","journal-title":"Dev. Biol."},{"key":"BFnature03648_CR10","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1002\/gene.10092","volume":"33","author":"M Logan","year":"2002","unstructured":"Logan, M. et al. Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis 33, 77\u201380 (2002)","journal-title":"Genesis"},{"key":"BFnature03648_CR11","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1101\/gad.205701","volume":"15","author":"F Spitz","year":"2001","unstructured":"Spitz, F. et al. Large scale transgenic and cluster deletion analysis of the HoxD complex separate an ancestral regulatory module from evolutionary innovations. Genes Dev. 15, 2209\u20132214 (2001)","journal-title":"Genes Dev."},{"key":"BFnature03648_CR12","doi-asserted-by":"publisher","first-page":"2741","DOI":"10.1242\/dev.00473","volume":"130","author":"C Rallis","year":"2003","unstructured":"Rallis, C. et al. Tbx5 is required for forelimb bud formation and continued outgrowth. Development 130, 2741\u20132751 (2003)","journal-title":"Development"},{"key":"BFnature03648_CR13","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1242\/dev.128.10.1911","volume":"128","author":"E van den Akker","year":"2001","unstructured":"van den Akker, E. et al. Axial skeletal patterning in mice lacking all paralogous group 8 Hox genes. Development 128, 1911\u20131921 (2001)","journal-title":"Development"},{"key":"BFnature03648_CR14","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1242\/dev.122.2.461","volume":"122","author":"C Fromental-Ramain","year":"1996","unstructured":"Fromental-Ramain, C. et al. Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning. Development 122, 461\u2013472 (1996)","journal-title":"Development"},{"key":"BFnature03648_CR15","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.cell.2004.07.024","volume":"118","author":"BD Harfe","year":"2004","unstructured":"Harfe, B. D. et al. Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell 118, 517\u2013528 (2004)","journal-title":"Cell"},{"key":"BFnature03648_CR16","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1006\/dbio.2001.0346","volume":"236","author":"C Chiang","year":"2001","unstructured":"Chiang, C. et al. Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev. Biol. 236, 421\u2013435 (2001)","journal-title":"Dev. Biol."},{"key":"BFnature03648_CR17","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S0925-4773(00)00492-5","volume":"100","author":"P Kraus","year":"2001","unstructured":"Kraus, P., Fraidenraich, D. & Loomis, C. A. Some distal limb structures develop in mice lacking Sonic hedgehog signalling. Mech. Dev. 100, 45\u201358 (2001)","journal-title":"Mech. Dev."},{"key":"BFnature03648_CR18","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/S0092-8674(01)00369-5","volume":"105","author":"PM Lewis","year":"2001","unstructured":"Lewis, P. M. et al. Cholesterol modification of sonic hedgehog is required for long-range signalling activity and effective modulation of signaling by Ptc1. Cell 105, 599\u2013612 (2001)","journal-title":"Cell"},{"key":"BFnature03648_CR19","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1242\/dev.00245","volume":"130","author":"MA Ros","year":"2003","unstructured":"Ros, M. A. et al. The chick oligozeugodactyly (ozd) mutant lacks sonic hedgehog function in the limb. Development 130, 527\u2013537 (2003)","journal-title":"Development"},{"key":"BFnature03648_CR20","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1242\/dev.124.22.4523","volume":"124","author":"V Knezevic","year":"1997","unstructured":"Knezevic, V. et al. Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop. Development 124, 4523\u20134536 (1997)","journal-title":"Development"},{"key":"BFnature03648_CR21","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1038\/nature01033","volume":"418","author":"Y Litingtung","year":"2002","unstructured":"Litingtung, Y., Dahn, R. D., Li, Y., Fallon, J. F. & Chiang, C. Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity. Nature 418, 979\u2013983 (2002)","journal-title":"Nature"},{"key":"BFnature03648_CR22","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1126\/science.1075620","volume":"298","author":"P te Welscher","year":"2002","unstructured":"te Welscher, P. et al. Progression of vertebrate limb development through SHH-mediated counteraction of GLI3. Science 298, 827\u2013830 (2002)","journal-title":"Science"},{"key":"BFnature03648_CR23","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/0169-5347(96)81089-5","volume":"11","author":"PDD Sordino","year":"1996","unstructured":"Sordino, P. D. D. A molecular approach to the evolution of vertebrate paired appendages. Trends Ecol. Evol. 11, 114\u2013119 (1996)","journal-title":"Trends Ecol. Evol."},{"key":"BFnature03648_CR24","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1038\/28197","volume":"394","author":"S Gonzalez-Crespo","year":"1998","unstructured":"Gonzalez-Crespo, S. et al. Antagonism between extradenticle function and Hedgehog signalling in the developing limb. Nature 394, 196\u2013200 (1998)","journal-title":"Nature"},{"key":"BFnature03648_CR25","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/46580","volume":"402","author":"N Mercader","year":"1999","unstructured":"Mercader, N. et al. Conserved regulation of proximodistal limb axis development by Meis1\/Hth. Nature 402, 425\u2013429 (1999)","journal-title":"Nature"},{"key":"BFnature03648_CR26","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/S1097-2765(00)80393-7","volume":"4","author":"J Capdevila","year":"1999","unstructured":"Capdevila, J., Tsukui, T., Rodriquez Esteban, C., Zappavigna, V. & Izpisua Belmonte, J. C. Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin. Mol. Cell 4, 839\u2013849 (1999)","journal-title":"Mol. Cell"},{"key":"BFnature03648_CR27","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/41710","volume":"388","author":"N Shubin","year":"1997","unstructured":"Shubin, N., Tabin, C. & Carroll, S. Fossils, genes and the evolution of animal limbs. Nature 388, 639\u2013648 (1997)","journal-title":"Nature"},{"key":"BFnature03648_CR28","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/361692a0","volume":"361","author":"CJ Tabin","year":"1993","unstructured":"Tabin, C. J. & Laufer, E. Hox genes and the evolutionary origin of the serial homology between fore and hind limbs. Nature 361, 692\u2013693 (1993)","journal-title":"Nature"},{"key":"BFnature03648_CR29","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1242\/dev.124.2.399","volume":"124","author":"V Dupe","year":"1997","unstructured":"Dupe, V. et al. In vivo functional analysis of the Hoxa-1 3\u2032 retinoic acid response element (3\u2032RARE). Development 124, 399\u2013410 (1997)","journal-title":"Development"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature03648.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature03648","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature03648.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:46:06Z","timestamp":1684417566000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature03648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":29,"journal-issue":{"issue":"7045","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["BFnature03648"],"URL":"https:\/\/doi.org\/10.1038\/nature03648","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1026697.323480","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1026697.326506","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}