{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:19:38Z","timestamp":1774527578745,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7092","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1038\/nature04791","type":"journal-article","created":{"date-parts":[[2006,5,24]],"date-time":"2006-05-24T15:58:15Z","timestamp":1148486295000},"page":"537-541","source":"Crossref","is-referenced-by-count":1384,"title":["Fatality in mice due to oversaturation of cellular microRNA\/short hairpin RNA pathways"],"prefix":"10.1038","volume":"441","author":[{"given":"Dirk","family":"Grimm","sequence":"first","affiliation":[]},{"given":"Konrad L.","family":"Streetz","sequence":"additional","affiliation":[]},{"given":"Catherine L.","family":"Jopling","sequence":"additional","affiliation":[]},{"given":"Theresa A.","family":"Storm","sequence":"additional","affiliation":[]},{"given":"Kusum","family":"Pandey","sequence":"additional","affiliation":[]},{"given":"Corrine R.","family":"Davis","sequence":"additional","affiliation":[]},{"given":"Patricia","family":"Marion","sequence":"additional","affiliation":[]},{"given":"Felix","family":"Salazar","sequence":"additional","affiliation":[]},{"given":"Mark A.","family":"Kay","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BFnature04791_CR1","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/418244a","volume":"418","author":"GJ Hannon","year":"2002","unstructured":"Hannon, G. J. RNA interference. Nature 418, 244\u2013251 (2002)","journal-title":"Nature"},{"key":"BFnature04791_CR2","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/430161a","volume":"430","author":"CD Novina","year":"2004","unstructured":"Novina, C. D. & Sharp, P. A. The RNAi revolution. Nature 430, 161\u2013164 (2004)","journal-title":"Nature"},{"key":"BFnature04791_CR3","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1146\/annurev.med.56.082103.104606","volume":"56","author":"DM Dykxhoorn","year":"2005","unstructured":"Dykxhoorn, D. M. & Lieberman, J. The silent revolution: RNA interference as basic biology, research tool, and therapeutic. Annu. Rev. Med. 56, 401\u2013423 (2005)","journal-title":"Annu. Rev. Med."},{"key":"BFnature04791_CR4","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/nature02870","volume":"431","author":"GJ Hannon","year":"2004","unstructured":"Hannon, G. J. & Rossi, J. J. Unlocking the potential of the human genome with RNA interference. Nature 431, 371\u2013378 (2004)","journal-title":"Nature"},{"key":"BFnature04791_CR5","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1128\/JVI.79.1.214-224.2005","volume":"79","author":"H Nakai","year":"2005","unstructured":"Nakai, H. et al. Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice. J. Virol. 79, 214\u2013224 (2005)","journal-title":"J. Virol."},{"key":"BFnature04791_CR6","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1038\/sj.gt.3301514","volume":"8","author":"DM McCarty","year":"2001","unstructured":"McCarty, D. M., Monahan, P. E. & Samulski, R. J. Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis. Gene Ther. 8, 1248\u20131254 (2001)","journal-title":"Gene Ther."},{"key":"BFnature04791_CR7","doi-asserted-by":"publisher","first-page":"281","DOI":"10.2174\/1566523034578285","volume":"3","author":"D Grimm","year":"2003","unstructured":"Grimm, D. & Kay, M. A. From virus evolution to vector revolution: use of naturally occurring serotypes of adeno-associated virus (AAV) as novel vectors for human gene therapy. Curr. Gene Ther. 3, 281\u2013304 (2003)","journal-title":"Curr. Gene Ther."},{"key":"BFnature04791_CR8","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.tig.2004.08.006","volume":"20","author":"AL Jackson","year":"2004","unstructured":"Jackson, A. L. & Linsley, P. S. Noise amidst the silence: off-target effects of siRNAs? Trends Genet. 20, 521\u2013524 (2004)","journal-title":"Trends Genet."},{"key":"BFnature04791_CR9","doi-asserted-by":"publisher","first-page":"6969","DOI":"10.1128\/JVI.75.15.6969-6976.2001","volume":"75","author":"H Nakai","year":"2001","unstructured":"Nakai, H. et al. Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo. J. Virol. 75, 6969\u20136976 (2001)","journal-title":"J. Virol."},{"key":"BFnature04791_CR10","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2004","unstructured":"Bartel, D. P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281\u2013297 (2004)","journal-title":"Cell"},{"key":"BFnature04791_CR11","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/nature02871","volume":"431","author":"V Ambros","year":"2004","unstructured":"Ambros, V. The functions of animal microRNAs. Nature 431, 350\u2013355 (2004)","journal-title":"Nature"},{"key":"BFnature04791_CR12","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1126\/science.1113329","volume":"309","author":"CL Jopling","year":"2005","unstructured":"Jopling, C. L., Yi, M., Lancaster, A. M., Lemon, S. M. & Sarnow, P. Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA. Science 309, 1577\u20131581 (2005)","journal-title":"Science"},{"key":"BFnature04791_CR13","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/S0960-9822(02)00809-6","volume":"12","author":"M Lagos-Quintana","year":"2002","unstructured":"Lagos-Quintana, M. et al. Identification of tissue-specific microRNAs from mouse. Curr. Biol. 12, 735\u2013739 (2002)","journal-title":"Curr. Biol."},{"key":"BFnature04791_CR14","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1261\/rna.7233305","volume":"11","author":"R Yi","year":"2005","unstructured":"Yi, R., Doehle, B. P., Qin, Y., Macara, I. G. & Cullen, B. R. Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs. RNA 11, 220\u2013226 (2005)","journal-title":"RNA"},{"key":"BFnature04791_CR15","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.1101\/gad.1158803","volume":"17","author":"R Yi","year":"2003","unstructured":"Yi, R., Qin, Y., Macara, I. G. & Cullen, B. R. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 17, 3011\u20133016 (2003)","journal-title":"Genes Dev."},{"key":"BFnature04791_CR16","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1261\/rna.5167604","volume":"10","author":"MT Bohnsack","year":"2004","unstructured":"Bohnsack, M. T., Czaplinski, K. & G\u00f6rlich, D. Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA 10, 185\u2013191 (2004)","journal-title":"RNA"},{"key":"BFnature04791_CR17","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1126\/science.1090599","volume":"303","author":"E Lund","year":"2004","unstructured":"Lund, E., Guttinger, S., Calado, A., Dahlberg, J. E. & Kutay, U. Nuclear export of microRNA precursors. Science 303, 95\u201398 (2004)","journal-title":"Science"},{"key":"BFnature04791_CR18","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/nrm1568","volume":"6","author":"EJ Sontheimer","year":"2005","unstructured":"Sontheimer, E. J. Assembly and function of RNA silencing complexes. Nature Rev. Mol. Cell Biol. 6, 127\u2013138 (2005)","journal-title":"Nature Rev. Mol. Cell Biol."},{"key":"BFnature04791_CR19","first-page":"197","volume-title":"Frontiers in Viral Hepatitis","author":"PL Marion","year":"2002","unstructured":"Marion, P. L., et al. in Frontiers in Viral Hepatitis (eds Schinazi, R. F., Rice, C. & Sommadossi, J.-P.) 197\u2013209 (Elsevier Science, Amsterdam, 2002)"},{"key":"BFnature04791_CR20","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/nature04303","volume":"438","author":"J Krutzfeldt","year":"2005","unstructured":"Krutzfeldt, J. et al. Silencing of microRNAs in vivo with \u2018antagomirs\u2019. Nature 438, 685\u2013689 (2005)","journal-title":"Nature"},{"key":"BFnature04791_CR21","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/nature02873","volume":"431","author":"G Meister","year":"2004","unstructured":"Meister, G. & Tuschl, T. Mechanisms of gene silencing by double-stranded RNA. Nature 431, 343\u2013349 (2004)","journal-title":"Nature"},{"key":"BFnature04791_CR22","first-page":"217","volume":"46","author":"W Cao","year":"2005","unstructured":"Cao, W., Hunter, R., Strnatka, D., McQueen, C. A. & Erickson, R. P. DNA constructs designed to produce short hairpin, interfering RNAs in transgenic mice sometimes show early lethality and an interferon response. J. Appl. Genet. 46, 217\u2013225 (2005)","journal-title":"J. Appl. Genet."},{"key":"BFnature04791_CR23","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1038\/nbt739","volume":"20","author":"H Xia","year":"2002","unstructured":"Xia, H., Mao, Q., Paulson, H. L. & Davidson, B. L. siRNA-mediated gene silencing in vitro and in vivo. Nature Biotechnol. 20, 1006\u20131010 (2002)","journal-title":"Nature Biotechnol."},{"key":"BFnature04791_CR24","doi-asserted-by":"publisher","first-page":"10380","DOI":"10.1073\/pnas.0403954101","volume":"101","author":"A Ventura","year":"2004","unstructured":"Ventura, A. et al. Cre-lox-regulated conditional RNA interference from transgenes. Proc. Natl Acad. Sci. USA 101, 10380\u201310385 (2004)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature04791_CR25","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1038\/nm964","volume":"9","author":"JD Hommel","year":"2003","unstructured":"Hommel, J. D., Sears, R. M., Georgescu, D., Simmons, D. L. & DiLeone, R. J. Local gene knockdown in the brain using viral-mediated RNA interference. Nature Med. 9, 1539\u20131544 (2003)","journal-title":"Nature Med."},{"key":"BFnature04791_CR26","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/nm1076","volume":"10","author":"H Xia","year":"2004","unstructured":"Xia, H. et al. RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia. Nature Med. 10, 816\u2013820 (2004)","journal-title":"Nature Med."},{"key":"BFnature04791_CR27","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/nbt824","volume":"21","author":"AP McCaffrey","year":"2003","unstructured":"McCaffrey, A. P. et al. Inhibition of hepatitis B virus in mice by RNA interference. Nature Biotechnol. 21, 639\u2013644 (2003)","journal-title":"Nature Biotechnol."},{"key":"BFnature04791_CR28","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/418038a","volume":"418","author":"AP McCaffrey","year":"2002","unstructured":"McCaffrey, A. P. et al. RNA interference in adult mice. Nature 418, 38\u201339 (2002)","journal-title":"Nature"},{"key":"BFnature04791_CR29","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/S1046-2023(02)00219-0","volume":"28","author":"D Grimm","year":"2002","unstructured":"Grimm, D. Production methods for gene transfer vectors based on adeno-associated virus serotypes. Methods 28, 146\u2013157 (2002)","journal-title":"Methods"},{"key":"BFnature04791_CR30","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1097\/01.TP.0000130180.42573.B1","volume":"78","author":"DD Jenkins","year":"2004","unstructured":"Jenkins, D. D. et al. Donor-derived, liver-specific protein expression after bone marrow transplantation. Transplantation 78, 530\u2013536 (2004)","journal-title":"Transplantation"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature04791.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature04791","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature04791.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:55:32Z","timestamp":1684418132000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature04791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":30,"journal-issue":{"issue":"7092","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["BFnature04791"],"URL":"https:\/\/doi.org\/10.1038\/nature04791","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1032928.374571","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1032928.375072","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}