{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T03:07:56Z","timestamp":1778987276988,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7103","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1038\/nature04926","type":"journal-article","created":{"date-parts":[[2006,7,21]],"date-time":"2006-07-21T08:06:55Z","timestamp":1153469215000},"page":"651-656","source":"Crossref","is-referenced-by-count":748,"title":["Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity"],"prefix":"10.1038","volume":"442","author":[{"given":"Olaf","family":"Gross","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Gewies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Finger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Sparwasser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Peschel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irmgard","family":"F\u00f6rster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Ruland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,7,12]]},"reference":[{"key":"BFnature04926_CR1","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nri1391","volume":"4","author":"S Akira","year":"2004","unstructured":"Akira, S. & Takeda, K. Toll-like receptor signalling. Nature Rev. Immunol. 4, 499\u2013511 (2004)","journal-title":"Nature Rev. Immunol."},{"key":"BFnature04926_CR2","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/S0092-8674(02)01201-1","volume":"111","author":"S Gordon","year":"2002","unstructured":"Gordon, S. Pattern recognition receptors: doubling up for the innate immune response. Cell 111, 927\u2013930 (2002)","journal-title":"Cell"},{"key":"BFnature04926_CR3","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/nri1086","volume":"3","author":"N Inohara","year":"2003","unstructured":"Inohara, N. & Nunez, G. NODs: intracellular proteins involved in inflammation and apoptosis. Nature Rev. Immunol. 3, 371\u2013382 (2003)","journal-title":"Nature Rev. Immunol."},{"key":"BFnature04926_CR4","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.smim.2004.08.022","volume":"16","author":"X Lin","year":"2004","unstructured":"Lin, X. & Wang, D. The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling. Semin. Immunol. 16, 429\u2013435 (2004)","journal-title":"Semin. Immunol."},{"key":"BFnature04926_CR5","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.it.2004.03.008","volume":"25","author":"G Bonizzi","year":"2004","unstructured":"Bonizzi, G. & Karin, M. The two NF-\u03baB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 25, 280\u2013288 (2004)","journal-title":"Trends Immunol."},{"key":"BFnature04926_CR6","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/nri1352","volume":"4","author":"M Thome","year":"2004","unstructured":"Thome, M. CARMA1, BCL-10 and MALT1 in lymphocyte development and activation. Nature Rev. Immunol. 4, 348\u2013359 (2004)","journal-title":"Nature Rev. Immunol."},{"key":"BFnature04926_CR7","doi-asserted-by":"publisher","first-page":"41082","DOI":"10.1074\/jbc.C000726200","volume":"275","author":"J Bertin","year":"2000","unstructured":"Bertin, J. et al. CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10\/CLAP and activates NF-\u03baB. J. Biol. Chem. 275, 41082\u201341086 (2000)","journal-title":"J. Biol. Chem."},{"key":"BFnature04926_CR8","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.immuni.2005.10.007","volume":"23","author":"R Matsumoto","year":"2005","unstructured":"Matsumoto, R. et al. Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-\u03baB activation. Immunity 23, 575\u2013585 (2005)","journal-title":"Immunity"},{"key":"BFnature04926_CR9","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.immuni.2005.09.014","volume":"23","author":"K Sommer","year":"2005","unstructured":"Sommer, K. et al. Phosphorylation of the CARMA1 linker controls NF-\u03baB activation. Immunity 23, 561\u2013574 (2005)","journal-title":"Immunity"},{"key":"BFnature04926_CR10","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/S1471-4906(03)00177-7","volume":"24","author":"M Thome","year":"2003","unstructured":"Thome, M. & Tschopp, J. TCR-induced NF-\u03baB activation: a crucial role for Carma1, Bcl10 and MALT1. Trends Immunol. 24, 419\u2013424 (2003)","journal-title":"Trends Immunol."},{"key":"BFnature04926_CR11","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1126\/science.127.3301.756-a","volume":"127","author":"FJ Di Carlo","year":"1958","unstructured":"Di Carlo, F. J. & Fiore, J. V. On the composition of zymosan. Science 127, 756\u2013757 (1958)","journal-title":"Science"},{"key":"BFnature04926_CR12","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/35092620","volume":"413","author":"GD Brown","year":"2001","unstructured":"Brown, G. D. & Gordon, S. Immune recognition. A new receptor for \u03b2-glucans. Nature 413, 36\u201337 (2001)","journal-title":"Nature"},{"key":"BFnature04926_CR13","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/44605","volume":"401","author":"DM Underhill","year":"1999","unstructured":"Underhill, D. M. et al. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 401, 811\u2013815 (1999)","journal-title":"Nature"},{"key":"BFnature04926_CR14","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S1074-7613(03)00233-4","volume":"19","author":"GD Brown","year":"2003","unstructured":"Brown, G. D. & Gordon, S. Fungal \u03b2-glucans and mammalian immunity. Immunity 19, 311\u2013315 (2003)","journal-title":"Immunity"},{"key":"BFnature04926_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.micinf.2003.09.020","volume":"6","author":"E Villamon","year":"2004","unstructured":"Villamon, E. et al. Toll-like receptor-2 is essential in murine defenses against Candida albicans infections. Microbes Infect. 6, 1\u20137 (2004)","journal-title":"Microbes Infect."},{"key":"BFnature04926_CR16","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1084\/jem.20021787","volume":"197","author":"BN Gantner","year":"2003","unstructured":"Gantner, B. N., Simmons, R. M., Canavera, S. J., Akira, S. & Underhill, D. M. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J. Exp. Med. 197, 1107\u20131117 (2003)","journal-title":"J. Exp. Med."},{"key":"BFnature04926_CR17","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.immuni.2005.03.004","volume":"22","author":"NC Rogers","year":"2005","unstructured":"Rogers, N. C. et al. Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity 22, 507\u2013517 (2005)","journal-title":"Immunity"},{"key":"BFnature04926_CR18","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1084\/jem.20021890","volume":"197","author":"GD Brown","year":"2003","unstructured":"Brown, G. D. et al. Dectin-1 mediates the biological effects of \u03b2-glucans. J. Exp. Med. 197, 1119\u20131124 (2003)","journal-title":"J. Exp. Med."},{"key":"BFnature04926_CR19","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nri1745","volume":"6","author":"GD Brown","year":"2005","unstructured":"Brown, G. D. Dectin-1: a signalling non-TLR pattern-recognition receptor. Nature Rev. Immunol. 6, 33\u201343 (2005)","journal-title":"Nature Rev. Immunol."},{"key":"BFnature04926_CR20","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/S1074-7613(00)80119-3","volume":"11","author":"O Takeuchi","year":"1999","unstructured":"Takeuchi, O. et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11, 443\u2013451 (1999)","journal-title":"Immunity"},{"key":"BFnature04926_CR21","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1126\/science.285.5428.736","volume":"285","author":"AO Aliprantis","year":"1999","unstructured":"Aliprantis, A. O. et al. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 285, 736\u2013739 (1999)","journal-title":"Science"},{"key":"BFnature04926_CR22","doi-asserted-by":"publisher","first-page":"5392","DOI":"10.4049\/jimmunol.165.10.5392","volume":"165","author":"O Takeuchi","year":"2000","unstructured":"Takeuchi, O., Hoshino, K. & Akira, S. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J. Immunol. 165, 5392\u20135396 (2000)","journal-title":"J. Immunol."},{"key":"BFnature04926_CR23","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S1074-7613(00)80086-2","volume":"11","author":"T Kawai","year":"1999","unstructured":"Kawai, T., Adachi, O., Ogawa, T., Takeda, K. & Akira, S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11, 115\u2013122 (1999)","journal-title":"Immunity"},{"key":"BFnature04926_CR24","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0092-8674(01)00189-1","volume":"104","author":"J Ruland","year":"2001","unstructured":"Ruland, J. et al. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-\u03baB and neural tube closure. Cell 104, 33\u201342 (2001)","journal-title":"Cell"},{"key":"BFnature04926_CR25","doi-asserted-by":"publisher","first-page":"30589","DOI":"10.1074\/jbc.M103824200","volume":"276","author":"LM McAllister-Lucas","year":"2001","unstructured":"McAllister-Lucas, L. M. et al. Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-\u03baB induction. J. Biol. Chem. 276, 30589\u201330597 (2001)","journal-title":"J. Biol. Chem."},{"key":"BFnature04926_CR26","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1074\/jbc.M506790200","volume":"281","author":"AG Eliopoulos","year":"2006","unstructured":"Eliopoulos, A. G., Das, S. & Tsichlis, P. N. The tyrosine kinase Syk regulates TPL2 activation signals. J. Biol. Chem. 281, 1371\u20131380 (2006)","journal-title":"J. Biol. Chem."},{"key":"BFnature04926_CR27","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/S1074-7613(03)00293-0","volume":"19","author":"J Ruland","year":"2003","unstructured":"Ruland, J., Duncan, G. S., Wakeham, A. & Mak, T. W. Differential requirement for Malt1 in T and B cell antigen receptor signaling. Immunity 19, 749\u2013758 (2003)","journal-title":"Immunity"},{"key":"BFnature04926_CR28","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1084\/jem.20051982","volume":"203","author":"S Klemm","year":"2006","unstructured":"Klemm, S. et al. The Bcl10-Malt1 complex segregates Fc\u025bRI-mediated nuclear factor \u03baB activation and cytokine production from mast cell degranulation. J. Exp. Med. 203, 337\u2013347 (2006)","journal-title":"J. Exp. Med."},{"key":"BFnature04926_CR29","doi-asserted-by":"publisher","first-page":"2991","DOI":"10.1002\/eji.200526192","volume":"35","author":"M Hammer","year":"2005","unstructured":"Hammer, M. et al. Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10. Eur. J. Immunol. 35, 2991\u20133001 (2005)","journal-title":"Eur. J. Immunol."},{"key":"BFnature04926_CR30","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1002\/(SICI)1521-4141(199806)28:06<2045::AID-IMMU2045>3.0.CO;2-8","volume":"28","author":"T Sparwasser","year":"1998","unstructured":"Sparwasser, T. et al. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur. J. Immunol. 28, 2045\u20132054 (1998)","journal-title":"Eur. J. Immunol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature04926.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature04926","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature04926.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:56:56Z","timestamp":1684418216000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature04926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,12]]},"references-count":30,"journal-issue":{"issue":"7103","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["BFnature04926"],"URL":"https:\/\/doi.org\/10.1038\/nature04926","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1005834.488929","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1005834.488970","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1005834.489798","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1005834.375842","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,12]]}}}