{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:12:25Z","timestamp":1784542345648,"version":"3.55.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"7123","license":[{"start":{"date-parts":[[2006,11,19]],"date-time":"2006-11-19T00:00:00Z","timestamp":1163894400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1038\/nature05384","type":"journal-article","created":{"date-parts":[[2006,11,22]],"date-time":"2006-11-22T14:19:13Z","timestamp":1164205153000},"page":"111-115","source":"Crossref","is-referenced-by-count":3253,"title":["Identification and expansion of human colon-cancer-initiating cells"],"prefix":"10.1038","volume":"445","author":[{"given":"Lucia","family":"Ricci-Vitiani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario G.","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Pilozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Biffoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Todaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Peschle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruggero","family":"De Maria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,11,19]]},"reference":[{"key":"BFnature05384_CR1","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3322\/canjclin.56.2.106","volume":"56","author":"A Jemal","year":"2006","unstructured":"Jemal, A. et al. Cancer statistics, 2006. CA Cancer J. Clinic. 56, 106\u2013130 (2006)","journal-title":"CA Cancer J. Clinic."},{"key":"BFnature05384_CR2","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/nm0797-730","volume":"3","author":"D Bonnet","year":"1997","unstructured":"Bonnet, D. & Dick, J. E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nature Med. 3, 730\u2013737 (1997)","journal-title":"Nature Med."},{"key":"BFnature05384_CR3","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/nrc1232","volume":"3","author":"R Pardal","year":"2003","unstructured":"Pardal, R., Clarke, M. F. & Morrison, S. J. Applying the principles of stem-cell biology to cancer. Nature Rev. Cancer 3, 895\u2013902 (2003)","journal-title":"Nature Rev. Cancer"},{"key":"BFnature05384_CR4","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/nature03128","volume":"432","author":"SK Singh","year":"2004","unstructured":"Singh, S. K. et al. Identification of human brain tumour initiating cells. Nature 432, 396\u2013401 (2004)","journal-title":"Nature"},{"key":"BFnature05384_CR5","doi-asserted-by":"publisher","first-page":"14720","DOI":"10.1073\/pnas.97.26.14720","volume":"97","author":"N Uchida","year":"2000","unstructured":"Uchida, N. et al. Direct isolation of human central nervous system stem cells. Proc. Natl Acad. Sci. USA 97, 14720\u201314725 (2000)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature05384_CR6","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1182\/blood.V90.12.5002","volume":"90","author":"AH Yin","year":"1997","unstructured":"Yin, A. H. et al. AC133, a novel marker for human hematopoietic stem and progenitor cells. Blood 90, 5002\u20135012 (1997)","journal-title":"Blood"},{"key":"BFnature05384_CR7","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1182\/blood-2002-03-0755","volume":"101","author":"P Salven","year":"2003","unstructured":"Salven, P., Mustjoki, S., Alitalo, R., Alitalo, K. & Rafii, S. VEGFR-3 and CD133 identify a population of CD34+ lymphatic\/vascular endothelial precursor cells. Blood 101, 168\u2013172 (2003)","journal-title":"Blood"},{"key":"BFnature05384_CR8","first-page":"205","volume":"31","author":"R Moll","year":"1998","unstructured":"Moll, R. Cytokeratins as markers of differentiation in the diagnosis of epithelial tumors. Subcell. Biochem. 31, 205\u2013262 (1998)","journal-title":"Subcell. Biochem."},{"key":"BFnature05384_CR9","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1309\/M877-QABM-D9GB-FJAX","volume":"118","author":"B Davidson","year":"2002","unstructured":"Davidson, B. et al. Detection of malignant epithelial cells in effusions using flow cytometric immunophenotyping: an analysis of 92 cases. Am. J. Clin. Pathol. 118, 85\u201392 (2002)","journal-title":"Am. J. Clin. Pathol."},{"key":"BFnature05384_CR10","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1093\/ajcp\/94.2.157","volume":"94","author":"K Sheahan","year":"1990","unstructured":"Sheahan, K. et al. Differential reactivities of carcinoembryonic antigen (CEA) and CEA-related monoclonal and polyclonal antibodies in common epithelial malignancies. Am. J. Clin. Pathol. 94, 157\u2013164 (1990)","journal-title":"Am. J. Clin. Pathol."},{"key":"BFnature05384_CR11","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/359235a0","volume":"359","author":"SM Powell","year":"1992","unstructured":"Powell, S. M. et al. APC mutations occur early during colorectal tumorigenesis. Nature 359, 235\u2013237 (1992)","journal-title":"Nature"},{"key":"BFnature05384_CR12","doi-asserted-by":"publisher","first-page":"7555","DOI":"10.1073\/pnas.87.19.7555","volume":"87","author":"NR Rodrigues","year":"1990","unstructured":"Rodrigues, N. R. et al. p53 mutations in colorectal cancer. Proc. Natl Acad. Sci. USA 87, 7555\u20137559 (1990)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature05384_CR13","first-page":"1689","volume":"48","author":"JM Jessup","year":"1988","unstructured":"Jessup, J. M. et al. Growth potential of human colorectal carcinomas in nude mice: association with the preoperative serum concentration of carcinoembryonic antigen in patients. Cancer Res. 48, 1689\u20131692 (1988)","journal-title":"Cancer Res."},{"key":"BFnature05384_CR14","doi-asserted-by":"publisher","first-page":"3983","DOI":"10.1073\/pnas.0530291100","volume":"100","author":"M Al-Hajj","year":"2003","unstructured":"Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J. & Clarke, M. F. Prospective identification of tumorigenic breast cancer cells. Proc. Natl Acad. Sci. USA 100, 3983\u20133988 (2003)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature05384_CR15","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1006\/exnr.1998.6998","volume":"156","author":"AL Vescovi","year":"1999","unstructured":"Vescovi, A. L. et al. Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation. Exp. Neurol. 156, 71\u201383 (1999)","journal-title":"Exp. Neurol."},{"key":"BFnature05384_CR16","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1101\/gad.1061803","volume":"17","author":"G Dontu","year":"2003","unstructured":"Dontu, G. et al. In vitro propagation and transcriptional profiling of human mammary stem\/progenitor cells. Genes Dev. 17, 1253\u20131270 (2003)","journal-title":"Genes Dev."},{"key":"BFnature05384_CR17","first-page":"5821","volume":"63","author":"SK Singh","year":"2003","unstructured":"Singh, S. K. et al. Identification of a cancer stem cell in human brain tumors. Cancer Res. 63, 5821\u20135828 (2003)","journal-title":"Cancer Res."},{"key":"BFnature05384_CR18","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1038\/modpathol.3880175","volume":"13","author":"P Chu","year":"2000","unstructured":"Chu, P., Wu, E. & Weiss, L. M. Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. Mod. Pathol. 13, 962\u2013972 (2000)","journal-title":"Mod. Pathol."},{"key":"BFnature05384_CR19","first-page":"586","volume":"147","author":"HC Ee","year":"1995","unstructured":"Ee, H. C., Erler, T., Bhathal, P. S., Young, G. P. & James, R. J. Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma. Am. J. Pathol. 147, 586\u2013592 (1995)","journal-title":"Am. J. Pathol."},{"key":"BFnature05384_CR20","doi-asserted-by":"publisher","first-page":"8549","DOI":"10.1158\/1078-0432.CCR-05-1624","volume":"11","author":"ME Witek","year":"2005","unstructured":"Witek, M. E. et al. The putative tumor suppressor Cdx2 is overexpressed by human colorectal adenocarcinomas. Clin. Cancer Res. 11, 8549\u20138556 (2005)","journal-title":"Clin. Cancer Res."},{"key":"BFnature05384_CR21","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.tcb.2005.07.004","volume":"15","author":"JC Wang","year":"2005","unstructured":"Wang, J. C. & Dick, J. E. Cancer stem cells: lessons from leukemia. Trends Cell Biol. 15, 494\u2013501 (2005)","journal-title":"Trends Cell Biol."},{"key":"BFnature05384_CR22","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1038\/ng1005-1027","volume":"37","author":"H Clevers","year":"2005","unstructured":"Clevers, H. Stem cells, asymmetric division and cancer. Nature Genet. 37, 1027\u20131028 (2005)","journal-title":"Nature Genet."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature05384.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature05384","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature05384.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:00:51Z","timestamp":1684418451000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature05384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,19]]},"references-count":22,"journal-issue":{"issue":"7123","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["BFnature05384"],"URL":"https:\/\/doi.org\/10.1038\/nature05384","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1053014.510899","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1053014.519088","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1053014.504972","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,19]]}}}