{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:27:42Z","timestamp":1776724062212,"version":"3.51.2"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"7138","license":[{"start":{"date-parts":[[2007,3,28]],"date-time":"2007-03-28T00:00:00Z","timestamp":1175040000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1038\/nature05732","type":"journal-article","created":{"date-parts":[[2007,3,28]],"date-time":"2007-03-28T13:21:58Z","timestamp":1175088118000},"page":"916-920","source":"Crossref","is-referenced-by-count":1512,"title":["TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity"],"prefix":"10.1038","volume":"446","author":[{"given":"Michaela U.","family":"Gack","sequence":"first","affiliation":[]},{"given":"Young C.","family":"Shin","sequence":"additional","affiliation":[]},{"given":"Chul-Hyun","family":"Joo","sequence":"additional","affiliation":[]},{"given":"Tomohiko","family":"Urano","sequence":"additional","affiliation":[]},{"given":"Chengyu","family":"Liang","sequence":"additional","affiliation":[]},{"given":"Lijun","family":"Sun","sequence":"additional","affiliation":[]},{"given":"Osamu","family":"Takeuchi","sequence":"additional","affiliation":[]},{"given":"Shizuo","family":"Akira","sequence":"additional","affiliation":[]},{"given":"Zhijian","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Satoshi","family":"Inoue","sequence":"additional","affiliation":[]},{"given":"Jae U.","family":"Jung","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2007,3,28]]},"reference":[{"key":"BFnature05732_CR1","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.immuni.2006.08.009","volume":"25","author":"K Honda","year":"2006","unstructured":"Honda, K., Takaoka, A. & Taniguchi, T. Type I interferon gene induction by the interferon regulatory factor family of transcription factors. Immunity 25, 349\u2013360 (2006); erratum 25, 849 (2006).","journal-title":"Immunity"},{"key":"BFnature05732_CR2","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1126\/science.1132505","volume":"314","author":"V Hornung","year":"2006","unstructured":"Hornung, V. et al. 5\u2032-Triphosphate RNA is the ligand for RIG-I. Science 314, 994\u2013997 (2006)","journal-title":"Science"},{"key":"BFnature05732_CR3","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.molcel.2006.05.012","volume":"22","author":"E Meylan","year":"2006","unstructured":"Meylan, E. & Tschopp, J. Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses. Mol. Cell 22, 561\u2013569 (2006)","journal-title":"Mol. Cell"},{"key":"BFnature05732_CR4","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1126\/science.1132998","volume":"314","author":"A Pichlmair","year":"2006","unstructured":"Pichlmair, A. et al. RIG-I-mediated antiviral responses to single-stranded RNA bearing 5\u2032-phosphates. Science 314, 997\u20131001 (2006)","journal-title":"Science"},{"key":"BFnature05732_CR5","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1084\/jem.20061377","volume":"203","author":"DB Stetson","year":"2006","unstructured":"Stetson, D. B. & Medzhitov, R. Antiviral defense: interferons and beyond. J. Exp. Med. 203, 1837\u20131841 (2006)","journal-title":"J. Exp. Med."},{"key":"BFnature05732_CR6","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/ni1087","volume":"5","author":"M Yoneyama","year":"2004","unstructured":"Yoneyama, M. et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nature Immunol. 5, 730\u2013737 (2004)","journal-title":"Nature Immunol."},{"key":"BFnature05732_CR7","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/nrmicro1248","volume":"3","author":"S Nisole","year":"2005","unstructured":"Nisole, S., Stoye, J. P. & Saib, A. TRIM family proteins: retroviral restriction and antiviral defence. Nature Rev. Microbiol. 3, 799\u2013808 (2005)","journal-title":"Nature Rev. Microbiol."},{"key":"BFnature05732_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.it.2005.11.004","volume":"27","author":"CL Johnson","year":"2006","unstructured":"Johnson, C. L. & Gale, M. CARD games between virus and host get a new player. Trends Immunol. 27, 1\u20134 (2006)","journal-title":"Trends Immunol."},{"key":"BFnature05732_CR9","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/nature04946","volume":"442","author":"E Meylan","year":"2006","unstructured":"Meylan, E., Tschopp, J. & Karin, M. Intracellular pattern recognition receptors in the host response. Nature 442, 39\u201344 (2006)","journal-title":"Nature"},{"key":"BFnature05732_CR10","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.immuni.2005.04.010","volume":"23","author":"H Kato","year":"2005","unstructured":"Kato, H. et al. Cell type-specific involvement of RIG-I in antiviral response. Immunity 23, 19\u201328 (2005)","journal-title":"Immunity"},{"key":"BFnature05732_CR11","doi-asserted-by":"publisher","first-page":"24406","DOI":"10.1074\/jbc.270.41.24406","volume":"270","author":"A Orimo","year":"1995","unstructured":"Orimo, A., Inoue, S., Ikeda, K., Noji, S. & Muramatsu, M. Molecular cloning, structure, and expression of mouse estrogen-responsive finger protein Efp. Co-localization with estrogen receptor mRNA in target organs. J. Biol. Chem. 270, 24406\u201324413 (1995)","journal-title":"J. Biol. Chem."},{"key":"BFnature05732_CR12","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1038\/nature00826","volume":"417","author":"T Urano","year":"2002","unstructured":"Urano, T. et al. Efp targets 14-3-3\u03c3 for proteolysis and promotes breast tumour growth. Nature 417, 871\u2013875 (2002)","journal-title":"Nature"},{"key":"BFnature05732_CR13","doi-asserted-by":"publisher","first-page":"3989","DOI":"10.1074\/jbc.M510787200","volume":"281","author":"W Zou","year":"2006","unstructured":"Zou, W. & Zhang, D. E. The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase. J. Biol. Chem. 281, 3989\u20133994 (2006)","journal-title":"J. Biol. Chem."},{"key":"BFnature05732_CR14","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1038\/nature04193","volume":"437","author":"E Meylan","year":"2005","unstructured":"Meylan, E. et al. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437, 1167\u20131172 (2005)","journal-title":"Nature"},{"key":"BFnature05732_CR15","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.cell.2005.08.012","volume":"122","author":"RB Seth","year":"2005","unstructured":"Seth, R. B., Sun, L., Ea, C. K. & Chen, Z. J. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-\u03baB and IRF 3. Cell 122, 669\u2013682 (2005)","journal-title":"Cell"},{"key":"BFnature05732_CR16","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.molcel.2005.08.014","volume":"19","author":"LG Xu","year":"2005","unstructured":"Xu, L. G. et al. VISA is an adapter protein required for virus-triggered IFN-\u03b2 signaling. Mol. Cell 19, 727\u2013740 (2005)","journal-title":"Mol. Cell"},{"key":"BFnature05732_CR17","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/ni1243","volume":"6","author":"T Kawai","year":"2005","unstructured":"Kawai, T. et al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nature Immunol. 6, 981\u2013988 (2005)","journal-title":"Nature Immunol."},{"key":"BFnature05732_CR18","doi-asserted-by":"publisher","first-page":"12027","DOI":"10.1073\/pnas.96.21.12027","volume":"96","author":"A Orimo","year":"1999","unstructured":"Orimo, A. et al. Underdeveloped uterus and reduced estrogen responsiveness in mice with disruption of the estrogen-responsive finger protein gene, which is a direct target of estrogen receptor \u03b1. Proc. Natl Acad. Sci. USA 96, 12027\u201312032 (1999)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature05732_CR19","doi-asserted-by":"publisher","first-page":"3353","DOI":"10.1038\/sj.emboj.7600808","volume":"24","author":"K Haglund","year":"2005","unstructured":"Haglund, K. & Dikic, I. Ubiquitylation and cell signaling. EMBO J. 24, 3353\u20133359 (2005)","journal-title":"EMBO J."},{"key":"BFnature05732_CR20","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.molcel.2006.03.026","volume":"22","author":"CK Ea","year":"2006","unstructured":"Ea, C. K., Deng, L., Xia, Z. P., Pineda, G. & Chen, Z. J. Activation of IKK by TNF\u03b1 requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol. Cell 22, 245\u2013257 (2006)","journal-title":"Mol. Cell"},{"key":"BFnature05732_CR21","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1038\/ncb0805-750","volume":"7","author":"DS Kirkpatrick","year":"2005","unstructured":"Kirkpatrick, D. S., Denison, C. & Gygi, S. P. Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics. Nature Cell Biol. 7, 750\u2013757 (2005)","journal-title":"Nature Cell Biol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature05732.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature05732","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature05732.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:03:47Z","timestamp":1684418627000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature05732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,28]]},"references-count":21,"journal-issue":{"issue":"7138","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["BFnature05732"],"URL":"https:\/\/doi.org\/10.1038\/nature05732","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1080832.533755","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1080832.535741","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,28]]}}}