{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T19:34:05Z","timestamp":1772134445469,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"7146","license":[{"start":{"date-parts":[[2007,5,16]],"date-time":"2007-05-16T00:00:00Z","timestamp":1179273600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1038\/nature05841","type":"journal-article","created":{"date-parts":[[2007,5,16]],"date-time":"2007-05-16T13:11:43Z","timestamp":1179321103000},"page":"823-828","source":"Crossref","is-referenced-by-count":384,"title":["MicroRNA silencing through RISC recruitment of eIF6"],"prefix":"10.1038","volume":"447","author":[{"given":"Thimmaiah P.","family":"Chendrimada","sequence":"first","affiliation":[]},{"given":"Kenneth J.","family":"Finn","sequence":"additional","affiliation":[]},{"given":"Xinjun","family":"Ji","sequence":"additional","affiliation":[]},{"given":"David","family":"Baillat","sequence":"additional","affiliation":[]},{"given":"Richard I.","family":"Gregory","sequence":"additional","affiliation":[]},{"given":"Stephen A.","family":"Liebhaber","sequence":"additional","affiliation":[]},{"given":"Amy E.","family":"Pasquinelli","sequence":"additional","affiliation":[]},{"given":"Ramin","family":"Shiekhattar","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2007,5,16]]},"reference":[{"key":"BFnature05841_CR1","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/nrm1644","volume":"6","author":"VN Kim","year":"2005","unstructured":"Kim, V. N. MicroRNA biogenesis: coordinated cropping and dicing. Nature Rev. Mol. Cell Biol. 6, 376\u2013385 (2005)","journal-title":"Nature Rev. Mol. Cell Biol."},{"key":"BFnature05841_CR2","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.cell.2005.10.022","volume":"123","author":"RI Gregory","year":"2005","unstructured":"Gregory, R. I., Chendrimada, T. P., Cooch, N. & Shiekhattar, R. Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell 123, 631\u2013640 (2005)","journal-title":"Cell"},{"key":"BFnature05841_CR3","doi-asserted-by":"publisher","first-page":"re1","DOI":"10.1126\/stke.3672007re1","volume":"2007","author":"RJ Jackson","year":"2007","unstructured":"Jackson, R. J. & Standart, N. How do microRNAs regulate gene expression? Sci. STKE 2007, re1 (2007)","journal-title":"Sci. STKE"},{"key":"BFnature05841_CR4","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1101\/gad.1399806","volume":"20","author":"MA Valencia-Sanchez","year":"2006","unstructured":"Valencia-Sanchez, M. A., Liu, J., Hannon, G. J. & Parker, R. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev. 20, 515\u2013524 (2006)","journal-title":"Genes Dev."},{"key":"BFnature05841_CR5","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/S0092-8674(04)00250-8","volume":"116","author":"HA Cook","year":"2004","unstructured":"Cook, H. A., Koppetsch, B. S., Wu, J. & Theurkauf, W. E. The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification. Cell 116, 817\u2013829 (2004)","journal-title":"Cell"},{"key":"BFnature05841_CR6","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/S0092-8674(04)00218-1","volume":"116","author":"Y Tomari","year":"2004","unstructured":"Tomari, Y. et al. RISC assembly defects in the Drosophila RNAi mutant armitage. Cell 116, 831\u2013841 (2004)","journal-title":"Cell"},{"key":"BFnature05841_CR7","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/nature02160","volume":"426","author":"M Ceci","year":"2003","unstructured":"Ceci, M. et al. Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly. Nature 426, 579\u2013584 (2003)","journal-title":"Nature"},{"key":"BFnature05841_CR8","doi-asserted-by":"crossref","first-page":"8796","DOI":"10.1016\/S0021-9258(19)86768-6","volume":"254","author":"DW Russell","year":"1979","unstructured":"Russell, D. W. & Spremulli, L. L. Purification and characterization of a ribosome dissociation factor (eukaryotic initiation factor 6) from wheat germ. J. Biol. Chem. 254, 8796\u20138800 (1979)","journal-title":"J. Biol. Chem."},{"key":"BFnature05841_CR9","doi-asserted-by":"crossref","first-page":"7712","DOI":"10.1016\/S0021-9258(18)34440-5","volume":"257","author":"DM Valenzuela","year":"1982","unstructured":"Valenzuela, D. M., Chaudhuri, A. & Maitra, U. Eukaryotic ribosomal subunit anti-association activity of calf liver is contained in a single polypeptide chain protein of Mr = 25,500 (eukaryotic initiation factor 6). J. Biol. Chem. 257, 7712\u20137719 (1982)","journal-title":"J. Biol. Chem."},{"key":"BFnature05841_CR10","doi-asserted-by":"crossref","first-page":"11930","DOI":"10.1016\/S0021-9258(20)71300-1","volume":"259","author":"P Raychaudhuri","year":"1984","unstructured":"Raychaudhuri, P., Stringer, E. A., Valenzuela, D. M. & Maitra, U. Ribosomal subunit antiassociation activity in rabbit reticulocyte lysates. Evidence for a low molecular weight ribosomal subunit antiassociation protein factor (Mr = 25,000). J. Biol. Chem. 259, 11930\u201311935 (1984)","journal-title":"J. Biol. Chem."},{"key":"BFnature05841_CR11","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/nature03868","volume":"436","author":"TP Chendrimada","year":"2005","unstructured":"Chendrimada, T. P. et al. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 436, 740\u2013744 (2005)","journal-title":"Nature"},{"key":"BFnature05841_CR12","doi-asserted-by":"publisher","first-page":"14285","DOI":"10.1073\/pnas.94.26.14285","volume":"94","author":"K Si","year":"1997","unstructured":"Si, K., Chaudhuri, J., Chevesich, J. & Maitra, U. Molecular cloning and functional expression of a human cDNA encoding translation initiation factor 6. Proc. Natl Acad. Sci. USA 94, 14285\u201314290 (1997)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature05841_CR13","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1016\/j.cub.2005.10.048","volume":"15","author":"G Meister","year":"2005","unstructured":"Meister, G. et al. Identification of novel argonaute-associated proteins. Curr. Biol. 15, 2149\u20132155 (2005)","journal-title":"Curr. Biol."},{"key":"BFnature05841_CR14","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1261\/rna.5181104","volume":"10","author":"PT Nelson","year":"2004","unstructured":"Nelson, P. T., Hatzigeorgiou, A. G. & Mourelatos, Z. miRNP:mRNA association in polyribosomes in a human neuronal cell line. RNA 10, 387\u2013394 (2004)","journal-title":"RNA"},{"key":"BFnature05841_CR15","doi-asserted-by":"publisher","first-page":"9198","DOI":"10.1128\/MCB.25.21.9198-9208.2005","volume":"25","author":"L Wu","year":"2005","unstructured":"Wu, L. & Belasco, J. G. Micro-RNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells. Mol. Cell. Biol. 25, 9198\u20139208 (2005)","journal-title":"Mol. Cell. Biol."},{"key":"BFnature05841_CR16","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1128\/MCB.21.5.1453-1462.2001","volume":"21","author":"U Basu","year":"2001","unstructured":"Basu, U., Si, K., Warner, J. R. & Maitra, U. The Saccharomyces cerevisiae TIF6 gene encoding translation initiation factor 6 is required for 60S ribosomal subunit biogenesis. Mol. Cell. Biol. 21, 1453\u20131462 (2001)","journal-title":"Mol. Cell. Biol."},{"key":"BFnature05841_CR17","doi-asserted-by":"publisher","first-page":"5516","DOI":"10.1128\/MCB.20.15.5516-5528.2000","volume":"20","author":"Z Strezoska","year":"2000","unstructured":"Strezoska, Z., Pestov, D. G. & Lau, L. F. Bop1 is a mouse WD40 repeat nucleolar protein involved in 28S and 5.8S RRNA processing and 60S ribosome biogenesis. Mol. Cell. Biol. 20, 5516\u20135528 (2000)","journal-title":"Mol. Cell. Biol."},{"key":"BFnature05841_CR18","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1128\/MCB.19.2.1416","volume":"19","author":"K Si","year":"1999","unstructured":"Si, K. & Maitra, U. The Saccharomyces cerevisiae homologue of mammalian translation initiation factor 6 does not function as a translation initiation factor. Mol. Cell. Biol. 19, 1416\u20131426 (1999)","journal-title":"Mol. Cell. Biol."},{"key":"BFnature05841_CR19","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1083\/jcb.144.5.823","volume":"14","author":"F Sanvito","year":"1999","unstructured":"Sanvito, F. et al. The B4 integrin interactor p27BBP\/eIF6 is an essential nuclear matrix protein involved in 60S ribosomal subunit assembly. J. Cell Biol. 14, 823\u2013837 (1999)","journal-title":"J. Cell Biol."},{"key":"BFnature05841_CR20","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.cell.2005.07.031","volume":"122","author":"S Bagga","year":"2005","unstructured":"Bagga, S. et al. Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell 122, 553\u2013563 (2005)","journal-title":"Cell"},{"key":"BFnature05841_CR21","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","volume":"75","author":"RC Lee","year":"1993","unstructured":"Lee, R. C., Feinbaum, R. L. & Ambros, V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75, 843\u2013854 (1993)","journal-title":"Cell"},{"key":"BFnature05841_CR22","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/0092-8674(93)90530-4","volume":"75","author":"B Wightman","year":"1993","unstructured":"Wightman, B., Ha, I. & Ruvkun, G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75, 855\u2013862 (1993)","journal-title":"Cell"},{"key":"BFnature05841_CR23","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/S0092-8674(00)81906-6","volume":"88","author":"EG Moss","year":"1997","unstructured":"Moss, E. G., Lee, R. C. & Ambros, V. The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA. Cell 88, 637\u2013646 (1997)","journal-title":"Cell"},{"key":"BFnature05841_CR24","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1006\/dbio.2001.0563","volume":"243","author":"K Seggerson","year":"2002","unstructured":"Seggerson, K., Tang, L. & Moss, E. G. Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation. Dev. Biol. 243, 215\u2013225 (2002)","journal-title":"Dev. Biol."},{"key":"BFnature05841_CR25","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1101\/gad.5.10.1825","volume":"5","author":"P Arasu","year":"1991","unstructured":"Arasu, P., Wightman, B. & Ruvkun, G. Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28. Genes Dev. 5, 1825\u20131833 (1991)","journal-title":"Genes Dev."},{"key":"BFnature05841_CR26","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1038\/35002607","volume":"403","author":"BJ Reinhart","year":"2000","unstructured":"Reinhart, B. J. et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403, 901\u2013906 (2000)","journal-title":"Nature"},{"key":"BFnature05841_CR27","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1006\/dbio.1999.9272","volume":"210","author":"R Feinbaum","year":"1999","unstructured":"Feinbaum, R. & Ambros, V. The timing of lin-4 RNA accumulation controls the timing of postembryonic developmental events in Caenorhabditis elegans. Dev. Biol. 210, 87\u201395 (1999)","journal-title":"Dev. Biol."},{"key":"BFnature05841_CR28","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0092-8674(01)00431-7","volume":"106","author":"A Grishok","year":"2001","unstructured":"Grishok, A. et al. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 106, 23\u201334 (2001)","journal-title":"Cell"},{"key":"BFnature05841_CR29","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0092-8674(04)00258-2","volume":"117","author":"JW Pham","year":"2004","unstructured":"Pham, J. W., Pellino, J. L., Lee, Y. S., Carthew, R. W. & Sontheimer, E. J. A. Dicer-2-dependent 80S complex cleaves targeted mRNAs during RNAi in Drosophila. Cell 117, 83\u201394 (2004)","journal-title":"Cell"},{"key":"BFnature05841_CR30","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1126\/science.1115079","volume":"309","author":"RS Pillai","year":"2005","unstructured":"Pillai, R. S. et al. Inhibition of translational initiation by Let-7 microRNA in human cells. Science 309, 1573\u20131576 (2005)","journal-title":"Science"},{"key":"BFnature05841_CR31","doi-asserted-by":"publisher","first-page":"16961","DOI":"10.1073\/pnas.0506482102","volume":"102","author":"DT Humphreys","year":"2005","unstructured":"Humphreys, D. T., Westman, B. J., Martin, D. I. & Preiss, T. MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E\/cap and poly(A) tail function. Proc. Natl Acad. Sci. USA 102, 16961\u201316966 (2005)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature05841_CR32","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.molcel.2006.01.031","volume":"21","author":"CP Petersen","year":"2006","unstructured":"Petersen, C. P., Bordeleau, M. E., Pelletier, J. & Sharp, P. A. Short RNAs repress translation after initiation in mammalian cells. Mol. Cell 21, 533\u2013542 (2006)","journal-title":"Mol. Cell"},{"key":"BFnature05841_CR33","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nature01278","volume":"421","author":"RS Kamath","year":"2003","unstructured":"Kamath, R. S. et al. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421, 231\u2013237 (2003)","journal-title":"Nature"},{"key":"BFnature05841_CR34","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/genetics\/157.1.199","volume":"157","author":"BJ Reinhart","year":"2001","unstructured":"Reinhart, B. J. & Ruvkun, G. Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning. Genetics 157, 199\u2013209 (2001)","journal-title":"Genetics"},{"key":"BFnature05841_CR35","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1101\/gad.1184704","volume":"18","author":"M Kiriakidou","year":"2004","unstructured":"Kiriakidou, M. et al. A combined computational-experimental approach predicts human microRNA targets. Genes Dev. 18, 1165\u20131178 (2004)","journal-title":"Genes Dev."},{"key":"BFnature05841_CR36","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1128\/MCB.23.3.899-907.2003","volume":"23","author":"X Ji","year":"2003","unstructured":"Ji, X., Kong, J. & Liebhaber, S. A. In vivo association of the stability control protein \u03b1CP with actively translating mRNAs. Mol. Cell. Biol. 23, 899\u2013907 (2003)","journal-title":"Mol. Cell. Biol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature05841","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature05841.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature05841.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:04:46Z","timestamp":1684418686000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature05841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,16]]},"references-count":36,"journal-issue":{"issue":"7146","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["BFnature05841"],"URL":"https:\/\/doi.org\/10.1038\/nature05841","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1084937.542138","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,16]]}}}