{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T02:24:13Z","timestamp":1776219853000,"version":"3.50.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"7183","license":[{"start":{"date-parts":[[2008,3,6]],"date-time":"2008-03-06T00:00:00Z","timestamp":1204761600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2008,3,6]],"date-time":"2008-03-06T00:00:00Z","timestamp":1204761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2008,3,6]]},"DOI":"10.1038\/nature06544","type":"journal-article","created":{"date-parts":[[2008,3,5]],"date-time":"2008-03-05T16:55:11Z","timestamp":1204736111000},"page":"45-50","source":"Crossref","is-referenced-by-count":731,"title":["Cyclical DNA methylation of a transcriptionally active promoter"],"prefix":"10.1038","volume":"452","author":[{"given":"Rapha\u00ebl","family":"M\u00e9tivier","sequence":"first","affiliation":[]},{"given":"Rozenn","family":"Gallais","sequence":"additional","affiliation":[]},{"given":"Christophe","family":"Tiffoche","sequence":"additional","affiliation":[]},{"given":"Christine","family":"Le P\u00e9ron","sequence":"additional","affiliation":[]},{"given":"Renata Z.","family":"Jurkowska","sequence":"additional","affiliation":[]},{"given":"Richard P.","family":"Carmouche","sequence":"additional","affiliation":[]},{"given":"David","family":"Ibberson","sequence":"additional","affiliation":[]},{"given":"Peter","family":"Barath","sequence":"additional","affiliation":[]},{"given":"Florence","family":"Demay","sequence":"additional","affiliation":[]},{"given":"George","family":"Reid","sequence":"additional","affiliation":[]},{"given":"Vladimir","family":"Benes","sequence":"additional","affiliation":[]},{"given":"Albert","family":"Jeltsch","sequence":"additional","affiliation":[]},{"given":"Frank","family":"Gannon","sequence":"additional","affiliation":[]},{"given":"Gilles","family":"Salbert","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BFnature06544_CR1","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1146\/annurev.biochem.72.121801.161724","volume":"72","author":"DL Spector","year":"2003","unstructured":"Spector, D. L. The dynamics of chromosome organization and gene regulation. Annu. Rev. Biochem. 72, 573\u2013608 (2003)","journal-title":"Annu. Rev. Biochem."},{"key":"BFnature06544_CR2","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1101\/gad.1307205","volume":"19","author":"JM Casolari","year":"2005","unstructured":"Casolari, J. M., Brown, C. R., Drubin, D. A., Rando, O. J. & Silver, P. A. Developmentally induced changes in transcriptional program alter spatial organization across chromosomes. Genes Dev. 19, 1188\u20131198 (2005)","journal-title":"Genes Dev."},{"key":"BFnature06544_CR3","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/S0092-8674(04)00044-3","volume":"116","author":"S Khorasanizadeh","year":"2004","unstructured":"Khorasanizadeh, S. The nucleosome: from genomic organization to genomic regulation. Cell 116, 259\u2013272 (2004)","journal-title":"Cell"},{"key":"BFnature06544_CR4","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s10577-006-1027-8","volume":"14","author":"N Dillon","year":"2006","unstructured":"Dillon, N. Gene regulation and large-scale chromatin organization in the nucleus. Chromosome Res. 14, 117\u2013126 (2006)","journal-title":"Chromosome Res."},{"key":"BFnature06544_CR5","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.tibs.2005.12.008","volume":"31","author":"RJ Klose","year":"2006","unstructured":"Klose, R. J. & Bird, A. P. Genomic DNA methylation: the mark and its mediators. Trends Biochem. Sci. 31, 89\u201397 (2006)","journal-title":"Trends Biochem. Sci."},{"key":"BFnature06544_CR6","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/S0960-9822(00)00448-6","volume":"10","author":"J Oswald","year":"2000","unstructured":"Oswald, J. et al. Active demethylation of the paternal genome in the mouse zygote. Curr. Biol. 10, 475\u2013478 (2000)","journal-title":"Curr. Biol."},{"key":"BFnature06544_CR7","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1038\/sj.emboj.7601012","volume":"25","author":"A Murayama","year":"2006","unstructured":"Murayama, A. et al. A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory. EMBO J. 25, 1081\u20131092 (2006)","journal-title":"EMBO J."},{"key":"BFnature06544_CR8","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1101\/gad.12.14.2108","volume":"12","author":"N Rougier","year":"1998","unstructured":"Rougier, N. et al. Chromosome methylation patterns during mammalian preimplantation development. Genes Dev. 12, 2108\u20132113 (1998)","journal-title":"Genes Dev."},{"key":"BFnature06544_CR9","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1093\/emboj\/17.5.1446","volume":"17","author":"K Matsuo","year":"1998","unstructured":"Matsuo, K. et al. An embryonic demethylation mechanism involving binding of transcription factors to replicating DNA. EMBO J. 17, 1446\u20131453 (1998)","journal-title":"EMBO J."},{"key":"BFnature06544_CR10","doi-asserted-by":"publisher","first-page":"6853","DOI":"10.1073\/pnas.0601109103","volume":"103","author":"T Morales-Ruiz","year":"2006","unstructured":"Morales-Ruiz, T. et al. Demeter and Repressor of Silencing 1 encode 5-methylcytosine DNA glycosylases. Proc. Natl Acad. Sci. USA 103, 6853\u20136858 (2006)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature06544_CR11","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","volume":"128","author":"T Kouzarides","year":"2007","unstructured":"Kouzarides, T. Chromatin modifications and their function. Cell 128, 693\u2013705 (2007)","journal-title":"Cell"},{"key":"BFnature06544_CR12","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1146\/annurev.biochem.71.110601.135400","volume":"71","author":"PB Becker","year":"2002","unstructured":"Becker, P. B. & Horz, W. ATP-dependent nucleosome remodeling. Annu. Rev. Biochem. 71, 247\u2013273 (2002)","journal-title":"Annu. Rev. Biochem."},{"key":"BFnature06544_CR13","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/S0092-8674(00)00188-4","volume":"103","author":"Y Shang","year":"2000","unstructured":"Shang, Y., Hu, X., DiRenzo, J., Lazar, M. A. & Brown, M. Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 103, 843\u2013852 (2000)","journal-title":"Cell"},{"key":"BFnature06544_CR14","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/S0092-8674(03)00934-6","volume":"115","author":"R Metivier","year":"2003","unstructured":"Metivier, R. et al. Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell 115, 751\u2013763 (2003)","journal-title":"Cell"},{"key":"BFnature06544_CR15","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1242\/jcs.00247","volume":"116","author":"M Robinson-Rechavi","year":"2003","unstructured":"Robinson-Rechavi, M., Escriva Garcia, H. & Laudet, V. The nuclear receptor superfamily. J. Cell Sci. 116, 585\u2013586 (2003)","journal-title":"J. Cell Sci."},{"key":"BFnature06544_CR16","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/39645","volume":"389","author":"AM Brzozowski","year":"1997","unstructured":"Brzozowski, A. M. et al. Molecular basis of agonism and antagonism in the oestrogen receptor. Nature 389, 753\u2013758 (1997)","journal-title":"Nature"},{"key":"BFnature06544_CR17","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1101\/gad.13.15.1924","volume":"13","author":"Y Zhang","year":"1999","unstructured":"Zhang, Y. et al. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev. 13, 1924\u20131935 (1999)","journal-title":"Genes Dev."},{"key":"BFnature06544_CR18","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/ng1516","volume":"37","author":"KN Harikrishnan","year":"2005","unstructured":"Harikrishnan, K. N. et al. Brahma links the SWI\/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing. Nature Genet. 37, 254\u2013264 (2005)","journal-title":"Nature Genet."},{"key":"BFnature06544_CR19","doi-asserted-by":"publisher","first-page":"5483","DOI":"10.1038\/sj.onc.1205699","volume":"21","author":"JK Christman","year":"2002","unstructured":"Christman, J. K. 5-Azacytidine and 5-aza-2\u2032-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene 21, 5483\u20135495 (2002)","journal-title":"Oncogene"},{"key":"BFnature06544_CR20","doi-asserted-by":"publisher","first-page":"6305","DOI":"10.1158\/0008-5472.CAN-04-2957","volume":"65","author":"B Brueckner","year":"2005","unstructured":"Brueckner, B. et al. Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Res. 65, 6305\u20136311 (2005)","journal-title":"Cancer Res."},{"key":"BFnature06544_CR21","doi-asserted-by":"publisher","first-page":"6370","DOI":"10.1158\/0008-5472.CAN-06-0402","volume":"66","author":"D Sharma","year":"2006","unstructured":"Sharma, D., Saxena, N. K., Davidson, N. E. & Vertino, P. M. Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes. Cancer Res. 66, 6370\u20136378 (2006)","journal-title":"Cancer Res."},{"key":"BFnature06544_CR22","doi-asserted-by":"publisher","first-page":"3267","DOI":"10.1093\/nar\/24.16.3267","volume":"24","author":"JM Zingg","year":"1996","unstructured":"Zingg, J. M., Shen, J. C., Yang, A. S., Rapoport, H. & Jones, P. A. Methylation inhibitors can increase the rate of cytosine deamination by (cytosine-5)-DNA methyltransferase. Nucleic Acids Res. 24, 3267\u20133275 (1996)","journal-title":"Nucleic Acids Res."},{"key":"BFnature06544_CR23","doi-asserted-by":"publisher","first-page":"14611","DOI":"10.1021\/bi001610e","volume":"39","author":"AN Sharath","year":"2000","unstructured":"Sharath, A. N., Weinhold, E. & Bhagwat, A. S. Reviving a dead enzyme: cytosine deaminations promoted by an inactive DNA methyltransferase and an S-adenosylmethionine analogue. Biochemistry 39, 14611\u201314616 (2000)","journal-title":"Biochemistry"},{"key":"BFnature06544_CR24","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1074\/jbc.274.1.67","volume":"274","author":"TR Waters","year":"1999","unstructured":"Waters, T. R., Gallinari, P., Jiricny, J. & Swann, P. F. Human thymine DNA glycosylase binds to apurinic sites in DNA but is displaced by human apurinic endonuclease 1. J. Biol. Chem. 274, 67\u201374 (1999)","journal-title":"J. Biol. Chem."},{"key":"BFnature06544_CR25","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1093\/nar\/gkl1052","volume":"35","author":"YQ Li","year":"2007","unstructured":"Li, Y. Q., Zhou, P. Z., Zheng, X. D., Walsh, C. P. & Xu, G. L. Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair. Nucleic Acids Res. 35, 390\u2013400 (2007)","journal-title":"Nucleic Acids Res."},{"key":"BFnature06544_CR26","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1210\/me.2006-0490","volume":"21","author":"R Gallais","year":"2007","unstructured":"Gallais, R. et al. Deoxyribonucleic acid methyl transferases 3a and 3b associate with the nuclear orphan receptor COUP-TFI during gene activation. Mol. Endocrinol. 21, 2085\u20132098 (2007)","journal-title":"Mol. Endocrinol."},{"key":"BFnature06544_CR27","doi-asserted-by":"publisher","first-page":"5363","DOI":"10.1128\/MCB.19.8.5363","volume":"19","author":"H Endoh","year":"1999","unstructured":"Endoh, H. et al. Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha. Mol. Cell. Biol. 19, 5363\u20135372 (1999)","journal-title":"Mol. Cell. Biol."},{"key":"BFnature06544_CR28","doi-asserted-by":"publisher","first-page":"3245","DOI":"10.1093\/nar\/27.16.3245","volume":"27","author":"JP Jost","year":"1999","unstructured":"Jost, J. P. et al. A chicken embryo protein related to the mammalian DEAD box protein p68 is tightly associated with the highly purified protein-RNA complex of 5-MeC-DNA glycosylase. Nucleic Acids Res. 27, 3245\u20133252 (1999)","journal-title":"Nucleic Acids Res."},{"key":"BFnature06544_CR29","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1093\/jb\/mvg095","volume":"133","author":"I Suetake","year":"2003","unstructured":"Suetake, I., Miyazaki, J., Murakami, C., Takeshima, H. & Tajima, S. Distinct enzymatic properties of recombinant mouse DNA methyltransferases Dnmt3a and Dnmt3b. J. Biochem. 133, 737\u2013744 (2003)","journal-title":"J. Biochem."},{"key":"BFnature06544_CR30","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1677\/joe.1.07009","volume":"191","author":"A Fritah","year":"2006","unstructured":"Fritah, A., Redeuilh, G. & Sabbah, M. Molecular cloning and characterization of the human WISP-2\/CCN5 gene promoter reveal its upregulation by oestrogens. J. Endocrinol. 191, 613\u2013624 (2006)","journal-title":"J. Endocrinol."},{"key":"BFnature06544_CR31","doi-asserted-by":"publisher","first-page":"4981","DOI":"10.1046\/j.1432-1033.2002.03198.x","volume":"269","author":"M Fatemi","year":"2002","unstructured":"Fatemi, M., Hermann, A., Gowher, H. & Jeltsch, A. Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA. Eur. J. Biochem. 269, 4981\u20134984 (2002)","journal-title":"Eur. J. Biochem."},{"key":"BFnature06544_CR32","doi-asserted-by":"publisher","first-page":"38586","DOI":"10.1074\/jbc.M304286200","volume":"278","author":"D Chen","year":"2003","unstructured":"Chen, D. et al. T:G mismatch-specific thymine-DNA glycosylase potentiates transcription of estrogen-regulated genes through direct interaction with estrogen receptor alpha. J. Biol. Chem. 278, 38586\u201338592 (2003)","journal-title":"J. Biol. Chem."},{"key":"BFnature06544_CR33","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0014-5793(02)03166-6","volume":"527","author":"JP Jost","year":"2002","unstructured":"Jost, J. P., Thiry, S. & Siegmann, M. Estradiol receptor potentiates, in vitro, the activity of 5-methylcytosine DNA glycosylase. FEBS Lett. 527, 63\u201366 (2002)","journal-title":"FEBS Lett."},{"key":"BFnature06544_CR34","doi-asserted-by":"publisher","first-page":"5135","DOI":"10.1073\/pnas.100107597","volume":"97","author":"B Zhu","year":"2000","unstructured":"Zhu, B. et al. 5-methylcytosine-DNA glycosylase activity is present in a cloned G\/T mismatch DNA glycosylase associated with the chicken embryo DNA demethylation complex. Proc. Natl Acad. Sci. USA 97, 5135\u20135139 (2000)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature06544_CR35","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.gde.2005.08.002","volume":"15","author":"F Fuks","year":"2005","unstructured":"Fuks, F. DNA methylation and histone modifications: teaming up to silence genes. Curr. Opin. Genet. Dev. 15, 490\u2013495 (2005)","journal-title":"Curr. Opin. Genet. Dev."},{"key":"BFnature06544_CR36","doi-asserted-by":"publisher","first-page":"9901","DOI":"10.1074\/jbc.M511100200","volume":"281","author":"M Oka","year":"2006","unstructured":"Oka, M., Rodic, N., Graddy, J., Chang, L. J. & Terada, N. CpG sites preferentially methylated by Dnmt3a in vivo. J. Biol. Chem. 281, 9901\u20139908 (2006)","journal-title":"J. Biol. Chem."},{"key":"BFnature06544_CR37","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1093\/nar\/gkl1035","volume":"35","author":"F Li","year":"2007","unstructured":"Li, F. et al. Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes. Nucleic Acids Res. 35, 100\u2013112 (2007)","journal-title":"Nucleic Acids Res."},{"key":"BFnature06544_CR38","doi-asserted-by":"publisher","first-page":"7500","DOI":"10.1074\/jbc.M008234200","volume":"276","author":"M Lucarelli","year":"2001","unstructured":"Lucarelli, M., Fuso, A., Strom, R. & Scarpa, S. The dynamics of myogenin site-specific demethylation is strongly correlated with its expression and with muscle differentiation. J. Biol. Chem. 276, 7500\u20137506 (2001)","journal-title":"J. Biol. Chem."},{"key":"BFnature06544_CR39","doi-asserted-by":"publisher","first-page":"11112","DOI":"10.1073\/pnas.0601793103","volume":"103","author":"C Kress","year":"2006","unstructured":"Kress, C., Thomassin, H. & Grange, T. Active cytosine demethylation triggered by a nuclear receptor involves DNA strand breaks. Proc. Natl Acad. Sci. USA 103, 11112\u201311117 (2006)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature06544_CR40","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nature05515","volume":"445","author":"G Barreto","year":"2007","unstructured":"Barreto, G. et al. Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature 445, 671\u2013675 (2007)","journal-title":"Nature"},{"key":"BFnature06544_CR41","doi-asserted-by":"crossref","first-page":"7893","DOI":"10.1016\/S0021-9258(17)37135-1","volume":"269","author":"F Leteurtre","year":"1994","unstructured":"Leteurtre, F. et al. Effects of DNA methylation on topoisomerase I and II cleavage activities. J. Biol. Chem. 269, 7893\u20137900 (1994)","journal-title":"J. Biol. Chem."},{"key":"BFnature06544_CR42","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1126\/science.1127196","volume":"312","author":"BG Ju","year":"2006","unstructured":"Ju, B. G. et al. A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. Science 312, 1798\u20131802 (2006)","journal-title":"Science"},{"key":"BFnature06544_CR43","doi-asserted-by":"publisher","first-page":"3739","DOI":"10.1093\/nar\/24.19.3739","volume":"24","author":"GM Lamm","year":"1996","unstructured":"Lamm, G. M., Nicol, S. M., Fuller-Pace, F. V. & Lamond, A. I. p72: a human nuclear DEAD box protein highly related to p68. Nucleic Acids Res. 24, 3739\u20133947 (1996)","journal-title":"Nucleic Acids Res."},{"key":"BFnature06544_CR44","doi-asserted-by":"publisher","first-page":"13341","DOI":"10.1074\/jbc.M413412200","volume":"280","author":"H Gowher","year":"2005","unstructured":"Gowher, H., Liebert, K., Hermann, A., Xu, G. & Jeltsch, A. Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L. J. Biol. Chem. 280, 13341\u201313348 (2005)","journal-title":"J. Biol. Chem."},{"key":"BFnature06544_CR45","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1016\/j.jmb.2006.01.035","volume":"357","author":"H Gowher","year":"2006","unstructured":"Gowher, H. et al. Mutational analysis of the catalytic domain of the murine Dnmt3a DNA-(cytosine C5)-methyltransferase. J. Mol. Biol. 357, 928\u2013941 (2006)","journal-title":"J. Mol. Biol."},{"key":"BFnature06544_CR46","doi-asserted-by":"publisher","first-page":"3653","DOI":"10.1038\/sj.emboj.7600377","volume":"23","author":"R Metivier","year":"2004","unstructured":"Metivier, R. et al. Transcriptional complexes engaged by apo-oestrogen receptor-alpha isoforms have divergent outcomes. EMBO J. 23, 3653\u20133666 (2004)","journal-title":"EMBO J."},{"key":"BFnature06544_CR47","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/0003-2697(92)90523-A","volume":"207","author":"JE Nelson","year":"1992","unstructured":"Nelson, J. E. & Krawetz, S. A. Purification of cloned and genomic DNA by guanidine thiocyanate\/isobutyl alcohol fractionation. Anal. Biochem. 207, 197\u2013201 (1992)","journal-title":"Anal. Biochem."}],"updated-by":[{"DOI":"10.1038\/nature08661","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2010,1,21]],"date-time":"2010-01-21T00:00:00Z","timestamp":1264032000000}}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature06544.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature06544","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature06544.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:13:03Z","timestamp":1684419183000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature06544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,6]]},"references-count":47,"journal-issue":{"issue":"7183","published-print":{"date-parts":[[2008,3,6]]}},"alternative-id":["BFnature06544"],"URL":"https:\/\/doi.org\/10.1038\/nature06544","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1103825.560393","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1103825.560596","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1103825.559953","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,6]]}}}