{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:46:14Z","timestamp":1771476374819,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"7254","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1038\/nature08150","type":"journal-article","created":{"date-parts":[[2009,7,6]],"date-time":"2009-07-06T08:43:34Z","timestamp":1246869814000},"page":"510-514","source":"Crossref","is-referenced-by-count":134,"title":["Partial penetrance facilitates developmental evolution in bacteria"],"prefix":"10.1038","volume":"460","author":[{"given":"Avigdor","family":"Eldar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasant K.","family":"Chary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Xenopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle E.","family":"Fontes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver C.","family":"Los\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Dworkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick J.","family":"Piggot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Elowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,7,5]]},"reference":[{"key":"BFnature08150_CR1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/genetics\/96.2.435","volume":"96","author":"HR Horvitz","year":"1980","unstructured":"Horvitz, H. R. & Sulston, J. E. Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans . Genetics 96, 435\u2013454 (1980)","journal-title":"Genetics"},{"key":"BFnature08150_CR2","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1038\/nature749","volume":"417","author":"C Queitsch","year":"2002","unstructured":"Queitsch, C., Sangster, T. A. & Lindquist, S. Hsp90 as a capacitor of phenotypic variation. Nature 417, 618\u2013624 (2002)","journal-title":"Nature"},{"key":"BFnature08150_CR3","doi-asserted-by":"publisher","first-page":"2963","DOI":"10.1073\/pnas.0712200105","volume":"105","author":"TA Sangster","year":"2008","unstructured":"Sangster, T. A. et al. HSP90 affects the expression of genetic variation and developmental stability in quantitative traits. Proc. Natl Acad. Sci. USA 105, 2963\u20132968 (2008)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature08150_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1099\/00221287-71-1-1","volume":"71","author":"JG Coote","year":"1972","unstructured":"Coote, J. G. Sporulation in Bacillus subtilis. Characterization of oligosporogenous mutants and comparison of their phenotypes with those of asporogenous mutants. J. Gen. Microbiol. 71, 1\u201315 (1972)","journal-title":"J. Gen. Microbiol."},{"key":"BFnature08150_CR5","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/ng0103-6","volume":"33","author":"SL Rutherford","year":"2003","unstructured":"Rutherford, S. L. & Henikoff, S. Quantitative epigenetics. Nature Genet. 33, 6\u20138 (2003)","journal-title":"Nature Genet."},{"key":"BFnature08150_CR6","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/sj.hdy.6800915","volume":"100","author":"MA Felix","year":"2008","unstructured":"Felix, M. A. & Wagner, A. Robustness and evolution: concepts, insights and challenges from a developmental model system. Heredity 100, 132\u2013140 (2008)","journal-title":"Heredity"},{"key":"BFnature08150_CR7","doi-asserted-by":"publisher","first-page":"6543","DOI":"10.1073\/pnas.0501844102","volume":"102","author":"MJ West-Eberhard","year":"2005","unstructured":"West-Eberhard, M. J. Developmental plasticity and the origin of species differences. Proc. Natl Acad. Sci. USA 102 (suppl. 1). 6543\u20136549 (2005)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature08150_CR8","first-page":"71","volume-title":"The Plausibility of Life: Resolving Darwin\u2019s Dilemma","author":"M Kirschner","year":"2005","unstructured":"Kirschner, M. & Gerhart, J. The Plausibility of Life: Resolving Darwin\u2019s Dilemma 71\u2013108 (Yale Univ. Press, 2005)"},{"key":"BFnature08150_CR9","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1128\/JB.103.3.811-813.1970","volume":"103","author":"LD Smith","year":"1970","unstructured":"Smith, L. D. Clostridium oceanicum, sp. n., a sporeforming anaerobe isolated from marine sediments. J. Bacteriol. 103, 811\u2013813 (1970)","journal-title":"J. Bacteriol."},{"key":"BFnature08150_CR10","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/nrmicro1096","volume":"3","author":"ER Angert","year":"2005","unstructured":"Angert, E. R. Alternatives to binary fission in bacteria. Nature Rev. Microbiol. 3, 214\u2013224 (2005)","journal-title":"Nature Rev. Microbiol."},{"key":"BFnature08150_CR11","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1128\/MMBR.68.2.234-262.2004","volume":"68","author":"DW Hilbert","year":"2004","unstructured":"Hilbert, D. W. & Piggot, P. J. Compartmentalization of gene expression during Bacillus subtilis spore formation. Microbiol. Mol. Biol. Rev. 68, 234\u2013262 (2004)","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"BFnature08150_CR12","doi-asserted-by":"publisher","first-page":"4425","DOI":"10.1128\/JB.182.16.4425-4429.2000","volume":"182","author":"A Khvorova","year":"2000","unstructured":"Khvorova, A., Chary, V. K., Hilbert, D. W. & Piggot, P. J. The chromosomal location of the Bacillus subtilis sporulation gene spoIIR is important for its function. J. Bacteriol. 182, 4425\u20134429 (2000)","journal-title":"J. Bacteriol."},{"key":"BFnature08150_CR13","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1046\/j.1365-2958.2001.02331.x","volume":"39","author":"ML Zupancic","year":"2001","unstructured":"Zupancic, M. L., Tran, H. & Hofmeister, A. E. Chromosomal organization governs the timing of cell type-specific gene expression required for spore formation in Bacillus subtilis . Mol. Microbiol. 39, 1471\u20131481 (2001)","journal-title":"Mol. Microbiol."},{"key":"BFnature08150_CR14","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1128\/MMBR.40.4.908-962.1976","volume":"40","author":"PJ Piggot","year":"1976","unstructured":"Piggot, P. J. & Coote, J. G. Genetic aspects of bacterial endospore formation. Bacteriol. Rev. 40, 908\u2013962 (1976)","journal-title":"Bacteriol. Rev."},{"key":"BFnature08150_CR15","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1073\/pnas.92.6.2012","volume":"92","author":"ML Karow","year":"1995","unstructured":"Karow, M. L., Glaser, P. & Piggot, P. J. Identification of a gene, spoIIR, that links the activation of sigma E to the transcriptional activity of sigma F during sporulation in Bacillus subtilis . Proc. Natl Acad. Sci. USA 92, 2012\u20132016 (1995)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature08150_CR16","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1046\/j.1365-2958.2001.02660.x","volume":"42","author":"P Eichenberger","year":"2001","unstructured":"Eichenberger, P., Fawcett, P. & Losick, R. A three-protein inhibitor of polar septation during sporulation in Bacillus subtilis . Mol. Microbiol. 42, 1147\u20131162 (2001)","journal-title":"Mol. Microbiol."},{"key":"BFnature08150_CR17","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1046\/j.1365-2958.1999.01255.x","volume":"31","author":"J Pogliano","year":"1999","unstructured":"Pogliano, J. et al. A vital stain for studying membrane dynamics in bacteria: a novel mechanism controlling septation during Bacillus subtilis sporulation. Mol. Microbiol. 31, 1149\u20131159 (1999)","journal-title":"Mol. Microbiol."},{"key":"BFnature08150_CR18","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.cell.2005.02.032","volume":"121","author":"J Dworkin","year":"2005","unstructured":"Dworkin, J. & Losick, R. Developmental commitment in a bacterium. Cell 121, 401\u2013409 (2005)","journal-title":"Cell"},{"key":"BFnature08150_CR19","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1038\/nrmicro1288","volume":"3","author":"CJ Paredes","year":"2005","unstructured":"Paredes, C. J., Alsaker, K. V. & Papoutsakis, E. T. A comparative genomic view of clostridial sporulation and physiology. Nature Rev. Microbiol. 3, 969\u2013978 (2005)","journal-title":"Nature Rev. Microbiol."},{"key":"BFnature08150_CR20","doi-asserted-by":"publisher","first-page":"10218","DOI":"10.1073\/pnas.95.17.10218","volume":"95","author":"ER Angert","year":"1998","unstructured":"Angert, E. R. & Losick, R. M. Propagation by sporulation in the guinea pig symbiont Metabacterium polyspora . Proc. Natl Acad. Sci. USA 95, 10218\u201310223 (1998)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature08150_CR21","doi-asserted-by":"publisher","first-page":"14089","DOI":"10.1073\/pnas.182539899","volume":"99","author":"J Dworkin","year":"2002","unstructured":"Dworkin, J. & Losick, R. Does RNA polymerase help drive chromosome segregation in bacteria? Proc. Natl Acad. Sci. USA 99, 14089\u201314094 (2002)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature08150_CR22","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1128\/JB.185.4.1326-1337.2003","volume":"185","author":"PS Lee","year":"2003","unstructured":"Lee, P. S., Lin, D. C., Moriya, S. & Grossman, A. D. Effects of the chromosome partitioning protein Spo0J (ParB) on oriC positioning and replication initiation in Bacillus subtilis . J. Bacteriol. 185, 1326\u20131337 (2003)","journal-title":"J. Bacteriol."},{"key":"BFnature08150_CR23","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0092-8674(02)00698-0","volume":"109","author":"S Ben-Yehuda","year":"2002","unstructured":"Ben-Yehuda, S. & Losick, R. Asymmetric cell division in B. subtilis involves a spiral-like intermediate of the cytokinetic protein FtsZ. Cell 109, 257\u2013266 (2002)","journal-title":"Cell"},{"key":"BFnature08150_CR24","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.1073\/pnas.0506914103","volume":"103","author":"MF Noirot-Gros","year":"2006","unstructured":"Noirot-Gros, M. F. et al. Functional dissection of YabA, a negative regulator of DNA replication initiation in Bacillus subtilis . Proc. Natl Acad. Sci. USA 103, 2368\u20132373 (2006)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature08150_CR25","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1099\/00207713-51-6-2095","volume":"51","author":"S Keis","year":"2001","unstructured":"Keis, S., Shaheen, R. & Jones, D. T. Emended descriptions of Clostridium acetobutylicum and Clostridium beijerinckii, and descriptions of Clostridium saccharoperbutylacetonicum sp. nov. and Clostridium saccharobutylicum sp. nov. Int. J. Syst. Evol. Microbiol. 51, 2095\u20132103 (2001)","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"BFnature08150_CR26","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/150563a0","volume":"150","author":"CH Waddington","year":"1942","unstructured":"Waddington, C. H. Canalization of development and the inheritance of acquired characters. Nature 150, 563\u2013565 (1942)","journal-title":"Nature"},{"key":"BFnature08150_CR27","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1080\/10409230701597782","volume":"42","author":"S Rutherford","year":"2007","unstructured":"Rutherford, S., Hirate, Y. & Swalla, B. J. The Hsp90 capacitor, developmental remodeling, and evolution: the robustness of gene networks and the curious evolvability of metamorphosis. Crit. Rev. Biochem. Mol. Biol. 42, 355\u2013372 (2007)","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"BFnature08150_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0147-619X(84)90061-1","volume":"12","author":"P Youngman","year":"1984","unstructured":"Youngman, P., Perkins, J. B. & Losick, R. Construction of a cloning site near one end of Tn917 into which foreign DNA may be inserted without affecting transposition in Bacillus subtilis or expression of the transposon-borne erm gene. Plasmid 12, 1\u20139 (1984)","journal-title":"Plasmid"},{"key":"BFnature08150_CR29","volume-title":"Molecular Biological Methods for Bacillus","author":"CR Harwood","year":"1990","unstructured":"Harwood, C. R. & Cutting, S. M. Molecular Biological Methods for Bacillus (Wiley, 1990)"},{"key":"BFnature08150_CR30","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1126\/science.1106914","volume":"307","author":"N Rosenfeld","year":"2005","unstructured":"Rosenfeld, N., Young, J. W., Alon, U., Swain, P. S. & Elowitz, M. B. Gene regulation at the single-cell level. Science 307, 1962\u20131965 (2005)","journal-title":"Science"},{"key":"BFnature08150_CR31","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/nature04588","volume":"440","author":"GM Suel","year":"2006","unstructured":"Suel, G. M., Garcia-Ojalvo, J., Liberman, L. M. & Elowitz, M. B. An excitable gene regulatory circuit induces transient cellular differentiation. Nature 440, 545\u2013550 (2006)","journal-title":"Nature"},{"key":"BFnature08150_CR32","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1126\/science.1137455","volume":"315","author":"GM Suel","year":"2007","unstructured":"Suel, G. M., Kulkarni, R. P., Dworkin, J., Garcia-Ojalvo, J. & Elowitz, M. B. Tunability and noise dependence in differentiation dynamics. Science 315, 1716\u20131719 (2007)","journal-title":"Science"},{"key":"BFnature08150_CR33","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1111\/j.1365-2958.2007.05992.x","volume":"66","author":"EC Becker","year":"2007","unstructured":"Becker, E. C. & Pogliano, K. Cell-specific SpoIIIE assembly and DNA translocation polarity are dictated by chromosome orientation. Mol. Microbiol. 66, 1066\u20131079 (2007)","journal-title":"Mol. Microbiol."},{"key":"BFnature08150_CR34","doi-asserted-by":"publisher","first-page":"6983","DOI":"10.1128\/JB.00722-08","volume":"190","author":"DR Zeigler","year":"2008","unstructured":"Zeigler, D. R. et al. The origins of 168, W23, and other Bacillus subtilis legacy strains. J. Bacteriol. 190, 6983\u20136995 (2008)","journal-title":"J. Bacteriol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature08150.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature08150","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature08150.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:25:42Z","timestamp":1684434342000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature08150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":34,"journal-issue":{"issue":"7254","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["BFnature08150"],"URL":"https:\/\/doi.org\/10.1038\/nature08150","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}